Impact of statin intensity on adverse cardiac and cerebrovascular events in older adult patients with myocardial infarction

作     者：In Tae Moon Si-Hyuck Kang Wonjae Lee Youngjin Cho Jin Joo Park Yeonyee EYoon Il-Young Oh Chang-Hwan Yoon Jung-Won Suh Tae-Jin Youn In-Ho Chae Dong-Ju Choi Young-Seok Cho In Tae Moon;Si-Hyuck Kang;Wonjae Lee;Youngjin Cho;Jin Joo Park;Yeonyee E.Yoon;Il-Young Oh;Chang-Hwan Yoon;Jung-Won Suh;Tae-Jin Youn;In-Ho Chae;Dong-Ju Choi;Young-Seok Cho

作者机构：Uijeongbu Eulji Medical CenterEulji University School of MedicineUijeongbuSouth Korea Seoul National University Bundang HospitalSeongnamSouth Korea Department of CardiologyIncheon Sejong HospitalIncheonSouth Korea 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2021年第18卷第8期

页      面：609-622页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：patients cardiac intensity 

摘      要：BACKGROUND There is insufficient evidence regarding the effect of high-intensity statin therapy in older *** study aimed to investigate the effects of high-intensity statin treatment on the clinical outcomes in older adults with myocardial infarc-tion(MI).METHODS Consecutive patients with MI aged at least 75 years were analyzed *** primary endpoint was major adverse cardiac and cerebrovascular events(MACCE),defined as a composite of all-cause death,MI,rehospitalization due to un-stable angina,repeat revascularization,and ischemic *** high-intensity group was compared to the low-to-moderate in-tensity group in the propensity score-matched *** Average age of total 546 patients was 81 *** them,84%of patients underwent percutaneous coronary *** unadjusted seven-year MACCE rate differed by statin intensity(high-intensity statin group:38%,moderate-intensity statin group:42%,low-intensity statin group:56%,and no-statin group:61%,P=0.004).However,among these groups,many baseline characteristics were significantly *** the 74 propensity score-matched pairs,which lacked any significant differences in all baseline characteristics,the high-intensity group had a significantly lower rate of MACCE than the low-to-moderate intensity group(37%vs.53%,P=0.047).Follow-up low-density lipoprotein cholesterol levels were significantly lower in the high-intensity group than that in the low-to-moderate intensity group(69.4±16.0 mg/dL vs.77.9±25.9 mg/dL,P=0.026).CONCLUSIONS In older adult patients with MI,the use of high-intensity statin caused significantly less occurrence of MACCE in comparison to that in low-to-moderate intensity for up to seven years of follow-up.