Integrated transcriptome analysis for the hepatic and jejunal mucosa tissues of broiler chickens raised under heat stress conditions
Integrated transcriptome analysis for the hepatic and jejunal mucosa tissues of broiler chickens raised under heat stress conditions作者机构：Department of Animal Science and TechnologyChung-Ang UniversityAnseong-siGyeonggi-do 17546Republic of Korea
出 版 物：《Journal of Animal Science and Biotechnology》 (畜牧与生物技术杂志（英文版）)
年 卷 期：2022年第13卷第6期
页 面：1768-1784页
核心收录：
基 金：supported by Basic Science Research Program through the National Research Foundation(NRF)funded by the Ministry of Science ICT and Future Planning(NRF-2019R1A2C4070556)
主 题：Broiler chicken Heat stress Jejunal mucosa Liver Transcriptome
摘 要：Background:Heat stress(HS)is one of the most important threats for the current poultry ***,many efforts have been made to ameliorate the adverse effect of HS on poultry production;however,physiological and molecular mechanisms pertaining to HS are still limited in ***,the objective of the current study was to investigate functional alterations based on individual and integrated transcriptomes in the liver and jejunal mucosa tissues of broiler chickens exposed to HS ***:Broiler chickens exposed to HS showed decreased growth performance and increased corticosterone concentrations in the *** the transcriptome analysis,the number of differentially expressed genes(DEGs)were identified in the liver and jejunal mucosa by HS *** the liver,genes related to amino acid oxidation,tryptophan metabolism,lipid metabolism,oxidative phosphorylation,and immune responses were altered by HS,which support the reason why heat-stressed poultry had decreased productive *** the jejunal mucosa,genes related to defense systems,glutathione metabolism,detoxification of xenobiotics,and immune responses were differently expressed by HS *** integrated transcriptome analysis with DEGs found in the liver and jejunal mucosa showed a considerable connectivity between the core nodes in the constructed networks,which includes glutathione metabolism,xenobiotic metabolism,carbon metabolism,and several amino acid ***:The core network analysis may indicate that increased requirement of energy and amino acids in the jejunal mucosa of broiler chickens exposed to HS conditions is likely compromised by increased oxidation and synthesis of amino acids in the ***,our results may provide comprehensive insights for molecular and metabolic alterations of broiler chickens raised under HS conditions,which can aid in the development of the novel strategies to ameliorate the negative effect of HS on poultry
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