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Gastroenterology Report 2014年第2期2卷 150-153页

作者： Nidia Alfonso Puentes carmen jimenez-alfaro larrazabal Maria Isabel Garcia Higuera Clinical Neurophysiology Department Hospital Universitario de BurgosSpain Department of Internal Medicine Hospital Universitario de BurgosSpain Department of Pathology Hospital Universitario de BurgosSpain

Small bowel malignant tumors are rare and sarcomatoid carcinomas have rarely been reported at this *** report a 56-year-old woman,with history of an excised gliosarcoma,who presented with recurrent obscure gastrointestinal *** underwent endoscopy and colonoscopy,which failed to identify the cause of the *** abdominal computed tomography scan located a tumor in the small *** revealed a jejunal sarcomatoid *** developed tumor recurrence and multiple liver metastases shortly after *** is required for accurate *** carcinoma is a rare cause of obscure gastrointestinal bleeding,which is associated with a poor prognosis.

关键词： obscure gastrointestinal bleeding small bowel tumors sarcomatoid carcinoma

Arylhydrazones Derivatives Containing a Benzothiazole Moiety, Efficient Ligands in the Palladium-Catalyzed Mizoroki-Heck and Suzuki-Miyaura Cross-coupling Reactions under IR Irradiation

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Chinese Journal of Chemistry 2017年第12期35卷 1881-1888页

作者： Fernando Ortega-Jiménez José Guillermo Penieres-Carrillo José Guadalupe López-Cortés M. carmen Ortega-alfaro Selene Lagunas-Rivera Departamento de Cieneias Qulmicas Facultad de Estudios Superiores Cuautitlān-UNAM Campo i Avenida lro. de Mayo s/n Cuautitlán Izcalli C.P. 54740 Estado de México México Instituto de Qulmiea UNAM Circuito Exterior Ciudad Universitaria Coyoacán C.P. 04360 Cuidad de México México Instituto de Ciencias Nucleares UNAM Circuito Exterior Ciudad Universitaria Coyoacán C.P. 04360 Ciudad de México México Catedrático CONA CyT-TecNM-Instituto Tecnológico de Tuxtla Gutiérrez Carretera Panamericana Km 1080 Col Juan Crispin Tuxtla Gutiérrez C.P. 29050 Chiapas México

A simple arylhydrazone containing the benzothiazole moiety which may be used as an efficient ligand in the palladium-catalyzed Mizoroki-Heck and Suzuki-Miyaura cross-coupling reactions, under infrared irradiation as an alternative source of energy, is presented. The reactions proceeded with extremely high efficiency under mild conditions and produced very good yields.

关键词： arylhydrazones palladium-catalyzed cross-coupling reaction IR-irradiation

Vigorous,but differential mononuclear cell response of cirrhotic patients to bacterial ligands

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World Journal of Gastroenterology 2011年第10期17卷 1317-1325页

作者： Varenka J Barbero-Becerra María Concepción Gutiérrez-Ruiz carmen Maldonado-Bernal Félix I Téllez-Avila Roberto alfaro-Lara Florencia Vargas-Vorácková Department of Gastroenterology Instituto Nacional de Ciencias Médicasy Nutrición Salvador Zubirán Laboratorio de Fisiología Celular División de Ciencias de la Salud Universidad Autónoma Metropolitana-Iztapalapa Unidad de Investigación Médica en Enfermedades Infecciosasy Parasitarias Hospital de Pediatría Unidad de Investigación en Enfermedades Oncológicas Hospital Infantil de México Federico Gómez

AIM： To study the role of gram-positive and gram-negative bacteria in the pathogenesis of liver injury, specifically the activation of inflammatory mediators. METHODS： Peripheral blood mononuclear cells of 20 out-patients were studied, 10 of them with cirrhosis,Peripheral blood mononuclear cells were isolated and exposed to lipopolysaccharide or lipoteichoic acid. CD14, Toll-like receptor 2 and 4 expression was determined by flow cytometry, and tumor necrosis factor （TNF） α, interleukin （1L）-1β, IL-6, IL-12 and IL-10 secretion in su- pernatants was determined by ELISA. RESULTS： Higher CD14, Toll-like receptor 2 and 4 expression was observed in peripheral blood mononudear cells from cirrhotic patients, （P 〈 0.01, P 〈 0.006, P 〈 0.111） respectively. Lipopolysaccharide and lipoteichoic acid induced a further increase in CD14 expression （P 〈 0.111 lipopolysaccharide, P 〈 0.013 lipoteichoic acid）, and a decrease in Toll-like receptor 2 （P 〈 0.008 lipopolysaccharide, P 〈 0.008 lipoteichoic acid） and Toll-like receptor 4 （P 〈 0.008 lipopolysaccharide, P 〈 0.028 li- poteichoic acid） expression. With the exception of TNFα, absolute cytokine secretion of peripheral blood mononuclear cells was lower in cirrhotic patients under nonexposure conditions （P 〈 0.070 IL-6, P 〈 0.009 IL-1]5, P 〈 0.022 IL-12）. Once exposed to lipopolysaccharide or lipoteichoic acid, absolute cytokine secretion of peripheral blood mononuclear cells was similar in cirrhotic and non-cirrhotic patients, determining a more vigorous response in the former （P 〈 0.005 TNFα, IL-1β, IL-6, IL-2 and IL-10 lipopolysaccharide; P 〈 0.037 TNFα; P 〈 0.006 IL-113; P 〈 0.005 IL-6; P 〈 0.007 IL-12; P 〈 0.014 IL-10 lipoteichoic acid）. Response of peripheral blood mononuclear cells was more intense after lipopolysaccharide than after lipoteichoic acid exposure. CONCLUSION： Peripheral blood mononuclear cells of cirrhotic patients are able to respond to a sudden bacterial ligand exposure, particularly lipopolysaccharide, sugg

关键词： Liver cirrhosis Toll-like receptors Cytokines Lipopolysaccharide Lipoteichoic acid

Immunotherapy and immunoescape in colorectal cancer

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World Journal of Gastroenterology 2007年第44期13卷 5822-5831页

作者： Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos alfaro Arantza Azpilicueta carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero Liver Unit Facultad de Ciencias Biomédicas Universidad Austral Presidente Perón 1500 (1635) Derqui-Pilar Buenos Aires Argentina Centro de Investigación Médica Aplicada and Clínica Universitaria Universidad de Navarra Pamplona Spain

Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma.

关键词： Colorectal carcinoma Immunotherapy Gene therapy interleukin-12 Dendritic cells CD137 indoleamine 2, 3 dioxygenase

Effect of Water Stress Induced by Polyethylene Glycol on Growth, Proline Accumulation in Agave americana L.

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Phyton-International Journal of Experimental Botany 2023年第2期92卷 629-643页

作者： alfaro-Corres Arnoldo Enrique Lecona-Guzman Carlos Alberto Gutiérrez-Miceli Federico Antonio Martínez-Esteves Manuel Silverio-Gómez María del carmen Medina-Lara María de Fátima Ruiz-Lau Nancy Laboratorio de Biotecnología vegetal Instituto Tecnológico de Tuxtla GutiérrezTuxtla Gutiérrez29050México Centro de Investigación Científica de Yucatán Unidad de Bioquímica y Biología Molecular de PlantasMérida97205México Insituto Nacional de Investigaciones Forestales Agrícolas y PecuariasHuimanguilloTabasco86400México CONACYT-Tecnológico Nacional de México/Instituto Tecnológico de Tuxtla Gutiérrez Tuxtla Gutiérrez29050México

The effect of water deficit was determined on both in vitro and soil seedling as well as in cells in suspension of Agave americana *** order to do the establishment of cells,the formation of callus was induced;for it two auxins were evaluated:2,4-dichlorophenoxyacetic acid(2,4-D)and 4-mino-3,5,6-trichloropicolinic acid(picloram)at three concentrations(0.25,0.5 and 0.75 mg L−1)in three explants(leaf,root and meristems)cultured in MS semisolid *** callogenesis response was related to the type and section of the explant,as well as the regulator used,and a cell suspension was established using 0.5 mg L−1 naphthaleneacetic acid(NAA)+0.5 mg L−1 Benzylaminopurine(BAP).Seedlings were exposed to polyethyleneglycol(15%and 30%w/v)with a water potential of−0.87 and−2.67 MPa,respectively,under soil *** stress was applied through restricted *** weight,root system growth,and chlorophyll concentration were some of the parameters that were affected by the effect of water deficit on *** *** concentration values were significantly decreased by 15 at 30%PEG(19.6 SPAD units)compared to the control *** in vitro plants,the highest concentration of proline was found in the roots,being the treatment with 30%polyethylene glycol where the highest concentration of this osmoregulator was obtained(62.5 mg g−1 DW).Under restricted irrigation conditions,an increase in proline concentration was observed both in the aerial part(2.2μg 100 g−1 DW)and in the root system(1.8μg 100 g−1 DW).However,the concentrations found were approximately ten times greater,less than those found under in vitro ***,the accumulation of proline can be considered an indicator of stress in Agave Americana *** in vitro.

关键词： Agave americana water deficit proline

Evolution of Acquired Humoral Immunity after Full Vaccination against SARS-CoV-2. IgG Levels in Healthcare Workers at 6 and 9 Months

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World Journal of Vaccines 2023年第2期13卷 13-32页

作者： Victoria Delicado-Useros Esther Navarro-Rodenas Indalecio-M Sánchez-Onrubia carmen Ortega-Martínez Antonia alfaro-Espín Juan-D Pérez-Serra Francisco García-Alcaraz Julia Lozano-Serra Lorena Robles-Fonseca Teresa Pérez-Domenech Nursing Faculty Castilla-La Mancha University Nursing & Society Research Group Albacete Spain Emergency Department General Hospital Almansa Spain Emergency Department General Hospital Albacete Spain Nursing Faculty Nursing & Society Research Group Universidad de Castilla-La Mancha Albacete Spain Emergency Department Son Espasses Universitary Hospital Palma de Mallorca Spain Departament of Clinical Microbiology in Albacete General Hospital Albacete Spain

Background: The COVID-19 pandemic continues to be a major worldwide health problem. The present study aims to contribute to surveillance of the immune and clinical response of vaccines to SARS-CoV-2. Methods: Observational medication study on acquired immunity and effectiveness of vaccines. Population: 620 workers in the health service of Almansa (Spain). Representative sample of 150 individuals. Sociodemographic, clinical, and epidemiological data and samples were recorded to determine anti-SARS-CoV-2 serum IgG levels 6 and 9 months after vaccination with Pfizer. Results: Mean age 46.45 years;76% women;85.1% working in a hospital. 19.3% had had COVID-19 in the year prior to vaccination. 96.7% were fully vaccinated with Pfizer/BioNTech. At 6 months, 100% seropositivity and mean IgG levels of 3017.2 AU/ml. Significant variations in IgG levels in individuals with prior COVID-19 infection and smokers. At 9 months, 99.3% remained seropositive;2.8% infected after vaccination. The repeated measures analysis showed a difference in means of 669.0 AU/ml (significant decrease in IgG levels of 28.9%). Conclusion: Antibody levels remained positive 6 and 9 months after vaccination, although IgG levels were found to decay.

关键词： Acquired Immunity SARS-CoV-2 Vaccine IgG level Healthcare Workers COVID-19 Incidence Rate

A Highly Sensitive In Situ Hybridization Assay For Hpv Detection In Mexican Women:Potential Marker Of Cervical Intraepithelial Neoplasia

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A Highly Sensitive In Situ Hybridization Assay For Hpv Detec...

Overexpression Of Protein P16ink4a As A Marker Of Squamous Intraepithelial Lesions Induced By High Risk Hpv Infection In Mexican Women

24th International Papillomavirus Conference and Clinical Workshop

作者： Luz del carmen Alarcon-Romero Elba Reyes-Maldonado Berenice Illades-Aguiar Eugenia Flores-alfaro Gloria Fernondez-Tilapa Amalia Vences Velozquez Esther Ivonne Lepez-Bayghen Victor Gabriel Hernondez Chavez Marco Antonio Teran-Porcayo Escuela Nacional de Ciencias Biologicas IPNMexicoD.F.Facultad de Ciencias Quimico BiologicasUniversidad Autonoma de GuerreroChilpancingoGuerreroMexico Escuela Nacional de Ciencias Biologicas IPNMexicoD.F. Facultad de Ciencias Quimico Biologicas Universidad Autonoma de GuerreroChilpancingoGuerreroMexico Facultad de Ciencias Quimico Biologicas Universidad Autonoma de GuerreroChilpancingoGuerreroMexico Escuela Nacional de Ciencias Biologicas IPNMexicoD.F.Facultad de Ciencias Quimico BiologicasUniversidad Autonoma de GuerreroChilpancingoGuerreroMexico Escuela Nacional de Ciencias Biologicas IPNMexicoD.F.Facultad de Ciencias Quimico BiologicasUniversidad Autonoma de GuerreroChilpancingoGuerreroMexico Depatamento de Genetica y Biologia Molecular CIVESTAV-IPNMexicoD.F. Departamento de Anatomia patologica del Hospital de Cardiologia del Centro Medico Nacional Siglo XXI del IMSS MexicoD.F Instituto Estatal de Cancerologia“Dr Arturo Beltran Ortega” AcapulcoGuerreroMexico

＜正＞Background:HPV infection is initiated with episomal virus,as state that is characterized by diffuse in situ hybridization（ISH） *** signal pattern correlates with the productive phenotype of HPV Integrated HPV has been found in association with invasive cervical carcinoma,and this event is characterized by a nuclear punctate ISH signal.

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Overexpression Of Protein P16ink4a As A Marker Of Squamous I...

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

24th International Papillomavirus Conference and Clinical Workshop

作者： Luz del carmen Alarcon-Romero Elba Reyes-Maldonado Berenice Illades-Aguiar Eugenia Flores-alfaro Amafia Vences Velazquez Gloria Fernondez-Tilapa Esther Ivonne Lopez-Bayghen Ethel A Garcia-Latorre Patricia Romero Neri Victor Gabriel Hernandez Chavez Marco Antonio Teron-Porcayo Escuela Nacional de Ciencias Biologicas IPNMexicoD.F.Facultad de Ciencias Quimico BiologicasUniversidad Autonoma de GuerreroChilpancingo.GuerreroMexico Escuela Nacional de Ciencias Biologicas IPNMexicoD.F Facultad de Ciencias Quimico Biologicas Universidad Autonoma de GuerreroChilpancingo.GuerreroMexico Facultad de Ciencias Quimico Biologicas Universidad Autonoma de GuerreroChilpancingo.GuerreroMexico Escuela Nacional de Ciencias Biologicas IPNMexicoD.F.Facultad de Ciencias Quimico BiologicasUniversidad Autonoma de GuerreroChilpancingo.GuerreroMexico Escuela Nacional de Ciencias Biologicas IPNMexicoD.F.Facultad de Ciencias Quimico BiologicasUniversidad Autonoma de GuerreroChilpancingo.GuerreroMexico Depatamento de Genetica y Biologia Molecular CIVESTAV-IPNMexicoD.F Escuela Nacional de Ciencias Biologicas IPNMexicoD.F Clinica de Displasias ChilpancingoGuerreroMexico Departamento de Anatomia patologica Hospital de Cardiologia Centro Medico Nacional Siglo XXI del IMSSMexicoD.F Instituto Estatal de Cancerologia‘Dr Arturo Beltran Ortega’ AcapulcoGuerreroMexico

＜正＞Background:Expression of the high-risk human papillomavirus（hr-hpv）e7-gene replicating epithelial cells results in disruption of the prb-e2f complex and degradation of prb This leads to strong overexpression o...

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Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González carmen Gómez-González Rocío González-León carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 ***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID