检索结果-南通市图书馆

Journal of Hydrodynamics 2021年第2期33卷 243-258页

作者： Feng Pan Li-zhong Mu Ying He chao-jie wang Shi-xiong Zhou School of Energy and Power Engineering Dalian University of TechnologyDalian 116024China

A thermal-hydrodynamic coupling model is used to investigate the interplay between the wall temperature distribution and the bubble departure during the nucleate boiling *** boiling process is modeled as the combination of three subprocesses:the transient heat conduction process in the solid heater,the evaporation of the microlayer underneath the bubble,and the bubble dynamics in the two-phase bulk fluid *** moving bubble interface is captured by the volume of fluid method in the OpenFOAM *** proposed model is validated against the experimental results of the boiling process of the water on an Indium Tin Oxide *** predicted results agree well with related measurements in the *** the validation,the effects of the boiling heat flux on the bubble departure period are *** results show that the bubble departure period decreases with the increase of the applied heat *** heat flux will cause irregularity in the departure periods for successive bubbles due to the influence of the wake flow evoked by the rising ***,the influence of the bubble contact angle on the boiling heat-transfer performance is *** is confirmed that the bubble departure diameter increases with the increase of the contact angle,meanwhile,the average wall temperature decreases with the increase of the contact angle.

关键词： Nucleate boiling thermal-hydrodynamic coupling simulation microlayer evaporation contact angle wall temperature distribution

The synthesis and bioevaluation of the dicyclic arene-homospermidine conjugates

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2007年第8期18卷 923-925页

作者： Peng Fei Cheng Jian Hong wang Song Qiang Xie Jin Zhao chao jie wang Institute of Natural Products ＆ Medicinal Chemistry College of Chemistry and Chemical Engineering Henan University Kaifeng 475001 China pharmaceutical College Henan University Kaifeng 475001 China

Four novel dicyclic arene-homospermidine conjugates （6a-d） were synthesized and evaluated for cytotoxicity in L1210, α- difluoromethylomithine （DFMO） treated L1210, melanoma B16, spermidine （SPD） treated B16, and Hela cells. In the DFMOtreated L 1210 experiments, 6a-d were more sensitive to DFMO than naphthalene-homospermidine （6e）, suggesting that 6a-d can utilize the polyamine transporter （PAT） to enter the cells as well as 6e. The diminished cytotoxicity in the SPD/B 16 experiments also supported this conclusion. In summary, the homospermidine is an efficacious vector to ferry dicyclic arenes into cells via PAT.

关键词： Polyamine conjugate Synthesis Bioevalution

Synthesis and biological evaluation of hydrazino-containing polyamine skeletons as drug delivery system

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2011年第1期22卷 119-122页

作者： Jian Hong wang Jun Jun Zhou Song Qing Xie Qian Li Jin Zhao chao jie wang Key Lab of Natural Medicinal and Immunotechnology of Henan Province Henan University Kaifeng 475004 China

A new series of polyamine-toxic cargo conjugates was synthesized with aryl aldehydes conjugating to hydrazino-containing triamine skeletons. The in vitro cytotoxicity of target compounds was evaluated in several cancer cell lines （e.g., L I 210, HeLa and B16） and the cellular entry of these polyamine conjugates via polyamine transporter was investigated on SPD- or DFMO-treated B 16 cell line. Of these compounds, 6c show significant cytotoxicity on L 1210, HeLa and B 16 cell lines （IC50 value, 3.74 μmol/L, 5.66μmol/L and 4.04 μmol/L, respectively）. The polyamine transporter assay demonstrated the suitability of hydrazino-containing polyamine backbones for application as vectors in drug delivery systems.

关键词： Polyamine conjugates Polyamine transporter Synthesis Biological activity

Synthesis and Antitumor Activities In Vitro of Solanesylpiperazinotriamine

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2006年第10期17卷 1301-1304页

作者： chao jie wang Jian Hong wang Ying GAN Zhi Yong CHEN Gang Jun DU Jin ZHAO College of Chemistry and Chemical Technology Henan University Kaifeng 475001 Key Lab of Special Function Material Henan University Kaifeng 475001 Medical College of Henan Unversity Kaifeng 475001

A series of novel antitumor agents-the solanesylpiperazinotriamine derivatives were designed and synthesized, their structures were confirmed by IR,^ 1H-NMR, MS, and element analysis. The preliminary tests showed that at low micromolar concentrations these compounds exhibited obvious toxicity on tumor cells in vitro, and the synergistic effect on clinical antitumor agent indicated that at noncytotoxic concentrations they also evidently enhanced the curative effect of vincristine.

关键词： Solanesylpiperazinotriamine antitumor activity synergistic effect.

Application of multi-algorithm ensemble methods in high-dimensional and small-sample data of geotechnical engineering:A case study of swelling pressure of expansive soils

在线全文

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1896-1917页

作者： chao Li Lei wang jie Li Yang Chen School of Urban Railway Transportation Shanghai University of Engineering ScienceShanghai201620China Discipline of Civil and Infrastructure Engineering RMIT UniversityMelbourne3001Australia School of Naval Architecture and Civil Engineering Shanghai Jiao Tong UniversityShanghai200240China

Geotechnical engineering data are usually small-sample and high-dimensional,which brings a lot of challenges in predictive *** paper uses a typical high-dimensional and small-sample swell pressure(P_(s))dataset to explore the possibility of using multi-algorithm hybrid ensemble and dimensionality reduction methods to mitigate the uncertainty of soil parameter *** on six machine learning(ML)algorithms,the base learner pool is constructed,and four ensemble methods,Stacking(SG),Blending(BG),Voting regression(VR),and Feature weight linear stacking(FWL),are used for the multi-algorithm ***,the importance of permutation is used for feature dimensionality reduction to mitigate the impact of weakly correlated variables on predictive *** results show that the proposed methods are superior to traditional prediction models and base ML models,where FWL is more suitable for modeling with small-sample datasets,and dimensionality reduction can simplify the data structure and reduce the adverse impact of the small-sample effect,which points the way to feature selection for predictive *** on the ensemble methods,the feature importance of the five primary factors affecting P_(s) is the maximum dry density(31.145%),clay fraction(15.876%),swell percent(15.289%),plasticity index(14%),and optimum moisture content(13.69%),the influence of input parameters on P_(s) is also investigated,in line with the findings of the existing literature.

关键词： Expansive soils Swelling pressure Machine learning(ML) Multi-algorithm ensemble Sensitivity analysis

Topology optimization of chiral metamaterials with application to underwater sound insulation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2024年第7期45卷 1119-1138页

作者： chao wang Honggang ZHAO Yang wang jie ZHONG Dianlong YU Jihong WEN Laboratory of Science and Technology on Integrated Logistics Support National University of Defense TechnologyChangsha410073China

Chiral metamaterials have been proven to possess many appealing mechanical phenomena,such as negative Poisson's ratio,high-impact resistance,and energy *** work extends the applications of chiral metamaterials to underwater sound *** chiral metamaterials with low acoustic impedance and proper stiffness are inversely designed using the topology optimization *** acoustic impedance enables the metamaterials to have a high and broadband sound transmission loss(STL),while proper stiffness guarantees its robust acoustic performance under a hydrostatic *** proof-of-concept demonstrations,two specimens are fabricated and tested in a water-filled impedance *** results show that,on average,over 95%incident sound energy can be isolated by the specimens in a broad frequency range from 1 k Hz to 5 k Hz,while the sound insulation performance keeps stable under a certain hydrostatic *** work may provide new insights for chiral metamaterials into the underwater applications with sound insulation.

关键词： chiral metamaterial topology optimization underwater sound insulation low acoustic impedance sound transmission loss(STL)

The synthesis and molecular recognization of the polyamine transporter of hydrazine-modified diamine conjugates

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2008年第1期19卷 99-101页

作者： Jun Jun Zhou Hao Huang Song Qiang Xie Yu Xiawang Jin Zhao chao jie wang Institute of Natural Products ＆ Medicinal Chemistry Henan University Kaifeng 475001 China Chemistry Department Henan University Kaifeng 475001 China Pharmacy College Henan University Kaifeng 475001 China

A series of four novel hydrazine-modified diamine conjugates （7a-b, 8a-b） were synthesized and evaluated for cytotoxicity against Melanoma B 16, α-difluoromethylornithine （DFMO）-treated B 16, spermidine （SPD）-treated B 16, Mouse leukemia L 1210 and Hela cell lines. Both the DFMO-B 16 and SPD-B 16 experiments indicated that conjugates 7a-b and 8a-b could recognize the polyamine transporter （PAT） and enter the cells in part or in whole via PAT, although they were not as efficient as the reference, 9- anthracenemethyl homospermidine （1）. 2007 chao jie wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Polyamine conjugate Synthesis Bioevaluation

Synthesis,DNA binding and topoisomerase inhibition of mononaphthalimide homospermidine derivatives

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2008年第5期19卷 509-512页

作者： Zhi Yong Tian Hong Xia Ma Song Qiang Xie Xue wang Jin Zhao chao jie wang Wen Yuan Gao School of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 China Institute of Natural Products ＆ Medicinal Chemistry ttenan University Kaifeng 475001 China Chemistry Department ttenan University Kaifeng 475001 China

Two novel mononaphthalimide homospermidine derivatives （2a, 2b） with three or four methylene unit as linkages were synthesized and evaluated for cytotoxicity against human leukemia K562, murine melanoma B 16 and Chinese hamster ovary CHO cell lines. The presence of homospermidine motif could greatly elevate the potency of 1,8-naphthalimide. Conjugate 2b with longer spacer exhibited higher in vitro cytotoxicity than 2a. The DNA binding experiments indicated that conjugates 2b could bind to herring sperm DNA. The topoisomerase Ⅱ poison trials revealed that 2b could inhibit the activity of top. Ⅱ.

关键词： Polyamine conjugate Synthesis Bioevalution

Effect of mechanical stresses on degradation behavior of high-purity magnesium in bone environments

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2024年第4期171卷 252-261页

作者： Yan Yao jie Xia Lizhen wang Yuanming Gao Xili Ding chao wang Yubo Fan Key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringSchool of Engineering MedicineBeihang UniversityBeijing 100083China

High-purity(HP)magnesium(Mg)has emerged as a promising biomaterial for supporting functional bone *** previous study found that mechanical stresses and the surrounding fibrotic tissue(subcuta-neous)both play crucial roles in the degradation of HP ***,due to challenges in the degradation and regeneration process in vivo,it remains unclear how stress affects HP Mg degradation in bone en-vironments,limiting its further *** this study,novel loading devices were designed and the effects of tensile and compressive stresses on HP Mg degradation in vivo and in vitro bone environments were quantitatively *** addition,bone osteointegration around HP Mg was explored *** stress increases the degradation rate of HP Mg in vivo and in *** Mg degradation in vivo is more sensitive to stress factors than in vitro,but the sensitivity decreases with corrosion *** volume loss rate of HP Mg is multilinear with the applied stress and degradation *** volume of bone tissue surrounding HP Mg is larger in the no-stress group compared to the stressed groups,which is more pronounced with increasing implantation *** results provide valuable insights for optimiz-ing the design of HP Mg-based implants considering load *** will help to achieve a balance between the degradation rate of the implant and the regeneration rate of the surrounding bone.

关键词： High-purity magnesium Quantitative stresses Degradation Bone environments In vivo and in vitro

Advances in selective conversion of carbohydrates into 5-hydroxymethylfurfural

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Green Energy & Environment 2024年第9期9卷 1384-1406页

作者： jie Liang Jianchun Jiang Tingting Cai chao Liu Jun Ye Xianhai Zeng Kui wang Institute of Chemical Industry of Forest Products Chinese Academy of Forestry National Engineering Lab.for Biomass Chemical Utilization Co-Innovation Center of Efficient Processing and Utilization of Forest Resources Nanjing Forestry University College of Energy State Key Laboratory of Physical Chemistry of Solid Surfaces Xiamen University

Converting carbohydrates into 5-hydroxymethylfurfural(5-HMF) is an attractive and promising route for value-added utilization of agricultural and forestry biomass resource. As an important platform compound, 5-HMF possesses high active furan structure with hydroxymethyl and aldehyde group for production of various bio-chemicals and materials, meanwhile, which suffer from low stability and poor yield during the industrial biorefinery process. Hence, selective production of 5-HMF with high-yield and low-cost has attracted extensive attention from scientific and industrial researchers. This review sorted and described the latest advanced research on solvent and catalyst system, as well as energy field effect for production of 5-HMF with different feedstock in detail, emphatically discussing the solvent effect and its synergistic effect with other aspects. Besides, the future prospects and challenges for production of 5-HMF from carbohydrates were also presented, which provide a profound insight into industrial 5-HMF process with economic and environmental feature.

关键词： 5-Hydroxymethylfurfural Biorefinery Solvent Selectivity Carbohydrate