Role of diet and gut microbiota on colorectal cancer immunomodulation
Role of diet and gut microbiota on colorectal cancer immunomodulation作者机构：Department of Surgery and Translational Medicine University of Florence Department of Surgery Stomatology Pathology and Radiology Bauru School of Dentistry S?o Paulo University Department of Experimental and Clinical Medicine University of Florence Department of Experimental and Clinical Medicine University of Florence and Department of Biomedicine Azienda Ospedaliera Universitaria Careggi (AOUC)
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2019年第25卷第2期
页 面：151-162页
核心收录：
学科分类：10[医学]
基 金：Supported by "The Programma Attuativo Regionale(Toscana)" funded by FAS(now FSC)-MICpROBIMM,the Italian Ministry of University and Research(MIUR) the Foundation ‘Ente Cassa di Risparmio di Firenze’
主 题：Colorectal cancer Diet Inflammation Immune response Gut microbiota
摘 要：Colorectal cancer(CRC) is one of the most commonly diagnosed cancers, and it is characterized by genetic and epigenetic alterations, as well as by inflammatory cell infiltration among malignant and stromal cells. However, this dynamic infiltration can be influenced by the microenvironment to promote tumor proliferation, survival and metastasis or cancer inhibition. In particular, the cancer microenvironment metabolites can regulate the inflammatory cells to induce a chronic inflammatory response that can be a predisposing condition for CRC retention. In addition, some nutritional components might contribute to a chronic inflammatory condition by regulating various immune and inflammatory pathways. Besides that, diet strongly modulates the gut microbiota composition,which has a key role in maintaining gut homeostasis and is associated with the modulation of host inflammatory and immune responses. Therefore, diet has a fundamental role in CRC initiation, progression and prevention. In particular,functional foods such as probiotics, prebiotics and symbiotics can have a potentially positive effect on health beyond basic nutrition and have antiinflammatory effects. In this review, we discuss the influence of diet on gut microbiota composition, focusing on its role on gut inflammation and ***, we describe the potential benefits of using probiotics and prebiotics to modulate the host inflammatory response, as well as its application in CRC prevention and treatment.
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