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Combination of microbiome and metabolome to analyze the cross-synergism mechanism of inulin and gut microbiota in vitro and vivo

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Food Bioscience 2022年第5期49卷 1299-1309页

作者： Chang Liu Yahui Guo He Qian yuliang cheng State Key Laboratory of Food Science and Technology Jiangnan UniversityNo.1800 Lihu AvenueWuxiJiangsu Province214122China School of Food Science and Technology Jiangnan UniversityNo.1800 Lihu AvenueWuxiJiangsu Province214122China Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province Jiangnan UniversityNo.1800 Lihu AvenueWuxiJiangsu Province214122China

Inulin can regulate the intestinal micro-ecological balance,but there are few studies on the changes of intestinal microbiota and its metabolites in vitro and vivo,SCFAs and amino acids in *** this study,the human fecal microbiota glycolysis model and a mouse model were used to study the mechanism of inulin on intestinal *** with metabolism of microbiome and metabolome,the cross-synergism mechanism of inulin-micribiota-metabolites-metabolism was *** results revealed that after inulin was fermented by human intestinal microbiota,the relative abundance of Lactobacillus,Bifidobacterium,Prevotella,Catenibacterium,and Agathobacter *** vivo,the concentration of SCFAs increased after inulin was fermented,and the abundance of Parabacteroides,Muribaculaceae and Alloprevotella *** in vivo and in vitro experiments revealed that inulin can regulate the expression of 5 genes involved in Valine,leucine and isoleucine *** addition,the metabolome results confirmed that Valine,leucine and isoleucine degradation,Tyrosine metabolism,and Synthesis and degradation of ketone bodies are regulatory pathways of *** importantly,L􀀀tryptophan,tyrosine,L􀀀fucose,L􀀀ornithine,D􀀀fructose,D􀀀erythrose,and pyruvic acid are hallmark metabolites of inulin metabolized by gut *** cross-synergism network greatly indicated the microbiota(Streptococcus,Lactobacillus,Muribaculaceae),metabolites(L-tryptophan,pyruvic acid),and metabolism(Lysine degradation,Tryptophan metabolism,Synthesis and degradation of ketone bodies)may be the key factors involved in the mechanisms regulating the in vitro and vivo effects of inulin.

关键词： Inulin Gut microbiota Metabolic function Metabolomics Cross-synergism

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Establishment of the thin-layer chromatography-surface-enhanced Raman spectroscopy and chemometrics method for simultaneous identification of eleven illegal drugs in anti-rheumatic health food

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Food Bioscience 2022年第5期49卷 556-568页

作者： Fangwei Yang cheng Wang Hang Yu Yahui Guo yuliang cheng Weirong Yao Yunfei Xie State Key Laboratory of Food Science and Technology Jiangnan UniversityNo.1800 Lihu AvenueWuxi214122Jiangsu ProvinceChina School of Food Science and Technology Jiangnan UniversityNo.1800 Lihu AvenueWuxi214122Jiangsu ProvinceChina Joint International Research Laboratory of Food Safety Jiangnan UniversityNo.1800 Lihu AvenueWuxi214122Jiangsu ProvinceChina

The risk of the illegal addition of anti-inflammatory and analgesic chemical drugs in anti-rheumatic health foods should not be *** supervision and rapid on-site detection technology need to be ***-layer chromatography-surface-enhanced Raman spectroscopy(TLC-SERS),which has the advantages of simple operation,fast separation,and qualitative and quantitative detection,was used in this *** these eleven chemical drugs(acetaminophen,acetylsalicylic acid,aminophenazone,dexamethasone,diclofenac sodium,hydrocortisone,indometacin,naproxen,phenylbutazone,piroxicam,prednisone 21-acetate)that may be added to anti-rheumatic health foods have been simultaneously identified by TLC-SERS combined with chemometrics *** characteristic signals of the separated drug spots were collected by SERS,which were optimized by the gold colloidal nanoparticles’volume and integration *** SERS was subjected to principal component analysis(PCA)to reduce dimensionality and combined with the pattern recognition methods in chemometrics,such as PCA-Linear Discriminant Analysis(LDA),PCA-K Nearest Neighbor and PCA-Support Vector Machine,and eleven drug components were judged and ***,the predictive performances of different models were also analyzed and *** results showed that the TLC plate and four organic solvents of petroleum ether,chloroform,ethyl acetate and acetic acid were selected as the developing *** dropping amount of gold colloidal nanoparticles and the integration time were set and *** limit of detection of the simultaneous detection method of SERS was 10-100 mg/***,SERS was preprocessed by Gap-Segment 2nd Derivative,and then the PCA-LDA model was established,and the model’s prediction accuracy can reach 100%.The method is simple,rapid,sensitive and accurate,and has low experimental instruments and equipment *** is suitable for the on-site simultaneous detection of various anti-inflammato

关键词： TLC-SERS Health food Illegal drugs Chemometrics Simultaneous identification Rapid detection

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Study on the hepatoprotective effect of Sporidiobolus pararoseus polysaccharides under the“gut microbiome-amino acids metabolism”network

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Food Bioscience 2022年第5期49卷 1318-1326页

作者： Chang Liu Hanyi Hua Yahui Guo He Qian Jingfang Liu yuliang cheng State Key Laboratory of Food Science and Technology Jiangnan UniversityNo.1800 Lihu AvenueWuxiJiangsu Province214122China Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province Jiangnan UniversityNo.1800 Lihu AvenueWuxiJiangsu Province214122China Institutional Center for Shared Technologies and Facilities of Institute of Microbiology Chinese Academy of SciencesNO.1 Beichen West RoadChaoyang DistrictBeijing100101China

The“gut-liver”axis plays an important role in the mechanism of alcoholic liver disease(ALD).Sporidiobolus pararoseus polysaccharides(SPP)have been shown to improve the gut barrier and liver damage in mice with ***,the process is modulated via the gut microbiome and amino acids in the gut-liver axis has not been *** this study,the gut microbiome and metabolic function were explored for the mechanism by which SPP improve *** results showed that after the SPP were metabolized by ALD mice,microbial diversity was altered,and the relative abundances of Lachnospiraceae,Alistipes,Eubacterium siraeum,and Bacteroides *** predicted results of microbiome functions promoted the biosynthesis of amino acids,tyrosine,tryptophan,valine,leucine,and isoleucine were *** results also confirmed that butanoate metabolism and biosynthesis of phenylalanine,tyrosine,and tryptophan are the main regulatory pathways of *** gut microbiome metabolizes the hallmark metabolites of SPP were L-tyrosine,L-histidine,and *** analysis and interaction network deeply mine gut microbiome(Lachnospiraceae,Eubacterium siraeum,Erysipelotrichaceae),metabolites(L􀀀serine,L􀀀tyrosine),and metabolism(biosynthesis of amino acids,valine,leucine,and isoleucine biosynthesis)may be key factors in the SPP-gut microbiome-metabolites-metabolism in ALD ***,SPP have the effect of proliferating beneficial gut microbiome that metabolize polysaccharides,promoting the production of amino acids,and regulating liver metabolic disorders.

关键词： Sporidiobolus pararoseus polysaccharides Gut microbiome Amino acids metabolism Bioinformatics

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Trans-cinnamaldehyde inhibits Penicillium italicum by damaging mitochondria and inducing apoptosis mechanisms

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Food Science and Human Wellness 2022年第4期11卷 975-981页

作者： Fangwei Yang Jiaqi Mi Fei Huang Prompong Pienpinijtham Yahui Guo yuliang cheng Weirong Yao Yunfei Xie School of Food Science and Technology Jiangnan UniversityWuxi 214122China State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China Qingdao Special Food Research Institute Qingdao 266109ShandongChina

Plant-derived essential oils have excellent antifungal effects and can be used for the preservation of fresh foods such as fruits and vegetables, but the detailed mechanism has not been fully elucidated. In this study, we investigated the inhibitory effects of trans-cinnamaldehyde on Penicillium italicum, a common pollution fungus in citrus, and explored the antifungal mechanism of trans-cinnamaldehyde by detecting fungal oxidative damage, mitochondrial metabolism, and cell apoptosis. These results showed that transcinnamaldehyde made the carboxylic acid cycle deregulated by altering the related enzyme activities(succinate dehydrogenase, malate dehydrogenase) and mid product. Moreover, the level of reactive oxygen species rose sharply while the redox level was out of regulation. The mitochondrial membrane potential collapsed, leading to the leakage of cytochrome c, and then triggering the activation of apoptotic protease, which was further confirmed by the significant increase in caspase-3 activity from(3.6 ± 0.6) U to(8.8 ± 1.1) U(P < 0.05). The cytochrome c in mitochondria was detected by confocal Raman microspectroscopy, the characteristic intensity index(I750/I2944) was decreased, indicating that the cytochrome c in mitochondria was reduced and leakage. Besides, the strong negative correlation between Raman intensity and the amount of cytochrome c leakage was established with the correlation coefficient of-0.981 7. This study revealed that destroying the integrity of the mitochondrial membrane, activating the mitochondrial-mediated apoptosis pathway was the in-depth antifungal mechanism of trans-cinnamaldehyde;and Raman spectroscopy technology provided new ideas to study this process with high sensitivity determination of cytochrome c.

关键词： trans-cinnamaldehyde Penicillium italicum Raman microspectroscopy Inhibition mechanism Cytochrome c Apoptosis

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Anti-fatigue activity of Brassica rapa *** and correlation among biochemical changes in forced swimming mice

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Food Bioscience 2022年第3期47卷 670-678页

作者： Zilin Li Hongkang Zhu Hanyi Hua Chang Liu yuliang cheng Yahui Guo Peng Du He Qian State Key Laboratory of Food Science and Technology School of Food Science and TechnologyJiangnan UniversityWuxi214122China International Joint Laboratory on Food Safety Jiangnan UniversityWuxi214122China People's Liberation Army Air Force PLABeijing100142China

Brassica rapa *** an edible and medical plant in China used for treating various diseases,especially in the Tibet *** this study,the chemical constituents of Brassica rapa ***(BE)was clarified by UHPLC-MS and anti-fatigue ability of BE was assessed through the behavior test and weight-loaded forced swimming test in *** we determined several biochemical parameters related to fatigue to explore possible *** indicate that BE could significantly enhance exercise performance in mice,and there was a significant improvement in both grip-strength and the time on ***,BE showed significant anti-fatigue effects by decreasing the blood lactic acid(BLA),blood urea nitrogen(BUN),and creatine kinase(CK)levels and increasing the lactate dehydrogenase(LDH)and malondialdehyde(MDA)*** in superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)were observed and reactive oxygen species(ROS)levels was *** and muscle glycogen levels and adenosine triphosphate(ATP)levels were also significantly *** correlation analysis indicates that fatigue-related indexes including metabolites and energy-related indexes were significantly correlated with antioxidant *** conclusion,BE possesses remarkable anti-fatigue activity,thereby shows great potential for improving exercise performance and alleviating physical fatigue and can be considered as a functional food supplement for further development.

关键词： Brassica rapa L. UHPLC-MS Anti-fatigue Behavioral experiment Energy metabolism

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Protein corona formed on the TiO_(2)nanoparticles promotes the hydrolysis of collagen in simulated gastrointestinal fluids

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Food Bioscience 2023年第3期53卷 2616-2625页

作者： Yulun Chen Qingrun Liu Hang Yu Yahui Guo yuliang cheng He Qian Yunfei Xie Weirong Yao State Key Laboratory of Food Science and Technology Jiangnan UniversityNo.1800 Lihu AvenueWuxi214122Jiangsu ProvinceChina Engineering Research Center of Dairy Quality and Safety Control Technology Ministry of EducationInner Mongolia UniversityNo.235 Daxue West RoadHohhot010021Inner Mongolia Autonomous RegionChina School of Food Science and Technology Jiangnan UniversityNo.1800 Lihu AvenueWuxi214122Jiangsu ProvinceChina Joint International Research Laboratory of Food Safety Jiangnan UniversityNo.1800 Lihu AvenueWuxi214122Jiangsu ProvinceChina

Titanium dioxide nanoparticles(TiO_(2) NPs)could interact with proteins in foods and gastrointestinal fluids,thus changing the properties and functions of *** research articles have only studied the interactions between TiO_(2) NPs and digestive enzymes or the gastrointestinal fate of TiO_(2) NPs without considering the effect of food ***,the interactions between TiO_(2) NPs and trypsin and its effects on the digestion of collagen in vitro were *** showed that the functionalization of amino acids(Asp,and Ser)significantly harmed the adsorption of trypsin by TiO_(2) *** fluorescence quenching and isothermal titration calorimetry confirmed that the hydrogen bond and van der Waals force played an essential role in the interactions between TiO_(2) NPs and ***β-sheet content of trypsin bound to TiO_(2) NPs decreased from 52.40%to 50.73%while the random coil content increased from 20.20%to 22.63%.Binding sites were identified by molecular ***,the digestibility of collagen was improved in vitro in the presence of TiO_(2) NPs analyzed by SDS-PAGE,hydroxyproline quantification,and the antioxidation of digested *** concentra-tion increased by nearly 25%and ABTS radical scavenging rate increased by 50%.This study provides a new insight into the impact of nanoparticles on gastrointestinal digestion.

关键词： TiO_(2)nanoparticles Protein corona Gastrointestinal digestion

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Study of the anti-fatigue properties of macamide,a key component in maca water extract,through foodomics and gut microbial genomics

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Food Bioscience 2022年第5期49卷 1265-1275页

作者： Chang Liu Hanyi Hua Hongkang Zhu Wenqian Xu Yahui Guo Weirong Yao He Qian yuliang cheng State Key Laboratory of Food Science and Technology Jiangnan UniversityNo.1800 Lihu AvenueWuxiJiangsu Province214122China School of Food Science and Technology Jiangnan UniversityNo.1800 Lihu AvenueWuxiJiangsu Province214122China Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province Jiangnan UniversityNo.1800 Lihu AvenueWuxiJiangsu Province214122China

Lepidium meyenii *** a type of food used to fight fatigue,and macamides is the key anti-fatigue component in Lepidium meyenii *** extract(Maca).The mechanisms of action of several foods with anti-fatigue properties lie in the oxidative balance of tissues;however,little attention has been given to the *** gut microbial community is closely related to dietary choices,as well as exercise-induced skeletal muscle *** such,this study used a foodomics approach to analyze the anti-fatigue properties of maca amide,a key component in maca,on the gut *** key components in maca were identified,and after validation in a mouse model,an analysis of the gut microbiome was *** results of database searches and network analyses showed that the key anti-fatigue component of maca was N-benzyl-9Z,12Z-octadecadienamide(Mm).Further analyses revealed that the key microbes metabolizing Mm belonged to Alistipes,Alloprevotella,Parabacteroides,and Butyricimonas genera and the Prevotellaceae in *** results of microbial analysis showed that Mm could improve exercise-induced skeletal muscle fatigue in mice by modulating the L-glutamate-ornithine-proline axis through the breakdown of histidine,arginine,and ***,from foodomics and gut microbial genomics perspectives,this study demonstrates that macamide is the key anti-fatigue component in maca,and these findings provide new insights for the development of foods that fight fatigue.

关键词： Maca N-Benzyl-9Z 12Z-octadecadienamide Foodmics Gut microbial genomics Anti-fatigue

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面向西南印度洋多源科考数据的可扩展管理系统

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浙江大学学报（理学版） 2017年第4期44卷 493-498页

作者：成玉良苏程章孝灿浙江大学空间信息技术研究所浙江杭州310027

为了使科考数据的存储和管理适应未来科学考察动态化、多样化发展的需要,在全面分析多源科考数据特点的基础上,结合成熟的数据库管理系统SQL Server以及空间数据库引擎ArcSDE,对多源科考数据的存储组织结构和可视化管理进行了分析和研究... 详细信息

为了使科考数据的存储和管理适应未来科学考察动态化、多样化发展的需要,在全面分析多源科考数据特点的基础上,结合成熟的数据库管理系统SQL Server以及空间数据库引擎ArcSDE,对多源科考数据的存储组织结构和可视化管理进行了分析和研究,提出了一套多源科考数据管理方案.设计并实现了西南印度洋多金属硫化物科学考察数据管理系统,该系统主要由多源科考数据的统一存储管理和可视化空间操作等功能模块组成,具有良好的适应性和扩展性,可满足实际应用需求.

关键词：西南印度洋多源科考数据空间数据库引擎数据库管理系统

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Torularhodin bilosomes attenuate high-fat diet-induced chronic kidney disease in mice by regulating the TLR4/NF-κB pathway

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Food Bioscience 2023年第1期51卷 888-897页

作者： Ciwan Wang Chang Liu Wenqian Xu yuliang cheng Yahui Guo Yong Zhao Fanglin Shen He Qian State Key Laboratory of Food Science and Technology Jiangnan UniversityNo.1800 Lihu AvenueWuxiJiangsu Province214122China Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province Jiangnan UniversityNo.1800 Lihu AvenueWuxiJiangsu Province214122China School of Food Science and Technology Jiangnan UniversityNo.1800 Lihu AvenueWuxiJiangsu Province214122China Affiliated Hospital of Jiangnan University Thoracic and Cardiac SurgeryNo.1000He Feng Road13WuxiJiangsu Province214122China Fudan University No.220Handan RoadYangpu DistrictShanghai200433China

Torularhodin is a carotenoid that exerts beneficial effects on chronic kidney disease(CKD),which is strongly linked to a high-fat diet(HFD),however,its functional properties have not yet been fully *** this study,torularhodin bilosomes,which feature good processing properties and physical stability,were chosen for *** evaluated their effect on mice with CKD induced by HFD and determined the relevant *** HFD-fed mice,both structural and functional renal injury was observed,including significant increases in BUN,SCr,urinary protein levels,capillary basement membrane thickening,and inflammatory cell *** results showed that SOD content,GSH-px content,and CAT activity were all significantly higher,while the MDA level was significantly lower in the tor-emu and tor-bilo groups,indicating that torularhodin effectively alleviated oxidative *** addition,the expression of the inflammatory factors TNF-a,IL-6,and IL-1βwas reduced in the torularhodin group compared with the model group,and both the transcription and expression of the TLR4,MyD88,TIRAP,TRIF,and NF-κB proteins related to the TLR4/NF-κB pathway were ***,torularhodin reduced the renal inflammatory response by decreasing TLR4 protein expression and the signaling of proteins such as MyD88,as well as preventing NF-κB from undergoing dissociation,reducing its transcriptional activity,and decreasing the release of downstream pro-inflammatory *** conclusion,torularhodin bilosomes can alleviate high-fat diet-induced CKD in mice by modulating the TLR4/NF-κB *** result further deepens the understanding of torularhodin activity and confirms the role of torularhodin as an effective health supplement.

关键词： Torularhodin Bilosomes High-fat diet Chronic kidney disease TLR4 NF-κB

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宏观审慎监管视角的金融监管目标实现程度的实证分析

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国际金融研究 2013年第1期 38-51页

作者：李成李玉良王婷西安交通大学经济与金融学院金融系

本文选择反映金融监管的经济变量解析宏观审慎监管的效应,运用定量方法对中、美、日、英四国的数据实证分析金融监管的有效性。研究结论显示,我国宏观审慎落实程度和金融监管目标实现程度均比较低,主要原因是,中央银行在金融稳定中的地... 详细信息

本文选择反映金融监管的经济变量解析宏观审慎监管的效应,运用定量方法对中、美、日、英四国的数据实证分析金融监管的有效性。研究结论显示,我国宏观审慎落实程度和金融监管目标实现程度均比较低,主要原因是,中央银行在金融稳定中的地位不够显著,金融监管存在顺周期性导致对系统性金融风险不够敏感;金融监管中的行政干预超越了金融法律制度影响,一定程度上影响了金融系统的内在运行机制。因此,实现我国宏观审慎监管需要提高中央银行在宏观金融稳定中的地位,完善金融法律制度和强化执法效率,构建宏观审慎监管与宏观经济稳定的政策协调机制。

关键词：宏观审慎金融监管金融稳定宏观经济

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