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Single-cell brain atlas of Parkinson's disease mouse model

Journal of Genetics and Genomics 2021年第4期48卷 277-288页

作者： Jixing Zhong Gen Tang Jiacheng Zhu Weiying Wu Ge Li Xiumei Lin Langchao Liang chaochao chai Yuying Zeng Feiyue Wang Lihua Luo Jiankang Li Fang Chen Zhen Huang Xiuqing Zhang Yu Zhang Hongde Liu Xin Qiu Shengping Tang Dongsheng Chen School of Biological Science&Medical Engineering Southeast UniversityNanjing 210096China BGI-Shenzhen Shenzhen 518083China Shenzhen Children's Hospital Shenzhen 518083China BGI Education Center University of Chinese Academy of SciencesShenzhen 518083China Department of Neurobiology NHC and CAMS Key Laboratory of Medical NeurobiologySchool of Brain Science and Brian MedicineAnd the MOE Frontier Science Center for Brain Research and Brain-Machine IntegrationZhejiang University School of MedicineHangzhou 310012China Guangdong Provincial Key Laboratory of Laboratory Animals Guangdong Laboratory Animals Monitoring InstituteGuangzhouGuangdong 510663China MGI BGI-ShenzhenShenzhen 518083China Life Science College Fujian Normal UniversityFuzhou 350108China Key Laboratory of Special Marine Bio-resources Sustainable Utilization of Fujian Province Fuzhou 350108China

Parkinson's disease(PD)is a neurodegenerative disease,leading to the impairment of movement *** pathogenesis has been largely investigated,either limited to bulk transcriptomic levels or at certain cell types,which failed to capture the cellular heterogeneity and intrinsic interplays among distinct cell ***,we report the application of single-nucleus RNA-seq on midbrain,striatum,and cerebellum of theα-syn-A53 T mouse,a well-established PD mouse model,and matched controls,generating the first single cell transcriptomic atlas for the PD model mouse brain composed of 46,174 individual ***,we comprehensively depicte the dysfunctions in PD pathology,covering the elevation of NF-k B activity,the alteration of ion channel components,the perturbation of protein homeostasis network,and the dysregulation of glutamatergic ***,we identify a variety of cell types closely associated with PD risk *** together,our study provides valuable resources to systematically dissect the molecular mechanism of PD pathogenesis at the single-cell resolution,which facilitates the development of novel approaches for diagnosis and therapies against PD.

关键词： Parkinson’s disease α-syn-A53T Single-nucleus RNA-Seq Pathogenesis Neuroinflammtion

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内部控制、市场竞争与企业创新绩效——来自中国上市公司的证据

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淮南师范学院学报 2021年第6期23卷 54-60页

作者：柴朝超李玲芮婷淮南师范学院经济与管理学院安徽淮南232000 南京航空航天大学经济与管理学院江苏南京210000

外部市场环境与企业内部治理对企业的战略决策有着重要的作用,为了进一步探究内部控制及市场竞争与企业研发之间的关系,文章以2017~2019年沪深A股上市公司中高科技服务行业上市公司为研究样本,实证检验了内部控制与市场竞争对企业研发... 详细信息

外部市场环境与企业内部治理对企业的战略决策有着重要的作用,为了进一步探究内部控制及市场竞争与企业研发之间的关系,文章以2017~2019年沪深A股上市公司中高科技服务行业上市公司为研究样本,实证检验了内部控制与市场竞争对企业研发创新绩效的影响。研究表明:内部控制与企业研发创新绩效显著正相关;市场竞争的加剧会显著降低企业研发创新绩效;进一步回归分析后发现,市场竞争会对内部控制与研发创新绩效之间的相互关系产生负向作用,激烈的竞争会弱化内部控制对企业研发创新绩效的促进作用。

关键词：内部控制市场竞争研发创新绩效

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Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing Li Zixuan He Weitai chai Meng Tian Huali Yu Xiaoxiao He Xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

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Single-cell atlas of domestic pig cerebral cortex and hypothalamus

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Science Bulletin 2021年第14期66卷 1448-1461,M0004页

作者： Jiacheng Zhu Fang Chen Lihua Luo Weiying Wu Jinxia Dai Jixing Zhong Xiumei Lin chaochao chai Peiwen Ding Langchao Liang Shiyou Wang Xiangning Ding Yin Chen Haoyu Wang Jiaying Qiu Feiyue Wang Chengcheng Sun Yuying Zeng Jian Fang Xiaosen Jiang Ping Liu Gen Tang Xin Qiu Xingliang Zhang Yetian Ruan Sanjie Jiang Jiankang Li Shida Zhu Xun Xu Fang Li Zhongmin Liu Gang Cao Dongsheng Chen College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China BGI-Shenzhen Shenzhen 518083China MGI BGI-ShenzhenShenzhen 518083China Department of Neurobiology NHC and CAMS Key Laboratory of Medical NeurobiologySchool of Brain Science and Brian Medicineand the MOE Frontier Science Center for Brain Research and Brain–Machine IntegrationZhejiang University School of MedicineHangzhou 310031China State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhan 430070China College of Veterinary Medicine Huazhong Agricultural UniversityWuhan 430070China School of Biological Science&Medical Engineering Southeast UniversityNanjing 210096China School of Basic Medicine Qingdao UniversityQingdao 266071China College of Life Science South China Agricultural UniversityGuangzhou 510642China Shenzhen Children’s Hospital Shenzhen 518083China Research Center for Translational Medicine East HospitalTongji University School of MedicineShanghai 200120China College of Biomedicine and Health Huazhong Agricultural UniversityWuhan 430070China

The brain of the domestic pig(Sus scrofa domesticus)has drawn considerable attention due to its high similarities to that of ***,the cellular compositions of the pig brain(PB)remain *** we investigated the single-nucleus transcriptomic profiles of five regions of the PB(frontal lobe,parietal lobe,temporal lobe,occipital lobe,and hypothalamus)and identified 21 cell *** cross-species comparison of mouse and pig hypothalamus revealed the shared and specific gene expression patterns at the single-cell ***,we identified cell types and molecular pathways closely associated with neurological disorders,bridging the gap between gene mutations and *** reported,to our knowledge,the first single-cell atlas of domestic pig cerebral cortex and hypothalamus combined with a comprehensive analysis across species,providing extensive resources for future research regarding neural science,evolutionary developmental biology,and regenerative medicine.

关键词： Domestic pig Brain cell atlas Single-cell transcriptome Neural science

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The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

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Could the Recent Taal Volcano Eruption Trigger an El Ni?o and Lead to Eurasian Warming?

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Advances in Atmospheric Sciences 2020年第7期37卷 663-670页

作者： Fei LIU Chen XING Jinbao LI Bin WANG Jing chai chaochao GAO Gang HUANG Jian LIU Deliang CHEN School of Atmospheric Sciences and Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies Sun Yat-sen UniversityZhuhai 519082China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China Earth System Modeling and Climate Dynamics Research Center Nanjing University of Information Science and TechnologyNanjing 210044China Department of Geography University of Hong KongPokfulamHong Kong Department of Atmospheric Sciences and International Pacific Research Center University of Hawaii at ManoaHonoluluHI 96822USA Department of Environmental Science Zhejiang UniversityHangzhou 310058China State key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Key Laboratory for Virtual Geographic Environment Ministry of EducationJiangsu Provincial State Key Laboratory Cultivation Base of Geographical Environment EvolutionSchool of Geography ScienceNanjing Normal UniversityNanjing 210023China Department of Earth Sciences University of GothenburgGothenburg 40530Sweden

The Taal Volcano in Luzon is one of the most active and dangerous volcanoes of the Philippines.A recent eruption occurred on 12 January 2020(Fig.1a),and this volcano is still active with the occurrence of volcanic *** eruption has become a deep concern worldwide,not only for its damage on local society,but also for potential hazardous consequences on the Earth’s climate and environment.

关键词： Volcano Philippines worldwide

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机械应力调控血管平滑肌细胞的凋亡

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中国组织工程研究 2025年第5期29卷 1064-1072页

作者：徐飞闫金强柴守栋北京航空航天大学生物与医学工程学院北京市100083 聊城市人民医院中心实验室山东省聊城市252000 聊城市人民医院病理科山东省聊城市252000 聊城市人民医院心外科山东省聊城市252000

背景:随着生物力学的发展,其在心血管疾病中的研究也日益广泛,通过研究血管的力学特性可以有效地揭示动脉粥样硬化、再狭窄等心血管疾病的发病机制,开发心血管疾病治疗的新思路和新方法。目的:综述机械应力刺激对血管平滑肌细胞凋亡的... 详细信息

背景:随着生物力学的发展,其在心血管疾病中的研究也日益广泛,通过研究血管的力学特性可以有效地揭示动脉粥样硬化、再狭窄等心血管疾病的发病机制,开发心血管疾病治疗的新思路和新方法。目的:综述机械应力刺激对血管平滑肌细胞凋亡的研究现状,寻找临床治疗潜在靶分子和信号通路,以期改善临床动脉粥样硬化及再狭窄等心血管疾病的临床治疗效果。方法:检索1992年1月至2023年5月在中国知网、PubMed及ScienceDirect数据库收录的文献。中文检索词为“血管平滑肌细胞,机械应力,剪切力,牵张力,凋亡”;英文检索词为“vascular smooth muscle cell,mechanical stress,shear stress,stretch stress,apoptosis”,最终纳入63篇文献进行综述分析。结果与结论:①血管平滑肌细胞的生理性和病理性凋亡都是为了适应血管力学变化而发生的适应性重构。不同部位的平滑肌细胞承受不同的力学刺激,其发病机制也不同。②低剪切力、生理剪切力和高剪切力可通过直接与平滑肌细胞表面分子、受体及蛋白等作用调控凋亡信号分子和抑制增殖实现对血管平滑肌细胞凋亡的调控,该部分未对促进增殖的研究进行综述。③低牵张力、生理牵张力和高牵张力可导致平滑肌细胞凋亡,但仍存在争议。平滑肌表面存在多种力学感受分子(如整合素及受体络氨酸激酶等)可以将力学信号转导为细胞内的化学信号(如Hippo通路),启动平滑肌细胞的凋亡信号,调控平滑肌细胞的凋亡。④总之,不同力学刺激通过多种信号分子,启动多个信号通路共同作用,调控平滑肌细胞的凋亡,例如剪切力主要通过刺激分泌前列腺素、转化生长因子等影响Fas/FasL、Akt通路;而牵张力主要通过Yes相关蛋白等调控YAP通路和Notch通路等。这些分子在不同的作用时间,或不同作用强度下可能发挥相反的双向作用,比如,小鼠血管平滑肌细胞受到10%生理牵张1 h时,其增殖增加;然而,人的血管平滑肌细胞牵张12 h后可以减少其增殖。临床可以通过寻找其关键作用时间点干扰力学转导关键分子,达到预防和治疗临床心血管疾病的目的。

关键词：血管平滑肌细胞机械应力凋亡牵张力剪切应力整合素受体络氨酸激酶 G蛋白偶联受体和G蛋白离子通道

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Surface proximity effect enables layer-by-layer growth of MoS2

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National Science Review 2022年第7期9卷 10-11页

作者： Yang chai Department of Applied Physics The Hong Kong Polytechnic University

Two-dimensional(2 D) monolayer semiconductors have shown great potential for continuous downward scaling to a 2-nm technology node [1].However,the monolayer characteristics make it quite challenging to completely manifest their intrinsic high *** the interface between semiconductors and dielectrics,the carriers are scattered by extrinsic impurities and remote optical phonons,which seriously degrade their carrier mobility;at the electrical contact,

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UNIFORM DECAY RATE FOR THE TRANSMISSION WAVE EQUATIONS WITH VARIABLE COEFFICIENTS

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Journal of Systems Science & Complexity 2011年第2期24卷 253-260页

作者： Shugen chai School of Mathevaatical Sciences Shanxi University Taiyuan 030006 China

This paper considers the stabilization of the transmission problem of wave equations with variable coefficients. By introducing both boundary feedback control and distribute feedback control near the transmission boun... 详细信息

关键词： Feedback stabilization transmission problem wave equation.

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宋代“鞫谳分司”制下司法参军的司法实践——以毛滂的“检法”实例为视角

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河北大学学报（哲学社会科学版） 2025年第1期50卷 44-52页

作者：柴荣陈泽北京师范大学法学院北京100875

在重视法律的历史背景下,宋代形成了以“防止奸弊”为目的,以“听”“断”分离为形式的“鞫谳分司”制度。司法参军作为“谳司”官员,是宋代地方州一级的重要司法属官,主要负责对“检出”的量刑法条进行核定与“驳正”。出生于簪缨之家... 详细信息

在重视法律的历史背景下,宋代形成了以“防止奸弊”为目的,以“听”“断”分离为形式的“鞫谳分司”制度。司法参军作为“谳司”官员,是宋代地方州一级的重要司法属官,主要负责对“检出”的量刑法条进行核定与“驳正”。出生于簪缨之家的毛滂,深受当时社会环境和家庭的影响,养成了较高的法律素养。分析毛滂在司法参军任上的“检法”实例,可以看出他在遵守法律的前提下,对“止杀”“仁民”“爱物”等司法活动多重价值的权衡取舍。结合具体的司法实践,可以更加深入地认识宋代重视法律的历史背景和“鞫谳分司”的运行机制,以及其与司法官员之间相互影响、相互作用的紧密关系。

关键词：重视法律 “鞫谳分司” 司法参军改易风俗

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