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Six families with balanced chromosome translocation associated with reproductive risks in Hainan Province: Case reports and review of the literature

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World Journal of Clinical Cases 2020年第1期8卷 222-233页

作者： Yun-Chun Chen Xu-Ning Huang chang-Ying kong Jian-Dong Hu Department of Laboratory Medicine Haikou Branch of Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese Medicine(Haikou Hospital of Traditional Chinese Medicine)Haikou 570300Hainan ProvinceChina Department of Ultrasound Medicine Second Affiliated Hospital of Hainan Medical UniversityHaikou 570300Hainan ProvinceChina Department of Gynecology Second Affiliated Hospital of Hainan Medical UniversityHaikou 570300Hainan ProvinceChina Department of Internal Medicine Haikou Branch of Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese Medicine(Haikou Hospital of Traditional Chinese Medicine)Haikou 570300Hainan ProvinceChina

BACKGROUND Balanced translocation refers to the process where breakage and reconnection of chromosomes occur at abnormal *** the genetic substance with balanced translocation in individuals does not change,which is usually characterized by normal phenotype and intelligence,the individuals seek medical service after many miscarriages,resulting in considerable mental and physical burdens of the family *** the current era with rapid advances in detection technology,cytogenetic examination,as a definitive approach,still plays an essential *** SUMMARY We report six cases with balanced chromosome translocation:Case 1:46,XY,t(3;12)(q27;q24.1),infertility after 3 years of marriage;Case 2:46,XX,t(4;16)(q31;q12),small uterus and irregular menstruation;Case 3:46,XY,t(4;5)(q33;q13),9qh+,not pregnant after arrested fetal development;Case 4:46,XX,t(11;17)(q13;p11.2),not pregnant after two times of spontaneous abortion;Case 5:46,XX,t(10;13)(q24;q21.2),not pregnant after arrested fetal development for once;Case 6:46,XX,t(1;4)(p36.1;q31.1),not pregnant after arrested fetal development for two *** first four cases had chromosomal aberration *** These results suggested that balanced chromosomal translocation carriers are associated with reproductive risks and a very high probability of abnormal *** discovery of the first four reported chromosomal aberration karyotypes provides an important basis for studying the occurrence of genetic diseases.

关键词： Reproductive risk Balanced translocation Abnormal pregnancy Genetic counseling Case report

Research on Wind Power Prediction Modeling Based on Adaptive Feature Entropy Fuzzy Clustering

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沈阳理工大学学报 2014年第4期33卷 75-80页

作者： HUANG Haixin kong chang Shenyang Ligong University Shenyang Institute of Automation Chinese Academy of Sciences

Wind farm power prediction is proposed based on adaptive feature weight entropy fuzzy clustering *** to the fuzzy clustering method,a large number of historical data of a wind farm in Inner Mongolia are analyzed and *** of adaptive entropy weight for clustering is *** power prediction model based on adaptive entropy fuzzy clustering feature weights is *** results show that the proposed method could distinguish the abnormal data and forecast more accurately and compute fastly.

关键词： fuzzy C-means clustering adaptive feature weighted entropy wind power prediction

Binding between Prion Protein and Aβ Oligomers Contributes to the Pathogenesis of Alzheimer’s Disease

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Virologica Sinica 2019年第5期34卷 475-488页

作者： chang kong Hao Xie Zhenxing Gao Ming Shao Huan Li Run Shi Lili Cai Shanshan Gao Taolei Sun Chaoyang Li School of Chemistry Chemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070China State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China Affiliated Cancer Hospital Institute of Guangzhou Medical UniversityGuangzhou 510095China

A plethora of evidence suggests that protein misfolding and aggregation are underlying mechanisms of various neurodegenerative diseases,such as prion diseases and Alzheimer's disease(AD).Like prion diseases,AD has been considered as an infectious disease in the past decades as it shows strain specificity and transmission *** it remains elusive how protein aggregation leads to AD,it is becoming clear that cellular prion protein(PrP^c)plays an important role in AD ***,we briefly reviewed AD pathogenesis and focused on recent progresses how PrP^c contributed to AD *** addition,we proposed a potential mechanism to explain why infectious agents,such as viruses,conduce AD *** infections cause AD deposition and upregulation of PrP^c,which lead to high affinity binding between AD oligomers and PrP^*** interaction between PrP^c and AP oligomers in turn activates the Fyn signaling cascade,resulting in neuron death in the central nervous system(CNS).Thus,silencing PrP^c expression may turn out be an effective treatment for PrP^c dependent AD.

关键词： Alzheimer’s disease(AD) Amyloid-βprotein Neurodegenerative disease Cellular prion protein(PrP^c)

Inhibitory effect of Cyrtomium falcatum on melanogenesis in α-MSH-stimulated B16F10 murine melanoma cells

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Asian Pacific Journal of Tropical Biomedicine 2023年第9期13卷 403-410页

作者： Xian-Rong Zhou Jung Hwan Oh Fatih Karadeniz Hyunjung Lee Hyo Eun Kim Migeon Jo Youngwan Seo chang-Suk kong Department of Bioscience Silla UniversityBusan 46958Korea Collaborative Innovation Center for Child Nutrition and Health Development Chongqing University of EducationChongqing 400067China Marine Biotechnology Center for Pharmaceuticals and Foods Silla UniversityBusan 46958Korea Nutritional Education Graduate School of EducationSilla UniversityBusan 46958Korea Department of Food and Nutrition Silla UniversityBusan 46958Korea Division of Convergence on Marine Science Korea Maritime and Ocean UniversityBusan 49112Korea

Objective:To explore the anti-melanogenic potential of Cyrtomium ***:The effects of Cyrtomium falcatum crude extract and its solvent fractions on tyrosinase activity,melanin content,and the expressions of melanogenesis-related genes and proteins were analyzed inα-melanocyte-stimulating hormone(α-MSH)-stimulated B16F10 ***:α-MSH treatment significantly increased tyrosinase activity,and extracellular and intracellular melanin content,as well as the expression levels of tyrosinase,microphthalmia-associated transcription factor(MITF),tyrosinase-related protein(TRP)-1,and TRP-2 in B16F10 *** with Cyrtomium falcatum crude extract and its solvent fractions reduced tyrosinase activity and extracellular and intracellular melanin content and downregulated the expression levels of tyrosinase,MITF,TRP-1,and TRP-2 in a dose-dependent ***:Cyrtomium falcatum has potential anti-melanogenesis effects and can be used as a potential source material in cosmeceutical industry for the research and development of novel lead molecules with whitening properties.

关键词： Cyrtomium falcatum Melanogenesis α-MSH B16F10 melanoma cells

Lentinula edodes extract inhibits matrix metalloproteinase expression and increases typeⅠprocollagen expression via the p38 MAPK/c-Fos signaling pathway in ultraviolet A and B-irradiated HaCaT keratinocytes

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Asian Pacific Journal of Tropical Biomedicine 2021年第4期11卷 164-173页

作者： Jung Im Lee Jung Hwan Oh Fatih Karadeniz So Young Park Hye Ran Kim Hyun Jin Jo Kyung Im Jung Byung-Jin Jeon chang-Suk kong Marine Biotechnology Center for Pharmaceuticals and Foods Silla UniversityBusan 46958Korea Department of Food and Nutrition College of Medical and Life SciencesSilla UniversityBusan 46958Korea Ocean Fisheries and Bio Center Busan technoparkBusan 46048Korea

Objective:To determine the effect of Lentinula edodes extract on ultraviolet(UV)A and UVB-induced changes in matrix metalloproteinase(MMP)and type I procollagen expression using human immortalized HaCaT ***:Lentinula edodes ethanol extract(LEE)was obtained by extraction with 80%ethanol for 4 h at 80℃.Effect of LEE on UVinduced alteration on the expression and production of MMPs and type I procollagen in keratinocytes was investigated using ELISA,RT-PCR,and Western blotting *** determine the underlying mechanism of LEE-mediated effects,mitogen-activated protein kinase(MAPK)and activator protein 1 signaling pathways were analysed by Western blotting ***:LEE significantly inhibited the expression of MMP-1 and MMP-9 and increased the expression of type I procollagen in UVA and UVB-irradiated HaCaT *** phosphorylation levels of p38 were significantly inhibited by LEE whereas it did not affect c-Jun N-terminal kinase and extracellular signal-regulated kinase *** of p38 phosphorylation was also accompanied by downregulation of UVA and UVB-induced increase in ***:LEE effectively inhibits the expression of MMP-1 and MMP-9 and increases type I procollagen production through the p38 MAPK/c-Fos signaling pathway in UVA and UVB-irradiated HaCaT *** findings suggest that Lentinula edodes may be developed as a cosmetic material to suppress UV exposuremediated skin aging.

关键词： Lentinula edodes Ultraviolet Matrix metalloproteinases TypeⅠprocollagen Ha Ca T

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南朝陵墓石刻研究的艺术史观和方法

艺术百家 2008年第3期24卷 69-84页

作者：章孔畅东南大学艺术学院江苏南京210018

本文梳理了现代学者对南朝陵墓石刻研究的艺术史观和基本研究方法。从20世纪20年代至今,不同时代的中外研究者,用不同的艺术史观和考证资料诠释了他们对南朝陵墓石刻包含的各种学术问题的不同观点。这些观点体现出艺术史观和研究方法对... 详细信息

本文梳理了现代学者对南朝陵墓石刻研究的艺术史观和基本研究方法。从20世纪20年代至今,不同时代的中外研究者,用不同的艺术史观和考证资料诠释了他们对南朝陵墓石刻包含的各种学术问题的不同观点。这些观点体现出艺术史观和研究方法对研究结果的决定性作用。今后,中国学者会出现在南朝陵墓石刻源流的传播线索的实地上,用新的史料和史观,开拓出新的学术空间。

关键词：南朝陵墓石刻艺术史观方法论

Numerical analysis on coupled thermo-mechanical behavior of rock mass around underground nuclear waste repository

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Numerical analysis on coupled thermo-mechanical behavior of ...

The 2001 ISRM International Symposium-2nd Asian Rock Mechanics Symposium(ISRM 2001-2nd ARMS)

作者： WON-KYONG SONG JOONG-HO SYNN kong-chang HAN Korea Institute of Geology Mining and MaterialsTaejonKorea

＜正＞Coupled thermo-mechanicai behavior of an underground repository has been numerically simulated using *** is assumed that the repository unit consists of double tunnels disposed in *** numerical model is symmetrical with respect to the center of the *** values for mechanical and thermal parameters were assigned to rock *** decay function was also used to consider a decrease of heat flux from *** simulation has been conducted up to 100 years after the deposition of *** temperature and stresses around the repository rapidly increased in the early time and reached the peak about 10 years after *** they slowly decreased with *** results show mutual affection between tunnels in the respect of temperature increase and stress *** is subjected to upward displacement in the opposite direction to the neighboring tunnel with a little amount of lateral shrinkage.

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健康教育与学校体育融合发展策略探讨

中国学校卫生 2019年第1期40卷 7-11页

作者：孔冲平杰上海体育学院体育教育训练学院上海200438 南阳师范学院体育学院

以健康教育与学校体育融合发展的理论逻辑研究为起点,探讨二者融合发展的现实困因与消解思路,重点研究健康素养导向下融合发展的优化策略。研究认为,健康教育与学校体育的融合是实现学校健康教育目标的必然趋势,学生健康素养是其融合发... 详细信息

以健康教育与学校体育融合发展的理论逻辑研究为起点,探讨二者融合发展的现实困因与消解思路,重点研究健康素养导向下融合发展的优化策略。研究认为,健康教育与学校体育的融合是实现学校健康教育目标的必然趋势,学生健康素养是其融合发展的诉求,指引着融合课程实施变革的方向;针对当前融合发展中的问题提出健康促进与健康管理并重、重视普及性教育与关注个性化干预并重、外部帮扶提供与内在动力激发并重等融合发展理念;及构建高效健全的健康管理体系、探寻个性化健康促进干预方案、注重学生自主参与意识与能力培养的干预实施、强化健康教育师资专业能力发展、改善学校健康教育环境等优化策略。

关键词：健康教育体育运动健康促进组织和管理

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传统肖像画中的命相观

艺术百家 2007年第A01期23卷 77-78,88页

作者：章孔畅东南大学艺术学院江苏南京210018

传统肖像画包含着中国传统文化中特有的对整体审美意蕴关注的特点,它注重表现的的确就是对象的整个人生状态,即使某些画家强调对象即时瞬间的状态,也只是寻求一种对象整体感受的最佳表现。中国古代人物画之始,画中人物带给观者的就不是... 详细信息

传统肖像画包含着中国传统文化中特有的对整体审美意蕴关注的特点,它注重表现的的确就是对象的整个人生状态,即使某些画家强调对象即时瞬间的状态,也只是寻求一种对象整体感受的最佳表现。中国古代人物画之始,画中人物带给观者的就不是他们人生精彩的瞬间而是他们整个人生意义的体现。传统肖像画通过特殊的造型语言把握对象的整体感觉。传统绘画中讲的"形",大不同于今日深受西方美术教育影响而所言的"造型"。传统肖像画对"形"有它独特的理解。

关键词：中国传统文化审美传统肖像画形命相观