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Innate immunity–the hallmark of Helicobacter pylori infection in pediatric chronic gastritis

World Journal of Clinical Cases 2021年第23期9卷 6686-6697页

作者： Lorena Elena meliț Cristina Oana mărginean maria Oana Săsăran Simona mocan Dana Valentina Ghiga Alina Bogliş carmen Duicu Department of Pediatrics I “George Emil Palade”University of MedicinePharmacySciences and Technology Târgu MureșTârgu Mureș540136Romania Department of Pediatrics III “George Emil Palade”University of MedicinePharmacySciences and Technology Târgu MureșTârgu Mureș540136Romania Department of Pathology Emergency County Hospital Târgu MureșTârgu Mureș540139Romania Scientific medical Research methodology “George Emil Palade”University of MedicinePharmacySciences and Technology Târgu MureșTârgu Mureș540136Romania Department of Genetics Center for Advanced Medical and Pharmaceutical Research“George Emil Palade”University of MedicinePharmacySciences and Technology Târgu MureșTârgu Mureș540136Romania

BACKGROUND Innate immunity was found to be associated with both persistence of Helicobacter pylori(***)infection and increased risk of gastric *** To identify the risk factors associated with *** infection and to establish the role of TLR9 rs352140 in suppressing or promoting inflammation related to this infection in *** We performed a study of 155 children with digestive symptoms,who were divided into two groups according to the histopathological exam:Group 1–48 children with ***-induced chronic gastritis,and Group 2–control *** Rural area and poor living conditions were significantly associated with *** chronic gastritis(P=0.0042/Pmmunoglobulin A anti *** and the rapid urease test were significantly associated with *** infection(Pmorphism and both leucocytes and neutrophils(P=0.0225/P=0.0292).CONCLUSION Variant TT genotype carriers of the TLR9 rs352140 gene polymorphism might have a more severe degree of inflammation.

关键词： Innate immunity Helicobacter pylori infection Children Chronic gastritis TLR9 Systemic inflammation

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Transepithelial leak in Barrett's esophagus patients: The role of proton pump inhibitors

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World Journal of Gastroenterology 2012年第22期18卷 2793-2797页

作者： Christopher Farrell melissa morgan Owen Tully Kevin Wolov Keith Kearney Benjamin Ngo Giancarlo mercogliano James J Thornton mary carmen Valenzano James m mullin Division of Gastroenterology Lankenau Hospital Wynnewood PA 19096 United States Lankenau Institute for medical Research Wynnewood PA 19096 United States

AIm： To determine if the observed paracellular sucrose leak in Barrett＇s esophagus patients is due to their pro- ton pump inhibitor （PPI） use. mETHODS： The in vivo sucrose permeability test was administered to healthy controls, to Barrett＇s patients and to non-Barrett＇s patients on continuous PPI thera- py. Degree of leak was tested for correlation with pres- ence of Barrett＇s, use of PPIs, and length of Barrett＇s segment and duration of PPI use. RESULTS： Barrett＇s patients manifested a near 3-fold greater, upper gastrointestinal sucrose leak than healthy controls. A decrease of sucrose leak was ob- served in Barrett＇s patients who ceased PPI use for 7 *** initial introduction of PPI use （in a PPI-na＇ive population） results in dramatic increase in sucrose leak, long-term, continuous PPI use manifested a slow spon- taneous decline in leak. The sucrose leak observed in Barrett＇s patients showed no correlation to the amount of Barrett＇s tissue present in the esophagus. CONCLUSION： Although future research is needed to determine the degree of paracellular leak in actual Barrett＇s mucosa, the relatively high degree of leak ob- served with in vivo sucrose permeability measurement of Barrett＇s patients reflects their PPI use and not their Barrett＇s tissue perse.

关键词： Barrett's esophagus Sucrose Tight junc-tion Paracellular, Omeprazole Proton pump inhibitor Transepithelial

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Growth of Four Varieties of Barley(Hordeum vulgare L.)in Soils Contaminated with Heavy metals and Their Effects on Some Physiological Traits

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American Journal of Plant Sciences 2013年第9期4卷 1799-1810页

作者： Agueda González m.carmen Lobo Instituto madrileno de Investigación y Desarrollo Rural Agrario y AlimentaciónMadridSpain

To evaluate the effect of zinc (Zn), cadmium (Cd), and chromium (Cr) on growth and selected physiological traits in barley, a greenhouse trial was performed using four barley varieties that were exposed to different concentration of these metals. The parameters quantified were growth, chlorophyll content, and chlorophyll fluorescence during three phenological stages: flag leaf, anthesis, and grain filling. The metal concentrations in both the plant and soil were also quantified. We determined that the varieties studied were more tolerant to Zn and Cd than to Cr. Treatment with Zn did not negatively affect growth, and only high concentrations of Cd decreased growth by approximately 4% to 8%. Plants treated with the highest Cr concentration stopped growing at the flag leaf stage. The amount of metal that accumulated in the plant increased with increasing metal concentration, and the highest amount of accumulated metal was recorded in the root and shoot. Both the plant height and dry weight were higher in the CB502 variety plants, followed by the Reinette, Pedrezuela, and Plaisant varieties. The same trend was observed for the chlorophyll content and fluorescence, with a significant correlation between the growth parameters and chlorophyll content (p mined that barley has variability in the studied traits.

关键词： Growth Heavy metal Barley Chlorophyll Content

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Anticlockwise metamorphic paths at ca.890–790 ma from the NE Baidrag block,mongolia,indicate back-arc compression at the Rodinia periphery

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Geoscience Frontiers 2023年第2期14卷 154-181页

作者： PavlaŠtípská Vít Peresty Igor Soejono Karel Schulmann RCAndrew Kylander-Clark carmen Aguilar Stephen Collett martin Racek Jitka míková Otgonbaatar Dorjsuren Nikol Novotná Czech Geological Survey 11821 Praha 1Czech Republic Institute of Petrology and Structural Geology Charles University in PragueAlbertov 6Praha 212800Czech Republic Institut Terre et Environnement de Strasbourg UMR 7063 Universitéde Strasbourg-CNRS1 Rue Blessig67084 StrasbourgCedexFrance Department of Earth Science University of CaliforniaSanta BarbaraCA 93106United States Department of mineralogy Petrology and Applied GeologyFaculty of Earth ScienceUniversity of Barcelona08028 BarcelonaSpain Institute of Geology Mongolian Academy of SciencesLabor Union StreetSonginokhairkhan DistrictUlaanbaatar 18080Mongolia

The processes leading to the assembly of the Rodinia supercontinent through Grenvillian collisional orogeny are relatively well *** contrast,accretionary orogenic processes occurring at the supercontinent periphery following Rodinia assembly are poorly *** fill this gap,we have identified metamorphic rocks in the mongolia collage of the Central Asian Orogenic Belt,where numerous data testify for meso-to Neoproterozoic magmatic *** tectono-metamorphic evolution of the periSiberian tract of the Central Asian Orogenic Belt is mainly characterized by the late Proterozoic–early Cambrian(Baikalian)***,we document here a Tonian age metamorphism at the northern part of the Precambrian Baidrag block,previously considered as a typical example of the Baikalian metamorphic *** study incorporates zircon and in-situ monazite geochronology linked to P-T modelling of Grt-Sil-Ky migmatite gneiss and Grt-St ***-Sil-Ky gneiss records initial burial to the sillimanite stability field at 720℃ and 6.0 kbar followed by further burial to the kyanite stability field at 750℃ and 9 kbar and decompression to 650℃ and 8 *** Grt-St schist records initial burial to the staurolite stability field at 620℃ and 6 kbar,followed by further burial to 590℃ and 8.5 *** monazite data yield a continuum of ^(207)Pb-corrected ^(238)U/^(206)Pb dates of ca.926–768 ma in the Grt-Sil-Ky gneiss,and ca.937–754 ma in the Grt-St *** on monazite textural positon,internal zoning,and REE patterns,the time of prograde burial to 6.0 kbar under a thermal gradient of 27–32℃/km is estimated at ca.890–853 *** is not clear whether such high-grade conditions prevailed until a phase of further burial under a geothermal gradient of 18–22℃/km dated at ca.835–815 *** late monazite recrystallization at ca.790 ma is related to ***,monazite with dates of ca.568–515 ma occur as whole grains or as rims with sharp boundaries on Tonian monaz

关键词： Central Asian Orogenic Belt Grenvillian-age metamorphism monazite in-situ U-Pb dating monazite REE composition Zircon U-Pb dating Thermodynamic modelling

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Efficiency in hydrocarbon degradation and biosurfactant production by Joostella sp.A8 when grown in pure culture and consortia

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Journal of Environmental Sciences 2018年第5期30卷 115-126页

作者： carmen Rizzo Alessandro Ciro Rappazzo Luigi michaud Emilio De Domenico Carlos Rochera Antonio Camacho Angelina Lo Giudice Department of Chemical BiologicalPharmaceutical and Environmental Sciences(ChiBioFarAm)University of MessinaViale Ferdinando Stagno d'Alcontres 3198166 MessinaItaly Institute for the Coastal marine Environment National Research Council(IAMC-CNR)Spianata San Raineri 8698122 MessinaItaly Cavanilles Institute for Biodiversity and Evolutionary Biology University of ValenciaCarrer del Catedratic Jose Beltran Martinez 246980 PaternaValenciaSpain Regional Centre for Water Studies(CREA) University of Castilla-La ManchaC/Altagracia 5013071 Ciudad RealSpain

Joostella strains are emerging candidates for biosurfactant production. Here such ability was analyzed for Joostella strain A8 in comparison with Alcanivorax strain A53 and Pseudomonas strain A6, all previously isolated from hydrocarbon enrichment cultures made of polychaete homogenates. In pure cultures Joostella sp. A8 showed the highest stable emulsion percentage（78.33%）, hydrophobicity rate（62.67%）, and an optimal surface tension reduction during growth in mineral medium supplemented with diesel oil（reduction of about 12 mN/m）, thus proving to be highly competitive with Alcanivorax and Pseudomonas strains. During growth in pure culture different level of biodegradation were detected for Alcanivorax strain A53（52.7%）,Pseudomonas strain A6（38.2%） and Joostella strain A8（26.8%）. When growing in consortia,isolates achieved similar abundance values, with the best efficiency that was observed for the Joostella-Pseudomonas co-culture. Gas-chromatographic analysis revealed an increase in the biodegradation efficiency in co-cultures（about 90%）, suggesting that the contemporary action of different bacterial species could improve the process. Results were useful to compare the efficiencies of well-known biosurfactant producers（i.e. Pseudomonas and Alcanivorax representatives） with a still unknown biosurfactant producer, i.e. Joostella, and to confirm them as optimal biosurfactant-producing candidates.

关键词： Joostella Biosurfactants Co-cultures Hydrocarbon degradation Biodegradation efficiency

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Dynamic assessment of variations in pupil diameter using swept‑source anterior segment optical coherence tomography after phakic collamer lens implantation

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Eye and Vision 2021年第6期8卷 396-403页

作者： Felix Gonzalez‑Lopez carmen Bouza‑miguens Victor Tejerina Vasyl Druchkiv Blas mompean Julio Ortega‑Usobiaga Rafael Bilbao‑Calabuig Department of Refractive Surgery Clinica BavieraMelchor Fernández Almagro928029 MadridSpain Department of Research and Development Clinica BavieraValenciaSpain

Purpose:To dynamically assess variations in pupil diameter induced by changes in brightness in myopic eyes implanted with an implantable collamer lens(ICL,STAAR Surgical)with a central ***:This prospective,observational single-center case series study comprised 65 eyes from 65 consecutive patients undergoing ICL implant.A modified commercially available swept-source Fourier-domain anterior segment optical coherence tomography(AS-OCT)device was used for imaging and performing dynamic pupillometry under changing light conditions before and after a mean follow-up interval of four months after ***:Preoperative mean pupil size under photopic conditions was 3.38±0.64 mm;after surgery,this increased to 3.48±0.61 *** pupil size under scotopic light conditions was 5.72±0.79 mm before surgery and 5.84±0.77 mm *** differences between preoperative and postoperative pupil diameter in miosis and mydriasis were 0.10±0.44 mm(P=0.078)and 0.12±0.58 mm(P=0.098),*** scotopic pupil exceeded the optic zone of the implanted lens in 39 eyes(60%).The mean central vault value was 412±177μm under maximum miosis and 506±190μm under maximum *** found a positive correlation between vault and differences in pupil diameter under all light conditions(Pmic AS-OCT enables a very precise determination of the pupillary diameter in the iris *** changes in the pupil diameter under different light conditions after the implantation of an ICL are related to the postoperative vault.

关键词： Phakic collamer lens ICL Pupil OCT Central hole Central port Posterior chamber phakic lens

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Gastric infiltration of diffuse large B-cell lymphoma: Endoscopic diagnosis and improvement of lesions after chemotherapy

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World Journal of Gastroenterology 2008年第27期14卷 4407-4409页

作者： Sergio Zepeda-Gómez Jesús Camacho Edgar Oviedo-Cárdenas carmen Lome-maldonado Department of Gastrointestinal Endoscopy Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán" Department of Pathology Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán"

Diffuse large B-cell lymphoma (DLBCL) is the most common histologic subtype of the non-Hodgkin’s lymphoma (NHL) accounting for about 40% of all NHLs. This is a case report about the endoscopic appearance of a DLBCL with infiltration to the stomach in a 39-year-old female. She had a 6-mo history of lumbar and left upper quadrant pain with intermittent episodes of melena. A computer tomograghy (CT) scan showed mural thickening of the gastric antrum. Endoscopic examination revealed multiple gastric ulcers. Definite diagnosis could be made by endoscopic biopsies and the patient had a good response to chemotherapy. This response correlated well with a further endoscopic follow-up. A follow-up endoscopic examination could be considered to evaluate a good response to chemotherapy in DLBCL patients with secondary gastric dissemination.

关键词： Diffuse large B-cell lymphoma Non-Hodgkin's lymphoma Gastric infiltration

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Scalable and low-cost fabrication of flexible WS_(2) photodetectors on polycarbonate

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npj Flexible Electronics 2022年第1期6卷 226-234页

作者： Jorge Quereda Sruthi Kuriakose carmen munuera Federico J.mompean Abdullah m.Al-Enizi Ayman Nafady Enrique Diez Riccardo Frisenda Andres Castellanos-Gomez GISC Departamento de Física de MaterialesUniversidad Complutense de MadridMadridSpain materials Science Factory Instituto de Ciencia de Materiales de Madrid(ICMMCSIC)28049 MadridSpain Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Nanotechnology Group USAL–NanolabUniversidad de Salamanca37008 SalamancaSpain

We present a low-cost and easy-to-implement technique to fabricate large-area WS_(2) photodetector devices onto transparent and flexible polycarbonate *** method relies on the deposition of large-area(in the cm scale)thin films(~30 nm thick)of WS_(2) by a recently introduced abrasion-induced *** electrical contacts are then deposited by thermal evaporation through a shadow *** photodetectors present well-balanced performances with an good trade-off between responsivity(up to 144 mA/W at a source-drain voltage of 10 V and illumination power of 1μW)and response time(down to~70µs)and a detectivity value of 10^(8) *** found that the devices perform very reversibly upon several illumination and straining cycles and we found a moderate device-to-device variation.

关键词： drain illumination cost

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Phytoclimatic Dynamics of mediterranean Forests under Climate Change. A Case Study in a Southern European <i>Pinus sylvestris</i>L. Stand

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American Journal of Plant Sciences 2013年第3期4卷 655-662页

作者： Javier m. García-López carmen Allué Regional Government of Castilla y León Environmental Service Burgos Spain Regional Government of Castilla y León Environmental Service Burgos Spain.

Some effects of climate change on the composition and competitive capacity of southern European Pinus sylvestris L. forests in the mediterranean basin were evaluated. The variation over the period 1910-2008 through 30-year mobile averages of a Phytoclimatic Suitability Index (PSI) of the main tree species of the forest cover are used to indicate the competitive hierarchy of Pinus sylvestris and Fagus sylvatica L. The methodology was applied at a specific location on the Spanish south-facing slopes of the Pyrenees mountain range in the Iberian Peninsula, where the increase in the average temperature was 1.4?C in the period of observation. The results indicated that the apparent equilibrium between the two species studied changed from the 1934-1963 average. Due to the loss of competitive capacity of Scots pine with respect to European beech, particularly from the years 1970-1999, the model predicted an inversion of the situation as it was up until now, so that beech had a higher PSI than pine. The phytoclimatic approach proposed here offers new methodological horizons for the study of the effects of climate change on the future of the forests.

关键词： Biodiversity Complexity Suitability Competition Phytoclimatology Scots Pine European Beech

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Pre-fire aboveground biomass, estimated from LiDAR, spectral and field inventory data, as a major driver of burn severity in maritime pine (Pinus pinaster) ecosystems

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Forest Ecosystems 2022年第2期9卷 234-246页

作者： Jose manuel Fernandez-Guisuraga Susana Suarez-Seoane Paulo mFernandes Victor Fernandez-Garcia Alfonso Fernandez-manso carmen Quintano Leonor Calvo Area of Ecology Department of Biodiversity and Environmental ManagementFaculty of Biological and Environmental SciencesUniversity of Leon24071LeonSpain Centro de Investigacao e de Tecnologias Agroambientais e Biologicas Universidade de Tras-os-Montes e Alto Douro5000-801Vila RealPortugal Department of Organisms and Systems Biology(Ecology Unit)and Research Unit of Biodiversity(ImIB UO-CSIC-PA)University of OviedoOviedoMieresSpain Agrarian Science and Engineering Department School of Agricultural and Forestry EngineeringUniversity of Leon24400PonferradaSpain Electronic Technology Department School of Industrial EngineeringUniversity of Valladolid47011ValladolidSpain Sustainable Forest management Research Institute University of Valladolid-Spanish National Institute for Agriculture and Food Research and Technology(INIA)34004PalenciaSpain

Background:The characterization of surface and canopy fuel loadings in fire-prone pine ecosystems is critical for understanding fire behavior and anticipating the most harmful ecological effects of ***,the joint consideration of both overstory and understory strata in burn severity assessments is often *** aim of this work was to assess the role of total,overstory and understory pre-fire aboveground biomass(AGB),estimated by means of airborne Light Detection and Ranging(LiDAR)and Landsat data,as drivers of burn severity in a megafire occurred in a pine ecosystem dominated by Pinus pinaster *** the western mediterranean ***:Total and overstory AGB were more accurately estimated(R^(2) equal to 0.72 and 0.68,respectively)from LiDAR and spectral data than understory AGB(R^(2)=0.26).Density and height percentile LiDAR metrics for several strata were found to be important predictors of *** severity responded markedly and non-linearly to total(R^(2)=0.60)and overstory(R ^(2)=0.53)AGB,whereas the relationship with understory AGB was weaker(R ^(2)=0.21).Nevertheless,the overstory plus understory AGB contribution led to the highest ability to predict burn severity(RmSE=122.46 in dNBR scale),instead of the joint consideration as total AGB(RmSE=158.41).Conclusions:This study novelty evaluated the potential of pre-fire AGB,as a vegetation biophysical property derived from LiDAR,spectral and field plot inventory data,for predicting burn severity,separating the contri-bution of the fuel loads in the understory and overstory strata in Pinus pinaster *** evidenced relationships between burn severity and pre-fire AGB distribution in Pinus pinaster stands would allow the implementation of threshold criteria to support decision making in fuel treatments designed to minimize crown fire hazard.

关键词： Aboveground biomass Burn severity Landsat LiDAR Pinus pinaster

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