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Clinicopathological Description of a Chronic Lymphocytic Leukemia in a Dog

Open Journal of Veterinary Medicine 2024年第7期14卷 155-162页

作者： Maria Clara Boni Raffi Giovanna Valverde Magalhães Barbosa Alana carolina Capais Rodrigues Sheila Canevese Rahal John P. Kastelic Luíz Guilherme Dercore Benevenuto Iolanda Simões Braga Beatriz Poloni Batista Felipe César Da Silva Brasileiro Fernanda Barthelson Carvalho de Moura Priscylla Tatiana Chalfun Guimarães Okamoto Regina Kiomi Takahira Alessandra Melchert Noeme Sousa Rocha Department of Veterinary Clinics School of Veterinary Medicine and Animal Science So Paulo State UniversityUNESP Botucatu SP Brazil Independent Veterinary Practitioner Department of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science So Paulo State UniversityUNESP Botucatu SP Brazil Faculty of Veterinary Medicine University of Calgary Calgary Canada

Hematopoietic tumors are associated with diagnostic and therapeutic challenges and a poor prognosis. Furthermore, their pathophysiology in dogs is not well understood. Chronic lymphocytic leukemia has been rarely reported in golden retrievers, perhaps due to difficulties in diagnosis and care. An 8-year-old spayed female golden retriever was referred to our hospital with a 2-month history of fatigue, weakness, and selective appetite. The dog was diagnosed with chronic lymphocytic leukemia based on blood smear evaluation. Despite treatment, the dog deteriorated and the owners opted for euthanasia. Histopathological examination revealed atypical lymphocytes in the spleen, extramedullary hematopoiesis in the spleen and liver, bone marrow depletion, moderate neutrophilic myocarditis, and acute renal tubular necrosis. In an immunohistochemical panel, cells in the spleen and bone marrow were positive for anti-CD20, anti-CD45, anti-CD3, anti-IBA-1, anti-Ki67, anti-MUM-1, and anti-PAX-5. In conclusion, the leukemia diagnosis was confirmed through reactive histiocytosis, marked extramedullary hematopoiesis, and other clinical and laboratory findings. Herein, we report a case of chronic lymphocytic leukemia in a female dog with clinical, laboratory, and necroscopy findings.

关键词： Canine Cancer Neoplasia Therapeutics

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Determination of gluten immunogenic peptides for the management of the treatment adherence of celiac disease: A systematic review

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World Journal of Gastroenterology 2021年第37期27卷 6306-6321页

作者： Laura Coto Irati Mendia carolina Sousa Julio César Bai Angel Cebolla Research and Development BiomedalCamas 41900SevilleSpain Human Nutrition and Food Science Doctoral Program University of GranadaGranada 18011Spain Molecular Biology Biomedicine and Clinical Research Doctoral ProgramUniversity of SevilleSeville 41012Spain Department of Microbiology and Parasitology University of SevilleSeville 41013Spain Department of Gastroenterology Dr.Carlos Bonorino Udaondo Gastroenterology HospitalBuenos Aires 1264Argentina Research Institutes Universidad del SalvadorBuenos Aires 1050Argentina

BACKGROUND Gluten is a complex mixture of proteins with immunogenic peptide sequences triggering the autoimmune activity in patients with celiac disease(CeD).Gluten immunogenic peptides(GIP)are resistant to gastrointestinal digestion and are then excreted via the stool and *** common detection methods applied in the follow-up visits for CeD patients such as serology tests,dietetic interviews,questionnaires,and duodenal biopsy have been proved to be inefficient,invasive,or inaccurate for evaluating gluten-free diet(GFD)*** of excreted GIP in stool and urine has been developed as a non-invasive,direct,and specific test for GFD *** To summarize published literature about the clinical utility of GIP determination in comparison to the tools employed for GFD *** PubMed and Web of Science searches were performed using the keywords“gluten immunogenic peptides”or“gluten immunogenic peptide”and a combination of the previous terms with“feces”,“stools”,“urine”,“celiac disease”,“gluten-free diet”,and“adherence”to identify relevant clinical studies published in English and Spanish between 2012 to January *** lists from the articles were reviewed to identify additional pertinent *** articles and abstracts reporting the clinical use of GIP determination in stool and/or urine for the follow-up of patients with CeD in comparison with other tools in use were *** reports,commentaries,reviews,conference papers,letters,and publications that did not focus on the aims of this review were *** Total of 15 publications were found that involved the use of GIP determination in stool and/or urine to monitor the adherence to the GFD in comparison to other *** included both children and adults diagnosed with CeD and healthy ***,these preliminary studies indicated that this novel technique was highly sensitive for the detection of GFD transgressions and therefore could fac

关键词： Celiac disease Gluten-free diet Gluten immunogenic peptides Immunoassays Stool Urine

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Gastroenterology training in Latin America

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World Journal of Gastroenterology 2011年第18期17卷 2283-2287页

作者： Henry Cohen Roque Saenz Luiz E de Almeida Troncon Maribel Lizarzabal carolina Olano Gastroenterology Clinic Montevideo Medical School University del Desarrollo University of So Paulo Ribeiro Preto. Rua Bernardino Campos Rua Bernardino Campos 1000 Ribeirao Preto SP 14015-130 Brazil University del Zulia

Latin America is characterized by ethnic, geographical, cultural, and economic diversity; therefore, training in gastroenterology in the region must be considered in this context. The continent’s medical education is characterized by a lack of standards and the volume of research continues to be relatively small. There is a multiplicity of events in general gastroenterology and in sub-disciplines, both at regional and local levels, which ensure that many colleagues have access to information. Medical education programs must be based on a clinical vision and be considered in close contact with the patients. The programs should be properly supervised, appropriately defined, and evaluated on a regular basis. The disparity between the patients’ needs, the scarce resources available, and the pressures exerted by the health systems on doctors are frequent cited by those complaining of poor professionalism. Teaching development can play a critical role in ensuring the quality of teaching and learning in universities. Continuing professional development programs activities must be planned on the basis of the doctors’ needs, with clearly defined objectives and using proper learning methodologies designed for adults. They must be evaluated and accredited by a competent body, so that they may become the basis of a professional regulatory system. The specialty has made progress in the last decades, offering doctors various possibilities for professional development. The world gastroenterology organization has contributed to the speciality through three distinctive, but closely inter-related, programs: Training Centers, Train-the-Trainers, and Global Guidelines, in which Latin America is deeply involved.

关键词： Training Gastroenterology Latin America

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High risk of temporomandibular disorder in irritable bowel syndrome: Is there a correlation with greater illness severity?

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World Journal of Gastroenterology 2017年第1期23卷 103-109页

作者： Serena Gallotta Vincenzo Bruno Santo Catapano Nicola Mobilio carolina Ciacci Paola Iovino Functional GI Disorders Center at Gastrointestinal Unit AOU S. Giovanni di Dio e Ruggi d’Aragona Department of Medicine and Surgery University of Salerno Dental School University of Ferrara

AIMTo investigate the prevalence and the risk of temporomandibular disorders (TMDs) in patients with irritable bowel syndrome (IBS) (including each subtype: constipation, diarrhoea, and mixed) compared to the general *** January 2014 and December 2015 we enrolled consecutively adult patients diagnosed with IBS at the outpatient clinic of the University of Salerno and healthy controls (HC) without IBS. At enrollment, we analyzed all patients for the presence of TMDs according to the Research Diagnostic Criteria for *** enrolled 91 IBS patients (23 IBS-D, 30 IBS-C and 38 IBS-M) and 57 HC in the study. We found a higher risk of having TMD (OR = 3.41, 95%CI: 1.66-7.01) compared to the HC. The risk of having TMD was independent of IBS-subtype. Multiple regression analysis showed that facial pain was positively related to abdominal pain and higher level of *** patients had a more than three times greater risk of TMD compared to HC. The risk of having TMD was similar in different IBS subtypes. IBS patients that also fulfilled criteria for TMD seem to share along with chronic facial and abdominal pain a significant co-occurrence with psychiatric disorders and female preponderance.

关键词： Temporomandibular disorders Irritable bowel syndrome Chronic pain Facial pain Abdominal pain Irritable bowel syndrome severity score symptoms Irritable bowel syndrome predominant diarrhea Irritable bowel syndrome predominant constipation Irritable bowel syndrome mixed

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Role of diet and gut microbiota on colorectal cancer immunomodulation

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World Journal of Gastroenterology 2019年第2期25卷 151-162页

作者： carolina Vieira De Almeida Marcela Rodrigues de Camargo Edda Russo Amedeo Amedei Department of Surgery and Translational Medicine University of Florence Department of Surgery Stomatology Pathology and Radiology Bauru School of Dentistry S?o Paulo University Department of Experimental and Clinical Medicine University of Florence Department of Experimental and Clinical Medicine University of Florence and Department of Biomedicine Azienda Ospedaliera Universitaria Careggi (AOUC)

Colorectal cancer(CRC) is one of the most commonly diagnosed cancers, and it is characterized by genetic and epigenetic alterations, as well as by inflammatory cell infiltration among malignant and stromal cells. However, this dynamic infiltration can be influenced by the microenvironment to promote tumor proliferation, survival and metastasis or cancer inhibition. In particular, the cancer microenvironment metabolites can regulate the inflammatory cells to induce a chronic inflammatory response that can be a predisposing condition for CRC retention. In addition, some nutritional components might contribute to a chronic inflammatory condition by regulating various immune and inflammatory pathways. Besides that, diet strongly modulates the gut microbiota composition,which has a key role in maintaining gut homeostasis and is associated with the modulation of host inflammatory and immune responses. Therefore, diet has a fundamental role in CRC initiation, progression and prevention. In particular,functional foods such as probiotics, prebiotics and symbiotics can have a potentially positive effect on health beyond basic nutrition and have antiinflammatory effects. In this review, we discuss the influence of diet on gut microbiota composition, focusing on its role on gut inflammation and ***, we describe the potential benefits of using probiotics and prebiotics to modulate the host inflammatory response, as well as its application in CRC prevention and treatment.

关键词： Colorectal cancer Diet Inflammation Immune response Gut microbiota

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A Rare Case of Non-small Cell Lung Carcinoma Squamous Phenotype with Epstein-Barr Virus Positivity with Prolonged Response to both Chemotherapy and Radiotherapy

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中国肺癌杂志 2021年第7期24卷 526-528页

作者： carolina Navarro RODRIGUEZ Muhammad Shahid IQBAL Max ROBINSON Graham BURNS Alastair GREYSTOKE Department of Clinical Oncology Freeman Hospital Department of Pathology Freeman Hospital Department of Respiratory Medicine Royal Victoria Infirmary Department of Medical Oncology Northern Centre for Cancer CareThe Newcastle-upon-Tyne Hospitals NHS Foundation TrustNewcastle-upon-TyneUK

We present a rare challenging case of metastatic non-small cell lung cancer with Epstein-Barr virus positivity that was also diagnosed with pulmonary tuberculosis at the same time. Palliative chemotherapy gemcitabine and carboplatin was started after two weeks of anti-tuberculosis treatment with the hopes that this period would be sufficient to keep acid fast bacilli non-viable to minimise risk of tuberculosis re-activation due to chemotherapy induced immunosuppression. She completed four cycles of chemotherapy and six months of anti-tuberculosis treatment with good results and minimal side effects. Two years later, there was disease recurrence in cervical and mediastinal lymph nodes which was treated with local treatment i.e. surgery and palliative radiotherapy. It has been two years since last radiotherapy and overall more than five years since diagnosis with no active disease at present. Given the complexity and rarity of this case, significant multidisciplinary team involvement, including oncologists and radiation oncologists, pulmonologists with special interest in tuberculosis and pathologists was necessary throughout.

关键词： Lung neoplasms Epstein-Barr Virus Tuberculosis Chemotherapy Radiotherapy

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Commercialization of disruptive innovations:Literature review and proposal for a process framework

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International Journal of Innovation Studies 2021年第3期5卷 127-144页

作者： Javier Nieto Cubero Saheed Adebayo Gbadegeshin carolina Consolación Design Processes Research Group EINACentre Universitari de Disseny I ArtUniversitat Autonoma De Barcelona08017BarcelonaSpain Department of Management and Entrepreneurship Turku School of EconomicsUniversity of Turku20014TurkuFinland Department of Management ETSEBCUniversitat Politecnica De Catalunya08034BarcelonaSpain

The challenges of disruptive innovations have gained significant attention from both academics and practitioners,commercialization being one of the most critical *** the same time,however,it is the less studied area of disruptive ***,this article examined scholarly papers on the commercialization of disruptive innovations through a multidisciplinary systematic literature *** resulted in the analysis of 64 high-quality peer-reviewed academic *** analysis highlighted the commercialization models and main constructs that are affecting the commercialization process:market orientation,market learning,user’s involvement,market configuration,adoption networks and stakeholders,and innovation *** study evidences how commercialization has evolved from a later stage in innovation to influence even the early phases of innovation,characterized in turn by exploration,learning and ecosystem creation ***,the analysis led to a proposition that established an integrated commercialization model for high uncertainty *** model has three phases:1)Concept/value proposition validation,2)Business model validation&Market creation,and 3)Creating sales in the majority ***,the article contributes to a better understanding of commercialization processes in high uncertainty innovations,bridging also the academic-practitioner divide.

关键词： Disruptive innovation Radical innovation Emerging technologies Commercialization process Market creation Scale-up Lean start-up

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In vivo epigenetic reprogramming of primary human colon cancer cells enhances metastases

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分子细胞生物学报:英文版 2016年第2期8卷 157-173页

作者： Grigori Singovski carolina Bernal Monika Kuciak Irene Siegl-Cachedenier Arwen Conod Ariel Ruiz i Altaba Department of Genetic Medicine and Development University of Geneva Medical SchoolCH-1211 GenevaSwitzerland

How metastases develop is not well understood and no genetic mutations have been reported as specific metastatic *** we have addressed the idea that epigenetic reprogramming by GLI-regulated pluripotent stemness factors promotes *** primary human colon cancer cells engrafted in mice,we find that transient expression of OCT4,SOX2,KLF41/2 cMYC establishes an enhanced pro-metastatic state in the primary tumor that is stable through sequential engraftments and is transmitted through clonogenic cancer stem *** reprogramming alters NANOG methylation and stably boosts NANOG and NANOGP8 *** and reprogrammed EMT-like phenotypes require endogenous NANOG,but enhanced NANOG is not sufficient to induce these ***,reprogrammed tumors enhance GLI2,and we show that GLI2high and AXIN2low,which are markers of the metastatic transition of colon cancers,are prognostic of poor disease outcome in *** propose that metastases arise through epigenetic reprogramming of cancer stem cells within primary tumors.

关键词： metastases epigenetic reprogramming NANOG GLI cancer stem cells

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零基础漫画英语入门

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作者： (美)carolina Han 耿小辉

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A long-term record of land use change impacts on sediments in Oualidia lagoon,Morocco

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International Journal of Sediment Research 2014年第1期29卷 1-10页

作者： Mehdi MAANAN Ana carolina RUIZ-FERNNDEZ Mohamed MAANAN Paul FATTAL Bendahhou ZOURARAH Mohamed SAHABI Géolittomer UMR 6554 LETG Université de Nantes Marine Geosciences Laboratory URAC 45Earth Sciences departmentFaculty of Sciences Universidad Nacional Autónoma de México.Instituto de Ciencias del Mary Limnología

An integrated approach,involving land use patterns and heavy metal contents of the surficial and cored sediment,was proposed to detect the characteristic spatial and temporal scale of point and non-point source human disturbances on the Oualidia lagoon in *** and description of the temporal and spatial distributions of the main contamination sources of heavy metals are analyzed using statistics and GIS *** results show that surficial sediments are highly enriched in heavy metals compared to their preindustrial background ***-use types affected lagoon sediment pollution in different ways:1) agricultural areas had the highest potential for sediment contamination by heavy metals,particularly Pb,Cu and Hg,2) Ni and Cr are the main pollutants originating from urban sewage and 3) oyster farming and traditional land uses such as salt flats,pastures showed low levels of others *** enrichment factors(normalized by Al) obtained from the sediment cores indicated that the lagoon is(strongly/moderately) polluted by all metals which were attributed to agricultural activities and wastewater discharges from urbanized areas.

关键词： Land use change(LUC) Geographical information systems(GIS) Sediment pollution Risk assessment

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