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基于多维服务模式的安全电子印章系统的设计与实现

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软件 2024年第7期45卷 98-104页

作者：高瞻罗军锋徐墨锁志海任炜西安交通大学网络信息中心陕西西安710049

随着信息技术的飞速发展和高校数字化转型的推进,电子印章平台成为各高校重要基础支撑平台。本文围绕高校师生盖章排队、跨校区奔波等“急难愁盼”现实困境,针对现有通用的电子印章软件存在的服务模式单一、业务办理不够便捷、平台支撑... 详细信息

随着信息技术的飞速发展和高校数字化转型的推进,电子印章平台成为各高校重要基础支撑平台。本文围绕高校师生盖章排队、跨校区奔波等“急难愁盼”现实困境,针对现有通用的电子印章软件存在的服务模式单一、业务办理不够便捷、平台支撑能力不足等问题,以可靠电子签名技术、自主可控的核心密码技术为支撑,设计了“121+N”的全新服务架构及“多重加密技术+分层防护策略”的安全架构,建立了一套完善的电子印章制发、管理和使用的统一电子印章服务平台,有力支撑了高校各类证明电子化,各类流程办理签章、签名移动化,推进高校数字化转型纵深发展。

关键词：多维服务模式电子印章电子签名系统安全

Correlation between thrombopoietin and inflammatory factors,platelet indices,and thrombosis in patients with sepsis:A retrospective study

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World Journal of Clinical Cases 2022年第13期10卷 4072-4083页

作者： Wan-Hua Xu Li-Chan mo Mao-Hua Shi Hui Rao Xiao-Yong zhan.mo Yang Department of Hematology Nanfang Hospital/The First School of Clinical MedicineSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Emergency Medicine The First People’s Hospital of FoshanFoshan 528000Guangdong ProvinceChina Department of Emergency Medicine Nanfang Hospital/The First School of Clinical MedicineSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Rheumatology and Immunology The First People’s Hospital of FoshanFoshan 528000Guangdong ProvinceChina Scientific Research Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107Guangdong ProvinceChina Department of Pediatrics Nanfang Hospital/The First School of Clinical MedicineSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

BACKGROUND Thrombopoietin(TPO)is a primary regulator of thrombopoiesis in physiological ***,in combination with its specific cytokine receptor c-Mpl,drives platelet production by inducing the proliferation and differentiation of ***,the role of TPO in sepsis is not well *** elevated levels of TPO are often accompanied by a decrease of platelet count(PLT)in systemic infected conditions,which is contrary to the view that TPO promotes platelet production under physiological *** addition,whether TPO mediates organ damage in sepsis remains *** To explore the relationships between TPO and inflammatory factors,platelet indices,and thrombotic indicators in *** A total of 90 patients with sepsis diagnosed and treated at the emergency medicine department of The First People’s Hospital of Foshan between January 2020 and March 2021 were enrolled in this *** addition,110 patients without sepsis who came to the emergency medicine department were included as *** and laboratory parameters including age,gender,TPO,blood cell count in peripheral blood,platelet indices,inflammatory factors such as high-sensitivity Creactive protein(hs-CRP),interleukin(IL)-21,and IL-6,organ damage indicators,and thrombotic indicators were collected and analyzed by using various statistical *** The results showed that the TPO levels were higher in the sepsis group than in controls[86.45(30.55,193.1)vs 12.45(0.64,46.09)pg/mL,P<0.001],but PLT was lower(P<0.001).Multivariable analysis showed that white blood cell count(WBC)[odds ratio(OR)=1.32;95%confidence interval(CI):1.01-1.722;P=0.044],TPO(OR=1.02;95%CI:1.01-1.04;P=0.009),IL-21(OR=1.02;95%CI:1.00-1.03;P=0.019),troponin I(OR=55.20;95%CI:5.69-535.90;P=0.001),and prothrombin time(PT)(OR=2.24;95%CI:1.10-4.55;P=0.027)were independent risk factors associated with *** levels were positively correlated with IL-21,IL-6,hs-CRP,creatinine,D-dimer,P

关键词： Sepsis Thrombopoietin Interleukin-21 Platelets Thrombosis

一种用于视频超分辨率和去运动模糊联合处理的深度学习网络

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测绘地理信息 2024年第3期49卷 91-95页

作者：方宁詹总谦王鑫武汉大学测绘学院湖北武汉430079

针对视频影像存在运动模糊及分辨率较低的问题,本文提出了一种视频超分辨率和去运动模糊联合处理的卷积神经网络(convolutional neural network,CNN),该网络可以应对剧烈的运动模糊干扰并恢复出清晰的高分辨率视频。首先,利用金字塔光... 详细信息

针对视频影像存在运动模糊及分辨率较低的问题,本文提出了一种视频超分辨率和去运动模糊联合处理的卷积神经网络(convolutional neural network,CNN),该网络可以应对剧烈的运动模糊干扰并恢复出清晰的高分辨率视频。首先,利用金字塔光流网络提取模糊帧中的清晰潜像并输出高分辨率的光流图来完成运动估计,并通过逐帧递归的方式完成运动补偿以充分利用时间先验信息;然后,以并联的方式分别提取超分辨率和去模糊特征;最后,利用通道注意力机制来增强两个分支的特征融合效率。在公开数据集上的实验结果表明,相比于现有的同类型超分辨率和去模糊算法,本文方法的重建结果更优。

关键词：超分辨率视频去模糊卷积神经网络运动模糊

新媒体环境下风险传播特质再探——以风险概念的重溯为路径

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河北经贸大学学报（综合版） 2024年第1期24卷 40-46页

作者：王瞻东北财经大学人文与传播学院辽宁大连116025

重溯人文与社会科学领域中的风险概念为新媒体环境下风险传播特质的探讨提供了路径。关系论视角下,风险区别于危险,是行为、责任与结果的统一体。在历时视域中,风险是诊断现代性的工具,社会发展阶段不同所面临的风险不同。在人类文化学... 详细信息

重溯人文与社会科学领域中的风险概念为新媒体环境下风险传播特质的探讨提供了路径。关系论视角下,风险区别于危险,是行为、责任与结果的统一体。在历时视域中,风险是诊断现代性的工具,社会发展阶段不同所面临的风险不同。在人类文化学领域中,风险作为一种集体构念是理解和处理危险的方法。新媒体环境下,传受关系的改变加剧了风险传播的不确定性,时空的压缩与重组带来了复杂的风险传播情景,而网络圈层的形成与扩张则增加了风险传播的多义性特质。

关键词：风险风险传播新媒体

In vitro evaluation of electrospun gelatin-glutaraldehyde nanofibers

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Frontiers of Materials Science 2016年第1期10卷 90-100页

作者： Jianchao zhan.Yosry moRSI Hany EI-HAMSHARY Salem S. AL-DEYAB Xiumei mo College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China College of Materials and Textile Engineering Jiaxing University Jiaxing 314001 China Faculty of Engineering and Industrial Sciences Swinburne University of Technology Hawthorn Vic 3122 Australia Department of Chemistry College of Science King Saud University Riyadh 11451 Saudi Arabia Department of Chemistry Faculty of Science Tanta University Tanta 31527 Egypt

The gelatin-glutaraldehyde （gelatin-GA） nanofibers were electrospun in order to overcome the defects of ex-situ crosslinking process such as complex process, destruction of fiber morphology and decrease of porosity. The morphological structure, porosity, thermal property, moisture absorption and moisture retention performance, hydrolytic resistance, mechanical property and biocompatibiUty of nanofiber scaffolds were tested and characterized. The gelatin-GA nanofiber has nice uniform diameter and more than 80% porosity. The hydrolytic resistance and mechanical property of the gelatin-GA nanofiber scaffolds are greatly improved compared with that of gelatin nanofibers. The contact angle, moisture absorption, hydrolysis resistance, thermal resistance and mechanical property of gelatin-GA nanofiber scaffolds could be adjustable by varying the gelatin solution concentration and GA content. The gelatin- GA nanofibers had excellent properties, which are expected to be an ideal scaffold for biomedical and tissue engineering applications.

关键词： nanofiber electrospinning gelatin tissue engineering

补肾中药复方对高盐摄入去卵巢大鼠骨代谢及ENaCα、NCC和ClC-3表达的影响

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中国病理生理杂志 2024年第1期40卷 141-147页

作者：崔琰孙珂焕詹小瑶莫枢肖雅雯王攀攀杨丽张荣华朱晓峰暨南大学附属第一医院广东广州510632 暨南大学中医学院广东广州510632 深圳市第二人民医院广东深圳518025 深圳市中医院广东深圳518000 暨南大学药学院广东广州510632

目的:探讨补肾中药复方(Bushen formulae,BHF)对高盐摄入去卵巢大鼠骨代谢的影响及其可能的作用机制。方法:80只SPF级SD雌性大鼠按随机数字表法分为假手术组、模型组、中高盐组、高盐组、补肾方组、补肾方+生理盐水组、补肾方+中高盐组... 详细信息

目的:探讨补肾中药复方(Bushen formulae,BHF)对高盐摄入去卵巢大鼠骨代谢的影响及其可能的作用机制。方法:80只SPF级SD雌性大鼠按随机数字表法分为假手术组、模型组、中高盐组、高盐组、补肾方组、补肾方+生理盐水组、补肾方+中高盐组、补肾方+高盐组,每组各10只,造模后给予不同饮食、补肾中药复方干预,中高盐饮食、高盐饮食中氯化钠添加浓度分别为2%w/w、8%w/w,补肾中药复方干预剂量为7.8 g·kg^(-1)·d^(-1),每日1次,连续给药12周。检测各组骨密度、骨微结构、骨参数、骨代谢生物标志物、骨组织病理变化情况以及采用Western blot检测骨组织上皮钠离子通道α(ENaCα)、钠-氯同向转运体(NCC)、电压门控性氯离子通道3(ClC-3)蛋白的表达。结果:与假手术组相比,模型组大鼠骨密度降低,骨微结构破坏;与模型组相比,中高盐、高盐饮食组大鼠骨微结构破坏更为明显,同时高盐组骨形成标志物骨钙素(BGP)、Ⅰ型原胶原氨基端前肽(PINP)水平显著上升(P<0.05),骨吸收标志物Ⅰ型胶原氨基端肽(NTX)、Ⅰ型胶原羧基端肽(CTX)、抗酒石酸酸性磷酸酶(TRACP)均显著增加(P<0.05),骨代谢处于高转换状态;高盐饮食加速骨小梁结构的破坏,Western blot结果显示高盐饮食引起股骨组织ENaCα、ClC-3蛋白表达水平下降(P<0.05),NCC蛋白表达水平升高(P<0.05),补肾中药复方干预后能够不同程度的调节高盐引起的相关离子通道的表达。结论:补肾中药复方能够不同程度的调节高盐引起的相关离子通道ENaCα、ClC-3、NCC的表达,对骨代谢失衡具有一定的改善和治疗作用。

关键词：高盐摄入骨代谢离子通道补肾中药复方

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Specific cellular immune responses in mice immunized with DNA,adeno-associated virus and adenoviral vaccines of Epstein-Barr virus-LMP2 alone or in combination

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Science China(Life Sciences) 2011年第3期54卷 263-266页

作者： WANG zhan.YANG SongMei ZHOU Ling DU HaiJun mo WuNing ZENG Yi State Key Laboratory for Infectious Disease Prevention and Control Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100052 China Laboratory Department The First Affiliated Hospital Guangxi Medical University Nanning 530021 China

Cellular immune responses,particularly those associated with CD3+CD8+ cytotoxic T lymphocytes (CTL),are critical factors in controlling viral *** carcinoma (NPC) is closely associated with persistent Epstein-Barr virus (EBV) *** vaccine studies have focused on enhancing specific antiviral CTL *** this study,three vaccines capable of expressing the EBV-latent membrane protein 2 (LMP2) (a DNA vector,an adeno-associated virus (AAV) vector,and a replication-defective adenovirus serotype 5 (Ad5) vector) were respectively used to immunize female Balb/c mice (4-6 weeks old) at weeks 0,2 and 4,either alone or in *** results suggest that combined immunization with DNA,AAV,and adenovirus vector vaccines induced specific cellular immunity more effectively than any of these vectors alone or a combination of two of the three,constituting a sound vaccine strategy for the prevention and treatment of NPC.

关键词： EBV-LMP2 DNA vaccine recombinant adenovirus vaccine recombinant adeno-associated virus vaccine combinatorial immunization specific cell-mediated immune responses

Cardioprotective effect of Yiqi Huoxue granule through regulation of mitophagy after myocardial infarction in rats

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Journal of Traditional Chinese Medical Sciences 2020年第2期7卷 171-180页

作者： Xi chen Jiangong Wu Shuwen Guo Hanrong mo Tianwei zhan.Fanghe Li Hui Wang Pengfei Feng Lulu Wei School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing100029China Department of Traditional Chinese Medicine Peking University People’s HospitalBeijing100044China Fangshan Hospital Beijing University of Chinese Medicine Beijing102499China

Objective:To investigate the cardioprotective effect of Yiqi Huoxue granule(YQHXG)in the regulation of autophagy in rats induced with myocardial infarction(MI).Methods:An acute MI animal model was established by ligation of the left anterior descending branch of the coronary artery in Sprague-Dawley ***,20 rats received sham operation were classified into a control *** remaining 59 rats were randomly divided into MI model group(n=19),YQHXG group(n=20),and perindopril group(n=20).Relevant indicators on days 7 and 28 were observed in each *** ventricular function was determined by *** structure and morphology of mitochondria,and the number of autophagic vesicles,were observed by transmission electron *** mRNA and protein expression levels of LC3,FUNDC1,Beclin-1,and BNIP3 were examined in the tissue of the MI marginal ***:Compared with the MI model group,YQHXG showed obvious improvements in cardiac *** the microscopic morphology of the heart tissue,myocardial tissue damage attenuated,autophagic signs of autophagosomes and autolysosomes reduced,vacuolization in mitochondria mitigated,and mitochondria arranged in *** could reduce the degree of tissue lesion after MI and regulate the expression of autophagy-related molecules at different *** Day 7,YQHXG significantly downregulated the expression of Fundc1,Becn1,Bnip3 mRNA and reduced the levels of FUNDC1,Beclin-1,BNIP3,and LC3 B proteins expression(all P<.001).On Day 28,YQHXG could upregulate the expression of Becn1,Fundc1 and Bnip3 mRNA and increased the levels of the corresponding proteins expression(all P<.001).Besides,it also increased LC3 B protein expression level(P=.0344).Conclusion:YQHXG regulated the expression of mitochondrial autophagy-related factors in myocardial tissue and mitochondrial autophagic activity at different stages to protect the heart following MI.

关键词： Myocardial infarction Yiqi Huoxue granule Mitochondrial autophagy

12Cr2mo1锻件带极埋弧堆焊Inconel625工艺研究

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化工设备与管道 2024年第1期61卷 24-30页

作者：湛立宁陈敏卢俊文周璐璐吴婷王肖逸河北省特种设备监督检验研究院河北石家庄050061 河北省承压设备检测评价技术创新中心河北石家庄050061

为保证12Cr2mo1锻件带极埋弧堆焊Inconel625质量达到设计文件要求,对锻件基材和Inconel625焊接性能进行了分析,模拟承制产品实际生产状态进行堆焊工艺评定试验,采用周向堆焊和直道堆焊相结合的方法制备评定试件,对堆焊层化学成分、弯曲... 详细信息

为保证12Cr2mo1锻件带极埋弧堆焊Inconel625质量达到设计文件要求,对锻件基材和Inconel625焊接性能进行了分析,模拟承制产品实际生产状态进行堆焊工艺评定试验,采用周向堆焊和直道堆焊相结合的方法制备评定试件,对堆焊层化学成分、弯曲性能、硬度指标、金相组织、耐腐蚀性能进行了检测。试验结果表明,采用EQ62-50/ES200的焊带/焊剂组合可以获得性能优良的堆焊层。对堆焊层进行腐蚀速率检测,其焊态试样腐蚀速率为1.50 mm/a,固溶态试样腐蚀速率为1.17mm/a,两者之比为1.28,满足JB/T 4756—2006标准规定比值小于或等于1.5的要求。根据评定合格的焊接工艺对热高分气/循环氢换热器管板进行了堆焊,堆焊产品已稳定运行三年,未出现焊接缺陷和腐蚀缺陷。

关键词： 12Cr2mo1 Inconel625 换热器管板带级埋弧堆焊腐蚀试验