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Exceptionally Preserved Conodont Natural Assemblages from the Middle Triassic Luoping Biota,Yunnan Province,China:Implications for Architecture of Conodont Feeding Apparatus

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Journal of Earth Science 2023年第6期34卷 1762-1776页

作者： Jinyuan Huang carlos martinez-perez Qiyue Zhang Kexin Zhang Mao Luo Wen Wen Changyong Zhou Xiao Min Zhixin Ma Tao Xie Michael J.Benton Philip C.J.Donoghue Chengdu Center China Geological Survey(Geosciences Innovation Center of Southwest China)Chengdu 610081China Cavanilles Institute of Biodiversity&Evolutionary Biology University of Valencia46980 ValenciaSpain Institute of Geological Survey China University of GeosciencesWuhan 430074China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of SciencesNanjing 210008China School of Earth Sciences and Engineering Nanjing UniversityNanjing 210023China School of Ocean Sciences China University of GeosciencesBeijing 100083China School of Earth Sciences University of BristolBristol BS81TQUK

Articulated natural assemblages contain direct evidence of the element numbers,morphologies,positions and structures for reconstructing the feeding apparatuses of conodont animals,but these kind of materials are very rare in fossil *** we report ten new conodont natural assemblages from Member II of the Guanling Formation in Luoping County,eastern Yunnan Province,southwestern *** assemblages were obtained from the fossil-bearing layers of the Luoping Biota,dated to the early Middle Triassic Anisian stage(Pelsonian substage).These fossiliferous laminated limestones mainly consist of calcites and dolomites,with platy clay minerals and pyrites as subordinate components,indicating that the conodont assemblages were preserved in a lower energy and anoxic sedimentary *** new natural assemblages preserve the primary collapse orientations of the Nicoraella feeding apparatus from the Luoping Biota,showing the relative original positions of the S,M and P elements,that could be further used to refine the architecture of this apparatus in space variable M elements and the position unclear P1 *** previously reported three-dimensional and bilaterally symmetrical fused clusters,we statistically analyze the size of the positional homogenous elements within different sized materials,in particular S4,S3,or S2 elements,indicates that elements ontogenic changes do not affect the apparatus *** of Nicoraella apparatus remains stable in the process of ontogeny,so our reconstructed model is *** is the first time that ample types of materials have been used to restore a conodont apparatus within one genus,namely natural assemblages(articulated and disarticulated),fused clusters(articulated,disarticulated,compressed,and relatively three-dimensional),and abundant discrete elements,*** materials together record the most complete information on architecture in the gondolelloid apparatuses,thus enabling us

关键词： conodont natural assemblage architecture fused cluster size variation limestone MiddleTriassic southwestern China

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In Vitro Evaluation of Polyurethane-Chitosan Scaffolds for Tissue Engineering

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Journal of Biomaterials and Nanobiotechnology 2012年第4期3卷 440-445页

作者： Imelda Olivas-Armendariz Perla Garcia-Casillas Adriana Martel Estrada Alberto martinez-Villafane Laura A.A.de la Rosa carlos A.martinez-perez Institute of Engineering and Technology Autonnomous University of the City of JuarezCiudad JuarezMexico Department of Physics of Materials Research Center of Advanced MaterialsChihuahuaMexico Institute of Biomedical Science Autonomous University of the City of JuarezCiudad JuarezMexico

In this work the use of Polyurethane (PU)-Chitosan(CH) scaffolds prepared by thermal induced phase separation (TIPS) for osteoblast proliferation and bone mineralization is described. Primary rat calvaria osteoblasts were seeded in the scaffolds and it was shown that supported cell adhesion and growth. The behavior osteoblast cells growing in the scaffold in function of the different ratio of PU and CH is presented. The results showed that TIPS is an appropriate technique for the production of PU-CH scaffolds with high potential for application as cell scaffolds in bone tissue engineering.

关键词： Biomaterials Composite

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Intense pulsed light‑based treatment for the improvement of symptoms in glaucoma patients treated with hypotensive eye drops

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Eye and Vision 2024年第2期10卷 12-21页

作者： Jose Maria martinez‑de‑la‑Casa carlos Oribio‑Quinto Almudena Milans‑del‑Bosch Pilar perez‑Garcia Laura Morales‑Fernandez Javier Garcia‑Bella Jose Manuel Benitez‑del‑Castillo Julian Garcia‑Feijoo David P.Pinero Ophthalmology Unit Department of Ophthalmology and ORLFaculty of MedicineHospital Clinico San-CarlosUniversidad Complutense de MadridInstituto de Investigacion Sanitaria del Hospital Clinico San-Carlos(IdISSC)28040 MadridSpain Department of Immunology Ophthalmology and ORLSchool of MedicineInstituto de Investigaciones Oftalmologicas Ramon CastroviejoUniversidad Complutense de MadridMadridSpain Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicanteSpain

Background:Ocular surface disease in glaucoma patients is a significant ocular co-morbidity that can affect 40%to 59%of these patients *** current study was aimed at evaluating the potential clinical benefit of an intense pulsed light(IPL)-based treatment in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop *** our knowledge,this is the first series analyzing the therapeutic effect of this treatment option in this type of ***:This non-comparative prospective case series study enrolled a total of 30 glaucoma patients ranging in age from 57 to 94 years old and treated with hypotensive eyedrops for years with dry eye *** patients received four sessions of IPL treatment using the Optima IPL system(Lumenis,Yokneam,Israel)adjusted to the official optimized Lumenis *** in symptomatology,corneal staining,conjunctival hyperemia,non-invasive break-up time(NIBUT),tear osmolarity,tear meniscus height(TMH),meiboscore and meibomian gland expressibility was analyzed after ***:Statistically significant reductions were observed after IPL treatment in the symptomatology scores measured with different questionnaires[ocular surface disease index(OSDI),standard patient evaluation of eye dryness(SPEED)and symptom assessment questionnaire in dry eye(SANDE)]as well as with the visual analogue scale(P<0.001).Mean change in OSDI was−15.0±11.3.A significant reduction was found after treatment in the corneal staining score(P<0.001).A significant reduction was found in tear film meniscus height(P=0.012),as well as in tear film osmolarity(P=0.001).A significant reduction was also found in meibomian gland expressibility(P=0.003),changing the percentage of grade 3 eyes from 44.4%before IPL to 17.2%after ***:IPL therapy combined with meibomian gland expression(MGX)seems to be an effective option to improve symptomatology in glaucomatous patients with ocular surface diseas

关键词： Glaucoma Intense pulsed light Dry eye Meibomian glands

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Muscle strength deficits are associated with low bone mineral density in young pediatric cancer survivors:The iBoneFIT project

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Journal of Sport and Health Science 2024年第3期13卷 419-427页

作者： Andres Marmol-perez Jose J.Gil-Cosano Esther Ubago-Guisado Francisco J.Llorente-Cantarero Juan Francisco Pascual-Gázquez Kirsten K.Ness Vicente martinez-Vizcaino Jonatan R.Ruiz Luis Gracia-Marco Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18011Spain Department of Epidemiology and Cancer Control St.Jude Children's Research HospitalMemphisTN 38105USA Department of Communication and Education Loyola University AndalusiaSeville 41704Spain Biosanitary Research Institute ibs.GranadaGranada 18012Spain Maimonides Biomedical Research Institute of Cordoba(IMIBIC) Cordoba 14004Spain CIBEROBN Biomedical Research Networking Center for Physiopathology of Obesity and NutritionCarlos III Health InstituteMadrid 28029Spain Department of Specific Didactics Faculty of EducationUniversity of CordobaCordoba 14071Spain Pediatric and adolescent hematology and oncology service Pediatrics and Pediatric Surgery Clinical Management UnitVirgen de las Nieves University HospitalGranada 18014Spain Health and Social Research Center Universidad de Castilla-La ManchaCuenca 13001Spain

Background Pediatric cancer survivors are at increased risk of muscle weakness and low areal bone mineral density(aBMD).However,the prevalence of muscle strength deficits is not well documented,and the associations of muscle strength with aBMD are unknown in this ***,this study aimed to investigate the prevalence of upper-and lower-body muscle strength deficits and to examine the associations of upper-and lower-body muscle strength with age-,sex,and race-specific aBMD Z-scores at the total body,total hip,femoral neck,and lumbar *** This cross-sectional study included 116 pediatric cancer survivors(12.1±3.3 years old,mean±SD;42.2%female).Upper-and lower-body muscle strength were assessed by handgrip and standing long jump test,***‑energy X‑ray absorptiometry was used to measure aBMD(g/cm2).Associations between muscle strength and aBMD were evaluated in multivariable linear regression *** regression was used to evaluate the contribution of muscle strength(1-decile lower)to the odds of having low aBMD(Z-score≤1.0).All analyses were adjusted for time from treatment completion,radiotherapy exposure,and body mass *** More than one-half of survivors were within the 2 lowest deciles for upper-(56.9%)and lower-body muscle strength(60.0%)in comparison to age-and sex-specific reference *** strength deficits were associated with lower aBMD Z-scores at all sites(B=0.133–0.258,p=0.001–0.032).Each 1-decile lower in upper-body muscle strength was associated with 30%–95%higher odds of having low aBMD Z-scores at all *** 1-decile lower in lower-body muscle strength was associated with 35%–70%higher odds of having low aBMD Z-scores at total body,total hip,and femoral *** Muscle strength deficits are prevalent in young pediatric cancer survivors,and such deficits are associated with lower aBMD Z-scores at all *** results suggest that interventions designed to improve muscle strength in t

关键词： Bone health Childhood cancer DXA Lean mass Resistance training

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Clinical profile and outcomes in very elderly patients with atrial fibrillation anticoagulated with rivaroxaban: data from the EMIR study

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Journal of Geriatric Cardiology 2024年第7期21卷 723-732页

作者： Francisco Marín Manuel Anguita Sánchez Iñaki Lekuona Marcelo Sanmartín Fernán-dez Vivencio Barrios carlos perez Muñoz Juan Cosín-Sales Alejandro IPérez Cabeza Vanesa Roldán Schilling Carles Rafols Priu Esteban Orenes-Piñero María Asunción Es-teve-Pastor Department of Cardiology Hospital Clínico Universitario Virgen de la ArrixacaIMIB-ArrixacaUniversity of MurciaCIBERCVMurciaSpain Department of Cardiology Hospital Reina Sofía CórdobaIMIBICUniversity of CordobaCIBERCVCórdobaSpain Hospital Galdakao-Usansolo BizkaiaSpain Department of Cardiology Hospital Uni-versitario Ramony CajalCIBERCVMadridSpain Department of Cardiology University Hospital Ramóny CajalAl-caláUniversityMadridSpain Medical Center La Capillita Sanlúcar de Barrameda.Private cardiology clinicJerez de la FronteraSpain Department of Cardiology Hospital Arnau de VilanovaValenciaSpain Department of Car-diology Virgen de la Victoria University HospitalCIBERCV.MalagaSpain Department of Haematology Hospital Clínico Universitario Virgen de la ArrixacaUniversity of MurciaMurciaSpain Department of Medical Affairs Bayer HispaniaBarcelonaSpain Department of Biochemistry and Molecular Biology-A University of MurciaMurciaSpain

Objectives To analyze the clinical profile,adequacy of treatment with rivaroxaban and outcomes in octogenarians with atrial fibrillation(AF),taking rivaroxaban in clinical *** Observational and non-interventional study that included AF adults recruited from 79 Spanish centers,anticoagulated with rivaroxaban ≥ 6 months before being *** were analyzed according to age(≥ 80 vs.< 80 years) at *** Out of 1433 patients,453(31.6%) were octogenarians at *** to younger patients,octogenarians had more comorbidities,higher CHA2DS2-VASc(4.5 ± 1.3 vs.3.0 ± 1.4;P < 0.001) and HAS-BLED scores(2.0 ± 1.0 vs.1.4 ± 1.0;P < 0.001).Overall,the dose of rivaroxaban was adequately prescribed in 83.4% of patients,but more frequently in the younger population(71.1% vs.89.1%;P = 0.039).After a mean follow-up of 2.2 ± 0.6 years,annual rates of stroke + systemic embolism + transient ischemic attack,MACE,cardiovascular death and major bleeding were 1.03%,1.24%,1.03% and 1.75%,respectively,in octogenarian *** for progressive heart failure death and major bleeding,rates of outcomes in octogenarians were similar compared to younger *** octogenarians,the concomitant use of antiplatelet agents and non-severe dementia were independently associated with the development of ischemic stroke,whereas previous coronary revascularization and heart failure with MACE,and higher HAS-BLED score with major *** In clinical practice,around one third of patients taking rivaroxaban are *** patients have many comorbidities and a high thromboembolic *** that,rates of adverse events remain *** is adequately prescribed in the majority of octogenarians.

关键词： patients atrial bleeding

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L^1→L^q Poincare Inequalities for 0

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Acta Mathematica Sinica,English Series 2002年第1期18卷 1-20页

作者： perez carlos Departamento dr Matematicas. Universidad Autónoma de Madrid. 28049 Madrid. Spain

Civen two doubling measures μ and v in a metric apace (S.p)of homogeneous type. let B_0 S be a given ball. It has been a well-known result bv now (see)[1 4])theat the validity of an L^1→L^1 Poincaré inequality of the following form: f_B|f-f_B|dv≤cr(B)f_Bgdμ. for all metric balls B B_0 S, implies a variant of representation formula of fractonal integral type: |f(x)-f_(B(11))|≤C integral from n=B_(11) g(y)p(x, y)/μ(B(x, p(x, y)))dμ(y)+C(r(B_0))/(μ(B_0))integral from n=B_0 g(y)dμ(y). One of the main results of this paper shows that an L^1 to L^q Poincaré inequality for some 01, i.e.. (f_B|f-f_B|~q dv)^(1/q)≤cr(B) f_B gdμ, for all metric balls B B_0. will suffice to imply the above representation formula. As an immediate corollary, we can show that the weak-type condition. sup_(λ>0)(λv({x ∈ B:|f(x)-f_B|>λ}))/v(B)≤Gr (B)f_B gdμ. also implies the same formula. Analogous theorems related to high-order Poincaréinequalities and Sobolev spaces in metric spaces are also proved.

关键词： Sobolev spaces Representation formulas High-order derivatives Vector fields Metric spaces Polynomials Doubling measures Poincare inequalities

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A Script-Based Prototyping Framework to Boost Agile-UX Developments

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Journal of Computer Science & Technology 2016年第6期31卷 1246-1261页

作者： Pedro Luis Mateo Navarro Gregorio martinez perez Diego Sevilla Ruiz Catedra Sociedad Anonima de Electrdnica Submarina ( SAES) Laboratories University of Murcia Murcia 30100 Spain

Prototypes are described as a successful mechanism to incorporate user-experience design （UX） into Agile de- velopments, but their integration into such developments is not exempt from difficulties. Prototypes and final applications are often developed using different tools, which hinders the collaboration between designers and developers and also compli- cates reuse. Moreover, integrating stakeholders such as clients and users into the Agile process of designing, evaluating, and refining a prototype is not straightforward mainly because of its iterative nature. In an attempt to tackle these problems, this work presents the design and implementation of a new framework in which scripting languages are used to code prototyped behaviors. Prototyping is then treated as a separate aspect that coexists and runs together with final functionality. Using this framework communication is enhanced because designers and developers work in parallel on the same software artifact. Prototypes are fully reused and iteratively added with final functionality while prototyped behaviors are removed. They can be also modified on the fly to implement participatory design techniques.

关键词： prototype Agile development aspect-oriented development scripting language participatory design

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Patellar reconstruction in primary total knee arthroplasty using bone chips from routine cuts:A case report and review of literature

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World Journal of Methodology 2024年第2期14卷 158-166页

作者： Juan Ignacio perez-Abdala Franco L De Cicco Tomas Nicolino Juan Astoul Institute of Orthopaedics“carlos E.Ottolenghi” Italian Hospital of Buenos AiresCapital Federal 1198Argentina

BACKGROUND Total patellectomy is currently reserved for exceptional cases,such as recalcitrant patellofemoral instability and comminuted fractures,due to its demonstrated negative impact on knee ***,managing patellectomy is crucial to mitigate its inherent deleterious *** techniques have been described,including autologous or allogeneic bone grafts for reconstruction and soft tissue realignment to enhance the extensor *** SUMMARY A 73-year-old male underwent a patellectomy due to a comminuted fracture,subsequently developing osteoarthritis and experiencing a decline in functional *** with total knee replacement,we conducted a patellar reconstruction,incorporating routine bone cuts and utilizing bone chips to fashion a new *** intervention resulted in the restoration of full extension and improvement of knee *** Patellar reconstruction demonstrates benefits on knee mechanics and stabilization,contributing to enhanced outcomes and satisfaction following knee *** present an affordable technique for managing patellectomized patients undergoing total knee replacement.

关键词： Patellectomy Patella Reconstruction Knee arthroplasty Autologous bone Knee osteoarthritis Case report

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An unsupervised pattern recognition methodology based on factor analysis and a genetic-DBSCAN algorithm to infer operational conditions from strain measurements in structural applications

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Chinese Journal of Aeronautics 2021年第2期34卷 165-181页

作者： Juan carlos PERAFAN-LOPEZ Julian SIERRA-perez Grupo de Investigacion en Ingenieria Aeroespacial Universidad Pontificia BolivarianaCircular 170-01Medellin 050031Colombia

Structural Health Monitoring(SHM) suggests the use of machine learning algorithms with the aim of understanding specific behaviors in a structural system. This work introduces a pattern recognition methodology for operational condition clustering in a structure sample using the well known Density Based Spatial Clustering of Applications with Noise(DBSCAN) *** methodology was validated using a data set from an experiment with 32 Fiber Bragg Gratings bonded to an aluminum beam placed in cantilever and submitted to cyclic bending loads under 13 different operational conditions(pitch angles). Further, the computational cost and precision of the machine learning pipeline called FA + GA-DBSCAN(which employs a combination of machine learning techniques including factor analysis for dimensionality reduction and a genetic algorithm for the automatic selection of initial parameters of DBSCAN) was measured. The obtained results have shown a good performance, detecting 12 of 13 operational conditions, with an overall precision over 90%.

关键词： Clustering DBSCAN Factor analysis FBGs Pattern recognition Strain field

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Generalized Multiscale RBF Networks and the DCT for Breast Cancer Detection

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International Journal of Automation and computing 2020年第1期17卷 55-70页

作者： carlos Beltran-perez Hua-Liang Wei Adrian Rubio-Solis Department of Automatic Control and Systems Engineering University of SheffieldSheffield S13JDUK Tecnologico de Monterrey Campus TolucaEduardo Monroy Cardenas 2000San Antonio BuenavistaToluca 50110Mexico

The use of the multiscale generalized radial basis function(MSRBF)neural networks for image feature extraction and medical image analysis and classification is proposed for the first time in this *** MSRBF networks hold a simple and flexible architecture that has been successfully used in forecasting and model structure detection of input-output nonlinear *** this work instead,MSRBF networks are part of an integrated computer-aided diagnosis(CAD)framework for breast cancer detection,which holds three stages:an input-output model is obtained from the image,followed by a high-level image feature extraction from the model and a classification module aimed at predicting breast *** the first stage,the image data is rendered into a multiple-input-single-output(MISO)*** order to improve the characterisation,the nonlinear autoregressive with exogenous inputs(NARX)model is introduced to rearrange the available input-output data in a nonlinear *** forward regression orthogonal least squares(FROLS)algorithm is then used to take advantage of the previous arrangement by solving the system as a model structure detection problem and finding the output layer weights of the NARX-MSRBF *** the second stage,once the network model is available,the feature extraction takes place by stimulating the input to produce output signals to be compressed by the discrete cosine transform(DCT).In the third stage,we leverage the extracted features by using a clustering algorithm for classification to integrate a CAD system for breast cancer *** test the method performance,three different and well-known public image repositories were used:the mini-MIAS and the MMSD for mammography,and the BreaKHis for histopathology images.A comparison exercise was also made between different database partitions to understand the mammogram breast density effect in the performance since there are few remarks in the literature on this *** results show that

关键词： Nonlinear system identification image processing discrete cosine transform radial basis functions computer-aided diagnosis neural networks

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