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Determination of gluten immunogenic peptides for the management of the treatment adherence of celiac disease: A systematic review

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World Journal of Gastroenterology 2021年第37期27卷 6306-6321页

作者： Laura Coto Irati Mendia carolina Sousa Julio César Bai Angel Cebolla Research and Development BiomedalCamas 41900SevilleSpain Human Nutrition and Food Science Doctoral Program University of GranadaGranada 18011Spain Molecular Biology Biomedicine and Clinical Research Doctoral ProgramUniversity of SevilleSeville 41012Spain Department of Microbiology and Parasitology University of SevilleSeville 41013Spain Department of Gastroenterology Dr.Carlos Bonorino Udaondo Gastroenterology HospitalBuenos Aires 1264Argentina Research Institutes Universidad del SalvadorBuenos Aires 1050Argentina

BACKGROUND Gluten is a complex mixture of proteins with immunogenic peptide sequences triggering the autoimmune activity in patients with celiac disease(CeD).Gluten immunogenic peptides(GIP)are resistant to gastrointestinal digestion and are then excreted via the stool and *** common detection methods applied in the follow-up visits for CeD patients such as serology tests,dietetic interviews,questionnaires,and duodenal biopsy have been proved to be inefficient,invasive,or inaccurate for evaluating gluten-free diet(GFD)*** of excreted GIP in stool and urine has been developed as a non-invasive,direct,and specific test for GFD *** To summarize published literature about the clinical utility of GIP determination in comparison to the tools employed for GFD *** PubMed and Web of Science searches were performed using the keywords“gluten immunogenic peptides”or“gluten immunogenic peptide”and a combination of the previous terms with“feces”,“stools”,“urine”,“celiac disease”,“gluten-free diet”,and“adherence”to identify relevant clinical studies published in English and Spanish between 2012 to January *** lists from the articles were reviewed to identify additional pertinent *** articles and abstracts reporting the clinical use of GIP determination in stool and/or urine for the follow-up of patients with CeD in comparison with other tools in use were *** reports,commentaries,reviews,conference papers,letters,and publications that did not focus on the aims of this review were *** Total of 15 publications were found that involved the use of GIP determination in stool and/or urine to monitor the adherence to the GFD in comparison to other *** included both children and adults diagnosed with CeD and healthy ***,these preliminary studies indicated that this novel technique was highly sensitive for the detection of GFD transgressions and therefore could fac

关键词： Celiac disease Gluten-free diet Gluten immunogenic peptides Immunoassays Stool Urine

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Exosomes:Small vesicles with big roles in cancer,vaccine development,and therapeutics

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Bioactive Materials 2022年第4期7卷 281-294页

作者： Abhimanyu Thakur Diana carolina Parra Pedram Motallebnejad Marcelo Brocchi Huanhuan Joyce Chen Pritzker School of Molecular Engineering The University of ChicagoUnited States Ben May Department for Cancer Research The University of ChicagoUnited States Tropical Disease Laboratory Department of GeneticsEvolutionMicrobiology and ImmunologyInstitute of BiologyUniversity of Campinas(UNICAMP)S˜ao PauloBrazil

Cancer is a deadly disease that is globally and consistently one of the leading causes of mortality every *** the availability of chemotherapy,radiotherapy,immunotherapy,and surgery,a cure for cancer has not been ***,exosomes have gained significant attention due to the therapeutic potential of their various components including proteins,lipids,nucleic acids,miRNAs,and *** constitute a set of tiny extracellular vesicles with an approximate diameter of 30-100 *** are released from different cells and are present in biofluids including blood,cerebrospinal fluid(CSF),and *** perform crucial multifaceted functions in the malignant progression of cancer via autocrine,paracrine,and endocrine *** ability of exosomes to carry different cargoes including drug and molecular information to recipient cells make them a novel tool for cancer *** this review,we discuss the major components of exosomes and their role in cancer *** also review important literature about the potential role of exosomes as vaccines and delivery carriers in the context of cancer therapeutics.

关键词： Cancer Exosome Therapeutics Extracellular vesicles Exosomal vaccine Exosomal delivery system

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Smart dental materials for antimicrobial applications

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Bioactive Materials 2023年第6期24卷 1-19页

作者： carolina Montoya Lina Roldan Michelle Yu Sara Valliani Christina Ta Maobin Yang Santiago Orrego Department of Oral Health Sciences Kornberg School of DentistryTemple UniversityPhiladelphiaPAUSA Bioengineering Research Group(GIB) Universidad EAFITMedellínColombia Department of Endodontology Kornberg School of DentistryTemple UniversityPhiladelphiaPAUSA Bioengineering Department College of EngineeringTemple UniversityPhiladelphiaPAUSA

Smart biomaterials can sense and react to physiological or external environmental stimuli(e.g.,mechanical,chemical,electrical,or magnetic signals).The last decades have seen exponential growth in the use and development of smart dental biomaterials for antimicrobial applications in *** biomaterial systems offer improved efficacy and controllable bio-functionalities to prevent infections and extend the longevity of dental *** review article presents the current state-of-the-art of design,evaluation,advantages,and limitations of bioactive and stimuli-responsive and autonomous dental materials for antimicrobial ***,the importance and classification of smart biomaterials are ***,the categories of bioresponsive antibacterial dental materials are systematically itemized based on different stimuli,including pH,enzymes,light,magnetic field,and *** each category,their antimicrobial mechanism,applications,and examples are ***,we examined the limitations and obstacles required to develop clinically relevant applications of these appealing technologies.

关键词： Antimicrobial Antibacterial Antifungal Smart dental materials Bioresponsive biomaterials Stimuli-responsive Restorative dentistry Biofilm Antibiofilm Bioactive

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Gastroenterology training in Latin America

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World Journal of Gastroenterology 2011年第18期17卷 2283-2287页

作者： Henry Cohen Roque Saenz Luiz E de Almeida Troncon Maribel Lizarzabal carolina Olano Gastroenterology Clinic Montevideo Medical School University del Desarrollo University of So Paulo Ribeiro Preto. Rua Bernardino Campos Rua Bernardino Campos 1000 Ribeirao Preto SP 14015-130 Brazil University del Zulia

Latin America is characterized by ethnic, geographical, cultural, and economic diversity; therefore, training in gastroenterology in the region must be considered in this context. The continent’s medical education is characterized by a lack of standards and the volume of research continues to be relatively small. There is a multiplicity of events in general gastroenterology and in sub-disciplines, both at regional and local levels, which ensure that many colleagues have access to information. Medical education programs must be based on a clinical vision and be considered in close contact with the patients. The programs should be properly supervised, appropriately defined, and evaluated on a regular basis. The disparity between the patients’ needs, the scarce resources available, and the pressures exerted by the health systems on doctors are frequent cited by those complaining of poor professionalism. Teaching development can play a critical role in ensuring the quality of teaching and learning in universities. Continuing professional development programs activities must be planned on the basis of the doctors’ needs, with clearly defined objectives and using proper learning methodologies designed for adults. They must be evaluated and accredited by a competent body, so that they may become the basis of a professional regulatory system. The specialty has made progress in the last decades, offering doctors various possibilities for professional development. The world gastroenterology organization has contributed to the speciality through three distinctive, but closely inter-related, programs: Training Centers, Train-the-Trainers, and Global Guidelines, in which Latin America is deeply involved.

关键词： Training Gastroenterology Latin America

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Role of diet and gut microbiota on colorectal cancer immunomodulation

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World Journal of Gastroenterology 2019年第2期25卷 151-162页

作者： carolina Vieira De Almeida Marcela Rodrigues de Camargo Edda Russo Amedeo Amedei Department of Surgery and Translational Medicine University of Florence Department of Surgery Stomatology Pathology and Radiology Bauru School of Dentistry S?o Paulo University Department of Experimental and Clinical Medicine University of Florence Department of Experimental and Clinical Medicine University of Florence and Department of Biomedicine Azienda Ospedaliera Universitaria Careggi (AOUC)

Colorectal cancer(CRC) is one of the most commonly diagnosed cancers, and it is characterized by genetic and epigenetic alterations, as well as by inflammatory cell infiltration among malignant and stromal cells. However, this dynamic infiltration can be influenced by the microenvironment to promote tumor proliferation, survival and metastasis or cancer inhibition. In particular, the cancer microenvironment metabolites can regulate the inflammatory cells to induce a chronic inflammatory response that can be a predisposing condition for CRC retention. In addition, some nutritional components might contribute to a chronic inflammatory condition by regulating various immune and inflammatory pathways. Besides that, diet strongly modulates the gut microbiota composition,which has a key role in maintaining gut homeostasis and is associated with the modulation of host inflammatory and immune responses. Therefore, diet has a fundamental role in CRC initiation, progression and prevention. In particular,functional foods such as probiotics, prebiotics and symbiotics can have a potentially positive effect on health beyond basic nutrition and have antiinflammatory effects. In this review, we discuss the influence of diet on gut microbiota composition, focusing on its role on gut inflammation and ***, we describe the potential benefits of using probiotics and prebiotics to modulate the host inflammatory response, as well as its application in CRC prevention and treatment.

关键词： Colorectal cancer Diet Inflammation Immune response Gut microbiota

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Commercialization of disruptive innovations:Literature review and proposal for a process framework

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International Journal of Innovation Studies 2021年第3期5卷 127-144页

作者： Javier Nieto Cubero Saheed Adebayo Gbadegeshin carolina Consolación Design Processes Research Group EINACentre Universitari de Disseny I ArtUniversitat Autonoma De Barcelona08017BarcelonaSpain Department of Management and Entrepreneurship Turku School of EconomicsUniversity of Turku20014TurkuFinland Department of Management ETSEBCUniversitat Politecnica De Catalunya08034BarcelonaSpain

The challenges of disruptive innovations have gained significant attention from both academics and practitioners,commercialization being one of the most critical *** the same time,however,it is the less studied area of disruptive ***,this article examined scholarly papers on the commercialization of disruptive innovations through a multidisciplinary systematic literature *** resulted in the analysis of 64 high-quality peer-reviewed academic *** analysis highlighted the commercialization models and main constructs that are affecting the commercialization process:market orientation,market learning,user’s involvement,market configuration,adoption networks and stakeholders,and innovation *** study evidences how commercialization has evolved from a later stage in innovation to influence even the early phases of innovation,characterized in turn by exploration,learning and ecosystem creation ***,the analysis led to a proposition that established an integrated commercialization model for high uncertainty *** model has three phases:1)Concept/value proposition validation,2)Business model validation&Market creation,and 3)Creating sales in the majority ***,the article contributes to a better understanding of commercialization processes in high uncertainty innovations,bridging also the academic-practitioner divide.

关键词： Disruptive innovation Radical innovation Emerging technologies Commercialization process Market creation Scale-up Lean start-up

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A Rare Case of Non-small Cell Lung Carcinoma Squamous Phenotype with Epstein-Barr Virus Positivity with Prolonged Response to both Chemotherapy and Radiotherapy

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中国肺癌杂志 2021年第7期24卷 526-528页

作者： carolina Navarro RODRIGUEZ Muhammad Shahid IQBAL Max ROBINSON Graham BURNS Alastair GREYSTOKE Department of Clinical Oncology Freeman Hospital Department of Pathology Freeman Hospital Department of Respiratory Medicine Royal Victoria Infirmary Department of Medical Oncology Northern Centre for Cancer CareThe Newcastle-upon-Tyne Hospitals NHS Foundation TrustNewcastle-upon-TyneUK

We present a rare challenging case of metastatic non-small cell lung cancer with Epstein-Barr virus positivity that was also diagnosed with pulmonary tuberculosis at the same time. Palliative chemotherapy gemcitabine and carboplatin was started after two weeks of anti-tuberculosis treatment with the hopes that this period would be sufficient to keep acid fast bacilli non-viable to minimise risk of tuberculosis re-activation due to chemotherapy induced immunosuppression. She completed four cycles of chemotherapy and six months of anti-tuberculosis treatment with good results and minimal side effects. Two years later, there was disease recurrence in cervical and mediastinal lymph nodes which was treated with local treatment i.e. surgery and palliative radiotherapy. It has been two years since last radiotherapy and overall more than five years since diagnosis with no active disease at present. Given the complexity and rarity of this case, significant multidisciplinary team involvement, including oncologists and radiation oncologists, pulmonologists with special interest in tuberculosis and pathologists was necessary throughout.

关键词： Lung neoplasms Epstein-Barr Virus Tuberculosis Chemotherapy Radiotherapy

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High risk of temporomandibular disorder in irritable bowel syndrome: Is there a correlation with greater illness severity?

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World Journal of Gastroenterology 2017年第1期23卷 103-109页

作者： Serena Gallotta Vincenzo Bruno Santo Catapano Nicola Mobilio carolina Ciacci Paola Iovino Functional GI Disorders Center at Gastrointestinal Unit AOU S. Giovanni di Dio e Ruggi d’Aragona Department of Medicine and Surgery University of Salerno Dental School University of Ferrara

AIMTo investigate the prevalence and the risk of temporomandibular disorders (TMDs) in patients with irritable bowel syndrome (IBS) (including each subtype: constipation, diarrhoea, and mixed) compared to the general *** January 2014 and December 2015 we enrolled consecutively adult patients diagnosed with IBS at the outpatient clinic of the University of Salerno and healthy controls (HC) without IBS. At enrollment, we analyzed all patients for the presence of TMDs according to the Research Diagnostic Criteria for *** enrolled 91 IBS patients (23 IBS-D, 30 IBS-C and 38 IBS-M) and 57 HC in the study. We found a higher risk of having TMD (OR = 3.41, 95%CI: 1.66-7.01) compared to the HC. The risk of having TMD was independent of IBS-subtype. Multiple regression analysis showed that facial pain was positively related to abdominal pain and higher level of *** patients had a more than three times greater risk of TMD compared to HC. The risk of having TMD was similar in different IBS subtypes. IBS patients that also fulfilled criteria for TMD seem to share along with chronic facial and abdominal pain a significant co-occurrence with psychiatric disorders and female preponderance.

关键词： Temporomandibular disorders Irritable bowel syndrome Chronic pain Facial pain Abdominal pain Irritable bowel syndrome severity score symptoms Irritable bowel syndrome predominant diarrhea Irritable bowel syndrome predominant constipation Irritable bowel syndrome mixed

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零基础漫画英语入门

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作者： (美)carolina Han 耿小辉

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High passage numbers induce resistance to apoptosis in C2C12muscle cells

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BIOCELL 2013年第1期37卷 1-9页

作者： LUCIA PRONSATO ANABELA LA COLLA ANA carolina RONDA LORENA MILANESI RICARDOBOLAND ANDREA VASCONSUELO Departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del Sur.San Juan 6708000 Bahía BlancaArgentina

Cell lines with high passage numbers exhibit alterations in cell morphology and *** thepresent work,C2C12 skeletal muscle cells with either low(60)passage numbers(identified as l-C2C12 or h-C2C12,respectively)were used to investigate the apoptotic response to H2O2 as a function ofculture age *** found that older cultures(h-C2C12 group)were depleted of mitochondrial DNA(mtDNA).When we analyzed the behavior of Bad,Bax,caspase-3 and mitochondrial transmembrane potential,we observed that cells in the h-C2C12 group were resistant to H2O2 induction of *** propose seriallycultured C2C12 cells as a refractory model to H2O2-induced *** addition,the data obtained in thiswork suggest that mtDNA is required for apoptotic cell death in skeletal muscle C2C12 cells.

关键词： over-subculturing changes aged muscle cultures mitochondrial DNA

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