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Successful treatment of liver abscess secondary to foreign body penetration of the alimentary tract: A case report and literature review

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World Journal of Gastroenterology 2014年第13期20卷 3703-3711页

作者： Lee-Won Chong cheuk-Kwan sun Chin-Chu Wu cheuk-kay sun Division of Hepatology and Gastroenterology Department of Internal MedicineShin Kong Wu Ho-Su Memorial Hospital Institute of Clinical Medicine School of MedicineNational Yang Ming University Department of Radiology Shin Kong Wu Ho-Su Memorial Hospital Department of Emergency Medicine E-Da HospitalI-Shou University School of Medicine Chung Shan Medical University School of Medicine College of MedicineFu Jen Catholic University School of Medicine College of MedicineTaipei Medical University

Hepatic abscess caused by foreign body penetration of the alimentary tract is rare. We report a case of gastric antrum penetration due to a toothpick complicated by liver abscess formation. A 41-year-old man was admitted to our hospital with the chief complaint of upper abdominal pain for 2 mo. Esophagogastroduodenoscopy performed at a local clinic revealed a toothpick penetrating the gastric antrum. Computed tomography (CT) of the abdomen at our hospital revealed a gastric foreign body embedded in the posterior wall of gastric antrum with regional phlegmon over the lesser sac and adhesion to the pancreatic body without notable vascular injury, and a hepatic abscess seven cm in diameter over the left liver lobe. Endoscopic removal of the foreign body was successfully performed without complication. The liver abscess was treated with parenteral antibiotics without drainage. The patient’s recovery was uneventful. Abdominal ultrasonography demonstrated complete resolution of the hepatic abscess six months after discharge. Relevant literature from the PubMed database was reviewed and the clinical presentations, diagnostic modalities, treatment strategies and outcomes of 88 reported cases were analyzed. The results showed that only 6 patients received conservative treatment with parenteral antibiotics, while the majority underwent either image-guided abscess drainage or laparotomy. Patients receiving abscess drainage via laparotomy had a significantly shorter length of hospitalization compared with those undergoing image-guided drainage. There was no significant difference in age between those who survived and those who died, however, the latter presented to hospitals in a more critical condition than the former. The overall mortality rate was 7.95%.

关键词： Hepatic abscess Foreign body Endoscopy Laparotomy Drainage

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Self-expandable metallic stents for malignant biliary obstruction:Efficacy on proximal and distal tumors

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World Journal of Gastroenterology 2006年第1期12卷 119-122页

作者： Jui-Hao Chen cheuk-kay sun Chao-Sheng Liao Chain-Smoke Chua Department of Gastroenterology Shin-Kong WuHo-Su Memorial HospitalTaipeiTaiwanChina

AIM： To compare the efficacy of self-expandable metallic stents （EMS） in the treatment of distal and proximal stricture of malignant biliary tumors. METHODS： From March 1995 to June 2004, 61 patients （40 males, 21 females） with malignant biliary obstruction who received self-expandable metallic stent implantation were reviewed retrospectively. The stents were inserted by an endoscopic or percutaneous transhepatic method. We tried to place two stents in the biliary system in T or Y configuration in cases of hilar tumors with bilateral hepatic duct obstruction. The end points of the study were stent occlusion or patient death. RESULTS： The mean time of stent patency was 421 ± 67 d in the group of proximal stricture（ group Ⅰ） and 168 ± 18 d in the group of distal stricture （group Ⅱ）. The difference was significant in borderline between the two groups （P = 0.0567）. The mean survival time was 574 ± 76 d in group I and 182 ± 25 d in group II. There was a significant difference between the two groups （P = 0.0005）. CONCLUSION： EMS implantation is a feasible, palliative method for unresectable malignant biliary obstruction. The clinical efficacy of EMS in patients with proximal hilar tumors is better than that in patients with distal tumors.

关键词： Metallic stent Biliary malignancy

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Atomscopic of ripple origins for two-dimensional monolayer transition metal dichalcogenides

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Nano Research 2024年第3期17卷 2136-2144页

作者： Haitao Yu Mingzi sun Xiao Wu cheuk Hei Chan Bolong Huang Zhong Lin Wang CAS Center for Excellence in Nanoscience Beijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100083China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityKowloon 999077Hong KongChina Research Centre for Carbon-Strategic Catalysis The Hong Kong Polytechnic UniversityKowloon 999077Hong KongChina School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGeorgia 30332USA

During the development of ultrathin two-dimensional(2D)materials,the appearance of ripples has been widely ***,the formation mechanisms and their influences are still rarely investigated,especially their contributions to the electronic structures and optical *** compensate for the knowledge gap,we have carried out comprehensive theoretical studies on the monolayer WSe_(2) with a series of ripple structures from 0 to 12Åin different lattice *** sensitivity of the formation energy,band structures,electronic structures,and optical properties to the ripple structures have been performed systematically for the first *** formation of ripples in Armchair and zigzag simultaneously are more energetically favorable,leading to more flexible optimizations of the optoelectronic *** improved charge-locking effect and extension of absorption ranges indicate the significant role of ripple *** spontaneous formation of ripples is associated with orbital rearrangements and structural *** leads to the unique charge carrier correlate inversion between W-5d and Se-4p orbitals,resulting in the pinning of the Fermi *** work has supplied significant references to understand ultrathin 2D structures and benefit their future developments and applications in high-performance optoelectronic devices.

关键词： two-dimensional(2D)materials ripples strain effect charge carrier correlation inversion optoelectronic properties

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High-Resolution Infrared-Vacuum Ultraviolet Photoion and Pulsed Field Ionization-Photoelectron Methods for Spectroscopic Studies of Neutrals and Cations

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Chinese Journal of Chemical Physics 2008年第3期21卷 193-201页

作者： Xi Xing Beth Reed Mi Kyung Bahng Peng Wang Hin Koo Woo sun Jong Baek Chee Shing Lain cheuk Yiu Ng Department of Chemistry University of California Davis Davis California 95616 USA

We show that by scanning the frequency of a single mode infrared （IR） optical parametric oscillator （IR- OPO） laser to excite the molecular species of interest and fixing the frequency of a vacuum ultraviolet （VUV） laser to photoionize the IR excited species, high-resolution IR spectra of polyatomic neutrals can be obtained with high sensitivity. The fact that this IR-VUV-photoion （IR-VUV-PI） method is based on VUV photoionization probe, and thus, allows the identification of the neutral IR absorber, makes it applicable for IR spectroscopy measurements of isotopemers, radicals, and clusters, which usually exist as impure samples. The highly resolved IR-VUV-PI measurements achieved using the single mode IR-OPO laser have made possible the selection of single rovibrational states of CH3X （X=Br and I）, C2H4, and C3H4 for VUV-pulsed field ionization-photoelectron （VUV-PFI-PE） measurements, resulting in rovibrationally resolved photoelectron spectra for these polyatomic molecules. These experiments show that the signal- to-noise ratios of the IR-VUV-PI and IR-VUV-PFI-PE spectra obtained by employing the high-resolution IR-OPO laser are significantly higher than those observed in previous IR-VUV-PI and IR-VUV-PFI-PE studies using a low-resolution IR-OPO laser. Further improvement in sensitivity of IR-VUV-PI and IR- VUV-PFI-PE measurements by using the collinear arrangement of IR-VUV lasers and molecular beam is discussed.

关键词： Vacuum ultraviolet Infrared Pulse-field photoelectron High resolution

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Patients with ST-segment elevation of myocardial infarction miss out on early reperfusion： when to undergo delayed revascularization

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Journal of Geriatric Cardiology 2017年第8期14卷 524-531页

作者： Wen ZHENG cheuk-Man YU Jing LIU Wu-Xiang XIE Miao WANG Yu-Jiao ZHANG Jian sun Shao-Ping NIE Dong ZHAO Department of Epidemiology Beijing Anzhen Hospital Capital Medical University Beijing Institute of Heart Lung and Blood Vessel Diseases No.2 Anzhen Road Chaoyang District Beijing China Emergency Critical Care Center Beijing Anzhen Hospital Capital Medical University Beijing China Prince of Wales Hospital Institute of Vascular Medicine the Chinese University of Hong Kong Hong Kong China Department of Infectious Disease China-Japan Friendship Hospital Beijing China Department of Cardiology the First Hospital of Jilin University Changchun Jilin China

Objective There are still a high proportion of patients with ST-segment elevation myocardial infarction （STEMI） missing out early reperfusion even in the primary percutaneous coronary intervention （PCI） era. Most of them are stable latecomers, but the optimal time to undergo delayed PCI for stable ones remains controversial. Methods We investigated all STEMI patients who underwent delayed PCI （2-28 days after STEMI） during 2007-2010 in Beijing and excluded patients with hemodynamic instability. The primary outcome was maj or adverse cardiovascular events （MACEs）. Results This study finally enrolled 5,417 STEMI patients and assigned them into three groups according to individual delayed time （Early group, 55.9%; Medium group, 35.4%; Late group, 8.7%）. During 1-year follow-up, MACEs occurred in 319 patients. The incidence of MACEs were respectively 7.1%, 5.6% and 6.7% among three groups. The Medium group had less recurrent myocardial infarction plus cardiac death （hazard ratio, 0.525; 95% confidence interval, 0.294-0.938, P = 0.030） than Late group and less repeat revascularization （hazard ratio, 0.640; 95% confidence interval, 0.463-0.883, P = 0.007） than Early group in pairwise comparisons. We depicted the incidence of major adverse cardiovascular event （MACE） by delayed time as a quadratic curve and found the bottom appeared at day 14. Conclusions The delayed PCI time varied in the real-world practice, but undergoing operations on the second week after STEMI had greater survival benefit and less adverse events for whom without early reperfusion and hemodynamic instability.

关键词： Angioplasty Epidemiology Latecomer Myocardial infarction Stents

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Microbiota-mediated phytate metabolism activates HDAC3 to contribute intestinal homeostasis

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Signal Transduction and Targeted Therapy 2020年第1期5卷 747-748页

作者： Xiaoxing Li Harry cheuk Hay Lau Jun Yu Institute of Precision Medicine First Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina Institute of Digestive Disease Department of Medicine and TherapeuticsState Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong KongSha TinNewTerritoriesHong Kong

In a recent study in Nature,Wu et *** a fundamental host–microbe interaction that is crucially involved in responding to dietary change thereby maintaining healthy intestinal dynamics.1 They demonstrated that HDAC3 a... 详细信息

关键词： metabolism HDAC3 homeostasis

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Neighboring effect in single-atom catalysts for the electrochemical carbon dioxide reduction reaction

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eScience 2024年第1期4卷 1-16页

作者： Hon Ho Wong Mingzi sun Tong Wu cheuk Hei Chan Lu Lu Qiuyang Lu Baian Chen Bolong Huang Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARChina Research Centre for Carbon-Strategic Catalysis The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARChina

Although single-atom catalysts(SACs)have attracted enormous attention for their applications in the electrochemical reduction of CO_(2)(CO_(2)RR)due to their extraordinary catalytic activity and well-defined active centers,neighboring effects and their influence on the electrochemical performance of SACs have not been well *** this review,we present a summary of the neighboring effects on SACs for the CO_(2)RR process,where the surrounding atoms not only induce electronic modulation of the metal atom but also participate in the CO_(2)*** theoretical and experimental studies have pointed out that the neighboring sites of the anchored metal center can provide second active/adsorption locations during the catalytic process,enhancing CO_(2)RR performance *** review supplies advanced insights into the significant roles and impacts of neighboring effects on the catalytic process,which also benefit the development of advanced SACs to achieve efficient electrocatalysis.

关键词： Carbon dioxide reduction Neighboring effect Atomic catalysts Electronic modulations Active sites

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Contemporary therapy of atrial fibrillation

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World Journal of Cardiovascular Diseases 2012年第3期2卷 111-117页

作者： Xing Sheng Yang Jing Ping sun cheuk Man Yu Division of Cardiology Prince of Wales Hospital The Chinese University of Hong Kong Hong Kong China

Atrial fibrillation (AF) is estimated that by 2010, approximately 2.6 million people will be affected in USA;by 2050, that number may increase to 10 million patients. Generally, rate control alone is reasonable in some AF patients, especially asymptomatic patients. Restoration and maintenance of sinus rhythm (SR) may be achieved by means of cardioversion, drugs or/ and catheter ablation. Pharmacological therapy can be useful to maintain SR and prevent tachycardia-induced cardiomyopathy. All patients with AF regardless of whether a rhythm or rate control strategy recommend anticoagulant, antiplatelet or both combined therapy for prevention of thromboembolism, except those with lone AF or contraindications. Drug selection should be based upon the absolute risk of stroke, bleeding, the relative risk and benefit for a given patient. Biventricular pacing may overcome many of the adverse hemodynamic effects associated with RV pacing alone. A target individual ectopic foci ablation within the pulmonary vein (PV) has evolved to circumferential electrical isolation of the entire PV musculature. Cavotricuspid isthmus should be considered as first-line therapy for patients with typical atrial flutter. Completely non-fluoroscopic ablation guided by Real-Time Magnetic Resonance Imaging (RTMRI) using a steerable and non-ferromagnetic catheter is a promising novel technology in interventional electrophysiology.

关键词： Atrial Fibrillation Antiarrhythmic Drug Anticoagulant Therapy Antiplatelet Therapy Cardioversion Catheter Ablation

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An integrative review on the applications of 3D printing in the field of in vitro diagnostics

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Chinese Chemical Letters 2022年第5期33卷 2231-2242页

作者： Jian Yang Yanxiang Cheng Xia Gong Shengzhu Yi cheuk-Wing Li Lelun Jiang Changqing Yi Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument School of Biomedical EngineeringSun Yat-sen UniversityShenzhen 518107China Research Institute of sun Yat-sen University in Shenzhen Shenzhen 518057China School of Science and Technology Nottingham Trent UniversityClifton LaneNottingham NG118NSUnited Kingdom

Biomedicine is one of the fastest growing areas of additive ***,in the field of in vitro diagnostics(IVD),contributions of 3D printing include i)rapid prototyping and iterative IVD proof-of-concept designing ranging from materials,devices to system integration;ii)conceptual design simpli-fication and improved practicality of IVD products;iii)shifting the IVD applications from centralized labs to point-of-care testing(POCT).In this review,the latest developments of 3D printing and its advantages in IVD applications are summarized.A series of 3D-printed objects for IVD applications,including single-function modules,multi-function devices which integrate several single-function modules for specific an-alytical applications such as sample pre-treatment and chemo-/bio-sensing,and all-in-one systems which integrate multi-function devices and the instrument operating them,are analyzed from the perspective of functional *** current and potential commercial applications of 3D-printed objects in the IVD field are *** features of 3D printing,especially rapid prototyping and low start-up,en-able the easy fabrication of bespoke modules,devices and systems for a range of analytical applications,and broadens the commercial IVD prospects.

关键词： 3D printing In vitro diagnostics Portable sensing device Point-of-care testing Stereolithography(SLA) Digital light projection(DLP) Fused deposition modeling(FDM)

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AN IMPROVED NUMERICAL METHOD FOR CALCULATIONS IN WAVE KINEMATICS

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Journal of Hydrodynamics 2009年第6期21卷 826-834页

作者： sun Yi-yan LIU Shu-xue LI Jin-xuan State kay Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024

The prediction of wave kinematics is a necessary basis for ocean engineering design. In this article, an improved method to calculate the wave kinematics especially in the crest region is presented. This method is based on the local approximation method. According to one measured wave surface, the proposed solution focuses on a Fourier series expansion in a somewhat larger segment of the wave surface record. The horizontal and vertical kinematics under the wave crest can be directly predicted. Good agreement between the numerical results and the theoretical Stokes waves verifies the validity of the numerical model. The effectiveness of the numerical method is also proved by the calculation of the wave kinematics of the laboratory focused wave groups.

关键词： Fourier series expansion wave kinematics focused wave

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