Evaluation of the association of C5 with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy

作     者：Ke Liu Li Ma Timothy Y.Y.Lai Marten E.Brelen Pancy O.S.Tam Clement C.Tham Chi Pui Pang Li Jia Chen Ke Liu;Li Ma;Timothy Y.Y.Lai;Marten E.Brelen;Pancy O.S.Tam;Clement C.Tham;Chi Pui Pang;Li Jia Chen

作者机构：Department of Ophthalmology and Visual SciencesThe Chinese University of Hong KongHong KongChina Department of Ophthalmology and Visual SciencesPrince of Wales HospitalHong KongChina 

出 版 物：《Eye and Vision》 (眼视光学杂志（英文）)

年 卷 期：2019年第6卷第1期

页      面：291-297页

核心收录：

学科分类：08[工学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：supported in part by the General Research Fund,Hong Kong(14120516[LJC]) the Direct Grant of Chinese University of Hong Kong Medical Panel,Hong Kong(4054281[LJC]) the Endowment Fund for Lim Por-Yen Eye Genetics Research Centre,Hong Kong 

主　　题：Age-related macular degeneration Polypoidal choroidal vasculopathy Complete component 5 C5 Genetic association Single-nucleotide polymorphism 

摘      要：Background:Neovascular age-related macular degeneration(AMD)and polypoidal choroidal vasculopathy(PCV)are sight-threatening maculopathies with both environmental and genetic risk *** have previously shown relative risks posed by genes of the complement pathways to neovascular AMD and ***:In this study,we investigated the haplotype-tagging single nucleotide polymorphisms(SNPs)in the complement component 5(C5)gene in 708 unrelated Chinese individuals:200 neovascular AMD patients,233 PCV patients and 275 *** tagging SNPs in C5 were *** single SNP association analysis,haplotype-based association analysis and gene-gene interaction analysis between C5 and other AMD-associated genes were ***:The results revealed none of the six tagging SNPs of the C5 gene had a significant association with neovascular AMD or PCV(P0.05).We also found insignificant haplotype-based association,and no significant SNPSNP interaction between C5 and other genes(including C2-CFB-RDBP-SKIV2L,SERPING1,CETP,ABCG1,PGF,ANGPT2,CFH and HTRA1)for neovascular AMD and ***:This study showed no statistical significance in the genetic association of C5 with neovascular AMD or PCV in a Hong Kong Chinese *** studies in large samples from different populations are warranted to elucidate the role of C5 in the genetic susceptibility of AMD and PCV.