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Plant-based vaccines against viral hepatitis: A panoptic review

World Journal of Virology 2024年第3期13卷 49-55页

作者： Devanathan Reka chandrashekaran girish Department of Pharmacology Jawaharlal Institute of Postgraduate Medical Education and ResearchPuducherry 605006India

The traditional vaccines against hepatitis have been instrumental in reducing the incidence of some types of viral hepatitis;however,the need for cost-effective,easily distributable,and needle-free vaccine alternatives has led to the exploration of plant-based ***-based techniques offer a promising avenue for producing viral hepatitis vaccines due to their low-cost cultivation,scalability,and the potential for oral *** review highlights the successful expression of hepatitis B surface antigens in plants and the subsequent formation of virus-like particles,which have shown immunogenicity in preclinical and clinical *** challenges such as achieving sufficient antigen expression levels,ensuring consistent dosing,and navigating regulatory frameworks,are *** review considers the potential of plant-based vaccines to meet the demands of rapid vaccine deployment in response to outbreaks and their role in global immunization strategies,particularly in resource-limited *** review underscores the significant strides made in plant molecular farming and the potential of plant-based vaccines to complement existing immunization methods against viral hepatitis.

关键词： Plant-based therapeutics Plant vaccines Edible vaccines Viral hepatitis Phytopharmacology and molecular pharming

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Role of immune dysfunction in drug induced liver injury

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World Journal of Hepatology 2021年第11期13卷 1677-1687页

作者： chandrashekaran girish Sukumaran Sanjay Department of Pharmacology Jawaharlal Institute of Postgraduate Medical Education and ResearchPuducherry 605006India

Drug-induced liver injury(DILI)is one of the leading causes of liver failure and withdrawal of drugs from the market.A poor understanding of the precipitating event aetiology and mechanisms of disease progression has rendered the prediction and subsequent treatment *** literature suggests that some drugs can alter the liver’s repair systems resulting in *** pathophysiology of DILI is complex,and immune dysfunction plays an important role in determining the course and severity of the *** dysfunction is influenced by the host response to drug toxicity.A deeper understanding of these processes may be beneficial in the management of DILI and aid in drug *** review provides a structured framework presenting DILI in three progressive stages that summarize the interplay between drugs and the host defence networks.

关键词： Immune dysfunction Liver damage Hepatotoxic drugs Drug-induced liver injury High mobility group box 1

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