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Self-assemblies of plasmonic gold/layered double hydroxides with highly efficient antiviral effect against the hepatitis B virus

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Nano Research 2015年第11期8卷 3512-3523页

作者： Gabriela Carja elena Florentina Grosu catalina Petrarean Norica Nichita Department of Chemical Engineering Faculty of Chemical Engineering and Environmental Protection Technical University 'Gh. Asachi' of lasi Bd. Mangeron No. 71 lasi 700554 Romania Department of Viral Glycoproteins Institute of Biochemistry of the Romanian Academy Splaiul Independentei 296 Bucharest 060031 Romania

Engineering complex nanocomposites that specifically target the hepatitis B virus （HBV） and overcome the limitations of current therapies such as limited efficacy and serious side effects is very challenging. Here, for the first time, the antiviral effect of engineered plasmonic gold and layered double hydroxide self-assemblies （AuNPs/LDHs） is demonstrated, using HBV as a model virus and hepatoma-derived HepG2.2.215 ceils for viral replication, assembly, and secretion of infectious virions and subviral particles. AuNPs/LDHs were obtained by a simple, cost-effective procedure in which small AuNPs （-3.5 nm） were directly obtained and organized on the surface of larger LDH nanoparticles （-150 nm） by exploiting the capability of MgLDH, ZnLDH, and MgFeLDH to manifest their ＂structural memory＂ in the aqueous solution of Au（O2CCH3）3. The self-assembly approach of AuNPs and LDHs was assessed by transmission electron microscopy （TEM）, X-ray photoelectron spectroscopy （XPS）, powder X-ray diffraction （PXRD）, and UV-Vis analysis （UV-Vis）. All AuNPs/LDHs tested reduced the amount of viral and subviral particles released from treated cells by up to 80% and exhibited good cytocompatibility. AuNPs/MgFeLDH showed the highest antiviral HBV response with more than 90% inhibition of HBV secretion for the whole concentration range. Preliminary studies on the mechanism of HBV inhibition reveals that in the presence of AuNPs/LDHs, HBV particles are sequestered within the treated cells. The antiviral and low cytotoxic plasmonic properties of these Au/LDH nanocomposites indicate that they hold significant potential to be tailored as novel efficient therapeutics for the treatment of hepatitis B.

关键词： plasmonic gold layered double hydroxides layered double hydroxide (LDH) antiviral effect HBV hepatitis cytotoxicity

Dysregulation of genes involved in the long-chain fatty acid transport in pancreatic ductal adenocarcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 199-206页

作者： Radu Cristian Poenaru elena Milanesi Andrei Marian Niculae Anastasia-Maria Dobre catalina Vladut Mihai Ciocîrlan Daniel Vasile Balaban Vlad Herlea Maria Dobre Mihail Eugen Hinescu Faculty of Medicine Carol Davila University of Medicine and PharmacyBucharest 050474Romania Department of Radiobiology Victor Babes National Institute of PathologyBucharest 050096Romania Department of Pathology Victor Babes National Institute of PathologyBucharest 050096Romania Department of Gastroenterology Prof.Dr.Agrippa Ionescu Clinical Emergency HospitalBucharest 011356Romania Department of Pathology Fundeni Clinical InstituteBucharest 022258Romania

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is an aggressive lethal malignancy with limited options for treatment and a 5-year survival rate of 11%in the United *** for other types of tumors,such as colorectal cancer,aberrant de novo lipid synthesis and reprogrammed lipid metabolism have been suggested to be associated with PDAC development and *** To identify the possible involvement of lipid metabolism in PDAC by analyzing in tumoral and non-tumoral tissues the expression level of the most relevant genes involved in the long-chain fatty acid(FA)import into *** A gene expression analysis of FASN,CD36,SLC27A1,SLC27A2,SLC27A3,SLC27A4,SLC27A5,ACSL1,and ACSL3 was performed by qRT-PCR in 24 tumoral PDAC tissues and 11 samples from non-tumoral pancreatic tissues obtained via fine needle aspiration or via surgical *** genes were considered significantly dysregulated between the groups when the p value was<0.05 and the fold change(FC)was≤0.5 and≥*** We found that three FA transporters and two long-chain acyl-CoA synthetases genes were significantly upregulated in the PDAC tissue compared to the non-tumoral tissue:SLC27A2(FC=5.66;P=0.033),SLC27A3(FC=2.68;P=0.040),SLC27A4(FC=3.13;P=0.033),ACSL1(FC=4.10;P<0.001),and ACSL3(FC=2.67;P=0.012).We further investigated any possible association between the levels of the analyzed mRNAs and the specific characteristics of the tumors,including the anatomic location,the lymph node involvement,and the presence of metastasis.A significant difference in the expression of SLC27A3(FC=3.28;P=0.040)was found comparing patients with and without lymph nodes involvement with an overexpression of this transcript in 17 patients presenting tumoral cells in the lymph *** Despite the low number of patients analyzed,these preliminary results seem to be *** lipid metabolism through a broad strategy could be a beneficial way to treat this *** in vitro and in vivo s

关键词： Carcinoma Pancreatic ductal Fatty acid transport Gene expression Biomarkers

Modulation Possibilities of the Tissue Wettability, Marker of the Physical Modifications Produced by Senescence versus Photo Senescence at Tegument Level

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Journal of Biomedical Science and Engineering 2014年第13期7卷 1049-1055页

作者： Laurentiu Badescu Carmen elena Cotrutz Raoul lupusoru Bogdan-Mihail Diaconescu Manuela Ciocoiu Magda Badescu Department of Cell and Molecular Biology University of Medicine and Pharmacy “Grigore T. Popa” Iasi Romania Department of Pathophysiology University of Medicine and Pharmacy “Grigore T. Popa” Iasi Romania Department of Pathophysiology University of Medicine and Pharmacy “Grigore T. Popa” Iasi Romania

We used an experimental model involving white Westar rats (young and old) who were subjected to precise doses of ultraviolet radiation (UV). The experiment aims to examine the influence of epidermis potential protection factors in photo senescence versus senescence. We have studied the in vivo effect of some natural polyphones extracted from black grapes seeds and zinc aspartate and in vitro effect of AED (deuterium depleted water). The substances were administered by intragastric gavages, at two days intervals for two weeks prior to UV irradiation and during the entire period of the experiment (28 days). In the end, we determined the degree of hydrophilicity of the skin, in vitro, by measuring the contact angle value, which was inversely proportional to the hydrophilicity of the tissue (the angle formed at the contact between a liquid and a solid surface). Using this method we found a large variability depending on the hydrophilicity of the epidermis (abdomen and back), the age of the animal and UV/non UV irradiation. The maintenance of the epidermis fragments in AED (for 6 hours) increased significantly the tissue wet ability degree both in the young rats subject to UV and in the senescent ones subject to UV (photo senescence).

关键词： Skin Photoimmunology Phototherapy

Giant androgen-producing adrenocortical carcinoma with atrial flutter: A case report and review of the literature

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World Journal of Clinical Cases 2021年第20期9卷 5575-5587页

作者： Mircea-Florin Costache Raluca-elena Arhirii Simona-Juliette Mogos Corina Lupascu-Ursulescu Cezara-Ioana Litcanu Adi-Ionut Ciumanghel catalina Cucu Cristina-Mihaela Ghiciuc Antoniu-Octavian Petris Nicolae Danila Surgery Clinic Saint Spiridon University Clinical Emergency HospitalIasi 700111Romania Cardiology Clinic Saint Spiridon University Clinical Emergency HospitalIasi 700111Romania Department of Endocrinology Faculty of MedicineGrigore T.Popa University of Medicine and PharmacyIasi 700115Romania Endocrinology Clinic Saint Spiridon University Clinical Emergency HospitalIasi 700111Romania Department of Radiology and Imaging Sciences Grigore T.Popa University of Medicine and PharmacyIasi 700115Romania Radiology Clinic Saint Spiridon University Clinical Emergency HospitalIasi 700111Romania Radiotherapy Clinic Regional Institute of OncologyIasi 700483Romania Anesthesia and Intensive Care Department Grigore T.Popa University of Medicine and PharmacyIasi 700115Romania Anesthesia and Intensive Care Department Saint Spiridon University Clinical Emergency HospitalIasi 700111Romania Histopatology Department Saint Spiridon University Clinical Emergency HospitalIasi 700111Romania Department of Pharmacology Clinical Pharmacology and AlgesiologyFaculty of MedicineGrigore T.Popa University of Medicine and PharmacyIasi 700115Romania Department of Cardiology Faculty of MedicineGrigore T.Popa University of Medicine and PharmacyIasi 700115Romania Surgery Clinic Faculty of MedicineGrigore T.Popa University of Medicine and PharmacyIasi 700115Romania

BACKGROUND Adrenocortical carcinoma(ACC),the second most aggressive malignant tumor,lacks epidemiological data worldwide;therefore,every new case can improve the understanding of the pathology and treatment of this *** SUMMARY We present the case of a 66-year-old Caucasian woman with a giant androgenproducing ACC(21 cm×17 cm×12 cm;2100 g),without metastases,which unusually presented with an acute onset of atrial flutter and congestive heart *** cardiac complications observed in our case support the hypothesis that androgen excess in women is a cardiovascular risk *** excess in women can be a rare cause of reversible dilated cardiomyopathy,therefore a comprehensive approach to the patient is essential to improve the recognition of androgen-secreting *** atrial flutter was remitted after initiation of drug treatment during *** severe heart failure was totally remitted at 6 mo after radical open surgery to remove the giant *** Radical open surgery to remove a giant androgen-producing ACC was the firstline treatment to cure the excess of androgen,which determined the total remission of cardiac complications at 6 mo after surgery in the women of this case report.

关键词： Adrenocortical carcinoma Adrenalectomy Androgen secreting tumor Heart failure Atrial flutter Case report

Three Uncommon Seaweeds of the Pacific Coast of Mexico

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American Journal of Plant Sciences 2015年第19期6卷 3187-3192页

作者： A. catalina Mendoza-González Luz elena Mateo-Cid Deisy Yazmín García-López Departamento de Botánica Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional Campus Santo Tomás México City México

This report describes a new record and two unusual and rare species of marine algae collected from Oaxaca, Michoacán, Jalisco and Baja California Sur at Mexican Pacific coast. Boodleopsis verticillata is the first record in the Pacific shore of Mexico, in the case of Melobesia polystromatica, this is the sixth record at tropical Pacific while Litholepis sonorensisis reported for the third time in the Gulf of California. These results suggest that the taxonomic inventory of seaweed in the Pacific coast of Mexico is not yet complete, so attention must be given to the epiphytes, and other small and delicate species that inhabit the coast of Mexico. Morphological descriptions, distributional range, reproductive stage and samples examined are included.

关键词： Bryopsidales Corallinales Distribution New Records Seaweeds

Characterization of oral yeasts isolated from healthy individuals attended in different Colombian dental clinics

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The Journal of Biomedical Research 2019年第5期33卷 333-342页

作者： Raul Eduardo Rivera Alejandra Zuluaga Karen Arango Itzjak Kadar Paola Andrea Pinillos Luis Fernando Montes Eugenia catalina Cepeda Ernesto Gonzalez Pedro Antonio Alfonso Andrea Alejandra Villalba Luis Fernando Casanova Adolfo Perez Armando Roa Martha Jhoana Arias Jorge Orlando Francisco Cuellar Lorena Pedraza Adiel Alberto Vasquez Blanca Lynne Suarez Beatriz LGomez catalina De Bedout Luz elena Cano Group of Investigation in Oral Health Faculty of DentistryAntonio Narino UniversityArmeniaQuindio 630001Colombia Medical and Experimental MycologyUnit Corporation for Biological Research(CIB)MedellinAntioquia 050034Colombia School of Medicine and Health Sciences Universidad del RosarioCarreraBogota 111221Colombia School of Microbiology University of AntioquiaMedellinAntioquia 050036Colombia.

The aim of this study was to identify the most frequent yeasts in the oral cavity of adult individuals without immune disorders and to associate the presence of these oral yeasts with different characteristics of each individual. Oral rinse samples were obtained from 96 healthy adults and cultured in Sabouraud dextrose agar media and CHROMagar. Yeasts were identified by sequencing the D1/D2 region of the 28 S rRNA gene. Probable association among the socio-demographic characteristics, body mass index, family and personal medical history,oral hygiene, tobacco and/or alcohol consumption habits and presence of oral fungi was analyzed. Contingency tables and logistic regression were employed to evaluate possible relationships between the presence of oral fungi and mixed colonization with these variables. 57.3% of the healthy individuals had oral yeasts and 21.8% had mixed colonization. The most prevalent yeasts were Candida albicans(52%), C. parapsilosis(17.9%), and ***(7.57%). Yeasts with most frequently mixed colonization were C. albicans and C. parapsilosis. No relationships were found among the variables analyzed. However, the presence of mixed colonization was related to the presence of dental prostheses(P<0.006), dental apparatuses(P=0.016) and O’Leary index(P=0.012). This is the first study that characterized oral yeasts in Colombian healthy individuals, determined the most prevalent oral yeasts C. albicans, C. parapsilosis and C. dublinensis and an association of mixed colonization with the use of dental prostheses and aparatology and poor hygiene.

关键词： oral yeast Candida species microbial epidemiology

Occurrence and Distribution of the Genus Jania J. V. Lamouroux (Corallinales, Rhodophyta) in the Pacific Coast of Baja California and Gulf of California, Mexico

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American Journal of Plant Sciences 2013年第12期4卷 1-13页

作者： Luz elena Mateo-Cid A. catalina Mendoza-González Luis E. Aguilar-Rosas Raúl Aguilar-Rosas Facultad de Ciencias Marinas Universidad Autónoma de Baja California Ensenada Baja California México Instituto de Investigaciones Oceanológicas Universidad Autónoma de Baja California Ensenada Baja California México Instituto Politécnico Nacional Escuela Nacional de Ciencias Biológicas Departamento de Botánica Ciudad de México México

This paper provides a description of the articulated species of the Tribe Janieae (Corallinales, Rhodophyta) in the Pacific coast of Baja California and Gulf of California, Mexico. This taxonomic report is based on newly collected data in the study area and material currently housed at several herbaria. As a result of the present study, the record of the tribe Janieae is represented at the Pacific coast of Mexico for one genus: Jania J. V. Lamouroux with nine species. Morphological, reproductive and anatomical descriptions are provided in detail. In addition, keys for determination are included, as well as habitat, nomenclature, comparisons with other species and information on distribution. Instead of eleven species of Jania currently recorded for the study area, we recognize only nine. Jania verrucosa is restricted to the occidental coast from the Peninsula of Baja California. The remainder of the species commonly occurs in the Gulf of California and the Pacific coast of Baja California’s Peninsula. On the other hand, the gametangial thalli of J. adhaerens and tetrasporangial conceptacle in J. longiarthra are reported for the first time in Mexico.

关键词： Janieae Morphology Distribution Pacific Mexico