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孕早期血清C1q肿瘤坏死因子相关蛋白12预测妊娠期糖尿病的价值

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中国糖尿病杂志 2024年第6期32卷 423-426页

作者：马秀英陈禄英赵苗深圳市龙华区妇幼保健院孕产群体保健科 518000 深圳市龙华区妇幼保健院孕产群体妇产科 518000

目的探讨孕早期血清C1q肿瘤坏死因子相关蛋白12(CTRP12)预测GDM的价值。方法选取2020年3月至2022年10月于我科行产前检查的孕妇182例,检测妊娠6~14周时血清CTRP12水平。孕24~28周时,依据OGTT结果分为糖耐量正常(NGT)组152例及GDM组30... 详细信息

目的探讨孕早期血清C1q肿瘤坏死因子相关蛋白12(CTRP12)预测GDM的价值。方法选取2020年3月至2022年10月于我科行产前检查的孕妇182例,检测妊娠6~14周时血清CTRP12水平。孕24~28周时,依据OGTT结果分为糖耐量正常(NGT)组152例及GDM组30例。比较两组血清CTRP12水平,分析血清CTRP12对GDM的预测价值。结果 182例孕妇中,GDM发病率为16.48%。GDM组年龄、妊娠前BMI、FPG、DM家族史高于NGT组,血清CTRP12低于NGT组(P<0.05)。Logistic回归分析显示,妊娠前BMI、DM家族史、FPG、血清CTRP12是GDM的影响因素。受试者工作特征曲线分析显示,血清CTRP12预测GDM的曲线下面积为0.822(95%CI 0.759~0.885),最佳截断值为5.66 ng/ml,敏感度为68.2%,特异度为90.3%。相较于CTRP12高水平组,CTRP12低水平组GDM发病率升高(P<0.05)。结论 GDM患者孕早期血清CTRP12水平降低,CTRP12是GDM的影响因素,对GDM有较好的预测价值。

关键词： C1q肿瘤坏死因子相关蛋白12 妊娠期糖尿病预测价值孕早期

适老化需求下历史文化街区更新策略研究——以福州三坊七巷为例

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艺术与设计（理论版） 2024年第4期 83-85页

作者：陈露颖林阳福建理工大学福州350118

通过调查福州三坊七巷历史文化街区当中景观环境和老年人行为活动之间的矛盾,探索适老化需求下的历史文化街区的更新策略。文章从空间可达性、场所组团类型多样性、公共空间标识引导性、公共设施合理性等多方面,运用实地调研的方法,对... 详细信息

通过调查福州三坊七巷历史文化街区当中景观环境和老年人行为活动之间的矛盾,探索适老化需求下的历史文化街区的更新策略。文章从空间可达性、场所组团类型多样性、公共空间标识引导性、公共设施合理性等多方面,运用实地调研的方法,对福州三坊七巷历史文化街区的环境现状与老年人的行为活动匹配度进行系统分析。试图从环境设计的角度出发为现代历史文化街区的适老化需求改造提供更新策略。

关键词：福州三坊七巷历史文化街区适老化更新策略

Media, Redemption, and Myth Superscription in Zhang Yimou＇s Riding Alone for Thousands of Miles

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2017年第3期11卷 510-535页

作者： luying chen Department of Humanities History and Social Sciences Columbia College Chicago 624 S Michigan USA

This article analyzes scenes of media and redemption in Zhang Yimou＇s 张艺谋 film Qianli zou danqi 千里走单骑（Riding Alone for Thousands of Miles, 2005） as a critique of Romantic Orientalism. Whereas in Western Romantic poetry, the themes of retreating to nature and journeying abroad are strengthened by imagining the Orient and appropriating the local voice, Riding Alone negates that motif by depicting the divided subjectivities of Kenichi, a historian of Oriental Art at Tokyo University, and his failed redemption during his journey to China. The film offers his father Takata＇s alternative journey, which involves the foreign traveler losing his subject position before asserting his own, leading to the revival of the Lord Guan story. Much of the historical myth-making of Lord Guan in Buddhist, Daoist, and Confucian religious practices involves a reinvention of a cultural tradition as a response to foreign threat; all share the features of what Prasenjit Duara calls ＂the apotheosization of a hero and his role as guardian＂ in a process of the ＂superscription of symbols.＂ By contrast, Riding Alone is secular and forward-thinking while reenacting several meanings of the Lord Guan myth such as repentance, sacrifice, redemption, and guardianship. The film interpolates the Japanese into a new ＂Oriental＂ subject position that has to lose its Western Orientalism as well as the negative impact of industrialism while retaining democratic subjectivity, and the Chinese into a new democratic subject position that maintains autonomy.

关键词： media Zhang Yimou Qianli zou danqi redemption

Anomaly traffic detection of database network based on flow statistical features

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Frontiers of Electrical and Electronic Engineering in China 2010年第1期5卷 85-90页

作者： Xinliang WANG Fang LIU luying chen Zhenming LEI School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

The traditional intrusion detection system has the problem of high false positive rate and false negative *** paper deeply analyzes the differences of statistical features between single-flow and multi-flow on the database network,and presents a group of features that are easy to acquire and can be used to detect the anomaly in database network *** applying this group of features in Fisher algorithm for anomaly detection,the false positive rate and false negative rate are dramatically ***,the model made by using the group of features has the advantages of low algorithm complexity,good detection result and strong generalization *** results show that there is higher accuracy when using the features of single-flow and multiflow to construct the anomaly detection model than only using single-flow features.

关键词： anomaly detection flow statistical feature Fisher statistical package for social sciences(SPSS)

采用慢病毒载体干扰TRAF2表达的MH7A细胞稳转株的构建及意义

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安徽医科大学学报 2024年第2期59卷 193-199页

作者：陈露颖蒋励萍王伟康左书俊蒯佳婕马旸韩陈陈魏伟安徽医科大学临床药理研究所、抗炎免疫药物教育部重点实验室、抗炎免疫药物安徽省协同创新中心合肥230032

目的用慢病毒载体构建干扰肿瘤坏死因子受体相关因子2(TRAF2)表达的类风湿关节炎(RA)患者滑膜细胞株MH7A细胞稳转株,研究TNF-α-TRAF2信号在MH7A异常增殖的作用。方法根据人TRAF2的基因序列和shRNA序列设计原则,设计并合成3对TRAF2-sh... 详细信息

目的用慢病毒载体构建干扰肿瘤坏死因子受体相关因子2(TRAF2)表达的类风湿关节炎(RA)患者滑膜细胞株MH7A细胞稳转株,研究TNF-α-TRAF2信号在MH7A异常增殖的作用。方法根据人TRAF2的基因序列和shRNA序列设计原则,设计并合成3对TRAF2-shRNA干扰序列,通过PCR对引物进行退火,通过双酶切PLKO.1-puro获得线性载体,将线性化载体与退火后引物通过Solution I连接,连接产物导入感受态细胞,涂板,挑取阳性菌落进行测序。构建3种不同的PLKO.1-TRAF2-shRNA慢病毒重组质粒,借助慢病毒包装质粒对对数生长期的HEK 293T细胞进行慢病毒包装,收集病毒液感染MH7A细胞,同时使用嘌呤霉素对TRAF2低表达的MH7A稳转株进行筛选。使用CCK-8法、Western blot、qPCR检测MH7A中肿瘤坏死因子TNF-α诱导TRAF2低表达的MH7A增殖功能及下游信号TRAF2、P65蛋白表达和mRNA水平。结果成功构建了PLKO.1-TRAF2-shRNA(1)、PLKO.1-TRAF2-shRNA(2)和PLKO.1-TRAF2-shRNA(3)慢病毒载体质粒和对照组慢病毒载体质粒PLKO.1-puro,将3个TRAF2-shRNA慢病毒载体质粒和对照组慢病毒载体质粒PLKO.1-puro分别与慢病毒包装质粒导入HEK 293T获得病毒液,将病毒液感染MH7A细胞后,经嘌呤霉素(2.00μg/ml)筛选,2 d得到MH7A稳转株;qPCR和Western blot结果显示,PLKO.1-TRAF2-shRNA(1) MH7A细胞稳转株中TRAF2 mRNA和蛋白的表达较阴性对照组明显下降;CCK-8和Western blot结果表明,MH7A中TRAF2敲低后,TNF-α诱导的TRAF2低表达的MH7A细胞增殖和P65的磷酸化水平明显下降。结论成功构建了PLKO.1-TRAF2-shRNA(1) MH7A细胞稳转株,研究TNF-α-TRAF2信号活化介导RA滑膜细胞异常增殖中的作用。

关键词：类风湿关节炎 MH7A 肿瘤坏死因子受体相关因子2 慢病毒载体

An intelligent active probing and trace-back scheme for IoT anomaly detection

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Digital Communications and Networks 2024年第1期10卷 168-181页

作者： luying Wang Lingyi chen Neal N.Xiong Anfeng Liu Tian Wang Mianxiong Dong School of Computer Science and Engineering Central South UniversityChangsha 410083China Department of Computer Science and Mathematics Sul Ross State UniversityAlpineTX 79830USA Artificial Intelligence and Future Networks Beijing Normal University&UICZhuhai 519087China Department of Information and Electronic Engineering Muroran Institute of TechnologyMuroran 050-8585Japan

Due to their simple hardware,sensor nodes in IoT are vulnerable to attack,leading to data routing blockages or malicious tampering,which significantly disrupts secure data *** Intelligent Active Probing and Trace-back Scheme for IoT Anomaly Detection(APTAD)is proposed to collect integrated IoT data by recruiting Mobile Edge Users(MEUs).(a)An intelligent unsupervised learning approach is used to identify anomalous data from the collected data by MEUs and help to identify anomalous nodes.(b)Recruit MEUs to trace back and propose a series of trust calculation methods to determine the trust of nodes.(c)The last,the number of active detection packets and detection paths are designed,so as to accurately identify the trust of nodes in IoT at the minimum cost of the network.A large number of experimental results show that the recruiting cost and average anomaly detection time are reduced by 6.5 times and 34.33%respectively,while the accuracy of trust identification is improved by 20%.

关键词： Anomaly detection Internet of things Integrating data collection Mobile edge users Intelligent

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互联网内容治理中的平台责任研究

出版发行研究 2020年第6期 12-18页

作者：陈璐颖中国人民大学新闻学院中国人民大学新闻与社会发展研究中心

互联网平台在信息传播中的枢纽地位及其掌握的技术治理手段,使其具备参与互联网内容治理的必要性;然而,平台作为私人主体参与公共事务管理,也存在私人利益与公共利益难平衡、缺乏违法内容判断及处置能力、程序正当性难保障等潜在问题,... 详细信息

互联网平台在信息传播中的枢纽地位及其掌握的技术治理手段,使其具备参与互联网内容治理的必要性;然而,平台作为私人主体参与公共事务管理,也存在私人利益与公共利益难平衡、缺乏违法内容判断及处置能力、程序正当性难保障等潜在问题,可能在一定程度上侵犯了公民的表达权。应对这些问题,需要多元治理主体形成合力,在法律法规不断完善的前提下,发挥政府监管、行业公约、用户监督的协同作用,保障互联网平台责任的有效落实。

关键词：平台责任内容治理互联网治理互联网平台

Modeling and Analysis of User Behavior of GPRS Network

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Modeling and Analysis of User Behavior of GPRS Network

Controlled growth of vertically stacked In_(2)Se_(3)/WSe_(2) heterostructures for ultrahigh responsivity photodetector

2011 International Conference on Information Management and Engineering(ICIME 2011)

作者： cheng Wei Wang chen Lei Zhenming chen luying Zhang Bo School of Information and Communication Engineering Beijing University of Posts and Telecommunications Network Management Center China Mobile Group Zhejiang Co.Ltd

ISBN: (纸本)9781612842387

The General Packet Radio Service (GPRS) has become a standard to extend the services provided by the Global System for Mobile Communications (GSM). Through the introduction of packet switching function entity, GPRS supports the use of packet data transmission, allowing a more efficient usage of the radio resources with a consequent improvement in the QoS of subscribers. In this paper we present some observations of the GPRS, by describing user behavior at Gn interface in GPRS core network. By disposing monitoring and analysis system at the Gn interface of real operational GPRS network, we analyzed the distribution of mobile user’s online duration and factors affect it, such as user’s business types and terminal types. At last we obtained the model of the user online duration distribution. And some methodological issues are involved in performing this type of analysis, for instance the potential bias introduced by some users.

关键词： GPRS Gn GTP user behavior online duration

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Nano Research 2024年第3期17卷 1856-1863页

作者： cheng Zhang Biyuan Zheng Guangcheng Wu Xueying Liu Jiaxin Wu chengdong Yao Yizhe Wang Zilan Tang Ying chen Lizhen Fang luying Huang Dong Li Shengman Li Anlian Pan Key Laboratory for Micro-Nano Physics and Technology of Hunan Province State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Materials Science and EngineeringHunan UniversityChangsha 410082China

Transition metal dichalcogenides(TMDCs)are promising candidates for future optoelectronic devices accounting for their high carrier mobility and excellent quantum ***,the limited light absorption efficiency in atomically thin layers significantly hinders photocarrier generation,thereby impairing the optoelectronic performance and hindering practical ***,we successfully synthesized In_(2)Se_(3)/WSe_(2) heterostructures through a typical two-step chemical vapor deposition(CVD)*** In_(2)Se_(3) nanosheet with strong light absorption capability,serving as the light absorption layer,was integrated with the monolayer WSe_(2),enhancing the photosensitivity of WSe_(2) *** laser irradiation with a wavelength of 520 nm,the In_(2)Se_(3)/WSe_(2) heterostructure device shows an ultrahigh photoresponsivity with a value as high as 2333.5 A/W and a remarkable detectivity reaching up to 6.7×10^(12) Jones,which is the highest among almost the reported TMDCs-based heterostructures grown via CVD even some fabricated by mechanical exfoliation(ME).Combing the advantages of CVD method such as large scale,high yield,and clean interface,the In_(2)Se_(3)/WSe_(2) heterostructures would provide a novel path for future high-performance optoelectronic device.

关键词： transition metal dichalcogenides(TMDCs) In_(2)Se_(3) heterostructure photodetector ultrahigh responsivity