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Effects of chronic epilepsy on heart rate variability A case-control study

Neural Regeneration Research 2010年第2期5卷 156-160页

作者： Yueloong hsin cheryl c h yang Terry B J Kuo Tomor harnod School of Medicine Tzu Chi University Department of Neurology Buddhist Tzu Chi General Hospital Institute of Brain Science National Yang Ming University Department of Neurosurgery Buddhist Tzu Chi General Hospital

BAcKGROUND： Dysfunctional autonomic cardiac regulation is thought to be associated with high mortality in epileptic patients. OBJEcTIVE： To explore changes in sympathetic and parasympathetic activities in epileptic patients with repetitive generalized tonic-clonic seizures by observing interictal heart rate. DESIGN, TIME AND SEI-I＇ING： A case-control study was performed at the Buddhist Tzu chi General hospital from July 2006 to May 2009. PARTIcIPANTS： A total of 30 patients, comprising 15 males and 15 females, who presented with chronic epilepsy and repetitive generalized tonic-clonic seizures according to International League Against Epilepsy guidelines （ILAE, 1989）, were selected. In addition, 30 matched, healthy volunteers were selected as controls. METhODS： Lead I electrocardiogram was performed in the epilepsy and control groups for 5 minutes during a daytime interictal period. Frequency-domain analysis of heart rate variability was performed using fast Fourier transformation. MAIN OUTcOME MEASURES： heart rate interval, high frequency （hF; 0.15-0.45 hz） power, low frequency （LF; 0.04-0.15 hz） power, and LF/（hF ＋ LF） expressed in normalized units （LF%）. RESULTS： compared with the control group, the epilepsy group exhibited a significantly lower mean heart rate interval and hF power, but a significantly greater LF% （P〈 0.01）. There was no significant difference in LF power between the groups （P = 0.17）. cONcLUSION： Patients with chronic epilepsy exhibited faster heart rates during interictal periods, which could contribute to hiclher sympathetic and lower parasympathetic activities.

关键词： autonomic epilepsy heart rate parasympathetic sympathetic

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Nitrogen-doping boosts *cO utilization and h2O activation on copper for improving cO2 reduction to c2+ products

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Green Energy & Environment 2024年第9期9卷 1459-1465页

作者： Yisen yang Zhonghao Tan Jianling Zhang Jie yang Renjie Zhang Sha Wang Yi Song Zhuizhui Su Beijing National Laboratory for Molecular Sciences CAS Laboratory of Colloid and Interface and Thermodynamics CAS Research/Education Center for Excellence in Molecular Sciences Center for Carbon Neutral Chemistry Institute of Chemistry Chinese Academy of Sciences School of chemical Sciences University of Chinese Academy of Sciences Key Laboratory of Photochemistry CAS Research/Education Center for Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences

To improve the electrocatalytic transformation of carbon dioxide （cO2） to multi-carbon (c2+) products is of great *** we developed a nitrogen-doped cu catalyst,by which the maximum c2+Faradaic efficiency can reach 72.7%in flow-cell system,with the partial current density reaching 0.62 A *** in situ Raman spectra demonstrate that the *cO adsorption can be strengthened on such a N-doped cu catalyst,thus promoting the*cO utilization in the subsequent c–c coupling ***,the water activation can be well enhanced by N doping on cu *** to the synergistic effects,the selectivity and activity for c2+products over the N-deoped cu catalyst are much improved.

关键词： Electrocatalytic cO 2 reduction reaction copper catalyst Doping Multi-carbon products In situ Raman measurement

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copper-catalyzed c(sp)-h aryl amination enables modular synthesis of quinolines and 2-quinolinones

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Science china chemistry 2024年第2期67卷 595-603页

作者： yang Gao haixia Li Simin yang Yanping huo Qian chen Xianwei Li Zhe Wang Xiao-Qiang hu School of chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou510006China Jieyang Branch of chemistry and chemical Engineering Guangdong Laboratory Jieyang515200China Key Laboratory of catalysis and Energy Materials chemistry of Ministry of Education&hubei Key Laboratory of catalysis and Materials Science School of Chemistry and Materials ScienceSouth-Central University for NationalitiesWuhan430074China

herein,we disclose a novel copper-catalyzed c(sp)-h aryl amination of terminal alkynes with anthranils,enabling the rapid generation of highly reactive secondary N-aryl ynamines for the modular synthesis of structurally diverse c2-substituted quinolines and *** in-situ formed carbonyl-ynamines are prone to tautomerize to carbonyl-ketenimines,which can efficiently react with a series of nucleophiles,including amines,alcohols,phenols,thiols,thiophenols,active-methylene compounds,and even water to produce various quinoline derivatives with the generation of h_(2)O as a sole and green *** method also unlocks a practical route to create various quinoline-fused heterocycles and can be successfully applied to the late-stage modification of complex molecules and the concise synthesis of bioactive *** studies reveal a coppercatalyzed inner-sphere nitrene transfer process by using anthranils as novel aryl nitrene precursors.

关键词： copper catalysis anthranils c(sp)-h aryl amination carbonyl-ketenimines quinolines

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SUV39h1-driven NFATc1 methylation is essential for the c-cbl-mediated degradation of NFATc1 in an osteoclast lineage

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Genes & Diseases 2024年第4期11卷 86-89页

作者： Do-Won Jeong hye-Jin Kim Jong-Wan Park Seulbee Lee hyeryeon Jung Eugene c.Yi Nacksung Kime yang-Sook chun Department of Biomedical Sciences Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Physiology Seoul National University College of MedicineSeoul 03080Republic of Korea Ischemic/hypoxic Disease Institute Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science and Technology and College of Medicine Or College of PharmacySeoul National UniversitySeoul 03080Republic of Korea Department of Pharmacology Chonnam National University Medical SchoolGwangju 61469Republic of Korea

Bone undergoes continuous remodeling by tightly-coordinated actions of bone-resorbing osteoclasts and boneforming osteoblasts.1 Recent studies document that the dysregulation of histone methylation profiles is associated with the progression of ***,the specific epigenetic modifiers are incompletely *** this study,we demonstrate an inhibitory role of a variegation 3-9 homolog 1(SUV39h1)in osteoclast formation.

关键词： osteoclast remodeling incomplete

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Genomic Mosaicism of the Brain:Origin,Impact,and Utility

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Neuroscience Bulletin 2024年第6期40卷 759-776页

作者： Jared h.Graham Johannes c.M.Schlachetzki Xiaoxu yang Martin W.Breuss Department of Pediatrics Section of Clinical Genetics and MetabolismUniversity of Colorado School of MedicineAurora80045-2581COUSA Department of cellular and Molecular Medicine University of California San DiegoLa Jolla92093-0021San DiegoCAUSA Department of Neurosciences University of California San DiegoLa Jolla92093-0021San DiegoCAUSA Rady children’s Institute for Genomic Medicine San Diego92123CAUSA

Genomic mosaicism describes the phenomenon where some but not all cells within a tissue harbor unique genetic ***,research focused on the impact of genomic mosaicism on clinical phenotype—motivated by its involvement in cancers and overgrowth *** recently,we increasingly shifted towards the plethora of neutral mosaic variants that can act as recorders of cellular lineage and environmental ***,we summarize the current state of the field of genomic mosaicism research with a special emphasis on our current understanding of this phenomenon in brain development and *** the field of genomic mosaicism has a rich history,technological advances in the last decade have changed our approaches and greatly improved our *** will provide current definitions and an overview of contemporary detection approaches for genomic ***,we will discuss the impact and utility of genomic mosaicism.

关键词： Genomics Brain development Brain homeostasis Genomic mosaicism

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coordination environments build up and tune a superior synergistic “genome” toward novel trifunctional (TM-N_(x)O_(4−x))@g- c_(16)N_(3)-h_(3): high-throughput inspection of ultra-high activity for water splitting and oxygen reduction reactions

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Nano Research 2024年第4期17卷 2337-2351页

作者： chunyao Fang Xian Wang Qiang Zhang Xihang Zhang chenglong Shi Jingcheng Xu Mengyu yang Department of Physics University of Shanghai for Science and TechnologyShanghai 200093China School of Materials and chemistry University of Shanghai for Science and TechnologyShanghai 200093China

Emerging as a prominent area of focus in energy conversion and storage technologies,the development of highly active metal-based single-atom catalysts(SAcs)holds great signiﬁcance in searching alternatives to replace precious metals toward the efficient,stable,and low-cost hydrogen evolution reaction(hER),as well as the oxygen evolution reaction(OER)and the oxygen reduction reaction(ORR).combining the tremendous tunability of ligand and coordination environment with rich metal-based electrocatalysts can create breakthrough opportunities for achieving both high stability and ***,we propose a novel and stable holey graphene-like carbon nitride monolayer g-c_(16)N5(N_(4)@g-c_(16)N_(3))stoichiometries interestingly behaving as a natural substrate for constructing SAcs((TM-N_(4))@g-c_(16)N_(3)),whose evenly distributed holes map rich and uniform nitrogen coordination positions with electron-rich lone pairs for anchoring transition metal(TM)***,we employed density functional theory(DFT)calculations to systematically investigate the electrocatalytic activity of(TM-N_(4))@g-c_(16)N_(3) toward hER/OER/ORR,meanwhile considering the synergistic modulation of h-loading and O-coordination((TM-N_(x)O_(4-x))@g-c_(16)N_(3)^(-)h_(3),x=0–4).Together a“four-step procedure”screening mechanism with the first-principles high-throughput calculations,we find that(Rh-N_(4))and(Ir-N_(2)O_(2)-II)distributed on g-c_(16)N_(3)^(-)h_(3) can modulate the adsorption strength of the adsorbates,thus achieving the best hER/OER/ORR performance among 216 candidates,and the lowest overpotential of 0.098/0.3/0.46 V and 0.06/0.48/0.45 V,***,the d-band center,crystal orbital hamilton population(cOhP),and molecular orbitals are used to reveal the OER/ORR activity ***,the Rh/Ir-d orbital is dramatically hybridized with the O-p orbital of the oxygenated adsorbates,so that the lone-electrons incipiently locate at the antibonding orbital pair up and popula

关键词： single atom catalysts loading and coordination hydrogen evolution reaction oxygen evolution reaction oxygen reduction reaction

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Photocatalytic in situ h_(2)O_(2) production and activation for enhanced ciprofloxacin degradation over ceO_(2)-co_(3)O_(4)/g-c_(3)N_(4):key role of ceO_(2)

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Rare Metals 2024年第6期43卷 2695-2707页

作者： hong-Jie Zhu Yi-Kai yang Ming-hui Li Lu-Ning Zou hai-Tao Zhao Shandong Provincial Key Laboratory of chemical Energy Storage and Novel cell Technology School of Chemistry and Chemical Engin college of Ecology and Environment Anhui Normal UniversityWuhu241002China Liaocheng YiLu Advanced Materials co. LtdLiaocheng 252000China

The abused ciprofloxacin antibiotics have caused significant environmental *** oxidative degradation of ciprofloxacin exhibits promising efficacy,it often entails excessive energy ***,it is necessary to explore an effective and ecologically sustainable degradation ***,we demonstrated that g-c_(3)N_(4) decorated with the coordinated ceO_(2)and co_(3)O_(4)(ceO_(2)-co_(3)O_(4)/cN)exhibited effective ciprofloxacin photodegradation via in situ h_(2)O_(2) production and activation *** indicate that the introduced ceO_(2) enhances the transference of photogenerated electrons to O_(2) by adjusting the oxygen vacancy of photocatalyst,thereby increasing the generation of superoxide radicals,which in turn generate h_(2)O_(2),resulting in a 22.4-fold increase in h_(2)O_(2) generation over g-c_(3)N_(4).Moreover,the in situ h_(2)O_(2)generation facilitated by ceO_(2) is confirmed to be essential for ciprofloxacin degradation via ceO_(2)-co_(3)O_(4)/cN,as it provides enough oxidant for co_(3)O_(4) to activate into hydroxyl radicals for the pollutants ***,ceO_(2)-co_(3)O_(4)/cN achieves a ciprofloxacin degradation ratio of 97.7%within 80 *** study introduces a novel approach that combines h_(2)O_(2) generation and activation,offering an innovative perspective for achieving clean and efficient purification of antibiotic-contaminated water.

关键词： ceO_(2) In situ h_(2)O_(2)generation ciprofloxacin degradation Photocatalyst

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Sulfur and carbon co-doped g-c_(3)N_(4)microtubes with enhanced photocatalytic h2 production activity

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Frontiers in Energy 2024年第1期18卷 110-121页

作者： yang GE Quanhao ShEN Qi ZhANG Naixu LI Danchen LU Zhaoming ZhANG Zhiwei FU Jiancheng ZhOU School of chemistry and chemical Engineering Southeast UniversityNanjing 211189China Shangdong Yellow Triangle Biotechnology Industry Research Institute co. Ltd.Dongying 257091China Xuzhou B&c chemical co. Ltd.Xuzhou 221300China

Metal-free graphitic carbon nitride(g-c_(3)N_(4))has captured significant attention as a low-cost and efficient hydrogen production photocatalyst *** regulating the microstructure and accelerating the separation of photogenerated carriers remain crucial strategies for promoting the photocatalytic performance of this ***,a novel sulfur–carbon co-doped g-c_(3)N_(4)(SccN)hierarchical microtubules filled with abundant nanosheets inside by thermal polymerization is *** nanosheets create abundant pores and cavities inside the SccN microtubes,thereby increasing the specific surface area of g-c_(3)N_(4)and providing sufficient reactant attachment ***,the hierarchical structure of SccN microtubules strengthens the reflection and scattering of light,and the utilization of visible light is favorably *** importantly,co-doping S and c has greatly improved the photocatalytic performance of graphitic carbon nitride,optimized the band gap structure and enhanced the photogenerated carrier ***,the SccN exhibits a remarkable photocatalytic h_(2)evolution rate of 4868μmol/(g·h).This work demonstrates the potential of multi-nonmetal doped g-c_(3)N_(4)as the ideal photocatalyst for h2 evolution.

关键词： carbon nitride photocatalysis hydrogen production

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Selective nickel-electrocatalyzed benzylic c-h oxygenation of functionalized alkyl arenes

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chinese chemical Letters 2024年第2期35卷 396-401页

作者： Shunyao Tang Siyi Wang Dongmei Zhang Xinxing Zhang Guang yang Yanwei Wang Youai Qiu State Key Laboratory of Elemento-Organic chemistry Frontiers Science Center for New Organic MatterCollege of ChemistryNankai UniversityTianjin 300071China college of chemistry Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education)Renewable Energy Conversion and Storage Center (RECAST)Frontiers Science Center for New Organic MatterNankai UniversityTianjin 300071China

herein, a site-selective paired electrochemical c–h oxidation of functionalized alkyl arenes promoted by nickel catalyst is disclosed. A Ni(Ⅱ)-dioxygen species formed in situ efficiently enable the oxidation process under mild conditions with a broad substrate scope with excellent functional group compatibilities,such as free carboxylic acid, aldehyde, halogen(including aryl iodide), amide and amino acid. The use of the nickel catalyst in combination with water provides a safe, green and economical method for oxidation of a range of molecules varying in complexity and drug derivatives, demonstrating its potential application in organic synthesis and the pharmaceutical industry. Reaction outcomes and mechanistic studies revealed the key role of the in situ Ni(Ⅱ)-dioxygen species for the subsequent oxidation of c(sp^(3))–h bonds,and short-lived reactive intermediates(aryl radical cation) was rapidly captured by the combination of a bipolar ultramicroelectrode(BUME) with nano-electrospray ionization mass spectrometry.

关键词： Electrochemical c-h oxidation Functionalized alkyl arenes Paired nickel-electrocatalysis h_(2)O oxidation Ketones

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Rhodium-catalyzed Regioselective c-O and c-c Bonds Formation of 3-Oxopent-4-enenitriles with Alkynes for the Synthesis of Polysubstituted 2h-Pyrans

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chinese Journal of chemistry 2024年第17期42卷 1986-1992页

作者： Kelu Yan Xiao Liu Jiangwei Wen Qiuyun Li Junjie Wang yang Zheng Xiu Wang Key Laboratory of Life-Organic Analysis of Shandong Province School of Chemistry and Chemical EngineeringQufu Normal UniversityQufuShandong273165China Faculty of chemistry and chemical Engineering Yancheng Institute of TechnologyYanchengJiangsu 224051China

The rhodium-catalyzed c-h bond activation and cyclization of 3-oxopent-4-enenitriles with alkynes proceed *** 2h-pyrans with multiple substituents are achieved in good yields through regioselective formation of c-O and c-c *** involving hydroxy-alkynoates resulted in products with a furo[3,4-b]pyran skeleton via further intramolecular ester exchange *** from the traditional"1-oxatrienes pathway",this method for the synthesis of useful 2h-pyrans possesses certain highlights in terms of readily available substrates,stable and easily derivatized products,gentle and convenient operation process,and step and atomeconomy.

关键词： Rhodium/c-h activation 3-Oxopent-4-enenitriles Alkynes 2h-Pyrans Transition metals Regioselectivity cyclization comprehensive Summary

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