Combating Drug Resistance in Colorectal Cancer Using Herbal Medicines

作     者：Lee Ga-Young Lee Jin-Seok Son Chang-Gue Lee Nam-Hun Lee Ga-Young;Lee Jin-Seok;Son Chang-Gue;Lee Nam-Hun

作者机构：Department of Clinical OncologyCheonan Korean Medicine Hospital of Daejeon UniversityCheonan31099Republic of Korea Liver&Immunology Research CenterDunsan Korean Medicine Hospital of Daejeon UniversityDaejeon35235Republic of Korea Department of Internal MedicineGraduated School of Korean MedicineUniversity of DaejeonDaejeon34520Republic of Korea 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2021年第27卷第7期

页      面：551-560页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by the Daejeon University Research Grants(2017) 

主　　题：colorectal cancer drug resistance herbal medicine 

摘      要：Colorectal cancer(CRC)is one of the most prevalent and lethal cancer types around the *** of the CRC patients are treated with chemotherapeutic drugs alone or ***,up to 90%of metastatic cancer patients experience the failure of treatment mostly because of the acquired drug resistance,which can be led to multidrug resistance(MDR).In this study,we reviewed the recent literature which studied potential CRC MDR reversal agents among herbal medicines(HMs).Among abundant HMs,6 single herbs,Andrographis paniculata,Salvia miltiorrhiza,Hedyotis diffusa,Sophora flavescens,Curcuma longa,Bufo gargarizans,and 2 formulae,Pien Tze Huang and Zhi Zhen Fang,were found to overcome CRC MDR by two or more different mechanisms,which could be a promising candidate in the development of new drugs for adjuvant CRC chemotherapy.