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Anterior cervical surgery methods for central cord syndrome without radiographic spinal fracture-dislocation

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Frontiers of Medicine 2009年第1期3卷 45-48页

作者： chengwei jing Qin FU Xiaojun XU Department of Orthopedics Second Hospital of Tianjin Medical UniversityTianjin 300211China Department of Orthopedics Shengjing Hospital of China Medical UniversityShenyang 110004China

This study was aimed to explore the anterior cervical surgery methods to treat central cord syndrome without radiographic spinal fracture-dislocation(CCSWORFD),retrospectively analyze the cases of CCSWORFD,and evaluate the curative effect of anterior cervical surgery methods for *** four cases of CCSWORFD(19 males and 5 females),all suffering from cervical hyperextension injury,between 45–68(average 59)years old,were operated on by anterior cervical surgery *** these,18 cases had been followed up for 6–24(average 15)months;18 cases,who had anterior decompression and plateﬁxation with titanium mesh bone grafting or iliac bone grafting achieved reliable effects based on the Japanese Orthopedics Association(JOA)evaluation(improved scores of cases with titanium mesh bone grafting,t=2.800,P0.05).Most of these cases had degeneration of cervical *** decompression which relieves the oppression to the spinal cord can help lessen edema of the spinal cord,and earlyﬁxation for stability of cervical vertebra is better for the recovery of spinal cord *** operation with titanium mesh bone grafting or iliac bone grafting are both reliable curative methods for CCSWORFD,and titanium mesh bone grafting can avoid the trauma of the supplying *** bone grafting can also shorten hospital stay.

关键词： central cord syndrome decompression,surgi-cal titanium mesh

Increased CD133^+ cell infiltration in the rat brain following fluid percussion injury

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Neural Regeneration Research 2012年第4期7卷 278-282页

作者： Ming Wei Ziwei Zhou Shenghui Li chengwei jing Dashi Zhi Jianning Zhang Tianjin Neurological Institute General Hospital Tianjin Medical University Tianjin 300052 China Department of Neurosurgery Second Hospital of Tianjin Medical University Tianjin 300070 China

The prominin-1/CD133 epitope is expressed in craniocerebral trauma in animal models of fluid undifferentiated cells. Studies have reported that percussion injury induces production of a specific stem cell subgroup. It has been hypothesized that fluid percussion injury induces CD133＋ cell infiltration in the brain tissue. The present study established a traumatic brain injury model through fluid percussion injury. Immunohistochemical staining showed significantly increased CD133 antigen expression in the rat brain following injury. CD133＋ cells were mainly distributed in hippocampal CA1 3 regions, as well as the dentate gyrus and hilus, of the lesioned hemisphere. Occasional cells were also detected in the cortex. In addition, reverse transcription-PCR revealed that no change in CD133 mRNA expression in injured brain tissue. These results suggested that fluid percussion injury induced CD133 antigen expression in the brain tissues as a result of conformational epitope changes, but not transcriptional expression.

关键词： prominin-1 immunohistochemistry reverse transcription-PCR traumatic brain injury neural regeneration

快速接地开关速度分散性大的原因及处理方案探讨

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电工技术 2024年第14期 207-209页

作者：刘传贺史鑫韩国振王磊敬成伟曹少华赵兴凯山东泰开高压开关有限公司

GIS用快速接地开关在进行机械特性测试时，发现设备显示分、合闸速度不稳定，分散性大，无法通过仪器测试的数据准确判断产品是否合格。通过对比分析不同条件下测试的速度结果，发现原因是测试设备未将采样点拟合成连续曲线导致速度分... 详细信息

GIS用快速接地开关在进行机械特性测试时，发现设备显示分、合闸速度不稳定，分散性大，无法通过仪器测试的数据准确判断产品是否合格。通过对比分析不同条件下测试的速度结果，发现原因是测试设备未将采样点拟合成连续曲线导致速度分散性大。通过缩短测试时长或采用能将离散采样点拟合成连续曲线的设备，解决了该问题。所提出的方法具有借鉴意义。

关键词：快速接地开关机械特性测试设备采样点

The chemical structures,biosynthesis,and biological activities of secondary metabolites from the culinary-medicinal mushrooms of the genus Hericium:a review

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Chinese Journal of Natural Medicines 2024年第8期22卷 676-698页

作者： QI Jianzhao WU jing KANG Shijie GAO jingming Hirokazu Kawagishi LIU Hongwei LIU chengwei Key Laboratory for Enzyme and Enzyme-Like Material Engineering of Heilongjiang College of Life ScienceNortheast Forestry UniversityHarbin 150040China Shaanxi Key Laboratory of Natural Products&Chemical Biology College of Chemistry&PharmacyNorthwest A&F UniversityYangling 712100China Faculty of Agriculture Shizuoka UniversityShizuoka 422-8529Japan State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

Fungal phytochemicals derived from higher fungi,particularly those from the culinary-medicinal genus Hericium,have gained significant attention in drug discovery and *** review aims to provide a comprehensive analysis of the chemical structures,biosynthetic pathways,biological activities,and pharmacological properties of monomeric compounds isolated from Hericium *** the past 34 years,253 metabolites have been identified from various Hericium species,including cyathane diterpenes,alkaloids,benzofurans,chromenes,phenols,pyrones,steroids,and other miscellaneous *** investigations into the biosynthesis of erinacines,a type of cyathane diterpene,have led to the discovery of novel cyathane *** research has highlighted the biological activities and pharmacological properties of Hericium-derived compounds,with particular emphasis on their neuroprotective and neurotrophic effects,immunomodulatory capabilities,anti-cancer activity,antioxidant properties,and antimicrobial *** A,in particular,has been extensively ***,transcriptomic,and proteomic analyses of Hericium species have facilitated the discovery of new compounds and provided insights into enzymatic reactions through genome *** diverse chemical structures and biological activities of Hericium compounds underpin their potential applications in medicine and as dietary *** review not only advances our understanding of Hericium compounds but also encourages further research into Hericium species within the realms of medicine,health,functional foods,and agricultural *** broad spectrum of compound types and their diverse biological activities present promising opportunities for the development of new pharmaceuticals and edible products.

关键词： Hericium Secondary metabolites Biological activity Biosynthesis

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断路器传动系统及运动部件的优化

电工技术 2024年第15期 126-128页

作者：刘传贺敬成伟史鑫韩国振曹少华王磊赵兴凯山东泰开高压开关有限公司山东泰安271000

断路器开断试验受机构的分、合闸速度影响很大。为此,利用断路器触头运动速度公式,计算得出原始结构分、合闸速度。为减少传动环节、能量损耗,重新设计传动系统,并进行减重及机械强度计算。最终理论与试验相结合,验证了优化的可行性和... 详细信息

断路器开断试验受机构的分、合闸速度影响很大。为此,利用断路器触头运动速度公式,计算得出原始结构分、合闸速度。为减少传动环节、能量损耗,重新设计传动系统,并进行减重及机械强度计算。最终理论与试验相结合,验证了优化的可行性和合理性,为后续该类型方案优化提供了技术指导。

关键词：断路器分闸速度合闸速度传动系统有限元

The chemical structures, biosynthesis, and biological activities of secondary metabolites from the culinary-medicinal mushrooms of the genus Hericium: a review

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Chinese Journal of Natural Medicines 2024年第08期 676-698页

作者： QI Jianzhao WU jing KANG Shijie GAO jingming Hirokazu Kawagishi LIU Hongwei LIU chengwei Key Laboratory for Enzyme and Enzyme-Like Material Engineering of Heilongjiang College of Life Science Northeast Forestry University Shaanxi Key Laboratory of Natural Products & Chemical Biology College of Chemistry & Pharmacy Northwest A&F University Faculty of Agriculture Shizuoka University State Key Laboratory of Mycology Institute of Microbiology Chinese Academy of Sciences

Fungal phytochemicals derived from higher fungi, particularly those from the culinary-medicinal genus Hericium, have gained significant attention in drug discovery and healthcare. This review aims to provide a comprehensive analysis of the chemical structures, biosynthetic pathways, biological activities, and pharmacological properties of monomeric compounds isolated from Hericium species. Over the past 34 years, 253 metabolites have been identified from various Hericium species, including cyathane diterpenes,alkaloids, benzofurans, chromenes, phenols, pyrones, steroids, and other miscellaneous compounds. Detailed investigations into the biosynthesis of erinacines, a type of cyathane diterpene, have led to the discovery of novel cyathane diterpenes. Extensive research has highlighted the biological activities and pharmacological properties of Hericium-derived compounds, with particular emphasis on their neuroprotective and neurotrophic effects, immunomodulatory capabilities, anti-cancer activity, antioxidant properties, and antimicrobial actions. Erinacine A, in particular, has been extensively studied. Genomic, transcriptomic, and proteomic analyses of Hericium species have facilitated the discovery of new compounds and provided insights into enzymatic reactions through genome mining. The diverse chemical structures and biological activities of Hericium compounds underpin their potential applications in medicine and as dietary supplements. This review not only advances our understanding of Hericium compounds but also encourages further research into Hericium species within the realms of medicine, health, functional foods, and agricultural microbiology. The broad spectrum of compound types and their diverse biological activities present promising opportunities for the development of new pharmaceuticals and edible products.

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Discovery of a potent and highly selective inhibitor of SIRT6 against pancreatic cancer metastasis in vivo

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1302-1316页

作者： Xinyuan Xu Qian Zhang Xufeng Wang jing Jin chengwei Wu Li Feng Xiuyan Yang Mingzhu Zhao Yingyi Chen Shaoyong Lu Zhen Zheng Xiaobing Lan Yi Wang Yan Zheng Xuefeng Lu Qiufen Zhang Jian Zhang State Key Laboratory of Medical Genomics National Research Center for Translational Medicine at ShanghaiRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Medicinal Chemistry and BioinformaticsCenter Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of General Surgery Huashan HospitalCancer Metastasis InstituteFudan UniversityShanghai 200040China Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease School of Basic Medicine and Medical CenterUniversity of Science and Technology of ChinaHefei 230026China Department of Assisted Reproduction Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China College of Pharmacy Ningxia Medical UniversityYinchuan 750004China Department of Pancreatic Surgery Shanghai General HospitalShanghai Key Laboratory of Pancreatic DiseaseInstitute of Pancreatic DiseaseShanghai Jiao Tong University School of MedicineShanghai 200080China

Pancreatic cancer,one of the most aggressive malignancies,has no effective treatment due to the lack of targets and drugs related to tumour ***6 can promote the migration of pancreatic cancer and could be a potential target for antimetastasis of pancreatic ***,highly selective and potency SIRT6 inhibitor that can be used in vivo is yet to be ***,we developed a noveSIRT6 allosteric inhibitor,compound 11e,with maximal inhibitory potency and an IC_(50) value of 0.98±0.13μmol/***,compound 11e exhibited significant selectivity against other histone deacetylases(HADC1-11 and SIRT1-3)at concentrations up to 100μmol/*** allosteric site and the molecular mechanism of inhibition were extensively elucidated by cocrystal complex structure and dynamic structural ***,we confirmed the antimetastatic function of such inhibitors in four pancreatic cancer cell lines as well as in two mouse models of pancreatic cancer liver *** our knowledge,this is the first study to reveal the in vivo effects of SIRT6 inhibitors on liver metastatic pancreatic *** not only provides a promising lead compound for subsequent inhibitor developmentargeting SIRT6 but also provides a potential approach to address the challenge of metastasis in pancreatic cancer.

关键词： SIRT6 Inhibitor Allosteric Selectivity Cocrystal Pancreatic cancer metastasis

电弧法分散碳纳米管中不同金属电极的实验性研究

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功能材料 2019年第2期50卷 2167-2172页

作者：何燕敬成伟侯朝兵罗亮青岛科技大学机电工程学院山东青岛266061

基于电弧法分散碳纳米管技术的提出,为碳纳米管的分散开辟了气相分散的崭新路径。在提出的电弧法分散碳纳米管的理论基础之上,针对电弧法分散碳纳米管技术中不同金属电极对碳纳米管分散的影响、以及电弧放电对不同金属电极腐蚀的影响进... 详细信息

基于电弧法分散碳纳米管技术的提出,为碳纳米管的分散开辟了气相分散的崭新路径。在提出的电弧法分散碳纳米管的理论基础之上,针对电弧法分散碳纳米管技术中不同金属电极对碳纳米管分散的影响、以及电弧放电对不同金属电极腐蚀的影响进行了实验研究,表征分析了不同金属电极分散的碳纳米管的微观形貌以及电弧对不同金属电极表面造成的影响,并通过对比分析选取出适合电弧法分散碳纳米管的金属电极。该研究为电弧法分散碳纳米管技术的深入研究打下了基础,并为金属表面的放电性腐蚀研究提供了依据。

关键词：电弧法碳纳米管分散金属电极放电性腐蚀

碳纳米管气凝胶/天然橡胶复合材料的性能研究

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功能材料 2018年第3期49卷 3136-3139页

作者：何燕崔连雷朱圣坤郭昌敬成伟青岛科技大学机电工程学院山东青岛266061

碳纳米管气凝胶是一种具有分散特性的碳纳米管,通过自主研究开发的实验装置制备了碳纳米管气凝胶,并通过传统工艺制备了碳纳米管气凝胶/天然橡胶复合材料,研究了该复合材料的机械性能和导热性能等,结果证明该复合材料的拉伸强度、撕裂... 详细信息

碳纳米管气凝胶是一种具有分散特性的碳纳米管,通过自主研究开发的实验装置制备了碳纳米管气凝胶,并通过传统工艺制备了碳纳米管气凝胶/天然橡胶复合材料,研究了该复合材料的机械性能和导热性能等,结果证明该复合材料的拉伸强度、撕裂强度和导热性能等较炭黑/天然橡胶复合材料分别提高了47%,52%,49.9%,同时揭示了碳纳米管气凝胶良好的分散特性及其广阔的应用前景。

关键词：碳纳米管气凝胶复合材料机械性能导热性能分散特性