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language and Semiotic Studies 2016年第1期2卷 146-157页

作者： carol l.webster Jonathan J.webster Hong Kong Polytechnic University China City University of Hong Kong China

In this paper, we present a comparative study of Obama's closing statements in the presidential debates, in particular, the first and third debates with Mitt Romney in 2012. Obama was considered to have done poorly in the first debate, but very well in the third debate. A systemic-functional analysis of Obama's closing statements in these two debates reveals the lexicogrammatical and rhetorical choices which contribute to the functional and aesthetic value of Obama's debate performance.

关键词： systemic-functional linguistics political discourse debate performance theme analysis

New insights into the vitamin D requirements during pregnancy

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Bone Research 2017年第3期5卷 161-176页

作者： Bruce W Hollis carol l Wagner Department of Pediatrics Darby Children's Research Institute Medical University of South Carolina

Pregnancy represents a dynamic period with physical and physiological changes in both the mother and her developing fetus. The dramatic 2-3 fold increase in the active hormone 1,25（OH）2D concentrations during the early weeks of pregnancy despite minimal increased calcium demands during that time of gestation and which are sustained throughout pregnancy in both the mother and fetus suggests an immunomodulatory role in preventing fetal rejection by the mother. While there have been numerous observational studies that support the premise of vitamin D＇s role in maintaining maternal and fetal well-being, until recently, there have been few randomized clinical trials with vitamin D supplementation. One has to exhibit caution, however, even with RCTs, whose results can be problematic when analyzed on an intent-to-treat basis and when there is high non-adherence to protocol （as if often the case）, thereby diluting the potential good or harm of a given treatment at higher doses. As such, a biomarker of a drug or in this case ＂vitamin＂ or pre-prohormone is better served. For these reasons, the effect of vitamin D therapies using the biomarker circulating 25（OH）D is a far better indicator of true ＂effect.＂ When pregnancy outcomes are analyzed using the biomarker 25（OH）D instead of treatment dose, there are notable differences in maternal and fetal outcomes across diverse racial/ethnic groups, with improved health in those women who attain a circulating 25（OH）D concentration of at least 100 nmol. l-1 （40 ng. ml-1）. Because ,an important issue is the timing or initiation of vitamin D treatment/supplementation, and given the potential effect of vitamin D on placental gene expression and its effects on inflammation within the placenta, it appears crucial to start vitamin D treatment before placentation （and trophoblast invasion）; however, this question remains unanswered. Additional work is needed to decipher the vitamin D requirements of pregnant women and the optimal timing of s

关键词： New insights into the vitamin D requirements during pregnancy

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精密冲击加速度计校准器

中国检验检测 1979年第3期 25-28页

作者： Herbert l.webster 郭营川

一、引言核武器可靠性的重要意义要求我们制定绝对可靠的武器设计计划和建立由原子能研究发展委员会(ERDA)直接领导的产品试验室。作为可靠性计划的一部分,在桑迪亚建立了基准试验室,这个试验室的责任是为整套设计和产品承包单位提供测... 详细信息

一、引言核武器可靠性的重要意义要求我们制定绝对可靠的武器设计计划和建立由原子能研究发展委员会(ERDA)直接领导的产品试验室。作为可靠性计划的一部分,在桑迪亚建立了基准试验室,这个试验室的责任是为整套设计和产品承包单位提供测量保证,包括测量检查,为了满足冲击测量的需要,在桑迪亚试验室建立了精密的冲击加速度计校准器。

关键词：冲击加速度计校准器试验室靶体

Praziquantel decreases fecundity in Schistosoma mansoni adult worms that survive treatment:evidence from a laboratory life-history trade-offs selection study

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Infectious Diseases of Poverty 2017年第1期6卷 988-998页

作者： Poppy H.l.lamberton Christina l.Faust Joanne P.webster Institute for Biodiversity Animal Healthand Comparative Medicine&Wellcome Centre for Molecular ParasitologyCollege of MedicalVeterinary&Life SciencesUniversity of GlasgowG128QQGlasgowUK london Centre for Neglected Tropical Disease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonSt Mary’s CampusW21PGLondonUK Centre for Endemic Emerging and Exotic DiseasesThe Royal Veterinary CollegeUniversity of LondonLondon AL97TAUK

Background:Mass drug administration of praziquantel is the World Health Organization’s endorsed control strategy for schistosomiasis.A decade of annual treatments across sub-Saharan Africa has resulted in significant reductions of infection prevalence and intensity levels,although‘hotspots’*** drug treatments place strong selective pressures on parasites,which may affect life-history traits that impact transmission *** drug treatment responses and the evolution of such traits can help inform on how to minimise the risk of drug resistance developing,maximise sustainable control programme success,and improve diagnostic ***:We performed a four-generation Schistosoma mansoni praziquantel selection experiment in mice and *** used three *** lines:a praziquantel-resistant isolate(R),a praziquantel-susceptible isolate(S),and a coinfected line(RS),under three treatment regimens:untreated,25 mg/kg praziquantel,or 50 mg/kg *** traits,including parasite adult-worm establishment,survival,reproduction(fecundity),and associated morbidity,were recorded in mice across all four *** variables were tested in a series of generalized linear mixed effects models to determine which factors had a significant influence on parasite life-history traits in definitive hosts under different selection ***:Praziquantel pressure significantly reduced adult-worm burdens across all generations and isolates,including within ***,previous drug treatment resulted in an increase in adult-worm establishment with increasing generation from P1 to *** highest worm numbers were in the co-infected RS *** treatment decreased adult-worm burden,but had a larger negative impact on the mean daily number of miracidia,a proxy for fecundity,across all three parasite ***:Our predicted cost of resistance was not supported by the traits we measured within the murine host.

关键词： Schistosoma mansoni Biomphalaria Mouse Praziquantel Resistance Establishment Survival Fecundity Trade-offs

Optical coherence tomography for ocular surface and corneal diseases: a review

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Eye and Vision 2018年第1期5卷 126-136页

作者： Nandini Venkateswaran Anat Galor Jianhua Wang carol l.Karp Bascom Palmer Eye Institute University of Miami Miller School of MedicineMcKnight Building Room 202A1638 NW 10th Avenue900 NW 17th StreetMiamiFL 33136USA Department of Ophthalmology Miami Veterans Administration Medical Center1201 NW 16th StreetMiamiFL 33125USA

The advent of optical coherence tomography(OCT)imaging has changed the way ophthalmologists image the ocular surface and anterior segment of the *** ability to obtain dynamic,high and ultra-high resolution,cross-sectional images of the ocular surface and anterior segment in a noninvasive and rapid manner allows for ease of *** this review,we focus on the use of anterior segment OCT,which provides an“optical biopsy”or in vivo imaging of various ocular surface and corneal pathologies,allowing the clinician to diagnose diseases otherwise not visualized by traditional *** utility of anterior segment OCT for various anterior segment pathologies is reviewed.

关键词： Anterior segment optical coherence tomography Ocular surface imaging Ocular surface lesions

Utility of high-resolution anterior segment optical coherence tomography in the diagnosis and management of sub-clinical ocular surface squamous neoplasia

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Eye and Vision 2019年第1期6卷 229-235页

作者： Ann Q.Tran Nandini Venkateswaran Anat Galor carol l.Karp Department of Ophthalmology Bascom Palmer Eye InstituteUniversity of Miami Miller School of Medicine900 NW 17th StMiamiFL 33136USA

Background:To evaluate the frequency and characteristics of sub-clinical ocular surface squamous neoplasia(OSSN)detected by high-resolution anterior segment tomography(HR-OCT)in patients with clinically unapparent disease following topical ***:A retrospective chart review of patients with OSSN identified through a pharmacy database at the Bascom Palmer Eye Institute from January 2013 to December 2018 was *** undergoing primary therapy with topical 5-fluorouracil 1%(5-FU)(4 times a day for 7 days with a 21-day break)or interferon-alpha-2b(IFN)(4 times a day)were *** were separated into two *** 1 included individuals whose clinical resolution of OSSN aligned with complete resolution on *** 2(sub-clinical OSSN group)included individuals with clinical OSSN resolution but with features of persistent disease on *** excluded included those treated at an outside institution and those who used topical therapy as a surgical ***:A total of 95 patients(95 eyes)were ***-clinical OSSN was detected at a frequency of 17%in our study patients(n=16 patients,9 treated with 5-FU and 7 treated with IFN).In the 16 individuals,the mean time to clinical resolution was 3.6±1.0 cycles for 5-FU and 4.0±0.0 months for *** additional 2.1±0.8 cycles for 5-FU and 1.2±0.4 months for IFN were needed to achieve HR-OCT resolution of *** in Group 1 was noted in 10 patients(12%)while no recurrences occurred in Group 2,the cohort with subclinical disease that received the extended medical *** mean follow-up was 24.0±17.9 ***:We found that at least 17%of individuals with apparent clinical resolution of OSSN have sub-clinical disease detected on *** information can be used to optimize treatment and extend therapy past the point of clinical resolution.

关键词： Ocular surface squamous neoplasia,High-resolution optical coherence tomography,Sub-clinical ocular surface squamous neoplasia,Ocular surface imaging ocular surface lesions

Update on Diagnosis and Management of Conjunctival Papilloma

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Eye and Vision 2019年第1期6卷 131-147页

作者： Despoina Theotoka Melina I.Morkin Anat Galor carol l.Karp Department of Ophthalmology Bascom Palmer Eye InstituteUniversity of Miami Miller School of Medicine900 NW 17th StreetMiamiFL 33136USA Miami Veterans Administration Medical Center 1201 NW 16th StreetMiami 33125FLUSA

Conjunctival papilloma is an acquired benign squamous cell tumor that can present at any age,but most frequently in the third and fourth decades of *** have been associated with human papilloma virus(HPV)infection,usually types 6 and *** histopathological diagnosis remains the gold standard,the advent of newer non-invasive imaging modalities such as optical coherence tomography(OCT)is transforming the way we diagnose and treat ocular surface tumors,including conjunctival *** of these lesions can prove a challenge to the treating physician since not all lesions respond to medical and/or surgical therapy and in fact may worsen after surgical *** this review,the epidemiology,pathophysiology,clinical characteristics,and diagnosis of conjunctival papilloma including the use of OCT are ***,efficacy,and side effects of currently available management options are also reviewed to guide the selection of the best treatment approach.

关键词： Conjunctival papilloma Squamous cell papilloma Optical coherence tomography Treatment Interferon Mitomycin Surgery Cryotherapy Human papilloma virus

Epidemiology of ocular surface squamous neoplasia in veterans: a retrospective casecontrol study

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Eye and Vision 2019年第1期6卷 99-104页

作者： logan M.Smith Shiv lamba carol l.Karp Anat Galor Miami Veterans Administration Medical Center 1201 NW 16th StMiamiFL 33125USA Bascom Palmer Eye Institute Department of OphthalmologyUniversity of Miami900 NW 17th StreetMiamiFL 33136USA Flint Hill School OaktonVirginiaUSA

Background:A number of risk factors have been evaluated in ocular surface squamous neoplasia,but few studies have assessed risk factors specific to the armed forces veteran ***:We conducted a retrospective case-control study on 55 patients and 55 age-matched controls with biopsy-proven ocular surface squamous neoplasia from the Miami Veterans Administration Hospital Eye Clinic to investigate potential risk factors encountered by veterans,including service-specific ***-specific risk factors included ionizing radiation exposure,Agent Orange exposure,deployment to Southwest Asia,and exposure to the series of biochemical warfare tests known as Project Shipboard Hazard and *** was analyzed with SPSS(SPSS Inc.,Chicago,Il)using t-tests,chi-squared,and logistic regression analysis,with a p-value oflly ***:The strongest risk factor for ocular surface squamous neoplasia was lifetime sun exposure both directly assessed via historical quantification of exposure by dermatology practitioners(Odds Ratio(OR)5.4,95%Confidence Interval(CI)2.27–12.847,pl cell carcinoma(OR 3.157,95%CI 1.286–7.748,p=0.010)and pingueculae(OR 5.267,95%CI 2.104–13.186,ployment were not associated with an increased risk of ocular surface squamous *** to ionizing radiation and involvement in Project Shipboard Hazard and Defense were not documented among any cases or ***:The results of our study are consistent with prior established risk factors,namely highlighting the important role of sun exposure in ocular surface squamous neoplasia among veterans.

关键词： Ocular surface squamous neoplasia Risk factors Veteran population

lacrimal gland tumors in Turkey：types,frequency,and outcomes

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International Journal of Ophthalmology(English edition) 2018年第8期11卷 1296-1302页

作者： Yagmur Seda Yesiltas Ahmet Kaan Gundiiz Esra Erden carol l. Shields Department of Ophthalmology Ankara University Faculty of Medicine Ankara 06620 Turkey Department of Pathology Ankara University Faculty of Medicine Ankara 06230 Turkey Ocular Oncology Service Wills Eye Hospital Thomas Jefferson University Philadelphia PA 19107 USA

AIM： To evaluate the clinical, radiological, and treatment features of lacrimal gland ***： Retrospective review of 99 eyes of 92 patients with lacrimal gland tumors diagnosed and managed in a single institution between January 1999 and March 2017. Clinical and radiological features, histopathology, treatment methods, and prognosis were ***： The mean patient age was 40.3（range： 7-80）*** diagnosis was made histopathologically in 91（91.9%） tumors and on a clinical and radiological basis in 8（8.1%） tumors. Final diagnoses included idiopathic orbital inflammation（pseudotumor） in 46（46.5%） lesions, pleomorphic adenoma in 14（14.1%）, adenoid cystic carcinoma in 12（12.1%）, granulomatous inflammation in 10（10.1%）, lymphoma in 5（5.0%）, benign reactive lymphoid hyperplasia in 3（3.0%）, dacryops in 3（3.0%）, carcinoma ex pleomorphic adenoma in 2（2.0%）, adenocarcinoma in 1（1.0%）, dermoid cyst in 1（1.0%）, cavernous hemangioma in 1（1.0%）, and leukemic infiltration in 1（1.0%）. Nonepithelial tumors comprised 64.6%（n=64） of all lacrimal gland tumors, epithelial tumors 32.3%（n=32）, dermoid cyst 1%（n=1）, cavernous hemangioma 1%（n=1）, and leukemic infiltration 1%（n=1）. There were in total 78（78.8%） benign and 21（21.2%） malignant tumors. CONClUSION： Overall, 65% of lacrimal gland tumors were of non-epithelial origin and 32% of epithelial origin. By histopathology and clinical evaluation, 79% of lacrimal gland tumors were benign. The most common lacrimal gland tumors include idiopathic orbital inflammation（46.5%）, epithelial（32.3%）, and lymphoproliferative（8.1%） lesions.

关键词： orbit lacrimal gland tumor inflammation epithelial tumor non-epithelial tumor

Classification, diagnosis, and management of conjunctival lymphoma

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Eye and Vision 2019年第1期6卷 175-190页

作者： Rebecca E.Tanenbaum Anat Galor Sander R.Dubovy carol l.Karp Department of Ophthalmology Bascom Palmer Eye InstituteUniversity of Miami Miller School of Medicine900 NW 17th St.MiamiMiamiFL 33136USA

lymphoma is a malignant lymphoproliferative tumor that can involve the *** 5–15%of all extranodal lymphomas are found in the ocular adnexal region,with approximately 25%of those involving the ***-eight percent of conjunctival lymphomas arise from *** most common subtype of conjunctival lymphoma is extranodal marginal zone lymphoma(80%),followed by follicular lymphoma(8%),diffuse large B-cell lymphoma(3%)and mantle cell lymphoma(3%).Natural killer and T cells(NK/T)are rare causes of *** most conjunctival lymphomas are localized to the ocular adnexa at the time of presentation,systemic examination and management are of key importance in the long-term care of the *** review outlines the classification,etiology,presentation,diagnosis,and management of conjunctival *** novel use of high resolution optical coherence tomography,both as a diagnostic tool and as a means for ongoing evaluation during treatment,is *** options discussed include external beam radiation,chemotherapy,immunotherapy,antibiotic therapy,and combination *** investigation of the etiology and pathogenesis of conjunctival lymphoma is expected to reveal opportunities for innovative and individualized therapeutic *** between multiple disciplines is key in the advancement of the field.

关键词： Conjunctiva Conjunctival tumor Extranodal marginal zone lymphoma lymphoma Optical coherence tomography Salmon patch