检索结果-南通市图书馆

Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram kim Myeong‑chang Sung Gwang‑Hee Lee Byoungjoon Hwang Sojung Seo Ji‑Hun Seo Dong‑Wan kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

神经鞘氨醇磷酸胆碱对人成纤维细胞差异表达基因的筛选

在线全文

学校读者我要写书评

暂无评论

中华皮肤科杂志 2006年第7期39卷 381-384页

作者：朱明姬姜日花金东成金昌德李增勋吉林大学中日联谊医院皮肤科长春130031 吉林省中医中药研究院韩国忠南大学医学部皮肤科

目的利用抑制性消减杂交(SSH)技术构建神经鞘氨醇磷酸胆碱(SPC)对人真皮成纤维细胞的差异表达cDNA消减杂交文库,从中克隆出差异表达基因。方法原代培养人皮肤成纤维细胞；提取经SPC处理和未处理的成纤维细胞总RNA,合成cDNA,进行2次消减... 详细信息

目的利用抑制性消减杂交(SSH)技术构建神经鞘氨醇磷酸胆碱(SPC)对人真皮成纤维细胞的差异表达cDNA消减杂交文库,从中克隆出差异表达基因。方法原代培养人皮肤成纤维细胞；提取经SPC处理和未处理的成纤维细胞总RNA,合成cDNA,进行2次消减杂交及2次抑制性PCR,将产物与T／A载体连接,构建SPC作用于人真皮成纤维细胞的差异表达cDNA消减杂交文库,用RNA印迹验证阳性克隆,测序并登陆基因库寻找同源性基因。结果成功构建了SPC作用于人真皮成纤维细胞的差异表达cDNA文库；从实验组筛查的28个差异表达克隆中确定了6个差异表达基因,其中已知基因5个、新基因1个,分别为基质金属蛋白酶2,血小板反应蛋白1,催产素受体,锌指转录因子,铁传递蛋白受体等。结论神经鞘氨醇磷酸胆碱可上调人真皮成纤维细胞基质金属蛋白酶、血小板反应蛋白1、催产素受体、锌指转录因子、铁传递蛋白受体等基因表达。

关键词：成纤维细胞基因文库神经鞘氨醇磷酸胆碱抑制性消减杂交

Connolly Surface on an Atomic Structure via Voronoi Diagram of Atoms

在线全文

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2006年第2期21卷 255-260页

作者： Joonghyun Ryu Rhohun Park deok-Soo kim Voronoi Diagram Research Center Hanyang University Seoul Korea Department of Industrial Engineering Hanyang University Seoul Korea

One of the most important geometric structures of a protein is the Connolly surface of protein since a Connolly surface plays an important role in protein folding, docking, interactions between proteins, amongst other things. This paper presents an algorithm for precisely and efficiently computing the Connolly surface of a protein using a proposed geometric construct called β-shape based on the Voronoi diagram of atoms in the protein. Given the Voronoi diagram of atoms based on the Euclidean distance from the atom surfaces, the proposed algorithm first computes a β-shape with an appropriate probe. Then, the Connolly surface is computed by employing the blending operation on the atomic complex of the protein by the given probe.

关键词： protein Connolly/molecular surface β-shape Voronoi diagram of atoms blending surface

Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第1期9卷 173-210页

作者： Md Entaz Bahar Hyun Joon kim deok Ryong kim Department of Biochemistry and Convergence Medical Sciences and Institute of Medical Science Gyeongsang National UniversityCollege of MedicineJinjuSouth Korea Department of Anatomy and Convergence Medical Sciences and Institute of Medical Science Gyeongsang National UniversityCollege of MedicineJinjuSouth Korea

Metastatic dissemination of solid tumors,a leading cause of cancer-related mortality,underscores the urgent need for enhanced insights into the molecular and cellular mechanisms underlying metastasis,chemoresistance,and the mechanistic backgrounds of individuals whose cancers are prone to *** most prevalent signaling cascade governed by multi-kinase inhibitors is the mitogen-activated protein kinase(MAPK)pathway,encompassing the RAS–RAF–MAPK kinase(MEK)–extracellular signal-related kinase(ERK)*** kinase is a primary mediator of the MAPK pathway,responsible for the sequential activation of downstream targets,such as MEK and the transcription factor ERK,which control numerous cellular and physiological processes,including organism development,cell cycle control,cell proliferation and differentiation,cell survival,and *** in this signaling cascade are associated with diseases such as *** inhibitors(RAFi)combined with MEK blockers represent an FDAapproved therapeutic strategy for numerous RAF-mutant cancers,including melanoma,non-small cell lung carcinoma,and thyroid ***,the development of therapy resistance by cancer cells remains an important ***,an intracellular lysosome-dependent catabolic recycling process,plays a critical role in the development of RAFi resistance in ***,targeting RAF and autophagy could be novel treatment strategies for RAF-mutant *** this review,we delve deeper into the mechanistic insights surrounding RAF kinase signaling in tumorigenesis and ***,we explore and discuss the ongoing development of next-generation RAF inhibitors with enhanced therapeutic ***,this review sheds light on the functional interplay between RAF-targeted therapies and autophagy in cancer.

关键词： RAF insight mechanism

A hybrid storage technology for low power consumption and high I/O performance in an IPTV set-top box

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Central South University 2012年第5期19卷 1267-1275页

作者： kim deok-hwan YANG Jun-sik Department of Electronics Engineering Inha UniversityIncheon 402-751Korea

A new method of prefetching data blocks from the NVCache to the page cache in main memory and cascading prefetching n-blocks from a hard disk to the NVCache together was proposed to reduce the spin-up frequency of a hybrid hard disk drive and thus enhance I/O *** proposed method consists of three steps:1) Analyzing the pattern of read requests in block units;2) Determining the number of blocks prefetched to the NVCache;3) Replacing blocks in the NVCache according to the block replacement *** proposed method can reduce the latency time of a hybrid hard disk and optimize the power consumption of an IPTV set-top *** results show that the proposed method provides better average response time compared to an existing adaptive multistream prefetching(AMP) method by 25.17%.It also reduces by 20.83% the average power consumption over that of the existing external caching in energy saving storage system(EXCES) method.

关键词： IPTV set-top box hybrid hard disk prefetching spin-down low power consumption

High-pressure triggered quantum tunneling tuning through classical percolation in a single nanowire of a binary composite

在线全文

学校读者我要写书评

暂无评论

Nano Research 2019年第6期12卷 1333-1338页

作者： Sudeshna Samanta Mokwon Lee deok-Soo kim Jaeyong kim Lin Wang Center for High Pressure Science & Technology Advanced Research Shanghai 201203China HYU-HPSTAR-CIS High Pressure Research Center Department of PhysicsHanyang UniversitySeoul 04763Republic of Korea Voronoi Diagram Research Center School of Mechanical EngineeringHanyang UniversitySeoul 04763Republic of Korea

In the era of miniaturization,the one-dimensional nanostructures presented numerous possibilities to realize operational nanosensors and devices by tuning their electrical transport *** size reduction,the physical properties of materials become extremely challenging to characterize and understand due to the complex interplay among structures,surface properties,strain effects,distribution of grains,and their internal coupling *** this report,we demonstrate the fabrication of a single metal-carbon composite nanowire inside a diamondanvil-cell and examine the in situ pressure-driven electrical transport *** nanowire manifests a rapid and reversible pressure dependence of the strong nonlinear electrical conductivity with significant zero-bias differential conduction revealing a quantum tunneling dominant carrier transport *** fully rationalize our observations on the basis of a metal-carbon framework in a highly compressed nanowire corroborating a quantum-tunneling boundary,in addition to a classical percolation boundary that exists beyond the percolation *** structural phase progressions were monitored to evidence the pressure-induced shape reconstruction of the metallic grains and modification of their intergrain interactions for successful explanation of the electrical transport *** pronounced sensitivity of electrical conductivity to an external pressure stimulus provides a rationale to design low-dimensional advanced pressure sensing devices.

关键词： single metal-carbon nanowire high pressure electrical transport Voronoi diagram

Integrated transcriptome analysis for the hepatic and jejunal mucosa tissues of broiler chickens raised under heat stress conditions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2022年第6期13卷 1768-1784页

作者： deok Yun kim Byeonghwi Lim Jun-Mo kim Dong Yong Kil Department of Animal Science and Technology Chung-Ang UniversityAnseong-siGyeonggi-do 17546Republic of Korea

Background:Heat stress(HS)is one of the most important threats for the current poultry ***,many efforts have been made to ameliorate the adverse effect of HS on poultry production;however,physiological and molecular mechanisms pertaining to HS are still limited in ***,the objective of the current study was to investigate functional alterations based on individual and integrated transcriptomes in the liver and jejunal mucosa tissues of broiler chickens exposed to HS ***:Broiler chickens exposed to HS showed decreased growth performance and increased corticosterone concentrations in the *** the transcriptome analysis,the number of differentially expressed genes(DEGs)were identified in the liver and jejunal mucosa by HS *** the liver,genes related to amino acid oxidation,tryptophan metabolism,lipid metabolism,oxidative phosphorylation,and immune responses were altered by HS,which support the reason why heat-stressed poultry had decreased productive *** the jejunal mucosa,genes related to defense systems,glutathione metabolism,detoxification of xenobiotics,and immune responses were differently expressed by HS *** integrated transcriptome analysis with DEGs found in the liver and jejunal mucosa showed a considerable connectivity between the core nodes in the constructed networks,which includes glutathione metabolism,xenobiotic metabolism,carbon metabolism,and several amino acid ***:The core network analysis may indicate that increased requirement of energy and amino acids in the jejunal mucosa of broiler chickens exposed to HS conditions is likely compromised by increased oxidation and synthesis of amino acids in the ***,our results may provide comprehensive insights for molecular and metabolic alterations of broiler chickens raised under HS conditions,which can aid in the development of the novel strategies to ameliorate the negative effect of HS on poultry

关键词： Broiler chicken Heat stress Jejunal mucosa Liver Transcriptome

An armature structure for 3D shapes

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics(A Journal of Chinese Universities) 2014年第4期29卷 422-437页

作者： JI Zhong-ping LIU Li-gang kim deok-soo School of Computer Science and Technology Hangzhou Dianzi University Graphics Geometric Computing Laboratory School of Mathematical Sciences University of Science and Technology of China Department of Industrial Engineering Hanyang University

We present a novel armature structure for 3D articulated shapes, called SBall short for skeletal balls, which includes two parts： a one-dimensional skeleton and incident balls. Our algorithm mainly focuses on constructing the armature structure. This structure is based on an approximation skeleton which is homotopy equivalent to the shape. Each ball in the structure connects a skeletal joint and an interior region of the shape. The boundary vertices on the shape surface are attached onto the SBall using the power diagram of the ball set. A bilateral O^tering algorithm and a variational segmentation algorithm are proposed to enhance the quality of SBall. Finally, applications of this structure are discussed.

关键词： armature structure prong feature thinning variational segmentation.

Distribution of Ge Self-Assembled Quantum Dots on Six Ge1 - x Buffer Layers

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2004年第Z2期22卷 133-135页

作者： Joonyeon chang Hyungjun kim Nano Device Research Center Korea Institute of Science and TechnologySeoul 136-791Korea Department of Electrical EngireeringUniversity of California LosAngelesCA 90095-1595USA

The effect of buried misfit dislocation on the distribution of Ge self-assembled quantum dots (SAQDs) grown on a relaxed SiGe buffer layer was investigated. The strain field of arrays of buried dislocations in a relaxed SiGe buffer layer provided preferential nucleation sites for quantum dots. Burgers vector analysis using plan-view transmission electron microscopy (TEM) verified that the preferential nucleation sites of Ge SAQDs depended on the Burgers vector direction of corresponding dislocations. The measurement of the lateral distance between SAQDs and dislocations together with crosssection TEM observation clarified that the location of SAQDs was at the intersection of the dislocation slip plane and the top surface. The misfit strain should be an additional factor governing the uniformity in size, shape and distribution of Ge SAQDs.

关键词： misfit dislocation Ge self assembled quantum dots molecular beam epitaxy transmission electron microscopy