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Mn-modified nitrogen-doped Pt-based electrocatalyst for efficient oxygen reduction in aluminum-air batteries

Nano Research 2024年第8期17卷 7126-7135页

作者： li Gao Yang Song Xuebing Xu chang li Chaoquan Hu State Key Laboratory of Mesoscience and Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Zhongke Nanjing Institute of Green Manufacturing Industry Nanjing 211135China

In this study,a Mn-modified Pt-based catalyst loaded on nitrogen-doped Ketjen black(Mn-Pt/NKB)is prepared using a simple ethylene glycol reduction *** size of Pt nanoparticles(NPs)is effectively controlled by doping with Mn and *** the smallest average particle size of 1.7 nm,Mn-Pt/NKB demonstrates half-wave potentials of 0.890 and 0.688 V in the alkaline and neutral electrolytes,respectively,which are superior to those of commercial platinum on activated carbon(Pt/C).When applied as an air cathode in aluminum-air battery,it exhibits ultra-high power densities of 190(alkaline)and 26.2 mW·cm^(−2)(neutral).Moreover,the voltage remains stable after 5 h of *** practical application performance of the Mn-Pt/NKB catalyst in an aluminum-air battery is better than that of commercial Pt/***,the oxygen reduction reaction(ORR)mechanism on surfaces with different particle sizes is analyzed using density functional *** cracking is the major pathway on the surface of the small particles with lower energy consumption of 0.5 eV,while water molecule cleavage is the major pathway on the surface of the large particles with higher energy consumption of 0.97 *** lower energy consumption of the oxygen cracking pathway further confirms the ORR mechanism for higher activity on small-sized *** study provides a direction for the rational design of Pt-based catalysts for ORR and sheds light on the commercial development of aluminum-air batteries.

关键词： oxygen reduction reaction precious metal catalysts aluminum-air battery density functional theory(DFT)calculations reaction pathway

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Comparison of biliary protein spectrum in gallstone patients with obesity and those with normal body weight

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 385-392页

作者： Min-zhi Chen Ping Xie Xiao-chang Wu Zhen-Hua Tan Hai Qian zhi-Hong Ma Xing Yao Department of Hepatopancreatobiliary Surgery Huzhou Central HospitalAffiliated Huzhou HospitalZhejiang University School of MedicineHuzhou 313000China Huzhou Key Laboratory of Molecular Medicine Huzhou Central HospitalAffiliated Huzhou HospitalZhejiang University School of MedicineHuzhou 313000China

Background: Obesity is a common public health issue and is currently deemed a disease. Research has shown that the risk of gallstones in individuals with obesity is elevated. This study aimed to explore the bile proteomics differences between cholelithiasis patients with obesity and normal body weight. Methods: Bile samples from 20 patients(10 with obesity and 10 with normal body weight) who underwent laparoscopic cholecystectomy at our center were subjected to tandem mass tag labeling(TMT) and liquid chromatography-tandem mass spectrometry(LC-MS/MS), followed by further bioinformatic analysis. Results: Among the differentially expressed proteins, 23 were upregulated and 67 were downregulated. Bioinformatic analysis indicated that these differentially expressed proteins were mainly involved in cell development, inflammatory responses, glycerolipid metabolic processes, and protein activation cascades. In addition, the activity of the peroxisome proliferator-activated receptor(PPAR, a subfamily of nuclear receptors) signaling pathway was decreased in the Kyoto Encyclopedia of Genes and Genomes(KEGG) enrichment analysis. Two downregulated proteins in the PPAR signaling pathway, APO A-Ⅰ and APO A-Ⅱ, were confirmed using enzyme-linked immunosorbent assay. Conclusions: The PPAR signaling pathway may play a crucial role in the development of cholelithiasis among patients with obesity. Furthermore, biliary proteomics profiling of gallstones patients with obesity is revealed, providing a reference for future research.

关键词： Proteome profiling Gallstones Obesity-associated gallstones Tandem mass tag labeling PPAR signaling

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Multifunctional semitransparent organic solar cells with excellent infrared photon rejection

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Chinese Chemical Letters 2020年第6期31卷 1608-1611页

作者： Xue li Ruoxi Xia Kangrong Yan Hin-Lap Yip Hongzheng Chen chang-zhi li State Key Laboratory of Silicon Materials MOE Key Laboratory of Macromolecular Synthesis and FunctionalizationDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China State Key Laboratory of Luminescent Materials and Devices School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510640China

Semitransparent organic solar cells(ST-OSCs)have the potentials to open promising applications that differ from those of conventional inorganic ones,such as see-through power windows with both energy generation and heat insulation ***,to achieve so,there remain significant challenges,especially for balancing critical parameters,such as power conversion efficiency(PCE),average visible transparency(AVT)and low energy infrared photon radiation rejection(IRR)to realize the full potentials of ***,we demonstrate the new design of ST-OSCs through the rational integration of organic materials,transparent electrode and infrared photon reflector in one *** the assistance of optical simulation,new ST-OSCs with precise layout exhibit state-of-art performance,with near 30%AVT and PCE of 7.3%,as well as an excellent IRR of over 93%(780-2500 nm),representing one of best multifunctional ST-OSCs with promising perspective for window application.

关键词： Semitransparent organic solar cell Distributed Bragg reflector Ultrathin silver film Infrared radiation rejection Average visible transparency

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Beyond 1,4-addition of in-situ generated(aza-)quinone methides and indole imine methides

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Chinese Chemical Letters 2024年第7期35卷 35-53页

作者： Yan-li li zhi-Ming li Kai-Kai Wang Xiao-Long He Medical College Xinxiang UniversityXinxiang 453000China School of Pharmacy Xinxiang UniversityXinxiang 453000China School of Food and Bioengineering Xihua UniversityChengdu 610039China

The conjugate addition of in-situ generated(aza-)quinone methides(QMs)and indole imine methides(IIMs)emerged as a powerful protocol to access densely functionalized benzenes and *** alcohols,aminobenzhydryl alcohols,and varied indolylmethanols served as most effective precursors for the in-situ generation of such reactive species under acid *** relevant propargylic alcohol has proven to be an elegant precursor to generate the propargylic-QMs and-IIMs via the acid promoted dehydration process,thus enabling diverse challenging remote activation to proceed conjugate1,6-and 1,***,the heteroarene has proven to be workable to transfer the LUMO of the p-QMs and 2-IIMs,thus inducing the remote nucleophilic dearomative *** conjugate additions of(aza-)p-QMs and varied IIMs has made significant contribution in the field of remote activation chemistry in past *** review summarizes the latest advances of the remote conjugate additions of the in-situ generated QMs and IIMs.

关键词： Conjugate addition QMs IIMs LUMO Remote activation Dearomative addition

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A new integrated model of deformation resistance and its application in prediction of rolling force of a thick plate

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Journal of Iron and Steel Research(International) 2024年第4期31卷 882-893页

作者： Shun-hu Zhang Yan li li-zhi Che Wen-hao Tian Shagang School of Iron and Steel Soochow UniversitySuzhou 215021JiangsuChina

The prediction accuracy of existing models of the rolling force of a thick plate is always very *** address this problem,a high-precision genetic algorithm-backpropagation network(GA-BP)model of deformation resistance was built,and its integration with the traditional fitted model was further ***,a novel rolling force model was obtained by embedding the integration model of deformation resistance in the original model of rolling *** to this research idea,the industrial data are normalized at *** this basis,the interactions among the process parameters were disclosed through the variance analysis,and then described by various virtual *** factors are set as part of input ***,the optimal structure of the GA-BP model of deformation resistance was determined and an integration model of deformation resistance was ***,a novel rolling force model is obtained by substituting the traditional fitted deformation resistance into the Sims model with the integration model of the deformation *** results proves that the introduction of virtual factors can increase the hit rate of±5%from 75.8%to 78%and can reduce the root mean square error from 4.72%to 4.48%.Besides,it is found that the mean relative error of the traditional fitted deformation resistance is 0.142,while that of the modified deformation resistance is only *** addition,the mean relative error in the original rolling force model is 0.145,while that of the present model is only 0.03.

关键词： Integration model-Deformation resistance Variance analysis Virtual factor Genetic algorithm-backpropagation network model

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Flexible tuning of multifocal holographic imaging based on electronically controlled metasurfaces

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Photonics Research 2024年第1期12卷 61-69页

作者： OWEN ZENG CHENXIA li BO FANG zhi HONG XUFENG JING Institute of Optoelectronic Technology China Jiliang UniversityHangzhou 310018China Centre for THz Research China Jiliang UniversityHangzhou 310018China College of Metrology&Measurement Engineering China Jiliang UniversityHangzhou 310018China

Programmable hyper-coded holography has the advantage of being programmable as well as being flexibly *** coded metamaterials with excellent electromagnetic modulation capability and the ability to control the phase to modulate the spatial radiation field through external excitation in the form of switching can be used to realize low-cost digital *** design a 1-bit encoded programmable metasurface,which is electrically connected to control the PIN diode in the switching state and to switch the condition of each metasurface cell between“0”and“1.”Using the designed programmable metasurface,we can randomly encode the cell structure to realize single-focus focusing,multi-focusing,and simple holographic letter *** on the nonlinear holographic model,we employ the Gerchberg-Saxton improvement algorithm to modulate the energy distribution at the focus by adjusting the phase ***,we introduce the Fourier convolution principle to regulate the holographic imaging focus flexibly.

关键词： holographic letter excitation

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MLDA:a multi-level k-degree anonymity scheme on directed social network graphs

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Frontiers of Computer Science 2024年第2期18卷 199-215页

作者： Yuanjing HAO Long li liang chang Tianlong GU Guangxi Key Laboratory of Trusted Software Guilin University of Electronic TechnologyGuilin 541004China Engineering Research Center of Trustworthy AI(Ministry of Education) Jinan UniversityGuangzhou 510632China

With the emergence of network-centric data,social network graph publishing is conducive to data analysts to mine the value of social networks,analyze the social behavior of individuals or groups,implement personalized recommendations,and so ***,published social network graphs are often subject to re-identification attacks from adversaries,which results in the leakage of users’***-anonymity technology is widely used in the field of graph publishing,which is quite effective to resist re-identification ***,the current researches still exist some issues to be solved:the protection of directed graphs is less concerned than that of undirected graphs;the protection of graph structure is often ignored while achieving the protection of nodes’identities;the same protection is performed for different users,which doesn’t meet the different privacy requirements of ***,to address the above issues,a multi-level-degree anonymity(MLDA)scheme on directed social network graphs is proposed in this ***,node sets with different importance are divided by the firefly algorithm and constrained connectedness upper approximation,and they are performed different-degree anonymity protection to meet the different privacy requirements of ***,a new graph anonymity method is proposed,which achieves the addition and removal of edges with the help of fake *** addition,to improve the utility of the anonymized graph,a new edge cost criterion is proposed,which is used to select the most appropriate edge to be ***,to protect the community structure of the original graph as much as possible,fake nodes contained in a same community are merged prior to fake nodes contained in different *** results on real datasets show that the newly proposed MLDA scheme is effective to balance the privacy and utility of the anonymized graph.

关键词： directed social network graph graph publishing k-degree anonymity community structure graph utility

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Antitumor Effect of Apcin on Endometrial Carcinoma via p21-Mediated Cell Cycle Arrest and Apoptosis

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Current Medical Science 2024年第3期44卷 623-632页

作者： Ke NI Zi-li li zhi-yong HU li HONG Department of Obstetrics and Gynecology Renmin Hospital of Wuhan UniversityWuhan430060China Institute of Reproductive Health Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Endometrial carcinoma(EC)is a prevalent gynecological malignancy characterized by increasing incidence and mortality *** underscores the critical need for novel therapeutic *** such potential target is cell division cycle 20(CDC20),which has been implicated in *** study investigated the effect of the CDC20 inhibitor Apcin on EC and elucidated the underlying mechanism *** The effects of Apcin on EC cell proliferation,apoptosis,and the cell cycle were evaluated using CCK8 assays and flow *** sequencing(RNA-seq)was subsequently conducted to explore the underlying molecular mechanism,and Western blotting and coimmunoprecipitation were subsequently performed to validate the *** studies were performed to evaluate the antitumor effects in *** analysis was also conducted to identify CDC20 as a potential therapeutic target in *** Treatment with Apcin inhibited proliferation and induced apoptosis in EC cells,resulting in cell cycle *** associated with apoptosis and the cell cycle were activated following treatment with ***,Apcin treatment led to the upregulation of the cell cycle regulator p21,which was verified to interact with CDC20 and consequently decrease the expression of downstream cyclins in EC *** vivo experiments confirmed that Apcin treatment significantly impeded tumor *** CDC20 expression was observed in EC tissue than in nonmalignant tissue,and increased CDC20 expression in EC patients was associated with shorter overall survival and progress free *** CDC20 is a novel molecular target in EC,and Apcin could be developed as a candidate antitumor drug for EC treatment.

关键词： endometrial carcinoma CDC20 apoptosis cell cycle arrest p21 BBC3

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A Hybrid Signal Processing Method Combining Mathematical Morphology and Walsh Theory for Power Quality Disturbance Detection and Classification

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 584-592页

作者： zhi Ding Tianyao Ji Mengshi li Q.H.Wu School of Electric Power Engineering South China University of Technology(SCUT)Guangzhou 510641China

In this paper, a novel signal processing method combining mathematical morphology (MM) and Walsh theory is proposed, which uses Walsh functions to control the structuring element (SE) and MM operators. Based on the Walsh-MM method, a scheme for power quality disturbances detection and classification is developed, which involves three steps: denoising, feature extraction and morphological clustering. First, various evolution rules of Walsh function are used to generate groups of SEs for the multiscale Walsh-ordered morphological operation, so the original signal can be denoised. Next, the fundamental wave of the denoised signal is suppressed by Hadamard matrix;thus, disturbances can be extracted. Finally, the Walsh power spectrum of the waveform extracted in the previous step is calculated, and the parameters of which are taken by morphological clustering to classify the disturbances. Simulation results reveal the proposed scheme can effectively detect and classify disturbances, and the Walsh-MM method is less affected by noise and only involves simple calculation, which has a potential to be implemented in hardware and more suitable for real-time application.

关键词： Hadamard matrix mathematical morphology morphological clustering power quality disturbance Walsh theory

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Effect of tubastatin A on NLRP3 inflammasome activation in macrophages under hypoxia/ reoxygenation conditions

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World Journal of Emergency Medicine 2024年第4期15卷 289-296页

作者： Hao li chang liu Ying Cui Panpan chang Wei Chong Department of Emergency Medicine the First Hospital of China Medical UniversityShenyang 110001China Trauma Medicine Center Peking University People's HospitalBeijing 100871China Key Laboratory of Trauma and Neural Regeneration Peking UniversityBeijing 100871China National Center for Trauma Medicine of China Beijing 100871China

BACKGROUND:There are currently no effective drugs to mitigate the ischemia/reperfusion injury caused by fluid resuscitation after hemorrhagic shock(HS).The aim of this study was to explore the potential of the histone deacetylase 6(HDAC6)-specific inhibitor tubastatin A(TubA)to suppress nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome activation in macrophages under hypoxia/reoxygenation(H/R)***:The viability of RAW264.7 cells subjected to H/R after treatment with different concentrations of TubA was assessed using a cell-counting kit-8(CCK8)***,2.5μmol/L TubA was used with RAW264.7 cells under H/R ***264.7 cells were divided into three groups,namely the control,H/R,and TubA *** levels of reactive oxygen species(ROS)in the cells were detected using fluorescence *** protein expression of HDAC6,heat shock protein 90(Hsp90),inducible nitric oxide synthase(iNOS),NLRP3,gasdermin-D(GSDMD),Caspase-1,GSDMD-N,and Caspase-1 p20 was detected by western *** levels of interleukin-1β(IL-1β)and IL-18 in the supernatants were detected using enzyme-linked immunosorbent assay(EliSA).RESULTS:HDAC6,Hsp90,and iNOS expression levels were significantly higher(P<0.01)in the H/R group than in the control group,but lower in the TubA group than in the H/R group(P<0.05).When comparing the H/R group to the control group,ROS levels were significantly higher(P<0.01),but significantly reduced in the TubA group(P<0.05).The H/R group had higher NLRP3,GSDMD,Caspase-1,GSDMD-N,and Caspase-1 p20 expression levels than the control group(P<0.05),however,the TubA group had significantly lower expression levels than the H/R group(P<0.05).IL-1βand IL-18 levels in the supernatants were significantly higher in the H/R group compared to the control group(P<0.01),but significantly lower in the TubA group compared to the H/R group(P<0.01).CONCLUSION:TubA inhibited the expression of HDAC6,Hsp90,and iNOS in macrophages

关键词： Hemorrhagic shock Hypoxia/reoxygenation Macrophage NLRP3 Tubastatin A

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