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Effects of variant UDP-glucuronosyltransferase 1A1 gene, glucose-6-phosphate dehydrogenase deficiency and thalassemia on cholelithiasis

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World Journal of Gastroenterology 2005年第36期11卷 5710-5713页

作者： Yang-Yang huang ching-shui huang Sien-Sing Yang Min-Shung Lin May-Jen huang ching-Shan huang Department of LaboratoryMedicine Cathay General Hospital Taipei Taiwan China Department of General Surgery Cathay GeneralHospital Taipei Taiwan China Department of Liver Unit Cathay GeneralHospital Taipei Taiwan China Department of Family Medicine Cathay General Hospital Taipei Taiwan China Department of Medical Technology FooyinUniversity Kaohsiung Taiwan China

AIM： To test the hypothesis that the variant UDP- glucuronosyltransferase 1A1 （UGT1A1） gene, glucose-6- phosphate dehydrogenase （G6PD） deficiency, and thalassemia influence bilirubin metabolism and play a role in the development of cholelithiasis. METHODS： A total of 372 Taiwan Chinese with cholelithiasis who had undergone cholecystectomy and 293 healthy individuals were divided into case and control groups, respectively. PCR and restriction fragment length polymorphism were used to analyze the promoter area and nucleotides 211, 686, 1 091, and 1 456 of the UGT1A1 gene for all subjects and the gene variants for thalassemia and G6PD deficiency. RESULTS： Variation frequencies for the cholelithiasis patients were 16.1%, 25.8%, 5.4%, and 4.3% for A（TA）6 TAA/A（TA）TTAA （6/7）, heterozygosity within the coding region, compound heterozygosity, and homozygosity of the UGT1A1 gene, respectively. Comparing the case and control groups, a statistically significant difference in frequency was demonstrated for the homozygous variation of the UGT1A1 gene （P = 0.012, Z2 test）, but not for the other variations. Further, no difference was demonstrated in a between-group comparison of the incidence of G6PD deficiency and thalassemia （2.7% vs 2.4% and 5.1% vs 5.1%, respectively）. The bilirubin levels for the cholelithiasis patients with the homozygous variant-UGT1A1 gene were significantly different from the control analog （18.0±6.5 and 12.7±2.9 μmol/L, respectively; P〈0.001, Student＇s ttest）.CONCLUSION： Our results show that the homozygous variation in the UGT1A1 gene is a risk factor for the development of cholelithiasis in Taiwan Chinese. 2005 The WJG Press and Elsevier Inc. All rights reserved

关键词： UGT1A1 gene, G6PD deficiency Thalassemia Cholelithiasis

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Features of Glucose Metabolism in Pleomorphic Hyalinizing Angiectatic Tumor (PHAT)

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Advances in Molecular Imaging 2014年第1期4卷 11-13页

作者： Po-Jui Chang Cher-Wei Liang ching-Huei Kung ching-shui huang Chung-Huei Hsu Department of Nuclear Medicine Taipei Medical University Hospital Taipei Taiwan Department of Pathology Cathay General Hospital Taipei Taiwan Department of Radiology Taipei Medical University Hospital Taipei Taiwan Department of Surgery Cathay General Hospital Taipei Taiwan

Pleomorphic Hyalinizing Angiectatic Tumor (PHAT) is a rare mesenchymal neoplasma. It is a pathological term describing a heterogeneous group of neoplasms of undetermined tumorigenesis and undefined malignancy. Based only on the morphological findings of histopathology, the biological potential of the tumor is indeterminate. Determination of glucose metabolism using FDG-PET revealed mildly increased FDG uptake in the tumor. We propose that FDG accumulation in the ectatic vessel, increased uptake of the pleomorphic cells and/or associated inflammatory cells, and increased permeability of the stroma lead to the imaging feature.

关键词： PHAT FDG-PET Sarcoma

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Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： Zhao-Jun Zhang Wen-Wei Wang Jing-shui Zhen Bo-Cheng Li De-Cheng Cai Yang-Yang Du Hui huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

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我国人才发展治理体系的特征、逻辑基础与发展路向

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三峡大学学报（人文社会科学版） 2025年第1期47卷 88-95页

作者：吴凡黄焕水广西大学公共管理学院广西南宁530004

人才发展治理体系是国家治理体系现代化的重要组成部分,是国家创新驱动和社会进步实现的驱动力。人才发展治理体系就是要从系统论角度,以国家战略、社会经济发展和人才可持续发展为目标,对人才资源进行全方位、全周期的管理与开发的综... 详细信息

人才发展治理体系是国家治理体系现代化的重要组成部分,是国家创新驱动和社会进步实现的驱动力。人才发展治理体系就是要从系统论角度,以国家战略、社会经济发展和人才可持续发展为目标,对人才资源进行全方位、全周期的管理与开发的综合性制度体系。梳理了我国人才发展治理体系发展的四个阶段,总结出我国人才发展治理体系的法制化、市场化、社会化、国际性、包容性五个特征,揭示我国人才发展治理体系运行的逻辑基础(即坚持党管人才、坚持本土化战略、遵循市场规律和坚持以人为本四个原则)。基于此,提出通过强化顶层设计、深化数字赋能以及加强人文关怀等对策建议,旨在构建符合中国国情的人才发展治理体系,为实现中华民族伟大复兴提供坚实的人才支撑。

关键词：人才发展治理体系治理特征治理逻辑发展路向

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甲烷在ZnO表面反应制合成气的微观机理研究

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原子与分子物理学报 2025年第6期42卷 1-9页

作者：黄琼谊楼波丁佳欣王水安华南理工大学电力学院广州510640

利用密度泛函(DFT)和过渡态理论对甲烷分子在ZnO表面的微观反应过程进行第一性原理研究,通过建立ZnO表面的吸附模型,计算了吸附能、过渡态参数和态密度,探讨了甲烷分子在氧化锌晶体表面H解离以及H_(2)和CO的生成过程,结果表明:CH_(4)在Z... 详细信息

利用密度泛函(DFT)和过渡态理论对甲烷分子在ZnO表面的微观反应过程进行第一性原理研究,通过建立ZnO表面的吸附模型,计算了吸附能、过渡态参数和态密度,探讨了甲烷分子在氧化锌晶体表面H解离以及H_(2)和CO的生成过程,结果表明:CH_(4)在ZnO(010)表面的最佳吸附位点为Zn位,吸附能为-4.65 kcal/mol,甲烷在氧化锌ZnO(010)面四次解离H(反应动力学上最有利路径)所需克服的能垒分别为38.6 kcal/mol、90.8 kcal/mol、53.2 kcal/mol和35.8 kcal/mol,其中甲烷第二次解离H_(2)过程能垒最高,是反应过程的决速步,降低该基元反应的活化能是关键,而-OH的形成抑制了-CH_(3)的解离.氧空位的形成增加活性位点的数量与提高位点的活性.甲烷与氧化锌表面的反应有两次H_(2)生成反应,第一次生成H_(2)的反应难度较大.

关键词：化学链重整甲烷反应机理密度泛函理论过渡态

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Simulation of Random Waves and Associated Laminar Bottom Shear Stresses

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China Ocean Engineering 2008年第3期22卷 477-490页

作者： ching-Jer huang Department of Hydraulic and Ocean Engineering National Cheng Kung University

This work presents a new approach for simulating the random waves in viscous fluids and the associated bottom shear stresses. By generating the incident random waves in a numerical wave flume and solving the unsteady two-dimensional Navier-Stokes equations and the fully nonlinear free surface boundaiy conditions for the fluid flows in the flume, the viscous flows and laminar bottom shear stresses induced by random waves axe determined. The deterministic spectral amplitude method implemented by use of the fast Fourier transform algorithm was adopted to generate the incident random waves. The accuracy of the numerical scheme is confirmed by comparing the predicted wave spectrum with the target spectrum and by comparing the nanlerical transfer function between the shear stress and the surface elevation with the theoretical transfer function. The maximum bottom shear stress caused by random waves, computed by this wave model, is compared with that obtained by Myrhaug＇ s model （1995）. The transfer function method is also employed to determine the maximum shear stress, and is proved accurate.

关键词： random waves laminar bottom shear stresses spectra Coda- JONSWAP spectral density transfer function Navier-Stokes equations boundary-layer flows

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Influence of rolling temperature on the interfaces and mechanical performance of graphene-reinforced aluminum-matrix composites

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International Journal of Minerals,Metallurgy and Materials 2019年第6期26卷 752-759页

作者： Chen-yang huang shui-ping Hu Kai Chen Institute of Engineering Technology University of Science and Technology BeijingBeijing 100083China School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China

To study the influence of rolling on the interfaces and mechanical performance of graphene-reinforced Al-matrix composites,a rolling method was used to process *** scanning electron microscopy(SEM),transmission electron microscopy(TEM),X-ray diffraction(XRD),Raman spectroscopy,and tensile testing,this study analyzed the micromorphology,interfaces,and mechanical performance of the composites before and after *** experimental results demonstrates that the composites after hot rolling has uniform structures with strong interfacial *** an increase in rolling temperature,the tensile strength and elastic modulus of the composites gradually ***,when the rolling temperature is higher than 500°C,granular and rod-like Al4C3 phases are observed at the interfaces and the mechanical performance of the composites is *** the rolling temperature is 480°C,the composites show the optimal comprehensive mechanical performance,with a tensile strength and elastic modulus of 403.3 MPa and 77.6 GPa,respectively,which represent increases of 31.6%and 36.9%,respectively,compared with the corresponding values prior to rolling.

关键词： rolling graphene composite interface mechanical performance

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Lipid Is Moving to the Forefront of Bio-Medical Research

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Journal of Genetics and Genomics 2014年第5期41卷 229-230页

作者： Guanghou shui Xun huang State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of Sciences

While conventionally perceived as major components of cellular membranes and lipid droplets （LDs）, lipids have now emerged as key players with distinctive roles involving in a wide range of biological processes such as signaling events, trafficking, and compartmentalization of macromolecules. One of the key concerns in lipid research is its homeostasis, which is fundamental to health maintenance of cells, living organisms and human beings. It is evident now that deregulated lipid metabolism plays very important roles in many human diseases such as type 2 diabetes, cardiovascular diseases, Alzheimer＇s disease （AD）, Parkinson＇s disease, cancer and infectious diseases （Lam and shui, 2013）.

关键词： In Lipid Is Moving to the Forefront of Bio-Medical Research

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Dry ball milling and wet ball milling for fabricating copper-yttria composites

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Rare Metals 2018年第10期37卷 859-867页

作者： Fei huang Hang Wang Jin-shui Chen Bin Yang School of Materials Science and Engineering Jiangxi University of Science and Technology Ganzhou 341000 China Editorial Office Nonferrous Metals of Science and EngineeringJiangxi University of Science and Technology Ganzhou 341000China Institute of Engineering Research Jiangxi University of Scienceand Technology Ganzhou 341000 China

Yttria-reinforced copper matrix composites were prepared by dry ball milling （DBM） and wet ball milling （WBM）, respectively, followed by spark plasma sintering （SPS）. It is to determine which milling process is better for fabricating Cu-Y2O3 composites. It is found that Cu-Y2O3 composites synthesized by DBM exhibit better densification, mechanical and electrical properties than those by WBM. Less agglomeration of reinforcements in the bulk composites by DBM is responsible for the better perfor- mances. To further understand the reason of less agglomeration of Y2O3 in the bulks by DBM, morphologies of prepared powders were investigated and analyzed. Higher ball＇s impact energy and the formation of copper oxide on the matrix surface during DBM process contribute to small matrix particles, which is beneficial for less agglomeration.

关键词： Cu-Y2O3 composites Dry ball milling Wet ball milling Spark plasma sintering Morphology

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Tuning active sites in MoS_(2)-based catalysts via H_(2)O_(2)etching to enhance hydrodesulfurization performance

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Petroleum Science 2023年第6期20卷 3875-3886页

作者： shui-Sen He Ting-Ting huang Chao Chen Yu Fan State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China State Key Laboratory Base for Eco-Chemical Engineering in College of Chemical Engineering Qingdao University of Science and TechnologyZhengzhou Road 53Qingdao266042ShandongChina

A H_(2)O_(2)etching strategy was adopted to introduce coordinatively unsaturated sites(CUS)on MoS_(2)-based catalysts for dibenzothiophene(DBT)hydrodesulfurization(HDS).The CUS concentrations on MoS_(2) slabs were finely regulated by changing the concentrations of H_(2)O_(2)*** the increasing H_(2)O_(2)concentrations(0.1–0.3 mol/L),The CUS concentrations on MoS_(2) slabs increased ***,the high-concentration H_(2)O_(2)etching(0.5 mol/L)increased the MoOxSy and MoO_(3) contents on MoS_(2) slabs compared to etching with the H_(2)O_(2)concentration of 0.3 mol/L,which led to the less CUS concentration in the sulfided Mo–H-0.5 catalyst than in the sulfided Mo–H-0.3 catalyst.A microstructure-activity correlation indicated that the CUS introduced by H_(2)O_(2)etching on MoS_(2) slabs significantly enhanced DBT *** Co loadings were further introduced into Mo–H-0.3,which had the most CUS concentration,and the corresponding 0.2-CoMo catalyst with the highest CoMoS content(3.853 wt%)exhibited the highest reaction rate constant of 6.95×10^(−6)mol g^(−1)s^(−1)among these CoMo catalysts.

关键词： H_(2)O_(2)etching Coordinatively unsaturated site concentrations CoMoS Hydrodesulfurization

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