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Anti-oxidant and anti-inflammatory effects of hydrogenrich water alleviate ethanol-induced fatty liver in mice

World Journal of Gastroenterology 2017年第27期23卷 4920-4934页

作者： ching-pin lin Wen-Chen Chuang Fung-Jou Lu Chih-Yen Chen Institute of Biochemistry Microbiology and ImmunologyChung Shan Medical University Division of Gastroenterology Department of Internal MedicineChung Shan Medical University Hospital Institute of Medicine Chung Shan Medical University Division of Gastroenterology and Hepatology Department of MedicineTaipei Veterans General Hospital Faculty of Medicine National Yang-Ming University School of Medicine

AIM To investigate the effects of hydrogen-rich water(HRW) treatment on prevention of ethanol(Et OH)-induced early fatty liver in *** In vitro reduction of hydrogen peroxide by HRW was determined with a chemiluminescence system. Female mice were randomly divided into five groups: control,Et OH,Et OH + silymarin,Et OH + HRW and Et OH + silymarin + HRW. Each group was fed a Lieber-De Carli liquid diet containing Et OH or isocaloric maltose dextrin(control diet). Silymarin was used as a positive control to compare HRW efficacy against chronic Et OH-induced hepatotoxicity. HRW was freshly prepared and given at a dosage of 1.2 m L/mouse trice daily. Blood and liver tissue were collected after chronic-binge liquid-diet feeding for 12 *** The in vitro study showed that HRW directly scavenged hydrogen peroxide. The in vivo study showed that HRW increased expression of acyl ghrelin,which was correlated with food intake. HRW treatment significantly reduced Et OH-induced increases in serum alanine aminotransferase,aspartate aminotransferase,triglycerol and total cholesterol levels,hepatic lipid accumulation and inflammatory cytokines,including tumor necrosis factor-alpha(TNF-α) and interleukin(IL)-6. HRW attenuated malondialdehyde level,restored glutathione depletion and increased superoxide dismutase,glutathione peroxidase and catalase activities in the liver. Moreover,HRW reduced TNF-α and IL-6 levels but increased IL-10 and IL-22 *** HRW protects against chronic Et OH-induced liver injury,possibly by inducing acyl ghrelin to suppress the pro-inflammatory cytokines TNF-α and IL-6 and induce IL-10 and IL-22,thus activating antioxidant enzymes against oxidative stress.

关键词： Hydrogen Chronic plus binge Et OH feeding Antioxidant Protective cytokine Acyl ghrelin Female mice

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Fecal calprotectin correlated with endoscopic remission for Asian inflammatory bowel disease patients

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World Journal of Gastroenterology 2015年第48期21卷 13566-13573页

作者： Wei-Chen lin Jau-Min Wong Chien-Chih Tung ching-pin lin Jen-Wei Chou Horng-Yuan Wang Ming-Jium Shieh Chin-Hao Chang Heng-Hsiu Liu Shu-Chen Wei Division of Gastroenterology Department of internal MedicineMackay Memorial Hospital Departments of Internal Medicine National Taiwan University Hospital Integrated Diagnostics and Therapeutics National Taiwan University Hospital Division of Gastroenterology Department of internal MedicineChung Shan Medical University Hospital Division of Gastroenterology Department of internal MedicineChina Medical University Hospital Medical Research National Taiwan University Hospital Institute of Epidemiology and Preventive Medicine College of Public HealthNational Taiwan University

AIM: To evaluate the correlation between fecal calprotectin(f C), C-reactive protein(CRP), and endoscopic disease score in Asian inflammatory bowel disease(IBD) ***: Stool samples were collected and assessed for calprotectin levels by Quantum Blue Calprotectin High Range Rapid test. Crohn's disease endoscopic index of severity(CDEIS) and ulcerative colitis endoscopic index of severity(UCEIS) were used for endoscopic lesion scoring. RESULTS: A total of 88 IBD patients [36 patients with Crohn's disease(CD) and 52 with ulcerative colitis(UC)] were enrolled. For CD patients, f C correlated with CDEIS(r = 0.465, P = 0.005) and CRP(r = 0.528, P = 0.001). f C levels in UC patients correlated with UCEIS(r = 0.696, P < 0.0001) and CRP(r = 0.529, P = 0.0005). Calprotectin could predict endoscopic remission(CDEIS < 6) with 50% sensitivity and 100% specificity(AUC: 0.74) in CD patients when using 918 μg/g as the cutoff. When using 191 μg/g as the cut-off in UC patients, calprotectin could be used for predicting endoscopic remission(UCEIS < 3) with 88% sensitivity and 75% specificity(AUC: 0.87). CONCLUSION: f C correlated with both CDEIS and UCEIS. f C could be used as a predictor of endoscopic remission for Asian IBD patients.

关键词： Inflammatory bowel disease Endoscopicscore Fecal calprotectin Crohn's disease Ulcerativecolitis

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Assessment of highway slope failure using neural networks

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第1期10卷 101-108页

作者： Tsung-lin LEE Hung-ming lin Yuh-pin LU 1Department of Construction and Facility Management Department of Resource and Environment Leader University

An artificial intelligence technique of back-propagation neural networks is used to assess the slope ***-site slope failure data from the South Cross-Island Highway in southern Taiwan are used to test the performance of the neural network *** numerical results demonstrate the effectiveness of artificial neural networks in the evaluation of slope failure potential based on five major factors,such as the slope gradient angle,the slope height,the cumulative precipitation,daily rainfall and strength of materials.

关键词： Neural network Prediction Highway Slope failure

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Human Action Recognition Based on Dense Trajectories Analysis and Random Forest

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Journal of Electronic Science and Technology 2016年第4期14卷 370-376页

作者： pin-Zhong Pan Chung-lin Huang Sonix Technology HsinChu 30265HsinChu Department of M-Commerce and Multimedia Applications Asia UniversityTaichung 41354Taichung

This paper presents a human action recognition method. It analyzes the spatio-temporal grids along the dense trajectories and generates the histogram of oriented gradients （HOG） and histogram of optical flow （HOF） to describe the appearance and motion of the human object. Then, HOG combined with HOF is converted to bag-of-words （BoWs） by the vocabulary tree. Finally, it applies random forest to recognize the type of human action. In the experiments, KTH database and URADL database are tested for the performance evaluation. Comparing with the other approaches, we show that our approach has a better performance for the action videos with high inter-class and low inter-class variabilities.

关键词： Bag-of-words (BoWs) dense trajectories histogram of optical flow (HOF) histogram of oriented gradient (HOG) random forest vocabulary tree.

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Botulinum toxin injection for Cockayne syndrome with muscle spasticity over bilateral lower limbs:A case report

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World Journal of Clinical Cases 2021年第18期9卷 4728-4733页

作者： lin-Chieh Hsu Po-Ying Chiang Wei-pin lin Yao-Hong Guo Pei-Chun Hsieh Ta-Shen Kuan Wei-Chih Lien Yu-ching lin Department of Physical Medicine and Rehabilitation National Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainan 704Taiwan Department of Physical Medicine and Rehabilitation College of MedicineNational Cheng Kung UniversityTainan 704Taiwan Medical Device Innovation Center National Cheng Kung UniversityTainan 704Taiwan

BACKGROUND Cockayne syndrome(CS)is a rare inherited disease characterized by progressive motor symptoms including muscle weakness,joint contracture,ataxia,and *** neurotoxin type A has been used for conditions such as dystonia and spasticity,but it has rarely been used in patients with *** SUMMARY We report a 6-year-and-9-mo old girl diagnosed with CS who received an injection of botulinum neurotoxin type A to manage her difficulty with walking.A total dose of 210 units of botulinum neurotoxin type A was administered into the bilateral tibialis posterior and gastrocnemius *** evaluate the treatment effects on spasticity,joint contracture,pain,and ataxia,measurement tools including the Modified Ashworth Scale,the passive range of motion,the Faces Pain Scale-Revised,and the Scale for the Assessment and Rating of Ataxia,were *** first week after the injection,the Modified Ashworth Scale score for the plantar flexors and foot invertors improved bilaterally,along with advancements in the passive range of motion of the bilateral ankles and a lower score for the Faces Pain *** treatment effects persisted to the 8th week post-injection,but returned to baseline values at the 12th week post-injection,except for the pain *** Botulinum toxin injection can thus be considered as a treatment option for lower extremity spasticity,joint contracture,and pain derived from CS.

关键词： Cockayne syndrome Botulinum toxin Spasticity Pain Ataxia Case report

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Tilting objects on tubular weighted projective lines: A cluster tilting approach

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Science China Mathematics 2021年第4期64卷 691-710页

作者： Jianmin Chen Yanan lin pin Liu Shiquan Ruan School of Mathematical Sciences Xiamen UniversityXiamen 361005China Department of Mathematics Southwest Jiaotong UniversityChengdu 610031China

Using the cluster tilting theory,we investigate the tilting objects in the stable category of vector bundles on a weighted projective line of weight type(2,2,2,2).More precisely,a tilting object consisting of rank-two bundles is constructed via the cluster tilting ***,the cluster tilting approach also provides a new method to classify the endomorphism algebras of the tilting objects in the category of coherent sheaves and the associated bounded derived category.

关键词： tilting object cluster tilting weighted projective line vector bundle cluster mutation

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Tensile and compressive behavior of Ti-based bulk metallic glass composites

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International Journal of Minerals,Metallurgy and Materials 2013年第6期20卷 582-588页

作者： Yong-sheng Wang Guo-jian Hao Jun-pin lin State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing

This article focuses on the tensile and compressive characteristics of a Ti-based bulk metallic glass composite （BMGC）. It is found that the yield stress, maximum strength, and fracture strain are 1380 MPa, 1516 MPa, and 4.3% for uniaxial tension, but 1580 MPa, 4010 MPa, and 29% for uniaxial compression, respectively. The composite displays a linear ＂work hardening＂ capacity under compression; however, the ＂work softening＂ behavior is observed in the true engineering stress-strain curve upon tensile loading. The fracture surfaces of specimens also exhibit dissimilar properties under the different loadings.

关键词： metallic glass composite materials tensile testing compression testing fracture

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Advances in phase relationship for high Nb-containing TiAl alloys

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Rare Metals 2016年第1期35卷 15-25页

作者： Yong-Feng Liang Xiang-Jun Xu Jun-pin lin State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing Materials and Chemistry School Zhongyuan University of Technology

γ-TiAl alloys,including two categories（the conventional TiAl and the high Nb-containing TiAl（high Nb-TiAl））,are technologically intriguing because of their applications at high ***,the service temperature of the high Nb-TiAl alloys is 60-100℃higher than that of conventional TiAl *** developed TiAl alloys,for example TNB,TNM,β-γ alloys,belong to the high Nb-TiAl alloys,displaying similar behavior in phase transformation,strengthening,oxidation at high temperatures,and relationships between composition,microstructure,and mechanical *** work presents an in-depth review of the high Nb-TiAl alloys regarding the advances in phase diagram,formation mechanism of the new γ_1 phase,microsegregation induced by adding a high content of alloying element Nb,and the mechanism of the B2/ω phase *** challenges in developing the high Nb-TiAl alloys are also discussed.

关键词： TiAl alloy Nb addition Phase diagram Microsegregation Microstructure

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CNOT extraction attack on “quantum asymmetric cryptography with symmetric keys”

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Science China(Physics,Mechanics & Astronomy) 2014年第5期57卷 1001-1003页

作者： lin ching-Ying HWANG Tzonelih Department of Computer Science and Information Engineering National Cheng Kung University

This paper is based on previous quantum encryption proposed by researchers developing a scheme for cryptography using symmetric *** study has pointed out that the scheme consists of a pitfall that could lead to a controlled-NOT(CNOT)extraction attack.A malicious user can obtain the secret message of a sender without being detected by using a sequence of single photons and a controlled-NOT gate.

关键词： quantum asymmetric cryptography symmetric key CNOT extraction attack

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FACTORS OF 3GWC SYSTEMS FOR DRAWING UP CUSTOMIZED STRATEGIES OF PROMOTION

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Journal of Systems Science and Systems Engineering 2011年第3期20卷 365-381页

作者： Hsin-pin FU Hwan-Yann SU Fang-Hua WANG ching-Yi CHANG Hung-Hsuan LEE Department of Marketing and Distribution Management National Kaohsiung First University of Science and Technology Kaohsiung Taiwan China Department of Asia-Pacific Industrial and Business Management National University of Kaohsiung Taiwan China Antai College of Economics ＆ Management Shanghai Jiao Tong University Shanghai China Antai College of Economics ＆ Management Shanghai Jiao Tong University Shanghai China Institute of Management National Kaohsiung First University of Science and Technology Taiwan China

This study utilizes fuzzy analytic hierarchy process （FAHP） to analyze decision-making pattems with regard to third-generation wireless communications （3GWC） service adoption, and to provide customized strategic recommendations to suppliers of 3GWC services regarding marketing and resource allocation in the context of the Chinese 3GWC market. First of all, a three-layer hierarchy of 3GWC adoption factors is developed by referring to the relevant literature and industry reports. A questionnaire of pairwise comparisons in the fuzzy AHP format is then designed and distributed to experts familiar with the handset market in Shanghai, China. These surveys are then analyzed using fuzzy AHP to establish an understanding of the weights and impacts of the various factors. The results show that the four most important factors for the adoption of 3GWC systems are：（i） handset price and voice and data-transmission fees; （ii） handset aesthetics; （iii） personalization; and （iv） network coverage. These findings suggest that providers of such services should customize and diversify the content/applications they offer and ensure the speed and reliability of network access. In addition, handset designs should be in accordance with consumer demands. If these steps can be achieved, then consumers will adopt 3GWC services more rapidly.

关键词： 3GWC (third generation mobile) adoption factors FAHP

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