Transepithelial leak in Barrett's esophagus patients: The role of proton pump inhibitors
Transepithelial leak in Barrett's esophagus patients: The role of proton pump inhibitors作者机构：Division of Gastroenterology Lankenau Hospital Wynnewood PA 19096 United States Lankenau Institute for Medical Research Wynnewood PA 19096 United States
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2012年第18卷第22期
页 面：2793-2797页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100214[医学-肿瘤学] 10[医学]
基 金：Supported by Sharpe-Strumia Research Foundation of the Bryn Mawr Hospital
主 题：质子泵抑制剂 泄漏 患者 食管 价格指数 PPI 测试管理 测试压力
摘 要：AIM: To determine if the observed paracellular sucrose leak in Barrett s esophagus patients is due to their proton pump inhibitor (PPI) use. METHODS: The in vivo sucrose permeability test was administered to healthy controls, to Barrett s patients and to non-Barrett s patients on continuous PPI therapy. Degree of leak was tested for correlation with presence of Barrett s, use of PPIs, and length of Barrett s segment and duration of PPI use. RESULTS: Barrett s patients manifested a near 3-fold greater, upper gastrointestinal sucrose leak than healthy controls. A decrease of sucrose leak was observed in Barrett s patients who ceased PPI use for 7 *** initial introduction of PPI use (in a PPI-na ve population) results in dramatic increase in sucrose leak, long-term, continuous PPI use manifested a slow spontaneous decline in leak. The sucrose leak observed in Barrett s patients showed no correlation to the amount of Barrett s tissue present in the esophagus. CONCLUSION: Although future research is needed to determine the degree of paracellular leak in actual Barrett s mucosa, the relatively high degree of leak observed with in vivo sucrose permeability measurement of Barrett s patients reflects their PPI use and not their Barrett s tissue per se .
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