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AI-Based Advanced Approaches and Dry Eye Disease Detection Based on Multi-Source Evidence:Cases,Applications,Issues,and Future Directions

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Big Data Mining and Analytics 2024年第2期7卷 445-484页

作者： Mini Han Wang Lumin Xing Yi Pan Feng Gu Junbin Fang Xiangrong Yu chi pui pang Kelvin Kam-Lung Chong Carol Yim-Lui Cheung Xulin Liao Xiaoxiao Fang Jie Yang Ruoyu Zhou Xiaoshu Zhou Fengling Wang Wenjian Liu Zhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University/The First Affiliated Hospital of Faculty of Medicine Macao University of Science and Technology) Zhuhai 519000China Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong 999077China Faculty of Data Science City University of MacaoMacao 999078China Zhuhai Institute of Advanced Technology chinese Academy of Sciences Zhuhai 519000China Perspective Technology Group Zhuhai 519000China First Affiliated Hospital of Shandong First Medical University Shandong Provincial Qianfoshan Hospital Jinan 250000China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518000China College of Staten Island The City University of New YorkNY 10314USA Department of Optoelectronic Engineering Jinan UniversityGuangzhou 510000China Zhuhai Aier Eye Hospital Zhuhai 519000China College of Artificial Intelligence Chongqing Industry and Trade PolytechnicChongqing 400000China Centre for Science and Technology Exchange and Cooperation between china and Portuguese-Speaking Countries Zhuhai 519000China School of Artificial Intelligence Hezhou UniversityHezhou 542899China

This study explores the potential of Artificial Intelligence(AI)in early screening and prognosis of Dry Eye Disease(DED),aiming to enhance the accuracy of therapeutic approaches for eye-care *** the promising opportunities,challenges such as diverse diagnostic evidence,complex etiology,and interdisciplinary knowledge integration impede the interpretability,reliability,and applicability of AI-based DED detection *** research conducts a comprehensive review of datasets,diagnostic evidence,and standards,as well as advanced algorithms in AI-based DED detection over the past five *** DED diagnostic methods are categorized into three groups based on their relationship with AI techniques:(1)those with ground truth and/or comparable standards,(2)potential AI-based methods with significant advantages,and(3)supplementary methods for AI-based DED *** study proposes suggested DED detection standards,the combination of multiple diagnostic evidence,and future research directions to guide further ***,the research contributes to the advancement of ophthalmic disease detection by providing insights into knowledge foundations,advanced methods,challenges,and potential future perspectives,emphasizing the significant role of AI in both academic and practical aspects of ophthalmology.

关键词： Artificial Intelligence(AI) ophthalmology Dry Eye Disease(DED)detection multi-source evidence

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Growth hormone-releasing hormone receptor signaling in experimental ocular inflammation and neuroprotection

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Neural Regeneration Research 2022年第12期17卷 2643-2648页

作者： Ling-Ping Cen Tsz Kin Ng Wai Kit Chu chi pui pang Joint Shantou International Eye Center of Shantou University and The chinese University of Hong Kong ShantouGuangdong ProvinceChina Shantou University Medical College ShantouGuangdong ProvinceChina Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong Kong Special Administrative RegionChina

Both inflammation and anti-inflammation are involved in the protection of retinal *** of the hypothalamic growth hormone-releasing hormone receptor(GHRHR)have been shown to possess potent anti-inflammatory properties in experimental disease models of various organs,some with systemic *** effects are also found in ocular inflammatory and neurologic injury *** experimental models of mice and rats,both growth hormone-releasing hormone receptor agonists and antagonists may alleviate death of ocular neural cells under certain experimental *** review explores the properties of growth hormone-releasing hormone receptor agonists and antagonists that lead to its protection against inflammatory responses induced by extrinsic agents or neurologic injures in ocular animal models.

关键词： neuroprotection ocular inflammation optic nerve injury retinal ganglion cells uveitis

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Peritoneal macrophages attenuate retinal ganglion cell survival and neurite outgrowth

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Neural Regeneration Research 2021年第6期16卷 1121-1126页

作者： Jia-Jian Liang Yu-Fen Liu Tsz Kin Ng Ci-Yan Xu Mingzhi Zhang chi pui pang Ling-Ping Cen Joint Shantou International Eye Center of Shantou University and the chinese University of Hong Kong ShantouGuangdong ProvinceChina Shantou University Medical College ShantouGuangdong ProvinceChina Department of Ophthalmology and Visual Sciences the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Inflammation is a critical pathophysiological process that modulates neuronal survival in the central nervous system after disease or ***,the effects and mechanisms of macrophage activation on neuronal survival remain *** the present study,we co-cultured adult Fischer rat retinas with primary peritoneal macrophages or zymosan-treated peritoneal macrophages for 7 *** analysis revealed that peritoneal macrophages reduced retinal ganglion cell survival and neurite outgrowth in the retinal explant compared with the control *** addition of zymosan to peritoneal macrophages attenuated the survival and neurite outgrowth of retinal ganglion *** media from peritoneal macrophages also reduced retinal ganglion cell survival and neurite *** result suggests that secretions from peritoneal macrophages mediate the inhibitory effects of these *** addition,increased inflammationand oxidation-related gene expression may be related to the enhanced retinal ganglion cell degeneration caused by zymosan *** summary,this study revealed that primary rat peritoneal macrophages attenuated retinal ganglion cell survival and neurite outgrowth,and that macrophage activation further aggravated retinal ganglion cell *** study was approved by the Animal Ethics Committee of the Joint Shantou International Eye Center of Shantou University and the chinese University of Hong Kong,Shantou,Guangdong Province,china,on March 11,2014(approval ***20140311(2)-P01).

关键词： in vitro inflammation macrophages model neurite outgrowth optic nerve retinal ganglion cells survival

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Glial cells and glaucomatous neuropathy

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chinese Medical Journal 2007年第4期120卷 326-335页

作者： ZHONG Yi-sheng Christopher Kai-shun Leung chi-pui pang Department of Ophthalmology Ruijin Hospital Shanghai JiaotongUniversity Shanghai 200025 China Department of-Ophthalmology and Visual Sciences ChineseUniversity of Hong Kong Hong Kong China

Glaucomatous optic neuropathy is characterized by progressive loss of retinal ganglion cells associated with visual functional deficits. As the ganglion cells die in glaucoma, there is a progressive thinning of the nerve fibre layer （NFL）.l The underlying pathophysiological mechanisms, however, remain unclear. Many mechanisms are involved in the initiation and process of irreversible ganglionic cell death in glaucoma. These include reduced axoplasmic transport, accumulation of toxic levels of neurotransmitter, increased nitric oxide and endothelin syntheses, and remodelling of the extracellular matrix, among others.

关键词： OPTIC-NERVE HEAD RETINAL GANGLION-CELLS NITRIC-OXIDE SYNTHASE NECROSIS-FACTOR-ALPHA OPEN-ANGLE GLAUCOMA CILIARY NEUROTROPHIC FACTOR ASTROCYTE PRECURSOR CELLS MULLER CELLS IN-VITRO REACTIVE ASTROCYTES

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TIMP-1 Production in Human Retinal Pigment Epithelial Cells after Laser Exposure

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Eye Science 2005年第1期21卷 31-37页

作者： Alvin K.H.Kwok Timothy Y.Y.Lai Hin-Fai Yam chi-pui pang Department of Ophthalmology & Visual Sciences Department of Ophthalmology & Visual SciencesDepartment of Ophthalmology & Visual SciencesDepartment of Ophthalmology & Visual Sciences The Chinese University of Hong KongHong Kong SAR Department of OphthalmologyHong Kong Sanatorium and HospitalHong Kong SARThe Chinese University of Hong KongHong Kong SARThe Chinese University of Hong KongHong Kong SARThe Chinese University of Hong KongHong Kong SAR

Purpose: To investigate changes in the production of tissue inhibitor of metalloproteinase type 1 (TIMP-1) by human retinal pigment epithelial (RPE) cells following argon laser ***: Human cultured ARPE19 cells were exposed to argon green laser at four different energy levels ranging from 60mW to 360mW. After laser exposure, the culture media were sampled at 0, 24, 72 and 144 hours for TIMP-1 concentration produced by the RPE cells. The levels of TIMP-1 in the cells treated with different laser energy levels were compared with a control group not exposed to laser *** for proliferating cell nuclear antigen (PCNA) was performed to detect any adverse effects on the RPE cells caused by laser ***: Immediately after laser exposure, the concentration of TIMP- 1 was not detectable. At 24 hours after laser exposure, the concentration of TIMP-1 increased significantly in RPE cells treated with 120mW and 240mW at 24 hours (P=0.006 and P=0.001respectively) compared with control cells. At 72 hours after treatment, RPE cells treated at 120mW, 240mW and 360mW demonstrated significantly increase in TIMP-1production compared with control (P=0.003, P ＜ 0.001 and P ＜ 0.001, respectively).No significant reduction in cell viability was observed following laser application as detected by PCNA ***: Our results demonstrated that early TIMP-1 production by RPE cells in cell cultures was enhanced following laser exposure.

关键词： TIMP-1 视网膜上皮细胞激光损伤免疫细胞学视色素

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Comparison of Dextran Perfusion and GSI-B4 Isolectin Staining in a Mouse Model of Oxygen-induced Retinopathy

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Eye Science 2015年第2期30卷 70-74页

作者： Shaofen Huang Jiajian Liang Gary Hin-Fai Yam Zhihao Lu chi pui pang Haoyu Chen Joint Shantou International Eye Center Shantou University & Chinese University of Hong Kong Singapore Eye Research Institute Department of Ophthalmology and Visual Sciences Chinese University of Hong Kong

Purpose: Oxygen-induced retinopathy(OIR) is a robust and widely used animal model for the study of retinal neovascularization(NV). Dextran perfusion and Griffonia simplicifolia isolectin B4(GSI-B4) staining are two common methods for examining the occurrence and extent of OIR. This study provides a quantitative comparison of the two for OIR ***: At postnatal day 7(PN7), fifteen C57 BL / 6J mice were exposed to a 75% hyperoxic condition for 5 days and then returned to room air conditions. At PN17, the mice received intravitreal injection of GSI-B4 Alexa Fluor 568 conjugate. After 10 hours, they were infused with FITC-dextran conjugate via the left ventricle. Retinal flat mounts were photographed by confocal microscopy. Areas with fluorescent signals and the total retinal areas were quantified by Image J ***:Both GSI-B4 and dextran detected the peripheral neovascular area. The mean hyper fluorescence area was 0.33 ±0.14% of whole retinal area determined by GSI-B4 staining and 0.25±0.28% determined by dextran perfusion. The difference between the two measures was 0.08%(95% CI:-0.59%,0.43%)..The Pearson correlation coefficient between the two methods was 0.386,P =0.035..The mean coincidence rates were 14.3 ±13.4% and 24.9 ±18.5% for GSI-B4 and dextran staining, ***:.Both methods can complement each other indemonstrating and quantitatively evaluating retinal NV. A poor agreement was found between the two methods;.GSI-B4 isolectin was more effective than FITC-dextran perfusion in evaluating the extent of retinal NV in a mouse model of OIR.

关键词：右旋糖酐小鼠模型视网膜凝集素染色灌注高氧病变

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Bilateral retinal nerve fiber layer thickness reduction in a 9-year-old myopic boy suffering from unilateral optic neuritis:A case report

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世界临床病例杂志 2023年第28期11卷 6806-6811页

作者： Fang-Fang Zhao Shi-Qi Yao Yun Wang Tai-Ping Li Jian-Feng Yang chi-pui pang Ling-Ping Cen Department of Medical Retina and Neuro-ophthalmology Joint Shantou International Eye Centre of Shantou University and The Chinese University of Hong KongShantou 515041Guangdong ProvinceChina Department of Ophthalmology&Visual Sciences The Chinese University of Hong KongHong Kong 999077China

BACKGROUND In this paper,we present a 9-year-old boy who demonstrates a complex interplay between myopia progression,axial length(AL)extension,and retinal nerve fiber layer(RNFL)thickness loss in both ***,concurrent optic neuritis has directly impacted RNFL thickness in his right eye,and its potential indirect influence on RNFL and macular ganglion cell layer(mGCL)thickness in his left eye is also *** SUMMARY A 9-year-old boy with bilateral myopia presented with diminished vision and pain in his right eye due to optic neuritis,while his left eye showed *** therapy improved his vision in the right eye,and 16-mo follow-up revealed recovery without recurrence despite myopia ***-up optical coherence tomography conducted 16 mo later revealed a notable thinning of the RNFL in both eyes,especially along with a reduction in mGCL thickness in the left *** intricate interaction between optic neuritis,myopia,and retinal changes underscores the need for comprehensive management,highlighting potential long-term visual implications in young *** The progression of myopia and AL extension led to the loss of RNFL thickness in both eyes in a 9-year-old ***,optic neuritis directly affected RNFL thickness in his right eye and may indirectly play a role in the thickness of RNFL and mGCL in his left eye.

关键词： Retinal nerve fiber layer Myopia Optic neuritis Macular ganglion cell Case report

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Evaluation of the association of C5 with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy

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Eye and Vision 2019年第1期6卷 291-297页

作者： Ke Liu Li Ma Timothy Y.Y.Lai Marten E.Brelen Pancy O.S.Tam Clement C.Tham chi pui pang Li Jia Chen Department of Ophthalmology and Visual Sciences The Chinese University of Hong KongHong KongChina Department of Ophthalmology and Visual Sciences Prince of Wales HospitalHong KongChina

Background:Neovascular age-related macular degeneration(AMD)and polypoidal choroidal vasculopathy(PCV)are sight-threatening maculopathies with both environmental and genetic risk *** have previously shown relative risks posed by genes of the complement pathways to neovascular AMD and ***:In this study,we investigated the haplotype-tagging single nucleotide polymorphisms(SNPs)in the complement component 5(C5)gene in 708 unrelated chinese individuals:200 neovascular AMD patients,233 PCV patients and 275 *** tagging SNPs in C5 were *** single SNP association analysis,haplotype-based association analysis and gene-gene interaction analysis between C5 and other AMD-associated genes were ***:The results revealed none of the six tagging SNPs of the C5 gene had a significant association with neovascular AMD or PCV(P>0.05).We also found insignificant haplotype-based association,and no significant SNPSNP interaction between C5 and other genes(including C2-CFB-RDBP-SKIV2L,SERPING1,CETP,ABCG1,PGF,ANGPT2,CFH and HTRA1)for neovascular AMD and ***:This study showed no statistical significance in the genetic association of C5 with neovascular AMD or PCV in a Hong Kong chinese *** studies in large samples from different populations are warranted to elucidate the role of C5 in the genetic susceptibility of AMD and PCV.

关键词： Age-related macular degeneration Polypoidal choroidal vasculopathy Complete component 5 C5 Genetic association Single-nucleotide polymorphism

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Differentiation potential of human adipose tissue derived stem cells into photoreceptors through explants culture and enzyme methods

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International Journal of Ophthalmology(English edition) 2017年第1期10卷 23-29页

作者： Wei-Wei Xu Li Huang Kelvin K.L.Chong Doreen S.Y.Leung Benjamin EL.Li Zheng-Qin Yin Yi-Fei Huang chi pui pang Department of Ophthalmology and Visual Sciences theChinese University of Hong KongHong Kong 999077China Department of Ophthalmology Chinese People's LiberationArmy General HospitalBeijing 100853China

AIM： To investigate the retinal photoreceptor differentiation potential of human orbital adipose tissue-derived stem cells （ADSCs） generated by enzyme （EN） and explant （EX） culture ***： We investigated potentials of human orbital ADSCs to differentiate into photoreceptors through EN and EX culture methods. EN and EX orbital ADSCs were obtained from the same donor during rehabilitative orbital decompression, and then were subject to a 3-step induction using Noggin, DKK-1, IGF-1 and b-FGF at different time points for 38d. Stem cell, eye-field and photoreceptor-related gene and protein markers were measured by reverse transcription-polymerase chain reaction （RT-PCR） and immunofluorescent （IMF） ***： Both EX and EN orbital ADSCs expressed CD133, a marker of cell differentiation. Moreover, PAX6 and rhodopsin, markers of the retinal progenitor cells, were detected from EX and EN orbital ADSCs. In EX orbital ADSCs, PAX6 mRNA was detected on the 17th day and then the rhodopsin mRNA was detected on the 24th day. In contrast, the EN orbital ADSCs expressed PAX6 and rhodopsin mRNA on the 31st day. EX orbital ADSCs expressed rhodopsin protein on the 24th day, while EN orbital ADSCs expressed rhodopsin protein on the 31st day. CONCLUSION： Orbital ADSCs isolated by direct explants culture show earlier and stronger expressions of markers towards eye field and retinal photoreceptor differentiation than those generated by conventional EN method.

关键词： photoreceptor cells cell differentiation adultstem cells tissue engineering explants culture enzymaticdigestion

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An impact sensitivity assessment method of spacecraft based on virtual exterior wall

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Defence Technology（防务技术） 2024年第1期31卷 142-157页

作者： Runqiang chi Yuyan Liu Diqi Hu Baojun pang Hypervelocity Impact Research Center Harbin Institute Of TechnologyHarbin150080China

The impact sensitivity assessment of spacecraft is to obtain the probability of spacecraft encountering the OD/M(orbital debris or meteoroid),which is a prerequisite for survivability assessment of on-orbit *** impact sensitivity assessment method of spacecraft based on virtual exterior wall was proposed to improve the computational *** method eliminates determination of the outermost surface elements of the spacecraft before generating the debris rays,which are assumed to originate from a non-concave virtual wall that completely wraps the *** Dist Mesh method was adopted for the generating of the virtual wall to ensure its mesh *** influences of the sizes,mesh densities,shapes of the virtual wall on the efficiency and accuracy were considered to obtain the best combination of the size and mesh density of the wall and *** results of this method were compared with those of S3DE(Survivability of Spacecraft in Space Debris Environment),BUMPER,MDPANTO,ESABASE2/Debris to verify the feasibility of the *** PchiP(Piecewise Cubic Hermite Interpolating Polynomial)was used to fit the size *** relationship of the space debris to acquire the impact probability of OD/M with arbitrary size on the spacecraft.

关键词： Sensitivity OD/M Spacecraft Virtual exterior wall

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