Single-cell atlas of domestic pig cerebral cortex and hypothalamus

作     者：Jiacheng Zhu Fang Chen Lihua Luo Weiying Wu Jinxia Dai Jixing Zhong Xiumei Lin Chaochao Chai Peiwen Ding Langchao Liang Shiyou Wang Xiangning Ding Yin Chen Haoyu Wang Jiaying Qiu Feiyue Wang Chengcheng Sun Yuying Zeng Jian Fang Xiaosen Jiang Ping Liu Gen Tang Xin Qiu Xingliang Zhang Yetian Ruan Sanjie Jiang Jiankang Li Shida Zhu Xun Xu Fang Li Zhongmin Liu Gang Cao Dongsheng Chen 朱佳成;陈芳;罗礼华;吴炜滢;戴金霞;钟集杏;林秀妹;柴超超;丁佩文;梁郎超;王诗友;丁香凝;陈银;王浩宇;邱嘉颖;王飞越;孙成成;曾瑜盈;方健;蒋晓森;刘萍;唐根;邱鑫;张星亮;阮烨畑;姜三杰;李健康;朱师达;徐讯;李芳;刘中民;曹罡;陈东升

作者机构：College of Life SciencesUniversity of Chinese Academy of SciencesBeijing 100049China BGI-ShenzhenShenzhen 518083China MGIBGI-ShenzhenShenzhen 518083China Department of NeurobiologyNHC and CAMS Key Laboratory of Medical NeurobiologySchool of Brain Science and Brian Medicineand the MOE Frontier Science Center for Brain Research and Brain–Machine IntegrationZhejiang University School of MedicineHangzhou 310031China State Key Laboratory of Agricultural MicrobiologyHuazhong Agricultural UniversityWuhan 430070China College of Veterinary MedicineHuazhong Agricultural UniversityWuhan 430070China School of Biological Science&Medical EngineeringSoutheast UniversityNanjing 210096China School of Basic MedicineQingdao UniversityQingdao 266071China College of Life ScienceSouth China Agricultural UniversityGuangzhou 510642China Shenzhen Children’s HospitalShenzhen 518083China Research Center for Translational MedicineEast HospitalTongji University School of MedicineShanghai 200120China College of Biomedicine and HealthHuazhong Agricultural UniversityWuhan 430070China 

出 版 物：《Science Bulletin》 (科学通报（英文版）)

年 卷 期：2021年第66卷第14期

页      面：1448-1461,M0004页

核心收录：

学科分类：0905[农学-畜牧学] 09[农学] 

基　　金：the China Postdoctoral Science Foundation(2017M622795) the Science,Technology and Innovation Commission of Shenzhen Municipality(JCYJ20180507183628543) the Fundamental Research Funds for the Central Universities(2662018PY025 and 2662017PY105) 

主　　题：Domestic pig Brain cell atlas Single-cell transcriptome Neural science 

摘      要：The brain of the domestic pig(Sus scrofa domesticus)has drawn considerable attention due to its high similarities to that of ***,the cellular compositions of the pig brain(PB)remain *** we investigated the single-nucleus transcriptomic profiles of five regions of the PB(frontal lobe,parietal lobe,temporal lobe,occipital lobe,and hypothalamus)and identified 21 cell *** cross-species comparison of mouse and pig hypothalamus revealed the shared and specific gene expression patterns at the single-cell ***,we identified cell types and molecular pathways closely associated with neurological disorders,bridging the gap between gene mutations and *** reported,to our knowledge,the first single-cell atlas of domestic pig cerebral cortex and hypothalamus combined with a comprehensive analysis across species,providing extensive resources for future research regarding neural science,evolutionary developmental biology,and regenerative medicine.