Praziquantel decreases fecundity in Schistosoma mansoni adult worms that survive treatment:evidence from a laboratory life-history trade-offs selection study

作     者：Poppy H.L.Lamberton Christina L.Faust Joanne P.Webster 

作者机构：Institute for BiodiversityAnimal Healthand Comparative Medicine&Wellcome Centre for Molecular ParasitologyCollege of MedicalVeterinary&Life SciencesUniversity of GlasgowG128QQGlasgowUK London Centre for Neglected Tropical Disease ResearchDepartment of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonSt Mary’s CampusW21PGLondonUK Centre for EndemicEmerging and Exotic DiseasesThe Royal Veterinary CollegeUniversity of LondonLondon AL97TAUK 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2017年第6卷第1期

页      面：988-998页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：PHLL and CLF are currently funded by PHLL’s European Research Council Starting Grant[680,088 SCHISTO_PERSIST] PHLL is also funded by a Wellcome Trust ISSF Grant[105,614/Z/14/Z] a Lord Kelvin Adam Smith Leadership Fellowship JPW’S current Schistosoma research is funded by a ZELS research grant(combined BBSRC,MRC,ESRC,NERC,DSTL&DFID:BB/L018985/1) a BBSRC Impact Accelerator Grant(BB/GCRF-IAA/19) a SCORE research grant(The University of Georgia Research Foundation,funded by the Bill and Melinda Gates Foundation:RR374-053/4785426) During the experiment study PHLL was funded by a Medical Research Council PhD studentship and JPW was funded by a Royal Society University Research Fellowship.Funding for the laboratory facilities was given from the Schistosomiasis Control Initiative 

主　　题：Schistosoma mansoni Biomphalaria Mouse Praziquantel Resistance Establishment Survival Fecundity Trade-offs 

摘      要：Background:Mass drug administration of praziquantel is the World Health Organization’s endorsed control strategy for schistosomiasis.A decade of annual treatments across sub-Saharan Africa has resulted in significant reductions of infection prevalence and intensity levels,although‘hotspots’*** drug treatments place strong selective pressures on parasites,which may affect life-history traits that impact transmission *** drug treatment responses and the evolution of such traits can help inform on how to minimise the risk of drug resistance developing,maximise sustainable control programme success,and improve diagnostic ***:We performed a four-generation Schistosoma mansoni praziquantel selection experiment in mice and *** used three *** lines:a praziquantel-resistant isolate(R),a praziquantel-susceptible isolate(S),and a coinfected line(RS),under three treatment regimens:untreated,25 mg/kg praziquantel,or 50 mg/kg *** traits,including parasite adult-worm establishment,survival,reproduction(fecundity),and associated morbidity,were recorded in mice across all four *** variables were tested in a series of generalized linear mixed effects models to determine which factors had a significant influence on parasite life-history traits in definitive hosts under different selection ***:Praziquantel pressure significantly reduced adult-worm burdens across all generations and isolates,including within ***,previous drug treatment resulted in an increase in adult-worm establishment with increasing generation from P1 to *** highest worm numbers were in the co-infected RS *** treatment decreased adult-worm burden,but had a larger negative impact on the mean daily number of miracidia,a proxy for fecundity,across all three parasite ***:Our predicted cost of resistance was not supported by the traits we measured within the murine host.