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Implementation of tactical maneuvers with maneuver libraries

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Chinese Journal of Aeronautics 2020年第1期33卷 255-270页

作者： Do hyeon lee chang-Joo KIM Sung wook HUR Seong han lee School of Aerospace Information Engineering Konkuk UniversitySeoul 05029Republic of Korea

This study creates and combines the general maneuver libraries for fixed-wing aircraft to implement tactical ***,the generalized maneuver libraries are established by analyzing the characteristics of tactical maneuvers required in *** 7th order polynomial is applied to both the creation of the maneuver libraries and the generation of the trajectories or flight paths for modal *** track the desired trajectory,we design the Attitude Command Attitude Hold(ACAH)system and the Rate Command Rate Hold(RCRH)system using Model Following Controller(MFC).Moreover,the Line-of-Sight(LOS)guidance law is *** particular,the CONDUIT~?is employed to optimize the gains so that the control systems meet the aircraft Handling Qualities(HQ)***,flight simulations are performed for the longitudinal loop,immelmann-turn,and climb-slalom-descent maneuvers to verify that tactical aggressive maneuvers are realizable via the combination of maneuver *** study can contribute to the development of flight techniques for aircraft tactical maneuvers and to the revision of air force operational manuals.

关键词： 7th order polynomial Attitude command attitude hold system Handling qualities Maneuver libraries Rate command rate hold system Tactical maneuvers

Biogenesis and regulation of the let-7 miRNAs and their functional implications

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Protein & Cell 2016年第2期7卷 100-113页

作者： Hosuk lee Sungwook Han chang Seob Kwon Daeyoup lee Department of Biological Sciences Korea Advanced Institute of Science and Technology Daejeon 305-701 Korea Department of Chemistry and Biology Korea Science Academy of KAIST Busan 614-822 Korea

The let-7 miRNAwas one of the first miRNAs discovered in the nematode, Caenorhabditis elegans, and its biological functions show a high level of evolutionary conservation from the nematode to the human. Unlike in C. elegans, higher animals have multiple isoforms of let-7 miRNAs; these isoforms share a consensus sequence called the ＇seed sequence＇ and these isoforms are categorized into let-7 miRNA family. The expression of let-7 family is required for developmental timing and tumor suppressor function, but must be suppressed for the self-renewal of stem cells. Therefore, let-7 miRNA biogenesis must be carefully controlled. To generate a let-7 miRNA, a primary transcript is produced by RNA polymerase Ⅱ and then subsequently processed by Drosha/DGCR8, TUTase, and Dicer. Because dysregulation of let-7 processing is deleterious, biogenesis of let-7 is tightly regulated by cellular factors, such as the RNA binding proteins, LIN28A/B and DIS3L2. In this review, we discuss the biological functions and biogenesis of let-7 miRNAs, focusing on the molecular mechanisms of regulation of let-7 biogenesis in ver- tebrates, such as the mouse and the human.

关键词： miRNA processing miRNA biogenesis,let-7 family TUTase LIN28A/B

Overview of Computational Modeling in Nano/Micro Scaled Thin Films Mechanical Properties and Its Applications

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Computer Modeling in Engineering & Sciences 2019年第8期120卷 239-260页

作者： chang-Chun lee Pei-Chen Huang Department of Power Mechanical Engineering National Tsing Hua UniversityNo.101Section 2Kuang-Fu RoadHsinchu 30013Taiwan

This research reviews the application of computational mechanics on the properties of nano/micro scaled thin films,in which the application of different computational methods is *** concept and fundamental theories of concerned applications,material behavior estimations,interfacial delamination behavior,strain engineering,and multilevel modeling are thoroughly ***,an example of an interfacial adhesion estimation is presented to systematically estimate the related mechanical reliability issue in the microelectronic *** presented results show that the peeled mode fracture is the dominant delamination behavior of layered material system,with high stiffness along the bonding ***,the shear mode fracture being dominated as the polymer cover plate with low moduli is *** occurrence of crack advance is also significantly influenced by the interfacial crack length and applied ***,this paper could serve as a guideline of several engineering cases with the assistance of computational mechanics.

关键词： Computational mechanics mechanical responses nano/micro thin films

Diversity patterns and phylogenetic structure of vascular plants along elevational gradients in a mountain ecosystem, South Korea

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Journal of Mountain Science 2018年第2期15卷 280-295页

作者： CHUN Jung-Hwa lee chang-Bae Division of Forest Ecology National Institute of Forest Science Global Resources Division Korea Forestry Promotion Institute

Recently, a phylogenetic diversity and community structure analysis as complementary to species-centric approaches in biodiversity studies provides new insights into the processes of community assembly. In this study, we analyzed species and phylogenetic diversity and community structures for woody and herbaceous plants along two elevational transects on Mt. Baekhwa, South Korea. The species richness and phylogenetic diversity of woody plants showed monotonic declining patterns with increasing elevation along all transects, whereas herbaceous plants showed different patterns, such as no relationship and a reversed unimodal pattern, between the study transects. The main drivers of these patterns were climate and habitat variables for woody and herbaceous plants, respectively. In addition, the phylogenetic community structure primarily showed phylogenetic clustering regulated by deterministic processes, especially environmental filtering, such as climate or habitat factors, along the two transects, although herbaceous plants along a transect depicted phylogenetic randomness as a result of a neutral process. Our findings suggest that deterministic and neutral processes may simultaneously control the community structures along small-scale elevational gradients such as local transects, although the deterministic process may be the predominant type.

关键词： Community structure Deterministicprocess Elevational gradient Neutral process Phylogenetic diversity Species richness

Impact of Horizontal Resolution and Cumulus Parameterization Scheme on the Simulation of Heavy Rainfall Events over the Korean Peninsula

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Advances in Atmospheric Sciences 2011年第1期28卷 1-15页

作者： Seung-Woo lee Dong-Kyou lee Dong-Eon chang School of Earth and Environmental Sciences Seoul National University National Institute of Meteorological Research Korea Meteorological Administration

In this paper, we present the results from high-resolution numerical simulations of three heavy rainfall events over the Korean Peninsula. The numerical results show that the prediction accuracy for heavy rainfall events improved as horizontal resolution increased. The fine-grid precipitation fields were much closer to the real precipitation fields in the case of large synoptic forcing over the Korean Peninsula. In the case of large convective available potential energy and weak synoptic forcing, it seems that even when using a high resolution, the models still showed poor performance in reproducing the observed high precipitation amounts. However, activation of the cumulus parameterization scheme in the intermediate resolution of 9 km, even at a grid spacing of 3 km, had a positive impact on the simulation of the heavy rainfall event.

关键词： high resolution cumulus parameterization scheme heavy rainfall numerical simulation

Emamectin benzoate 9.7%SL as a new formulation for a trunkinjections against pine wood nematode,Bursaphelenchus xylophilus

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Journal of Forestry Research 2020年第4期31卷 1399-1403页

作者： Sung-Chan lee Hyo-Rim lee Dong-Soo Kim Jun-hyeong Kwon Min-Jung Huh Il-Kwon Park Department of Forest Sciences College of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Republic of Korea Research Institute of Agriculture and Life Science College of Agriculture and Life SciencesSeoul National UniversitySeoul 08826Republic of Korea Forest Biomaterials Research Center National Institute of Forest ScienceJinjuGyeongnam 52817Republic of Korea

In this study,we investigated the preventive effects of emamectin benzoate 9.7%SL,which was newly developed to reduce the injection volume and number of injection holes required to protect against pine wood *** of the Pinus thunbergii trees injected with emamectin benzoate 9.7%SL at 0.3 mL/cm diameter at breast height(DBH)died within 2 years of inoculation with pine wood *** benzoate 9.7%SL injected at 0.6 mL/cm DBH resulted in no tree mortality for 3 *** residue of emamectin benzoate 9.7%SL in pine twigs injected with 0.3 mL/cm DBH was 0.490μg/g at 1 year after injection and 0.303μg/g after 2 *** residues values are greater than 0.031μg/g,previously determined IC95 value for emamectin benzoate against the pine wood *** field experiment and residue analysis showed that emamectin benzoate 9.7%SL could be a substitute agent for emamectin benzoate 2.15%EC,which is widely used to prevent pine wood nematode in the field and that injection volume and number of injection holes can be greatly educed using this new formulation,which will reduce injury to the cambium,interruption of water movement,and infection of inoculation wounds by wood-decay or blue stain fungi.

关键词： Emamectin benzoate 9.7%SL Emamectin benzoate 2.15%EC Trunk injection Pine wood nematode Residue

Optimal design considering structural efficiency of compressed natural gas fuel storage vessels for automobiles

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Transactions of Nonferrous Metals Society of China 2011年第A01期21卷 199-204页

作者： Myung-chang KANG Hyung Woo lee Chul KIM National Core Research Center for Hybrid Materials Solution Pusan National University Research Institute of Mechanical Technology Pusan National University

The shape and thickness of the dome were investigated with the aim of optimizing the type II CNG storage vessels by using a finite element analysis technique. The thickness of the liners and reinforcing materials was optimized based on the requirement of the cylinder and dome parts. In addition, the shape of the dome, which is most suitable for type lI CNG storage vessels, was proposed by a process of review and analysis of various existing shapes, and the minimum thickness was established in this sequence： metal liners, composite materials and dome parts. Therefore, the new proposed shape products give a mass reduction of 4.8 kg（5.1%）

关键词： CNG fuel storage vessel mechanical property dome part bursting structural analysis

Performance Investigation of Capillary Tubes for Machine Tool Coolers Retrofitted with HFC-407C Refrigerant

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Chinese Journal of Mechanical Engineering 2012年第5期25卷 933-939页

作者： WANG Fujen chang Tongbou CHIANG Weiming lee Haochung Department of Refrigeration and Air Conditioning Engineering Chin-Yi University of Technology Department of Mechanical Engineering Southern Taiwan University Energy & Environment Research Laboratories Industrial Technology Research Institute

The machine tool coolers are the best managers of coolant temperature in avoiding the deviation of spindle centerline for machine tools. However, the machine coolers are facing the compressed schedule to phase out the HCFC （hydro-chloro-floro-carbon） refrigerant and little attention has been paid to comparative study on sizing capillary tube for retrofitted HFC （hydro-floro-carbon） refrigerant. In this paper, the adiabatic flow in capillary tube is analyzed and modeled for retrofitting of HFC-407C refrigerant in a machine tool cooler system. A computer code including determining the length of sub-cooled flow region and the two phase region of capillary tube is developed. Comparative study of HCFC-22 and HFC-407C in a capillary tube is derived and conducted to simplify the traditional trial-and-error method of predicting the length of capillary tubes. Besides, experimental investigation is carried out by field tests to verify the simulation model and cooling performance of the machine tool cooler system. The results from the experiments reveal that the numerical model provides an effective approach to determine the performance data of capillary tube specific for retrofitting a HFC-407C machine tool cooler. The developed machine tool cooler system is not only directly compatible with new HFC-407C refrigerant, but can also perform a cost-effective temperature control specific for industrial machines.

关键词： machine tool cooler capillary tube refrigerant retrofitting

Combating Drug Resistance in Colorectal Cancer Using Herbal Medicines

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Chinese Journal of Integrative Medicine 2021年第7期27卷 551-560页

作者： lee Ga-Young lee Jin-Seok Son chang-Gue lee Nam-Hun Department of Clinical Oncology Cheonan Korean Medicine Hospital of Daejeon UniversityCheonan31099Republic of Korea Liver&Immunology Research Center Dunsan Korean Medicine Hospital of Daejeon UniversityDaejeon35235Republic of Korea Department of Internal Medicine Graduated School of Korean MedicineUniversity of DaejeonDaejeon34520Republic of Korea

Colorectal cancer(CRC)is one of the most prevalent and lethal cancer types around the *** of the CRC patients are treated with chemotherapeutic drugs alone or ***,up to 90%of metastatic cancer patients experience the failure of treatment mostly because of the acquired drug resistance,which can be led to multidrug resistance(MDR).In this study,we reviewed the recent literature which studied potential CRC MDR reversal agents among herbal medicines(HMs).Among abundant HMs,6 single herbs,Andrographis paniculata,Salvia miltiorrhiza,Hedyotis diffusa,Sophora flavescens,Curcuma longa,Bufo gargarizans,and 2 formulae,Pien Tze Huang and Zhi Zhen Fang,were found to overcome CRC MDR by two or more different mechanisms,which could be a promising candidate in the development of new drugs for adjuvant CRC chemotherapy.

关键词： colorectal cancer drug resistance herbal medicine