Plant-based vaccines against viral hepatitis: A panoptic review
作者机构：Department of PharmacologyJawaharlal Institute of Postgraduate Medical Education and ResearchPuducherry 605006India
出 版 物：《World Journal of Virology》 (世界病毒学杂志)
年 卷 期：2024年第13卷第3期
页 面：49-55页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Plant-based therapeutics Plant vaccines Edible vaccines Viral hepatitis Phytopharmacology and molecular pharming
摘 要：The traditional vaccines against hepatitis have been instrumental in reducing the incidence of some types of viral hepatitis;however,the need for cost-effective,easily distributable,and needle-free vaccine alternatives has led to the exploration of plant-based ***-based techniques offer a promising avenue for producing viral hepatitis vaccines due to their low-cost cultivation,scalability,and the potential for oral *** review highlights the successful expression of hepatitis B surface antigens in plants and the subsequent formation of virus-like particles,which have shown immunogenicity in preclinical and clinical *** challenges such as achieving sufficient antigen expression levels,ensuring consistent dosing,and navigating regulatory frameworks,are *** review considers the potential of plant-based vaccines to meet the demands of rapid vaccine deployment in response to outbreaks and their role in global immunization strategies,particularly in resource-limited *** review underscores the significant strides made in plant molecular farming and the potential of plant-based vaccines to complement existing immunization methods against viral hepatitis.
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