Site-Dependent Osseointegration of Biodegradable High-Purity Magnesium for Orthopedic Implants in Femoral Shaft and Femoral Condyle of New Zealand Rabbits

作     者：Pengfei Cheng Changli Zhao Pei Han Jiahua Ni Shaoxiang Zhang Xiaonong Zhang Yimin Chai 

作者机构：Orthopaedic DepartmentShanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China State Key Laboratory of Metal Matrix CompositesSchool of Materials Science and EngineeringShanghai fiao Tong UniversityShanghai 200240China Suzhou Origin Medical Technology Co.Ltd.Suzhou 215513China 

出 版 物：《Journal of Materials Science & Technology》 (材料科学技术（英文版）)

年 卷 期：2016年第32卷第9期

页      面：883-888页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.51271117 and 81371935) the Biomedical Program of Science and Technology Innovation Project supported by Shanghai(Nos.14441901800 and 14441901802) 

主　　题：Osseointegration High purity magnesium Site dependent Femoral shaft and condyle Bioadaption 

摘      要：Magnesium （Mg） has been widely accepted as osteoconductive biomaterial, but osseointegration of Mg device at different implantation sites is still unclear. In the present study, high-purity magnesium （HP Mg） pins were implanted into femoral shaft and condyle of New Zealand rabbits concurrently. 2, 8, 12 and 16 weeks after surgery, rabbit femurs were harvested for micro-computed tomography （micro-CT） scanning and subsequent histological examinations. HP Mg pins were retrieved for scanning electron microscope and energy dispersive spectrum （SEM/EDS） analyses. HP Mg pins at both implantation sites performed stable corrosion with mineral deposition and bone incorporation on surface. However, difference in distribution of contact osteogenesis centers and biological properties of peri-implant bone tissues was detected between femoral shaft and femoral condyle. In femoral condyle, contact osteogenesis centers originated from both periosteum and cancellous bones and the whole HP Mg pin was encapsuled in trabecular bone at 16 weeks. Meanwhile, bone volume to total bone volume （BV/TV） and bone mineral density （BMD） of peri-implant bone tissues were above those of normal bone tissues. In femoral shaft, contact osteogenesis centers were only from periosteum and direct bone contact was confined in cortical bone, while BV/TV and BMD kept lower than normal. Furthermore, new formation of peri-implant bone tissues was more active in femoral condyle than in femoral shaft at 16 weeks. Therefore, although HP Mg performed good biocompatibility and corrosion behavior in vivo, its bioadaption of osseointegration at different implantations sites should be taken into consideration. Bone metaphysic was suitable for Mg devices where peri-implant bone tissues regenerated rapidly and the biological properties were close to normal bone tissues.