Botulinum toxin injection for Cockayne syndrome with muscle spasticity over bilateral lower limbs:A case report

作     者：Lin-Chieh Hsu Po-Ying Chiang Wei-Pin Lin Yao-Hong Guo Pei-Chun Hsieh Ta-Shen Kuan Wei-Chih Lien Yu-Ching Lin 

作者机构：Department of Physical Medicine and RehabilitationNational Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainan 704Taiwan Department of Physical Medicine and RehabilitationCollege of MedicineNational Cheng Kung UniversityTainan 704Taiwan Medical Device Innovation CenterNational Cheng Kung UniversityTainan 704Taiwan 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2021年第9卷第18期

页      面：4728-4733页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Cockayne syndrome Botulinum toxin Spasticity Pain Ataxia Case report 

摘      要：BACKGROUND Cockayne syndrome(CS)is a rare inherited disease characterized by progressive motor symptoms including muscle weakness,joint contracture,ataxia,and *** neurotoxin type A has been used for conditions such as dystonia and spasticity,but it has rarely been used in patients with *** SUMMARY We report a 6-year-and-9-mo old girl diagnosed with CS who received an injection of botulinum neurotoxin type A to manage her difficulty with walking.A total dose of 210 units of botulinum neurotoxin type A was administered into the bilateral tibialis posterior and gastrocnemius *** evaluate the treatment effects on spasticity,joint contracture,pain,and ataxia,measurement tools including the Modified Ashworth Scale,the passive range of motion,the Faces Pain Scale-Revised,and the Scale for the Assessment and Rating of Ataxia,were *** first week after the injection,the Modified Ashworth Scale score for the plantar flexors and foot invertors improved bilaterally,along with advancements in the passive range of motion of the bilateral ankles and a lower score for the Faces Pain *** treatment effects persisted to the 8th week post-injection,but returned to baseline values at the 12th week post-injection,except for the pain *** Botulinum toxin injection can thus be considered as a treatment option for lower extremity spasticity,joint contracture,and pain derived from CS.