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Continuous Lumbar Plexus Catheter Removal in Postoperative Total Hip Replacement Patients Receiving Warfarin Thromboprophylaxis: A Retrospective Analysis

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Open Journal of Anesthesiology 2013年第6期3卷 293-297页

作者： Joseph Marino Jay Curtin carol patrick Kara Theal Cristina Sison George Koutsouras Scott Alpert W. Healy III Oonagh Dowling Renee Pekmezaris J. E. Chelly Biostatistics Unit The Feinstein Institute for Medical Research Manhasset USA Biostatistics Unit The Feinstein Institute for Medical Research Manhasset USA Department of Anesthesiology Franklin Hospital Medical Center Valley Stream USA Department of Anesthesiology Huntington Hospital Huntington USA Department of Cardiology Huntington Hospital Huntington USA Department of Information Services Huntington Hospital Huntington USA Department of Orthopedic Anesthesia and Acute Interventional Pain University of Pittsburgh School of Medicine Pittsburgh USA Department of Orthopedics Huntington Hospital Huntington USA Department of Population Health North Shore LIJ Health System Great Neck USA Department of Population Health North Shore LIJ Health System Great Neck USA

Background and Objectives: Based on the case reports of hemorrhagic complications, recommendations for the removal of lumbar plexus catheters in anticoagulated patients were created. These guidelines are controversial as they limit the use of lumbar plexus blocks in postoperative anticoagulated patients. This study was designed to evaluate the incidence of hemorrhagic complications and coagulation status using International Normalized Ratio (INR) at the time of lumbar plexus catheter removal in patients receiving warfarin after total hip replacement. Methods: A retrospective study of 371 patients on warfarin thromboprophylaxis who received continuous lumbar plexus catheters for postoperative analgesia after total hip surgery was performed. The primary outcome measure was the incidence of bleeding complications after catheter removal;secondary outcome measures included warfarin dose, bridge therapy, incidence of deep vein thrombosis, pulmonary embolism (DVT/PE) and INR values upon catheter removal. Results: Almost all lumbar plexus catheters (93%;344/371) were removed at 72 hours. At the time of catheter removal, mean INR was 1.99 [1.42-2.41] (p = 0.015);67% of patients had an INR > 1.5 and half of these patients had INRs between 2.0-3.0;5% had INR’s between 3.0-4.0. There were no adverse bleeding complications or nerve injury after the removal of catheters. Conclusions: We observed no incidence of bleeding after lumbar plexus catheter removal despite 67 % of patients demonstrating INR’s > 1.5. Our retrospective analysis illustrates the relative safety of catheter removal in anticoagulated patients and suggests that the removal of lumbar plexus catheters can be safely performed with an INR > 1.5 in patients receiving warfarin.

关键词： Lumbar Plexus Block Warfarin Prophylaxis Deep Vein Thrombosis Pulmonary Embolism

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Moving beyond the opposition of diverse knowledge systems for food security and nutrition

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Journal of Integrative Agriculture 2020年第1期19卷 291-293页

作者： Nathanaël PINGAULT patrick CARON Alicia KOLMANS Stefanie LEMKE carol KALAFATIC Sabine ZIKELI Ann WATERS-BAYER carolin CALLENIUS QIN Yong-jun High Level Panel of Experts Committee on World Food SecurityFood and Agriculture Orgnization of the United NationsRome 00153Italy Universitéde Montpellier Montpellier 34090France Research Center Global Food Security and Ecosystems University of HohenheimStuttgart 70599Germany Centre for Agroecology Water and ResilienceCoventry UniversityCV83LG CoventryUK Center for Organic Farming University of HohenheimStuttgart 70593Germany Agrecol Association Guggenhausen 88379Germany Shanxi Academy of Agricutural Sciences Taiyuan 030031P.R.China

Food Security and Nutrition(FSN) is influenced by diverse and complex factors, and therefore requires a holistic approach to agriculture and food systems plus integration of knowledge from diverse sources in science and society. Using the results of a colloquium held at the University of Hohenheim(Germany) in September 2016 leading up to the recent High Level Panel of Experts(HLPE) Note on Critical and Emerging Issues for Food Security and Nutrition, this article underlines the role of research and innovation as a social and political process and draws attention to neglected types of knowledge. It illustrates the potential of knowledge co-production and co-innovation to transform food systems in order to achieve the Sustainable Development Goals.

关键词： food security nutrition innovation Sustainable Development Goals

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信息通讯技术英语教程

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丛书名：大学专门用途英语系列教材

2012年

作者： patrick Fitzgerald Marie McCullagh carol Tabor原

本书由12个单元组成。每个单元的内容基本上可以分为四个部分，第一部分主要介绍和集中训练相关词汇；第二部分集中训练专业知识背景下的听力或阅读技能，强调专业和语言学习过程中基本信息输入的质和量这两个要素；第三部分是上一环节... 详细信息

ISBN: (纸本)9787040352757

本书由12个单元组成。每个单元的内容基本上可以分为四个部分，第一部分主要介绍和集中训练相关词汇；第二部分集中训练专业知识背景下的听力或阅读技能，强调专业和语言学习过程中基本信息输入的质和量这两个要素；第三部分是上一环节的延续和发展，重点训练专业和语言学习过程中信息加工和产出所需要的基本技能；第四部分为口语或写作练习，强化产出技能训练。

关键词：通信技术

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A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong

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Virologica Sinica 2016年第1期31卷 41-48页

作者： Cyril C.Y.Yip carol S.F.Lam Hayes K.H.Luk Emily Y.M.Wong Rodney A.Lee Lok-Yee So Kwok-Hung Chan Vincent C.C.Cheng Kwok-Yung Yuen patrick C.Y.Woo Susanna K.P.Lau Department of Microbiology The University of Hong Kong Department of Microbiology Pamela Youde Nethersole Eastern Hospital Department of Paediatrics and Adolescent Medicine Pamela Youde Nethersole Eastern Hospital Research Centre of Infection and Immunology The University of Hong Kong State Key Laboratory of Emerging Infectious Diseases The University of Hong Kong

We conducted a six-year epidemiological study on human coronaviruses（HCoVs） circulating in Hong Kong, using 8275 nasopharyngeal samples from patients with acute respiratory tract infections. HCoVs were detected in 77（0.93%） of the samples by a pan-HCoV RT-PCR assay. The most frequently detected HCoV species was HCoV-OC43（0.58%）, followed by HCoV-229E（0.15%）,HCoV-HKU1（0.13%） and HCoV-NL63（0.07%）. HCoVs were detected throughout the study period（September 2008–August 2014）, with the highest detection rate from September 2010 to August2011（22/1500, 1.47%）. Different seasonal patterns of each HCoV species in Hong Kong were ***-OC43 was predominant in the fall and winter, whereas HCoV-HKU1 showed peak activity in winter, with a few cases occurred in spring and summer. HCoV-229 E mainly occurred in winter and spring, while HCoV-NL63 was predominant in summer and autumn. HCoVs most commonly infect the elderly and young children, with median age of 79.5 years（range, 22 days to 95 years）.Intriguingly, the detection rate of HCoV-OC43 in the age group of ＆gt; 80 years（26/2380, 1.09%） was significantly higher than that in the age group of 0–10 years（12/2529, 0.47%）（P 〈 0.05）. These data provides new insight into the epidemiology of coronaviruses.

关键词： epidemiology human coronaviruses respiratory tract infections

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A prolonged cholera outbreak caused by drinking contaminated stream water,Kyangwali refugee settlement,Hoima District,Western Uganda:2018

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Infectious Diseases of Poverty 2020年第6期9卷 107-108页

作者： Fred Monje Alex Riolexus Ario Angella Musewa Kenneth Bainomugisha Bernadette Basuta Mirembe Dativa Maria Aliddeki Daniel Eurien Godfrey Nsereko carol Nanziri Esther Kisaakye Vivian Ntono Benon Kwesiga Daniel Kadobera Lilian Bulage Godfrey Bwire patrick Tusiime Julie Harris Bao-Ping Zhu Uganda Public Health Fellowship Program KampalaUganda 不详

Background: On 23 February 2018,the Uganda Ministry of Health(MOH)declared a cholera outbreak affecting more than 60 persons in Kyangwali Refugee Settlement,Hoima District,bordering the Democratic Republic of Congo(DRC).We investigated to determine the outbreak scope and risk factors for transmission,and recommend evidence-based control ***:: We defined a suspected case as sudden onset of watery diarrhoea in any person aged≥2 years in Hoima District,1 February–9 May 2018.A confirmed case was a suspected case with Vibrio cholerae cultured from a stool *** found cases by active community search and record reviews at Cholera Treatment *** calculated case-fatality rates(CFR)and attack rates(AR)by sub-county and *** a case-control study,we compared exposure factors among case-and *** estimated the association between the exposures and outcome using Mantel-Haenszel *** conducted an environmental assessment in the refugee settlement,including testing samples of stream water,tank water,and spring water for presence of fecal *** tested suspected cholera cases using cholera rapid diagnostic test(RDT)kits followed by culture for ***: We identified 2122 case-patients and 44 deaths(CFR=2.1%).Case-patients originating from Demographic Republic of Congo were the most affected(AR=15/1000).The overall attack rate in Hoima District was 3.2/1000,with Kyangwali sub-county being the most affected(AR=13/1000).The outbreak lasted 4 months,which was a multiple *** assessment showed that a stream separating two villages in Kyangwali Refugee Settlement was a site of open defecation for *** three water sources tested,only stream water was feacally-contaminated,yielding>100 CFU/100 *** 130 stool samples tested,124(95%)yielded *** by *** water was most strongly associated with illness(odds ratio[OR]=14.2,95%CI:1.5–133),although tank water also appeared to

关键词： Outbreak Cholera Refugees Uganda

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Romance of the three domains:how cladistics transformed the classifi cation of cellular organisms

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Protein & Cell 2013年第9期4卷 664-676页

作者： Chi-Chun Ho Susanna K.P.Lau patrick C.Y.Woo Department of Microbiology The University of Hong KongHong KongChina State Key Laboratory of Emerging Infectious Diseases The University of Hong KongHong KongChina Research Centre of Infection and Immunology The University of Hong KongHong KongChina carol Yu Centre of Infection The University of Hong KongHong KongChina

Cladistics is a biological philosophy that uses genealogi-cal relationship among species and an inferred sequence of divergence as the basis of classifi *** review critically surveys the chronological development of bio-logical classification from Aristotle through our post-genomic era with a central focus on *** 1957,Julian Huxley coined cladogenesis to denote splitting from *** 1960,the English translation of Willi Hennig’s 1950 work,Systematic Phylogenetics,was published,which received strong opposition from phenet-icists,such as numerical taxonomists Peter Sneath and Robert Sokal,and evolutionary taxonomist,Ernst Mayr,and sparked acrimonious debates in *** 1977-1990,Carl Woese pioneered in using small subunit rRNA gene sequences to delimitate the three domains of cellu-lar life and established major prokaryotic *** has since dominated *** being compatible with modern microbiological observations,*** with unusual phenotypes,restricted expression of charac-teristics and occasionally being uncultivable,increasing recognition of pervasiveness and abundance of horizon-tal gene transfer has challenged relevance and validity of *** mosaic nature of eukaryotic and prokary-otic genomes was also gradually *** the mid-2000s,high-throughput and whole-genome sequencing became routine and complex geneologies of organisms have led to the proposal of a reticulated web of *** genomics only indirectly leads to understanding of func-tional adaptations to ecological niches,computational modeling of entire organisms is underway and the gap between genomics and phenetics may soon be *** are not expected to settle as taxonomic classifi cations shall remain subjective to serve the human scientist,not the classifi ed.

关键词： cladistics phenetics phylogeny classifi ca-tion evolution

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年轻人离开原生家庭后安置不稳定性及可能的心理健康影响（英文）

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上海精神医学 2017年第2期29卷 85-94页

作者： Simon RICE Sue COTTON Kristen MOELLER-SAXONE Cathrine MIHALOPOULOS Anne MAGNUS carol HARVEY Cathy HUMPHREYS Stephen HALPERIN Angela SCHEPPOKAT patrick MCGORRY Helen HERRMAN Orygen The National Centre of Excellence in Youth Mental Health Centre for Youth Mental Health The University of Melbourne Orygen Youth Health NorthWestern Mental HealthMelbourne Health Deakin Health Economics Centre for Population Health ResearchFaculty of HealthDeakin University Psychosocial Research Centre Department of PsychiatryThe University of Melbourne NorthWestern Mental Health Department of Social Work The University of Melbourne

背景:收容机构中的儿童青少年和同龄人相比可能存在较差的心身健康水平。稳定的机构照料环境对改善早期童年经历所致破坏性影响是非常重要的,童年经历包括心理创伤、虐待和忽视。目前,澳大利亚或其他国家很少有关收容机构中儿童青少年... 详细信息

背景:收容机构中的儿童青少年和同龄人相比可能存在较差的心身健康水平。稳定的机构照料环境对改善早期童年经历所致破坏性影响是非常重要的,童年经历包括心理创伤、虐待和忽视。目前,澳大利亚或其他国家很少有关收容机构中儿童青少年的安置稳定性高质量研究的数据。目标:首次针对澳大利亚在收容机构生活中的儿童青少年进行系统的背景、照料类型、和安置稳定性特征的调查。方法:2014年收集了墨尔本市区的四家民间儿童青少年社区服务机构的数据。样本包括322名年轻人(女性占52.8%),年龄在12-17岁之间[平均年龄=14.86,(SD=1.63)年]。结果:在收容机构中,相对于社区收容照料类型(35.7%),大多数年轻人(64.3%)是基于家庭养育照料模式(即寄养、治疗型寄养照料、青少年照料模式、亲属照料、以及认领照料)。然而,与所有收容照料的孩子相比,这个年龄组被社区收容比例是较高的(5%)。第一次被社区收容的平均年龄为9岁(SD=4.54)。不同的照料类型均无性别差异。其中有248人(76.9%)曾在收容照料系统中有一个以上的安置场所,有117人(36.5%)经历了超过5个安置场所。相对于家庭养育照料者,社区收容的儿童青少年经历了更显著的安置不稳定性(χ~2=63.018,p<0.001)。结论:安置不稳定性在收容照料机构是常见的现象。需要一个稳定的照料环境来改善被虐待儿童所导致的心理创伤和健康影响。精心设计并以干预为基础的研究能够增加安置稳定性,包括强化对儿童青少年收容照料者的治疗能力。

关键词：收容照料社区照料寄养照料青少年心理健康

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Two-dimensional gel electrophoresis in bacterial proteomics

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Protein & Cell 2012年第5期3卷 346-363页

作者： Shirly O.T.Curreem Rory M.Watt Susanna K.P.Lau patrick C.Y.Woo Department of Microbiology The University of Hong KongQueen Mary HospitalHong KongChina Oral Biosciences Faculty of DentistryThe University of Hong KongQueen Mary HospitalHong KongChina State Key Laboratory of Emerging Infectious Diseases Department of MicrobiologyThe University of Hong KongQueen Mary HospitalHong KongChina Research Centre of Infection and Immunology The University of Hong KongQueen Mary HospitalHong KongChina carol Yu Centre of Infection The University of Hong KongHong KongChina

Two-dimensional gel electrophoresis(2-DE)is a gel-based technique widely used for analyzing the pro-tein composition of biological *** is capable of resolving complex mixtures containing more than a thousand protein components into individual protein spots through the coupling of two orthogonal bio-physical separation techniques:isoelectric focusing(first dimension)and polyacrylamide gel electrophore-sis(second dimension).2-DE is ideally suited for ana-lyzing the entire expressed protein complement of a bacterial cell:its *** relative simplicity and good reproducibility have led to 2-DE being widely used for exploring proteomics within a wide range of envi-ronmental and medically-relevant *** we give a broad overview of the basic principles and his-torical development of gel-based proteomics,and how this powerful approach can be applied for studying bacterial biology and *** highlight specific 2-DE applications that can be used to analyze when,where and how much proteins are *** links between proteomics,genomics and mass spectrometry are *** explore how proteomics involving tandem mass spectrometry can be used to analyze(post-translational)protein modifications or to identify proteins of unknown origin by de novo peptide *** use of proteome fractionation tech-niques and non-gel-based proteomic approaches are also *** highlight how the analysis of pro-teins secreted by bacterial cells(secretomes or exo-proteomes)can be used to study infection processes or the immune *** review is aimed at non-specialists who wish to gain a concise,compre-hensive and contemporary overview of the nature and applications of bacterial proteomics.

关键词： two-dimensional gel electrophoresis bacte-ria proteomics

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Pilot trial evaluating maternal docosahexaenoic acid consumption during pregnancy: Decreased postpartum depressive symptomatology

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International Journal of Nursing Sciences 2014年第4期1卷 339-345页

作者： Michelle P.Judge Cheryl T.Beck Holiday Durham Michele M.McKelvey carol J.Lammi-Keefe University of Connecticut School of NursingStorrsCT 06269-4026USA Pennington Biomedical Research Center Baton RougeLA 70808USA Louisiana State University School of Nutrition and Food SciencesAgricultural CenterBaton RougeLA 70808USA

Objective:Docosahexaenoic acid(DHA,22:6,n-3)is a major structural component of neural tissue critical to neurotransmission and mood *** maternal dietary intake coupled with accelerated maternal-fetal transfer of DHA compound risk for maternal *** objective of this investigation was to determine if maternal DHA supplementation is efficacious in reducing symptoms of postpartum ***:This pilot investigation was a randomized,double-blinded,placebo controlled investigation of the role of DHA in preventing risk for postpartum *** were assigned to:i)Placebo(no DHA,corn oil capsule),ii)DHA(300 mg DHA,fish oil capsule).Capsules were consumed from 24 to 40 weeks gestation(1 capsule 5 days/week).Forty-two participants were recruited(n=20,intervention;n=22,placebo).Maternal DHA status and depressive symptoms were followed from 24 to 40 weeks gestation using the Center for Epidemiologic Studies Depression Scale(CES-D)and the Postpartum Depression Screening Scale(PDSS)from 2 weeks to 6 months ***:PDSS total scores were significantly lower(p=0.016;46.03±2.17,intervention vs.52.11±2.4,placebo)in the intervention group with less anxiety/insecurity(p=0.03),emotional lability(p=0.04)and loss of self(p=0.02).Conclusions:Women in the DHA intervention group had fewer symptoms of postpartum depression compared to the placebo *** results support the notion that the consumption of DHA by pregnant women can be efficacious in preventing depressive symptoms and highlight a need for further larger-scale investigations using the PDSS in tandem with a diagnostic evaluation.

关键词： Docosahexaenoic acid Postpartum depression n-3 polyunsaturated fatty acids Depression Pregnancy

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谁做了帕特里克的作业？

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新东方英语（中学版） 2015年第3期 52-53页

作者： carol Moore 古娟

遇到困难,我们总是习惯于求助他人。殊不知,有时自己努努力,也是可以做到的,而且可能会做得更好。帕特里克从来不做作业。"太无聊了。"他说。取而代之,他打棒球、篮球,玩任天堂的游戏。他的老师们告诉他:"帕特里克,你要做作业!否则,你... 详细信息

遇到困难,我们总是习惯于求助他人。殊不知,有时自己努努力,也是可以做到的,而且可能会做得更好。帕特里克从来不做作业。"太无聊了。"他说。取而代之,他打棒球、篮球,玩任天堂的游戏。他的老师们告诉他:"帕特里克,你要做作业!否则,你什么也学不到。"确实是这样。有时他的确觉得自己像个傻子。但他能怎么办?他讨厌作业。后来在圣帕特里克节那天,他家的猫在玩一个小玩偶,他一把把那个玩偶给抢了过来。

关键词：帕特里克圣帕特里克节努努相信自己爱尔兰人地念声地 doubled subtraction 最后一天

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