Beyond 1,4-addition of in-situ generated(aza-)quinone methides and indole imine methides

作     者：Yan-Li Li Zhi-Ming Li Kai-Kai Wang Xiao-Long He Yan-Li Li;Zhi-Ming Li;Kai-Kai Wang;Xiao-Long He

作者机构：Medical CollegeXinxiang UniversityXinxiang 453000China School of PharmacyXinxiang UniversityXinxiang 453000China School of Food and BioengineeringXihua UniversityChengdu 610039China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2024年第35卷第7期

页      面：35-53页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the financial support from the National Natural Science Foundation of China(No.22001216) the Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province(No.CSPC202315) the Science and Technology Department of Sichuan Province,China(No.2022NSFSC1203) the Higher Education Institution Key Research Project Plan of Henan Province(No.24B150031) the Program for Youth Backbone Teacher Training in University of Henan Province(No.2021GGJS163) 

主　　题：Conjugate addition QMs IIMs LUMO Remote activation Dearomative addition 

摘      要：The conjugate addition of in-situ generated(aza-)quinone methides(QMs)and indole imine methides(IIMs)emerged as a powerful protocol to access densely functionalized benzenes and *** alcohols,aminobenzhydryl alcohols,and varied indolylmethanols served as most effective precursors for the in-situ generation of such reactive species under acid *** relevant propargylic alcohol has proven to be an elegant precursor to generate the propargylic-QMs and-IIMs via the acid promoted dehydration process,thus enabling diverse challenging remote activation to proceed conjugate1,6-and 1,***,the heteroarene has proven to be workable to transfer the LUMO of the p-QMs and 2-IIMs,thus inducing the remote nucleophilic dearomative *** conjugate additions of(aza-)p-QMs and varied IIMs has made significant contribution in the field of remote activation chemistry in past *** review summarizes the latest advances of the remote conjugate additions of the in-situ generated QMs and IIMs.