A Rare Case of Non-small Cell Lung Carcinoma Squamous Phenotype with Epstein-Barr Virus Positivity with Prolonged Response to both Chemotherapy and Radiotherapy

作     者：Carolina Navarro RODRIGUEZ Muhammad Shahid IQBAL Max ROBINSON Graham BURNS Alastair GREYSTOKE Carolina Navarro RODRIGUEZ;Muhammad Shahid IQBAL;Max ROBINSON;Graham BURNS;Alastair GREYSTOKE

作者机构：Department of Clinical OncologyFreeman Hospital Department of PathologyFreeman Hospital Department of Respiratory MedicineRoyal Victoria Infirmary Department of Medical OncologyNorthern Centre for Cancer CareThe Newcastle-upon-Tyne Hospitals NHS Foundation TrustNewcastle-upon-TyneUK 

出 版 物：《中国肺癌杂志》 (Chinese Journal of Lung Cancer)

年 卷 期：2021年第24卷第7期

页      面：526-528页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Lung neoplasms Epstein-Barr Virus Tuberculosis Chemotherapy Radiotherapy 

摘      要：We present a rare challenging case of metastatic non-small cell lung cancer with Epstein-Barr virus positivity that was also diagnosed with pulmonary tuberculosis at the same time. Palliative chemotherapy gemcitabine and carboplatin was started after two weeks of anti-tuberculosis treatment with the hopes that this period would be sufficient to keep acid fast bacilli non-viable to minimise risk of tuberculosis re-activation due to chemotherapy induced immunosuppression. She completed four cycles of chemotherapy and six months of anti-tuberculosis treatment with good results and minimal side effects. Two years later, there was disease recurrence in cervical and mediastinal lymph nodes which was treated with local treatment i.e. surgery and palliative radiotherapy. It has been two years since last radiotherapy and overall more than five years since diagnosis with no active disease at present. Given the complexity and rarity of this case, significant multidisciplinary team involvement, including oncologists and radiation oncologists, pulmonologists with special interest in tuberculosis and pathologists was necessary throughout.