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Flexible capacitive pressure sensor based on interdigital electrodes with porous microneedle arrays for physiological signal monitoring

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Nanotechnology and Precision Engineering 2024年第1期7卷 18-31页

作者： Jiahui Xu Minghao Wang Minyi Jin Siyan Shang Chuner Ni Yili Hu Xun Sun jun Xu Bowen Ji Le Li Yuhua cheng Gaofeng Wang school of Electronics&Information MOE Engineering Research Center of Smart Microsensors and MicrosystemsHangzhou Dianzi UniversityHangzhou 310018China Wenzhou Institute of Hangzhou Dianzi {2. Wenzhou 310018China Key Laboratory of Intelligent Operation and Maintenance Technology&Equipment for Urban rail Transit of Zhejiang Province College of EngineeringInstitute of Precision Machinery and Smart StructureZhejiang Normal UniversityJinhua 321004China Institute of Guizhou Aerospace Measuring and Testing Technology Guiyang 550009China Unmanned System research Institute Northwestern Polytechnical UniversityXi’an 710072China research&Development Institute of Northwestern Polytechnical univ.r.ity in Shenzhen Shenzhen 518057China

Flexible pressure sensors have many potential applications in the monitoring of physiological signals because of their good biocompatibil-ity and ***,their relatively low sensitivity,linearity,and stability have hindered their large-scale commercial ***,aﬂexible capacitive pressure sensor based on an interdigital electrode structure with two porous microneedle arrays(MNAs)is *** porous substrate that constitutes the MNA is a mixed product of polydimethylsiloxane and *** to its porous and interdigital structure,the maximum sensitivity(0.07 kPa-1)of a porous MNA-based pressure sensor was found to be seven times higher than that of an imporous MNA pressure sensor,and it was much greater than that of aﬂat pressure sensor without a porous MNA ***-element analysis showed that the interdigital MNA structure can greatly increase the strain and improve the sensitivity of the *** addition,the porous MNA-based pressure sensor was found to have good stability over 1500 loading cycles as a result of its bilayer parylene-enhanced conductive electrode *** importantly,it was found that the sensor could accurately monitor the motion of aﬁnger,wrist joint,arm,face,abdomen,eye,and Adam’s ***,preliminary semantic recognition was achieved by monitoring the movement of the Adam’s ***,multiple pressure sensors were integrated into a 33 array to detect a spatial pressure distribu-×*** to the sensors reported in previous works,the interdigital electrode structure presented in this work improves sensitivity and stability by modifying the electrode layer rather than the dielectric layer.

关键词： Capacitive pressure sensor Microneedle array Porous PDMS Interdigital electrode

Pushing the high-k scalability limit with a superparaelectric gate layer

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Journal of Advanced Ceramics 2024年第4期13卷 539-547页

作者： Kun Wang Chao Liu Yuan Zhang fuyu Lv jun Ouyang {2.bing Huang rui-Long Yang Yu-Yao Zhao Hongbo cheng Hanfei Zhu Xiaoming Shi Yun Tian Institute of Advanced Energy Materials and Chemistry Jinan Engineering Laboratory for Multi-scale Functional MaterialsSchool of Chemistry and Chemical EngineeringQilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Key Laboratory for Liquid-Solid Structure Evolution and Processing of Materials(Ministry of Education) School of Materials Science and EngineeringShandong UniversityJinan 250061China china Tobacco Shandong Industrial Co. Ltd.Jinan 250104China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Key Laboratory of Key Film Materials&Application for Equipments(Hunan Province) School of Material Sciences and EngineeringXiangtan UniversityXiangtan 411105China Advanced research Institute of Multidisciplinary Science and School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education School of Chemistry and Materials ScienceShanxi Normal UniversityTaiyuan 030032China

To meet the expectation set by Moore’s law on transistors,the search for thickness-scalable high dielectric constant(k)gate layers has become an emergent research *** investigations have failed to solve the“polarizability–scalability–insulation robustness”*** this work,we show that this trilemma can be solved by using a gate layer of a high k ferroelectric oxide in its superparaelectric(SPE)*** the SPE,its polar order becomes local and is dispersed in an amorp{2.s matrix with a crystalline size down to a few nanometers,leading to an excellent dimensional scalability and a good field-stability of the k *** an example,a stable high k value(37±3)is shown in ultrathin SPE films of(Ba_(0.95),Sr_(0.05))(Zr_(0.2.,Ti_(0.8))O_(3)deposited on LaNiO_(3)-buffered Pt/Ti/SiO_(2./(100)Si down to a 4 nm thickness,leading to a small equivalent oxide thickness of~0.46 *** aforementioned characteristic microstructure endows the SPE film a high breakdown strength(~10.5 MV·cm^(−1)for the 4 nm film),and hence ensures a low leakage current for the operation of the complementary metal oxide semiconductor(CMOS)***,a high electrical fatigue resistance is displayed by the SPE *** results reveal a great potential of superparaelectric materials as gate dielectrics in the next-generation microelectronics.

关键词： high-k transistors Moore's law superparaelectric insulation robustness

治吏与“和平”——论康熙“中正和平”之道对吏治的影响

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史学集刊 2011年第4期 34-43页

作者：成积春曲阜师范大学历史文化学院山东曲阜273165

在国家元气未苏、民困兵乏的特殊社会背景下,玄烨将"中正和平"之道施行于地方统治,强调"不生事"、"不扰民",培养国家之元气,清朝社会出现了"天下粗安,四海承平"的治理局面。但康熙将其"中正和平"之道施行于吏治,则产生了极其消极的影响... 详细信息

在国家元气未苏、民困兵乏的特殊社会背景下,玄烨将"中正和平"之道施行于地方统治,强调"不生事"、"不扰民",培养国家之元气,清朝社会出现了"天下粗安,四海承平"的治理局面。但康熙将其"中正和平"之道施行于吏治,则产生了极其消极的影响。康熙朝中期以后,玄烨极力强调"和平"、"安静",认为"多一事不如少一事"、"凡事不可深究者极多",不能严禁浮费和规银,宽纵州县火耗和亏空,至康熙晚年,整个清王朝吏治废弛,贪贿公行,个别地区出现暴动和骚乱,统治秩序奏出了不和谐音符。

关键词：康熙中正和平吏治思想

The Bright Single Pulse Emission from PSr B1133+16

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research in Astronomy and Astrophysics 2024年第4期24卷 253-261页

作者： jun Tan Zhi-Gang Wen Zhen Wang Xue-Feng Duan Hong-Guang Wang Na Wang Vishal Gajjar Jian-Ping Yuan rai Yuen Wen-Ming Yan Jian-Ling Chen Wei Han Hui Wang cheng-Bing Lyu Ai-jun Dong Maths and Information Technology school Yuncheng UniversityYuncheng 044000China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Xinjiang Key Laboratory of radio Astrophysics Urumqi 830011China school of Physics and Materials Science Guangzhou UniversityGuangzhou 510006China Space Science Laboratory University of CaliforniaBerkeley 94710USA Department of Physics and Electronic Engineering Yuncheng UniversityYuncheng 044000China school of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550025China

We have conducted a comprehensive investigation into the bright single pulse emission from PSr B1133+16using the Giant Metrewave radio *** time resolution data(61μs)were obtained at a center frequency of 32. MHz with a bandwidth of 32.MHz over a continuous observation period of 7.45 hr.A total of 1082.bright pulses were sporadically detected with peak flux densities ranging from 10 to 2. times stronger than the average pulse ***,no giant pulse-like emission with a relative pulse energy larger than 10 and extremely short duration was detected,indicating that these bright pulses cannot be categorized as giant pulse *** majority of these bright pulses are concentrated in pulse phases at both the leading and trailing windows of the average pulse profile,with an occurrence ratio of approximately *** pulse energy distribution for all individual pulses can be described by a combination of two Gaussian components and a cutoff power-law with an index of α=-*** updated nulling fraction of 15.35%±0.45% was determined from the energy *** emission of individual pulses follows a log-normal distribution in peak flux density *** is imperative that regular phase drifting in bright pulse sequence is identified in both the leading and trailing components for the first *** physical mechanisms are discussed in detail to provide insights into these observations.

关键词： (stars:)pulsars:general (stars:)pulsars:individual(PSr B1133+16) methods:observational methods:data analysis

An engineered DNA aptamer-based PrOTAC for precise therapy of p53-r175H hotspot mutant-driven cancer

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Science Bulletin 2024年第13期69卷 2122-2135页

作者： Lingping Kong Fanlu Meng Ping Zhou ruixin Ge Xiaoshan Geng Zhihao Yang Guo Li Linlin Zhang Jing Wang Jinfeng Ma cheng Dong {2. Zhou Sijin Wu Diansheng Zhong Songbo Xie Department of Medical Oncology Tianjin Medical University General HospitalTianjin 300052China Center for Cell Structure and function Collaborative Innovation Center of Cell Biology in Universities of ShandongCollege of Life SciencesShandong Normal UniversityJinan 250014China The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease(Ministry of Education)School of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment Lung Cancer InstituteTianjin Medical University General HospitalTianjin 300052China Haihe Laboratory of Cell Ecosystem State Key Laboratory of Medicinal Chemical BiologyCollege of Life SciencesNankai UniversityTianjin 300071China Wisdom Lake Academy of Pharmacy Xi’an Jiaotong-Liverpool UniversitySuzhou 215028China Department of Ophthalmology Tianjin Medical University General HospitalLaboratory of Molecular OphthalmologyTianjin Key Laboratory of Ocular TraumaTianjin Medical UniversityTianjin 300052China

Targeting oncogenic mutant p53 represents an attractive strategy for cancer treatment due to the high frequency of gain-of-function mutations and ectopic expression in various cancer *** extensive efforts,the absence of a druggable active site for small molecules has rendered these mutants therapeutically *** we develop a selective and effective proteolysis-targeting chimera(PrOTAC)for p53-r175H,a common hotspot mutant with dominant-negative and oncogenic *** a novel iterative molecular docking-guided post-SELEX(systematic evolution of ligands by exponential enrichment)approach,we rationally engineer a high-performance DNA aptamer with improved affinity and specificity for *** this resulting aptamer as a binder for PrOTACs,we successfully developed a selective p53-r175H degrader,named ***53m induces the ubiquitin–protea some-dependent degradation of p53-r175H while sparing wildtype ***,dp53m demonstrates significant antitumor efficacy in p53-r175H-driven cancer cells both in vitro and in vivo,without ***,dp53m significantly and synergistically improves the sensitivity of these cells to cisplatin,a commonly used chemotherapy *** findings provide evidence of the potential therapeutic value of dp53m in p53-r175H-driven cancers.

关键词： P53 Aptamer PrOTAC Cancer Drug resistance

Chiral phonon activated spin Seebeck effect in chiral materials

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Science china(Physics,Mechanics & Astronomy) 2024年第3期67卷 149-155页

作者： Xiao Li Jinxin Zhong Jinluo cheng Hao Chen Huiqian Wang jun Liu Dali Sun Lifa Zhang jun Zhou Phonon Engineering research Center of Jiangsu Province Center for Quantum Transport and Thermal Energy ScienceSchool of Physics and TechnologyNanjing Normal UniversityNanjing 210023China Center for Phononics and Thermal Energy Science China-EU Joint Lab for NanophononicsSchool of Physics Science and EngineeringTongji UniversityShanghai 200092China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of ScienceChangchun 130033China Department of Mechanical and Aerospace Engineering North Carolina State UniversityRaleigh NC 27606USA Department of Physics North Carolina State UniversityRaleigh NC 27695USA Organic and Carbon Electronics Laboratories(OraCEL) North Carolina State UniversityRaleigh NC 27606USA

Efficient generation of spin polarization is very important for spintronics and quantum computation. In chiral materials without magnetic order nor spin-orbit coupling, we find a new spin selectivity effect—chiral phonon activated spin Seebeck(CPASS)effect. Starting with the nonequilibrium distribution of chiral phonons under a temperature gradient, the CPASS coefficients are computed based on the Boltzmann transport theory. With both the phonon-drag and band transport contributions, the spin accumulations generated by the CPASS effect exhibit quadratic dependence on the temperature gradient. The strength of the CPASS effect and the relative magnitude of both contributions are tunable by the chemical potential modulation. The CPASS effect, which gives a promising explanation on the traditional chiral-induced spin selectivity effect, provides opportunities for the exploration of advanced spintronic devices based on chiral materials even in the absence of any magnetic order and spin-orbit coupling.

关键词： spin Seebeck effect chiral phonon phonon-drag contribution efficient spin generation

“开学化学第一课”的教学现状调查及实施对策

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化学教育（中英文） 2024年第11期45卷 91-96页

作者：刘志强程俊王后雄华中师范大学人工智能教育学部湖北武汉430079 中山市中山纪念中学广东中山528454 广东省教育研究院广东广州510035

对化学第一课的重要性、教学形式、实施困扰进行调查。从课标教材、生活实践、科技前沿、新闻热点等4个方面归纳化学第一课的教学素材。提出生活情境式、提纲挈领式、知识进阶式和方法指引式等4种教学范式;从立德树人的落实、生涯规划... 详细信息

对化学第一课的重要性、教学形式、实施困扰进行调查。从课标教材、生活实践、科技前沿、新闻热点等4个方面归纳化学第一课的教学素材。提出生活情境式、提纲挈领式、知识进阶式和方法指引式等4种教学范式;从立德树人的落实、生涯规划的融入、教学素材的选择、教材顺序的编排和深度广度的把控等5个方面提出化学第一课的实施对策。

关键词：化学第一课教学素材教学范式立德树人

The Pressure in Operator Algebras

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Acta Mathematica Sinica,English Series 2008年第6期24卷 983-996页

作者： cheng jun {2. Department of Mathematics Qufu Normal University Qufu 273165 P. R. China

We introduce two notions of the pressure in operator algebras, one is the pressure Pα（π, T） for an automorphism α of a unital exact C^＊-algebra A at a self-adjoint element T in A with respect to a faithful unital ＊-representation π the other is the pressure Pτ,α（T） for an automorphism α of a hyperfinite von Neumann algebra M at a self-adjoint element T in M with respect to a faithful {2. α-invariant state τ. We give some properties of the pressure, show that it is a conjugate invaxiant, and also prove that the pressure of the implementing inner automorphism of a crossed product A×α Z at a self-adjoint operator T in A equals that of α at T.

关键词： exact C^*-algebra hyperfinite von Neumann algebra entropy pressure crossed product

Output-Feedback Stabilization for More General Stochastic High-Order Nonlinear Systems

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Output-Feedback Stabilization for More General Stochastic Hi...