Microbiota-mediated phytate metabolism activates HDAC3 to contribute intestinal homeostasis
作者机构：Institute of Precision MedicineFirst Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina Institute of Digestive DiseaseDepartment of Medicine and TherapeuticsState Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong KongSha TinNewTerritoriesHong Kong
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2020年第5卷第1期
页 面：747-748页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：supported was supported by National Key R&D Program of China(No.2018YFC1315000/2018YFC1315004) RGC-CRF Hong Kong(C4039-19G) RGC-GRF Hong Kong(14163817)
主 题：metabolism HDAC3 homeostasis
摘 要：In a recent study in Nature,Wu et *** a fundamental host–microbe interaction that is crucially involved in responding to dietary change thereby maintaining healthy intestinal dynamics.1 They demonstrated that HDAC3 activity can be promoted by microbiota-mediated phytate metabolism to contribute intestinal homeostasis and repair.
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