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Is percutaneous endoscopic gastrostomy tube placement safe in patients with ventriculoperitoneal shunts?

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World Journal of Gastroenterology 2009年第25期15卷 3148-3152页

作者： Jin-Soo Kim Yong-Wan Park Hyung-Keun Kim Young-Seok cho Sung-Soo Kim Na-Ri Youn Hiun-Suk chae Division of Gastroenterology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaUijeongbu St. Mary's Hospital

AIM:To investigate whether percutaneous endoscopic gastrostomy (PEG) tube placement is safe in patients with ventriculoperitoneal (VP) ***: This was a retrospective study of all patients undergoing PEG insertion at our institution between June 1999 and June 2006. Post-PEG complications were compared between two groups according to the presence or absence of VP shunts. VP shunt infection rates, the interval between PEG placement and VP shunt catheter insertion, and long-term follow-up were also ***: Fifty-five patients qualified for the study. Seven patients (12.7%) had pre-existing VP shunts. All patients received prophylactic antibiotics. The complication rate did not differ between VP shunt patients undergoing PEG (PEG/VP group) and non-VP shunt patients undergoing PEG (control group) [1 (14.3%) vs 6 (12.5%), P=1.000]. All patients in the PEG/VP group had undergone VP shunt insertion prior to PEG placement. The mean interval between VP shunt insertion and PEG placement was 308.7 d (range, 65-831 d). The mean follow-up duration in the PEG/VP group was 6.4 mo (range, 1-15 mo). There were no VP shunt infections, although one patient in the PEG/VP group developed a minor peristomal infection during ***: Complications following PEG placement in patients with VP shunts were infrequent in this study.

关键词： Percutaneous endoscopic gastrostomy Ventriculoperitoneal shunt Complication Ventriculo- peritoneal shunt infection Prophylactic antibiotic

埃万妥单抗联合拉泽替尼治疗EGFR突变晚期NSCLC患者的临床研究

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中国临床药理学杂志 2024年第17期40卷 2478-2478页

作者： cho B C 戴荣源

韩国延世大学医学院cho团队研究了埃万妥单抗联合拉泽替尼治疗初治表皮生长因子受体(epidermal growth factor receptor,EGFR)突变晚期非小细胞肺癌(non-small-cell lung cancer,NSCLC)患者的临床疗效与安全性。在这项Ⅲ期国际随机试验... 详细信息

韩国延世大学医学院cho团队研究了埃万妥单抗联合拉泽替尼治疗初治表皮生长因子受体(epidermal growth factor receptor,EGFR)突变晚期非小细胞肺癌(non-small-cell lung cancer,NSCLC)患者的临床疗效与安全性。在这项Ⅲ期国际随机试验中,研究团队按2∶2∶1的比例将先前未经治疗的EGFR突变(外显子19缺失或L858R)、局部晚期或转移性NSCLC患者分配接受埃万妥单抗-拉泽替尼(试验组,以开放标签方式)、奥西替尼(以盲法方式)或拉泽替尼(盲法方式,评估治疗成分的作用)。主要终点是与奥西替尼组相比,试验组的无进展生存率。

关键词： EGFR突变晚期非小细胞肺癌表皮生长因子受体晚期NSCLC 评估治疗随机试验盲法拉泽

A Study on the Design Method of Hybrid MOSFET-CNTFET Based SRAM-A Secondary Publication

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Journal of Electronic Research and Application 2024年第1期8卷 106-112页

作者： Geunho cho Department of Electronic Engineering Seokyeong UniversitySeoulSouth Korea

More than 10,000 carbon nanotube field-effect transistors(CNTFETs)have been successfully integrated into one semiconductor chip using conventional semiconductor design procedures and manufacturing *** transistors offer advantages such as high carrier mobility,large saturation velocity,low intrinsic capacitance,flexibility,and *** three-dimensional multilayer structure of the CNTFET semiconductor chip,along with ongoing research in CNTFET manufacturing processes,increases the potential for creating a hybrid MOSFET-CNTFET semiconductor *** chip combines conventional metal-oxide-semiconductor field-effect transistors(MOSFETs)and CNTFETs in one integrated *** paper discusses a methodology to design 6T binary static random-access memory(SRAM)using a hybrid *** paper introduces a method for designing a hybrid MOSFET-CNTFET SRAM by leveraging existing MOSFET SRAM or CNTFET SRAM design ***,this paper compares its performance with conventional MOSFET SRAM and CNTFET SRAM designs.

关键词： MOSFET CNTFET SRAM Hybrid Carbon nanotube

Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma

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World Journal of Gastroenterology 2020年第32期26卷 4833-4845页

作者： Jae H Yoon Young J Goo chae-Jun Lim Sung K choi Sung B cho Sang S Shin Chung H Jun Department of Gastroenterology Chonnam National University Hospital and Medical SchoolGwangju 61469South Korea Department of Gastroenterology Hwasun Chonnam National University Hospital and Medical SchoolHwasun 58128South Korea Department of Radiology Chonnam National University Hospital and Medical SchoolGwangju 61469South Korea Department of Internal Medicine Mokpo Hankook HospitalMokpo 58643South Korea

BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor ***,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain *** To elucidate the characteristics and risk factors of EHM after RFA for *** From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary *** inclusion criteria were age≥18 years,a diagnosis of HCC,and *** computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 *** analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as *** EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 *** 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,*** recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first *** was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level *** multivariate analysis,recurrence-free survival400 IU/mL were associated with a high EHM *** EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for *** especially with high-risk factors require close follow-up for

关键词： Hepatocellular carcinoma Metastasis Radiofrequency ablation Surveillance Risk factor

Impact of statin intensity on adverse cardiac and cerebrovascular events in older adult patients with myocardial infarction

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Journal of Geriatric Cardiology 2021年第8期18卷 609-622页

作者： In Tae Moon Si-Hyuck Kang Wonjae Lee Youngjin cho Jin Joo Park Yeonyee EYoon Il-Young Oh Chang-Hwan Yoon Jung-Won Suh Tae-Jin Youn In-Ho chae Dong-Ju choi Young-Seok cho Uijeongbu Eulji Medical Center Eulji University School of MedicineUijeongbuSouth Korea Seoul National University Bundang Hospital SeongnamSouth Korea Department of Cardiology Incheon Sejong HospitalIncheonSouth Korea

BACKGROUND There is insufficient evidence regarding the effect of high-intensity statin therapy in older *** study aimed to investigate the effects of high-intensity statin treatment on the clinical outcomes in older adults with myocardial infarc-tion(MI).METHODS Consecutive patients with MI aged at least 75 years were analyzed *** primary endpoint was major adverse cardiac and cerebrovascular events(MACCE),defined as a composite of all-cause death,MI,rehospitalization due to un-stable angina,repeat revascularization,and ischemic *** high-intensity group was compared to the low-to-moderate in-tensity group in the propensity score-matched *** Average age of total 546 patients was 81 *** them,84%of patients underwent percutaneous coronary *** unadjusted seven-year MACCE rate differed by statin intensity(high-intensity statin group:38%,moderate-intensity statin group:42%,low-intensity statin group:56%,and no-statin group:61%,P=0.004).However,among these groups,many baseline characteristics were significantly *** the 74 propensity score-matched pairs,which lacked any significant differences in all baseline characteristics,the high-intensity group had a significantly lower rate of MACCE than the low-to-moderate intensity group(37%vs.53%,P=0.047).Follow-up low-density lipoprotein cholesterol levels were significantly lower in the high-intensity group than that in the low-to-moderate intensity group(69.4±16.0 mg/dL vs.77.9±25.9 mg/dL,P=0.026).CONCLUSIONS In older adult patients with MI,the use of high-intensity statin caused significantly less occurrence of MACCE in comparison to that in low-to-moderate intensity for up to seven years of follow-up.

关键词： patients cardiac intensity

Efficacy of cap-assisted endoscopy for routine examining the ampulla of Vater

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World Journal of Gastroenterology 2013年第13期19卷 2037-2043页

作者： Young Rak choi Joung-Ho Han Young Shim cho Hye-Suk Han Hee Bok chae Seon Mee Park Sei Jin Youn Department of Internal Medicine College of MedicineChungbuk National University

AIM: To determine the efficacy of a cap-assisted endoscopy (CAE) to completely visualize the ampulla of Vater (AV) in patients failed by conventional endoscopy. METHODS: A prospective study was conducted on 120 patients > 20 years of ages who visited the Health Promotion Center of Chungbuk National University Hospital for conscious sedation esophagogastroduodenoscopy (EGD) as a screening test from July to October, 2011. First, forward-viewing endoscopy was performed with reasonable effort using a push and pull method. We considered complete visualization of the AV when we could observe the entire AV including the orifice clearly, and reported the observation as complete or incomplete (partial or not found at all). Second, in cases of complete failure of the observation, an additional AV examination was conducted by attaching a short cap (D-201-10704, Olympus Medical Systems, Tokyo, Japan) to the tip of a forward-viewing endoscope. Third, if the second method failed, we replaced the short cap with a long cap (MH-593, Olympus Medical Systems) and performed a re-examination of the AV. RESULTS: Conventional endoscopy achieved complete visualization of the AV in 97 of the 120 patients (80.8%) but was not achieved in 23 patients (19.2%). Age (mean ± SD) and gender [male (%)] were not significantly different between the complete observation and the incomplete observation groups. Additional short CAE was performed in patients in whom we could not completely visualize the AV. This group included 13 patients (10.9%) with partial observation of the AV and 10 (8.3%) in which the AV was not found. Short CAE permitted a complete observation of the AV in 21 of the 23 patients (91.3%). Patients in whom visualization of the AV failed with short CAE had satisfactory outcomes by replacing the short cap with a long cap. The additional time for CAE took an average of 141 ± 88 s. There were no complications and no significant mucosal trauma. CONCLUSION: CAE is safe to use as a salvage me

关键词： Ampulla of Vater Conventional endoscopy Cap-assisted endoscopy Screening test Complete observation

Flexible highly-effective energy harvester via crystallographic and computational control of nanointerfacial morphotropic piezoelectric thin film

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Nano Research 2017年第2期10卷 437-455页

作者： Chang Kyu Jeong Sung Beom cho Jae Hyun Han Dae Yong Park Suyoung Yang Kwi-II Park Jungho Ryu Hoon Sohn Yong-chae Chung Keon Jae Lee Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) 291 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea KAISTInstitute for the NanoCentury (KINC) 291 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea Division of Materials Science and Engineering Hanyang University 222 Wangsimni-ro Seongdong-gu Seou104763 Republic of Korea Department of Civil and Environmental Engineering KAIST 291 Daehak-ro Yuseong-gu Daejeon 34141 Republic of Korea Department of Energy Engineering Gyeongnam National University of Science and Technology 33 Dongjin-ro Jinju Gyeongnam 52725 Republic of Korea Functional Ceramic Group Korea Institute of Materials Science (KIMS) 797 Changwon-daero Seongsan-gu Changwon Gyeongnam.51508 Republic of Korea

Controlling the properties of piezoelectric thin films is a key aspect for designing highly efficient flexible electromechanical devices. In this stud）~ the crystallographic phenomena of PbZr1-xTixO3 （PZT） thin films caused by distinguished interfacial effects are deeply investigated by overlooking views, including not only an experimental demonstration but also ab initio modeling. The polymorphic phase balance and crystallinity, as well as the crystal orientation of PZT thin films at the morphotropic phase boundary （MPB）, can be stably modulated using interfacial crystal structures. Here, interactions with MgO stabilize the PZT crystallographic system well and induce the texturing influences, while the PZT film remains quasi-stable on a conventional A1203 wafer. On the basis of this fundamental understanding, a high-output flexible energy harvester is developed using the controlled-PZT system, which shows significantly higher performance than the unmodified PZT generator. The voltage, current, and power densities are improved by 556%, 503%, and 822%, respectively, in comparison with the previous flexional single-crystalline piezoelectric device. Finally, the improved flexible generator is applied to harvest tiny vibrational energy from a real traffic system, and it is used to operate a commercial electronic unit. These results clearly indicate that atomic-scale designs can produce significant impacts on macroscopic applications.

关键词： energy harvesting morphotropic phaseboundary (MPB) piezoelectric first-principles calculation lead zirconium titanate(PZT)

Damage and penetration behavior of aluminum foam at various impacts

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Journal of Central South University 2014年第9期21卷 3442-3448页

作者： cho Hosun cho Jaeung Division of Mechanical Engineering Graduate School Kongju National University Division of Mechanical and Automotive Engineering Kongju National University

In this work, the damage and penetration behavior of aluminum foam at various types of impact were examined through experiments. The impact energy of a striker was applied on the fixed aluminum foam having a thickness of 25 mm while increasing its impact by 2 J at each strike from 6 J to 16 J. The results show that the impact energies from 6 J to 12 J could not penetrate aluminum foam. However, the aluminum foam applied with the impact energy of 12 J incurred severe damages on its lower part. Finally, the aluminum foam applied with the impact energy of 14 J was penetrated. The striker having the impact energy of 6 J could penetrate aluminum foam around 10 mm. At this moment, aluminum foam could absorb the impact energy of around 9 J. When the impact energy of 14 J was applied on the aluminum foam, the aluminum foam was penetrated and it absorbed the impact energy of around 17.2 J. It is possible to create the safer structure against impact using the results of this work. The simulation results for the verification of the experimental results imply that the results for all the experiments in this work are reliable. It is possible to predict the structural safety of the aluminum foam for an impact if the impact behavior of aluminum foam performed in this work is utilized.

关键词： aluminum foam absorbed energy finite element analysis impact energy impact load

GENUS MINIMIZING IN SYMPLECTIC 4-MANIFOLDS

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Chinese Annals of Mathematics,Series B 2000年第1期21卷 115-120页

作者： cho YONGSEUNG cho MISUNG Department of Mathematics Ewha Women’s University Seoul Korea

The authors show that a symplectically embedded surface in a symplectic 4-manifold with hi greater than one minimizes genus in its homology class.

关键词： Generalized Thom Conjecture Seiberg-Witten invariant Symplectic 4-manifolds