Synthesis and Antitumor Activities In Vitro of Solanesylpiperazinotriamine

作     者：Chao Jie WANG Jian Hong WANG Ying GAN Zhi Yong CHEN Gang Jun DU Jin ZHAO 

作者机构：College of Chemistry and Chemical Technology Henan University Kaifeng 475001 Key Lab of Special Function Material Henan University Kaifeng 475001 Medical College of Henan Unversity Kaifeng 475001 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2006年第17卷第10期

页      面：1301-1304页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：This work was supported by the National Natural Science Foundation of China (No. 20472016) as well as by Henan Natural Science Foundation (No. 0423031800 No. 512001300) 

主　　题：Solanesylpiperazinotriamine antitumor activity synergistic effect. 

摘      要：A series of novel antitumor agents-the solanesylpiperazinotriamine derivatives were designed and synthesized, their structures were confirmed by IR,^ 1H-NMR, MS, and element analysis. The preliminary tests showed that at low micromolar concentrations these compounds exhibited obvious toxicity on tumor cells in vitro, and the synergistic effect on clinical antitumor agent indicated that at noncytotoxic concentrations they also evidently enhanced the curative effect of vincristine.