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Hydrogen-bonding regulated supramolecular chirality with controllable biostability

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Nano Research 2022年第3期15卷 2226-2234页

作者： Jinying Liu Yu zhao changli zhao Xiaoqiu Dou Xiaoyu Ma Shaokang Guan Yu Jia Chuanliang Feng State Key Lab of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Key Laboratory for Special Functional Materials of Ministry of Education School of Materials Science and EngineeringHenan UniversityKaifeng 475004China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China International Laboratory for Quantum Functional Materials of Henan and School of PhysicsZhengzhou UniversityZhengzhou 450001China

The regulation of natural helical nanostructures is principally supported and actuated by hydrogen bonds(H-bonds)formed from hydrogen-bonding groups(peptide bonds and base pairs)to realize biological activities and specific biofunctional ***,studying the role of H-bonding patterns on the handedness of supramolecular assemblies is still challenging,since supramolecular assemblies will be disassembled or destabilized with slightly varying H-bonding groups for most *** circumvent this issue,herein,two types of self-assembled C2-symmetric phenylalanine derivatives differed by a single H-bonding group(ester or amide)are systematically designed for deciphering the role of H-bonding pattern on the chirality of supramolecular assemblies and their related *** handedness nanofibrous structures with tailorable diameter and helical pitch are achieved with the transition from ester to amide groups in the *** and theoretical evidence suggests that helical orientation of ester-containing gelators ascribes to intermolecular *** contrast,the helical direction for the amide-counterparts is mainly due to intra-and intermolecular ***,these H-bonding groups greatly influence their stability,as revealed by in vitro and in vivo degradation experiments and the left-handed assemblies are more stable than the right-handed ***,the study offers a feasible model to have valuable insight into understanding the role of H-bonding patterns in biological folding.

关键词： supramolecular chirality helical structures hydrogen-bonding group hydrogen-bonding pattern biostability

Increased osteoblast adhesion on nanophase Ti6Al4V

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Chinese Science Bulletin 2008年第11期53卷 1757-1762页

作者： JI WeiPing HAN Pei zhao changli JIANG Yao ZHANG XiaoNong No.6 People's Hospital of Shanghai Jiao Tong University Shanghai 200233 China School of Materials Science and Engineering of Shanghai Jiao Tong University Shanghai 200240 China

The objective of the present study was to prepare a novel nanostructured surface of Ti6Al4V alloy by the severe plastic deformation (SPD) and the chemical treatment process and to evaluate the adhesion of osteoblast on the nanophase titanium alloy. In the in vitro study, the primary cultured osteoblasts of neonatal rat calvaria were cultured on the nanophase and the as-received smooth Ti6Al4V substrates. Then osteoblasts adhesion behaviors on different substrates were observed by the fluorescence mi-croscopy, scanning electron microscopy (SEM) and RT-PCR analysis. The results of our research showed increased osteoblast adhesion on the nanophase titanium alloy compared with the as-received case. On the nanophase substrate, the presence of extensive filopodia, strong cellular adhesion and early cellular confluency could be observed. In addition, the expression of the adhesion-related integrin β1 mRNA was also higher on the nanophase substrate. It suggested that the nano technology could be further considered for orthopedic implant applications.

关键词： Ti6Al4V合金纳米结构生物材料造骨细胞

Site-Dependent Osseointegration of Biodegradable High-Purity Magnesium for Orthopedic Implants in Femoral Shaft and Femoral Condyle of New Zealand Rabbits

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Journal of Materials Science & Technology 2016年第9期32卷 883-888页

作者： Pengfei Cheng changli zhao Pei Han Jiahua Ni Shaoxiang Zhang Xiaonong Zhang Yimin Chai Orthopaedic Department Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai fiao Tong UniversityShanghai 200240China Suzhou Origin Medical Technology Co.Ltd. Suzhou 215513China

Magnesium （Mg） has been widely accepted as osteoconductive biomaterial, but osseointegration of Mg device at different implantation sites is still unclear. In the present study, high-purity magnesium （HP Mg） pins were implanted into femoral shaft and condyle of New Zealand rabbits concurrently. 2, 8, 12 and 16 weeks after surgery, rabbit femurs were harvested for micro-computed tomography （micro-CT） scanning and subsequent histological examinations. HP Mg pins were retrieved for scanning electron microscope and energy dispersive spectrum （SEM/EDS） analyses. HP Mg pins at both implantation sites performed stable corrosion with mineral deposition and bone incorporation on surface. However, difference in distribution of contact osteogenesis centers and biological properties of peri-implant bone tissues was detected between femoral shaft and femoral condyle. In femoral condyle, contact osteogenesis centers originated from both periosteum and cancellous bones and the whole HP Mg pin was encapsuled in trabecular bone at 16 weeks. Meanwhile, bone volume to total bone volume （BV/TV） and bone mineral density （BMD） of peri-implant bone tissues were above those of normal bone tissues. In femoral shaft, contact osteogenesis centers were only from periosteum and direct bone contact was confined in cortical bone, while BV/TV and BMD kept lower than normal. Furthermore, new formation of peri-implant bone tissues was more active in femoral condyle than in femoral shaft at 16 weeks. Therefore, although HP Mg performed good biocompatibility and corrosion behavior in vivo, its bioadaption of osseointegration at different implantations sites should be taken into consideration. Bone metaphysic was suitable for Mg devices where peri-implant bone tissues regenerated rapidly and the biological properties were close to normal bone tissues.

关键词： Osseointegration High-purity magnesium Site-dependent Femoral shaft and condyle Bioadaption

Comparative Study about Degradation of High-purity Magnesium Screw in Intact Femoral Intracondyle and in Fixation of Femoral Intracondylar Fracture

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Journal of Materials Science & Technology 2017年第3期33卷 305-310页

作者： Pei Han Pengfei Cheng changli zhao Shaoxiang Zhang Runhua Zhou Xiaonong Zhang Yimin Chai Orthopaedic Department ShanghaiJiao Tong University Affiliated Sixth People's Hospital Shanghai 200233 China State Key Laboratory of Metal Matrix Composites School of Materials Science and Engineering ShanghaiJiao Tong University Shanghai 200240 China Suzhou Origin Medical Technology Co. Ltd. Suzhou 215513 China

Bone screws encounter complex mechanical environment in fracture fixation of weight-bearing *** the present study, high-purity magnesium（HP Mg） screws were applied in fixation of rabbit femoral intracondylar fracture with 3 mm gap. In the control group, HP Mg screws of the same design were implanted at corresponding position of contralateral leg. At 4, 8 and 16 weeks after surgery, retrieved femurs went through micro-computed tomography（micro-CT） scanning and hard tissue processing. Under mechanical stress involved in fracture fixation, bending of screw bolt was observed at the portion exposed to facture gap at 4 weeks. Then local corrosion at the same portion was detected 16 weeks after surgery,which indicated the accumulation effect of mechanical stress on Mg corrosion. HP Mg screws in the fracture group had no significant difference with the control group in screw volume, surface area, surfaceto-volume ratio（S/V）. And peri-implant bone volume/tissues volume（BV/TV） and bone volume density（BMD） in the fracture group was comparable to that in the control group. Furthermore, histological analysis showed new formed bone tissues in fracture gap and fracture healing 16 weeks after surgery. Under mechanical stress, HP Mg screw suffered bolt bending and local corrosion at the portion exposed to fracture gap. But it had no influence on the integral corrosion behaviors, osseointegration of HP Mg screw and the fracture healing. Therefore, HP Mg screws possessed good potential in fracture fixation of weightbearing bones.

关键词： High-purity magnesium Fracture fixation Femoral intracondylar Corrosion Osseointegration

In Vitro Evaluation of Effects of Mg-6Zn Alloy Extracts on Apoptosis of Intestinal Epithelial Cells

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Journal of Wuhan University of Technology(Materials Science) 2016年第6期31卷 1387-1393页

作者：王啸虎 CHEN Yigang YU Song WANG Zhigang ZHANG Xiaonong zhao changli ZHANG Shaoxiang 阎钧谷宝军 Department of Urology Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai 200233 China Department of General Surgery Nanjing Medical University affiliated Wuxi No. 2 People's Hospital Nanjing 214002 China Department of General Surgery Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai 200233 China State Key Laboratory of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China Suzhou Origin Medical Technology Co. Ltd. Changshu Economic and Technology Development Zone Changshu 215513 China

We assessed the in vitro cytotoxicity of Mg-6Zn alloy and analyzed the cell apoptosis rate and the expression of caspase-3 to evaluate the effects of Mg-6Zn alloy extracts on apoptosis of intestinal epithelial cells（IEC）-6. IEC-6 cells were cultured in different concentrations of Mg-6Zn alloy extracts（40%, 20%） and in the control group. The indirect effects of Mg-6Zn alloy on IEC-6 cells were studied by calculating the cell relative growth rate（RGR）, measuring the apoptosis of IEC-6 cells through flow cytometry, and investigating the expression of caspase-3 using real-time polymerase chain reaction. The experimental results show that the cytotoxicity of these extracts is Grade 0-1. The level of apoptosis in IEC-6 cells cultured in 40% Mg-6Zn alloy extracts is significantly higher than that in cells treated with 20% extract and the control group. The expression of caspase-3 is found to be up-regulated in the 40% extract as compared to 20% extract and the control group. Taken together, the data show that the Mg-6Zn alloy in 40% and 20% concentration extracts proves noncytotoxicity. But the 40% concentration of Mg-6Zn alloy extract can induce the apoptosis and the related caspase-3 expression in vitro.

关键词： Mg-6Zn alloy intestinal epithelial cell apoptosis

Study of Cell Behaviors on Anodized TiO_2 Nanotube Arrays with Coexisting Multi-Size Diameters

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Nano-Micro Letters 2016年第1期8卷 61-69页

作者： Yifan Chen Jiahua Ni Hongliu Wu Ruopeng Zhang changli zhao Wenzhi Chen Feiqing Zhang Shaoxiang Zhang Xiaonong Zhang State Key Laboratory of Metal Matrix Composites School of Material Science and Engineering Shanghai Jiao Tong University Suzhou Origin Medical Technology Co. Ltd.

It has been revealed that the different morphologies of anodized TiO_2 nanotubes, especially nanotube diameters, triggered different cell behaviors. However, the influence of TiO_2 nanotubes with coexisting multi-size diameters on cell behaviors is seldom reported. In this work, coexisting four-diameter TiO_2 nanotube samples, namely,one single substrate with the integration of four different nanotube diameters(60, 150, 250, and 350 nm), were prepared by repeated anodization. The boundaries between two different diameter regions show well-organized structure without obvious difference in height. The adhesion behaviors of MC3T3-E1 cells on the coexisting fourdiameter TiO_2 nanotube arrays were investigated. The results exhibit a significant difference of cell density between smaller diameters(60 and 150 nm) and larger diameters(250 and 350 nm) within 24 h incubation with the coexistence of different diameters, which is totally different from that on the single-diameter TiO_2 nanotube arrays. The coexistence of four different diameters does not change greatly the cell morphologies compared with the singlediameter nanotubes. The findings in this work are expected to offer further understanding of the interaction between cells and materials.

关键词： Coexisting multi-size TiO2 nanotubes Repeated anodization MC3T3-E1 cells Cell adhesion behaviors Cell-material interaction

Biphenyl-Induced Superhelix in L-Phenylalanine-Based Supramolecular Self-Assembly with Dynamic Morphology Transitions

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CCS Chemistry 2022年第8期4卷 2816-2828页

作者： Laiben Gao Yueyue Feng Chao Xing Yu zhao Meng Sun Yunqing Zou changli zhao Xiaoqiu Dou Chuanliang Feng State Key Lab of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240 College of Chemistry and Materials Science Shanghai Normal UniversityShanghai 200234 School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001

Dynamic transitions of supramolecular assemblies between lower-order structures and higher-order superhelical structures(e.g.,double-helical DNA,helical biopolymers)are of vital importance in many physiological processes,but still remain a great challenge to be realized in artificially assembled ***,a novel biphenyl central core symmetrically coupled with phenylalanine groups drives the construction of the dynamic superhelix.

关键词： superhelix biphenyl chirality morphological transition cell release

Doping inorganic ions to regulate bioactivity of Ca–P coating on bioabsorbable high purity magnesium

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Progress in Natural Science:Materials International 2014年第5期24卷 479-485页

作者： Hongliu Wu Ruopeng Zhang Xiao Li Jiahua Ni changli zhao Yang Song Jiawei Wang Shaoxiang Zhang Yufeng Zheng Xiaonong Zhang State Key Laboratory of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University Department of Mechanical Engineering The University of Hong Kong Suzhou Origin Medical Technology Co. Ltd. 4. State Key Laboratory for Turbulence and Complex System Department of Materials Science and EngineeringCollege of EngineeringPeking University

Performance of biomaterials was strongly affected by their surface properties and could be designed artificially to meet specific biomedical requirements. In this study, F(F), Si O2 4(Si), or HCO 3(C)-doped Ca–P coatings were fabricated by biomimetic deposition on the surface of biodegradable high-purity magnesium(HP Mg). The crystalline phases, morphologies and compositions of Ca–P coatings had been characterized by X-ray diffraction(XRD), scanning electron microscopy(SEM) and energy-dispersive spectroscopy(EDS). The biomineralization and corrosion resistance of doped Ca–P coatings had also been investigated. The results showed that the Ca–P coating with or without doped elements mainly contained the plate-like dicalcium phosphate dehydrate(DCPD) phase. The doped F, Si, or C changed the surface morphology of Ca–P coatings after mineralization. Doped F enhanced the mineralization of Ca–P coating, and doped Si retarded the mineralization of Ca–P ***, H2 evolution of HP Mg discs with different Ca–P coatings was close to 0.4–0.7 ml/cm2 after two-week immersion. That meant that the corrosion resistance of the Ca–P coatings with different or without doped elements did not change significantly.

关键词： Calcium phosphate coating Adjustable bioactivity Magnesium Biomimetic deposition In vitro

Biocompatibility of bio-Mg-Zn alloy within bone with heart, liver, kidney and spleen

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Chinese Science Bulletin 2009年第3期54卷 484-491页

作者： HE YaoHua TAO HaiRong ZHANG Yan JIANG Yao ZHANG ShaoXiang zhao changli LI JiaNan ZHANG BeiLei SONG Yang ZHANG XiaoNong Department of Orthopedics Shanghai Sixth People's Hospital Shanghai Jiao Tong University Shanghai 200233 China School of Materials Science and Engineering Shanghai Jiao Tong University Shanghai 200240 China

A magnesium-zinc alloy rod was implanted into the marrow cavity of the distal femur in New Zealand rabbits. The femur with the implanted alloy was compared with the contralateral femur in which a bone tunnel without implant was formed as a control. Degradation of the magnesium-zinc alloy was analyzed via X-ray, scanning electron microscopy, and element energy spectrum analysis. Serum magnesium, liver and kidney function tests, and myocardial enzymes were measured. Heart, liver, kidney and spleen were sectioned for pathological analysis, and the effects of the implanted material on the histology and function of important organs were analyzed. Magnesium-zinc alloy was resorbed from the bone marrow cavity of the femur; 87% of the alloy was degraded within 14 weeks after the surgery. There were no significant differences in serum magnesium, liver or kidney function tests, or myocardial enzymes be- fore the surgery and after degradation of the magnesium-zinc alloy. Histology of the heart, liver, kidney, and spleen did not change. This study demonstrated that magnesium-zinc alloy can be resorbed in bone, and that the degradation products have good biocompatibility with heart, liver, kidney, and spleen.

关键词：镁锌合金骨生物相容性心脏肝脾