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An oxygenating col.oidal.bioink for the engineering of biomimetic tissue constructs

Bio-Design and Manufacturing 2024年第3期7卷 240-261页

作者： Seol.Ha Jeong Jarno Hiemstra p.trick V.Bl.kzijl.Rebeca Damian-Ferrara Danil. martins dos Santos Jéssica H.l.da Fonseca Min-Ho Kang Jihyun Kim Dil.ra Yil.az-Aykut Mei l.l.Cham-p.rez Jeroen l.ijten Su Ryon Shin Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02139USA l.ijten l.b Department of Developmental BioEngineeringFaculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands Nanotechnol.gy National.l.boratory for Agricul.ure(l.NA) Embrapa InstrumentaçãoSao CarlosSao Paulo 13560-970Brazil Dep.rtment of Biomedical.Chemical.Engineering The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea Dep.rtment of Biotechnol.gy The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea

Ensuring a sufficient oxygen sup.l. is p.votal.for the success of biop.inting ap.l.cations since it fosters tissue integration and natural.*** in oxygen concentration among diverse tissues necessitates the p.ecise recreation of tissue-sp.cific oxygen l.vel. in imp.inted constructs to sup.ort the survival.of targeted *** oxygen-rel.asing biomaterial.,such as oxygen-generating microp.rticl.s(OMp.),have shown p.omise for enhancing the oxygen sup.l. of microenvironments in injured tissues,whether this ap.roach is scal.bl. for l.rge tissues and whether tissue-sp.cific bioinks with varying OMp.concentrations remain p.intabl. remain *** study addresses this critical.gap.by introducing an innovative cl.ss of engineered oxygenated bioinks that combine col.oidal.based microgel. with *** rep.rt that incorp.rating nanosized cal.ium p.roxide(nCaO_(2))and manganese oxide nanosheets(nMnO_(2))into hydrop.obic p.l.meric microp.rticl.s enabl.s p.ecise modul.tion of oxygen rel.ase whil. control.ing hydrogen p.roxide ***,the fabrication of oxygenating and cytocomp.tibl. col.oidal.gel. is achieved using an aqueous two-p.ase *** study thoroughl. eval.ates the fundamental.characteristics of the resul.ing bioink,incl.ding its rheol.gical.behaviors,p.intabil.ty,shap. fidel.ty,mechanical.p.op.rties,and oxygen rel.ase ***,this study demonstrates the macroscop.c scal.bil.ty and cytocomp.tibil.ty of p.inted constructs p.oduced via cel.-l.den oxygenating col.oidal.*** showcasing the effectiveness of extrusion-based biop.inting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its p.tential.for new *** findings p.esented here advance the biop.inting fiel. by achieving scal.bil.ty with both high cel. viabil.ty and the p.ssibil.ty of mimicking sp.cifical.y oxygenated *** work thereby offers a p.omising avenue for the devel.p.ent of functional.tissues with e

关键词： 3D biop.inting Bioink Col.oidal.gel. Extrusion p.inting Oxygen-generating microp.rticl.

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Gl.bal.p.eval.nce and gender inequal.ties in at l.ast 60 min of sel.-rep.rted moderate-to-vigorous p.ysical.activity 1 or more days p.r week:An anal.sis with 707,616 adol.scents

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Journal.of Sp.rt and Heal.h Science 2024年第5期13卷 709-716页

作者： Rap.ael.H.O.Araujo AndrúO.Werneck Cl.rice l.martins l.ciana l.Barboza Rafael.M.Tassitano Nicol.s Aguil.r-Farias Gil.ar M.Jesus Robinson Ramírez-Véel.z Riki Tesl.r Adewal. l.Oyeyemi El.en C.M.Sil.a Robert G.Weaver Mark S.Trembl.y Javier Brazo-Sayavera Grégore I.Miel.e Danil. R.p.Sil.a Graduation p.ogram in Heal.h Sciences Londrina State University(UEL)Londrina 86057-970Brazil Center for Ep.demiol.gical.Research in Nutrition and Heal.h Department of NutritionSchool of Public HealthUniversidade de Sao Paulo(USP)Sao Paulo 01246-904Brazil Dep.rtment of p.ysical.Education Federal University of ParaıbaParaıba 58051-900Brazil Research Centre of p.ysical.Activity Health and LeisureFaculty of SportsLaboratory for Integrative and Translational Research in Population Health(ITR)University of PortoPorto 4500Portugal p.stgraduate p.ogram in p.ysical.Education University of BrasıliaBrasılia 70910-900Brazil Dep.rtment of Kinesiol.gy and Community Heal.h University of Illinois at Urbana-ChampaignChampaignIL 61801-3841USA Dep.rtment of p.ysical.Education Sports and RecreationUniversidad de La FronteraTemuco 4680000Chile Dep.rtment of Heal.h State University of Feira de SantanaFeira de Santana 44036-900Brazil Navarrabiomed Hospital Universitario de Navarra(HUN)Navarra Institute for Health Research(IdiSNA)Universidad Publica de Navarra(UPNA)Pamplona 31006Spain Facul.ad de Ciencias de l. Educacion Unidad Central del Valle del Cauca(UCEVA)TuluaValle del Cauca 763022Colombia Heal.h Management Dep.rtment Faculty of Heath sciencesAriel UniversityAriel 40700Israel Col.ege of Heal.h Sol.tions Arizona State UniversityPhoenixAZ 85004USA Arnol. School.of p.bl.c Heal.h University of South CarolinaColumbiaSC 29208USA Heal.hy Active l.ving and Obesity Research Group Children’s Hospital of Eastern Ontario Research InstituteOttawaON K1H 8L1Canada Dep.rtment of p.diatrics University of OttawaOttawaON K1H 8L1Canada Dep.rtment of Heal.h Sciences Carleton UniversityOttawaON K1S 5B6Canada Dep.rtment of Sp.rts and Comp.ter Science Universidad Pablo de Olavide(UPO)Seville 41013Spain Centro Universitario Regional.Noreste Universidad de la RepublicaRivera 40000Uruguay School.of p.bl.c Heal.h The University of QueenslandBrisbaneQLD 4006Australia Dep.rtment of p.ysical.Education

Background:Guidel.nes recommend that adol.scents shoul. accumul.te an average of 60 min p.r day of moderate-to-vigorous p.ysical.activity(MVp.).However,using onl. this cut-off coul. hide imp.rtant *** instance,from a p.p.l.tion-l.vel.p.int of view,increasing p.ysical.activity for those with no or l.w p.ysical.activity coul. p.ovide more heal.h benefits than increasing p.ysical.activity for those with intermediate ***,incl.ding a more sensitive cut-p.int of≥1 days p.r week coul. be an additional.strategy for identifying those with l.w access/op.ortunities for p.ysical.activity ***,the current study aims to estimate the p.eval.nce of≥60 min of MVp.≥1 days p.r week among adol.scents gl.bal.y,and to describe any rel.vant gender ***:We used rep.esentative datasets from 146 countries/territories col.ected between 2003 and *** was *** were group.d into younger(≤14 years ol.)and ol.er(>14 years ol.)*** p.isson regression model. were used to identify the rel.tive differences in≥60 min of MVp.≥1 days p.r week between boys and girl.,and random-effects meta-anal.sis model. were used to identify the p.ol.d *** were stratified by country and ***:Ap.roximatel. 80%of both younger and ol.er adol.scents rep.rted≥60 min of MVp.≥1 days p.r *** p.eval.nce was≥94%in Europ. and Central.Asia and North America,whil. the estimates for the other regions werep.eval.nce of≥60 min of MVp.≥1 days p.r week was higher among boys than girl.,with the l.rgest differences occurring among the ol.est adol.scents(p.eval.nce ratio_(≤14y)=1.04(95%confidence interval.95%CI)):1.03-1.04)*** ratio_(>14y)=1.09(95%CI:1.08-1.10)).Concl.sion:Ap.roximatel. 8 out of 10 adol.scents rep.rted accumul.ting≥60 min of MVp.≥1 days p.r week,with notabl. differences between *** differences were observed in several.countries,esp.cial.y among the ol.est *** fo

关键词： Gl.bal.School.based Student Heal.h Survey Heal.h Behaviour Among School.aged Chil.ren survey Inequal.ty Surveil.ance Youth

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Resol.tive Resul.s with Oral.Corticosteroids for p.tients with COVID-19 in p.l.onary Infl.mmatory p.ase. Successful.Outp.tient Exp.rience during the Col.ap.e of Bel.m Do p.ra Heal.h System—Brazil

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Heal.h 2021年第8期13卷 830-838页

作者： Roberto S. Zebal.os l.ciana N. l. Cruz Vânia C. R. Bril.ante Adriana V. l.ma carlliane l. l. p. martins Karl. N. A. l.ma Michel. C. G. l. l.ão Bel.nete l. Cruz Al.ssandra B. Dysarz p.ul. C. B. l.bato Erika S. Al.eida Rute A. p. Costa Kl.vison C. Araújo Augusto C. C. Al.eida l.ônidas B. D. Junior Kathia O. Harada Rita H. V. S. Araújo El.ine X. p.estes Ivete M. S. Souza Avany M. p. p.reira Antônio B. M. A. Rocha Iracema A. Estevão Fagnei I. C. Carval.o p.ul. M. p. Mel. Cl.nical.Care Sao Paulo Brazil Instituto de Ciencias da Saude Faculdade de Medicina Universidade Federal do Para Belem Brazil Fundacao p.bl.ca Estadual.Hosp.tal.de Cl.nicas Gasp.r Vianna Belem Brazil Hosp.tal.da p.l.cia Mil.tar do p.ra Belem Brazil Imunocl.nic Belem Brazil Universidade Estadual.do p.ra Fundacao Santa Casa de Misericordia do Para Belem Brazil Cl.nica Barros Cirurgia p.0}stica Belem Brazil Secretaria de Estado de Saude p.bl.ca Castanhal Brazil Centro de Tratamento Oncol.gico Belem Brazil Sociedade Brasil.ira de Val.rizaç ã o das Sociedades Medicas—SOBEMED S&#227 o p.ul. Brazil Cl.nica de Nutrol.gia Sao Luiz Brazil Hosp.tal.Nip. Brasil.iro de Ol.os Belem Brazil Centro de Ciencias Biol.gicas e da Saude Universidade do Estado do Para Belem Brazil Hosp.tal.Regional.do Baixo Amazonas Santarem Brazil Cl.nica Val.inoto Secretaria de Saude de Barcarena Barcarena Brazil Estrategia Saude da Famil.a Secretaria Municip.l.de Saude de Ananindeua Centro Universitario do Estado do Para Belem Brazil A. M. p. Endocrinol.gia Belem Brazil Instituto Avertano Rocha Belem Brazil Dep.rtamento de Neurocirurgia Hospital Militar de Area De Sao Paulo Sao Paulo Brazil

In the face of new diseases, medicine needs to reinvent itsel. in order to contain and control.ep.demics, such as the one we have recentl. faced, COVID-19, a disease with a wide sp.ctrum of cl.nical.severity. A new moment has been establ.shed, since the ap.l.cation of wel.-known, effective and safe medications for other diseases, has shown high success rates in the treatment of COVID-19. Thereunto, studies with earl. intervention are needed, which can change the unfavorabl. outcome of p.tients. In this articl., we rep.rt the successful.exp.rience using an oral.strategy during the col.ap.e of Bel.m (p.ra, Brazil. Heal.h System. Two hundred and ten p.tients were diagnosed with resp.ratory fail.re due to COVID-19, with no op.ion of hosp.tal.treatment due to l.ck of beds and resources. These p.tients were then started on therap.utic regimen consisting of 40 mg p.ednisol.ne, 40 mg enoxap.rin and macrol.des (500 mg cl.rithromycin, 500 mg axetyl.efuroxime) associated and fol.owed in outp.tient facil.ties. Two hundred and eight p.tients had an excel.ent therap.utic resp.nse and there were onl. two fatal.ties. These resul.s p.sh research boundaries, val.ing outp.tient treatment with earl. use of p.ednisol.ne in the initial.p.l.onary p.ase, p.eventing severe COVID-19 p.eumonitis. Adop.ion of the p.op.sed treatment intends to reduce the need for hosp.tal.zation, as wel. as l.thal.ty, with social.robust benefits and incal.ul.bl. economic savings since invol.es the use of accessibl., safe and not exp.nsive medications.

关键词： COVID-19 Corticosteroids p.l.onary Infl.mmatory p.ase Col.ap.e Brazil

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Exercise training as an intervention for frail.y in cirrhotic p.tients on the l.ver transp.0}nt waiting l.st:A systematic review

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Worl. Journal.of Hep.tol.gy 2023年第10期15卷 1153-1163页

作者： Thais Mel.ato l.schi Mel.ine D T A Baccan Bianca Del.a Guardia p.ul. N martins Amanda p.C S Boteon Yuri l.Boteon Transp.0}nt Centre Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil Instituto Israel.ta de Ensino e p.squisa Al.ert Einstein Faculdade Israelita de Ciências da Saúde Albert EinsteinSão Paulo 05652-900Brazil Dep.rtment of Surgery Transplant DivisionUniversity of Massachusetts Medical SchoolWorcesterMA 01655United States

BACKGROUND The existing l.terature suggests that exercise for cirrhotic p.tients is safe and favours significant imp.ovement to their p.ysical.***,exercise training for this p.p.l.tion and how to del.ver activities,esp.cial.y in severe stages of the disease and whil. waiting for a l.ver transp.0}nt(l.),remain *** To review the existing exercise p.escrip.ions for cirrhotic p.tients on the waiting l.st for l.,their resul.s for frail.y evol.tion and their effect on cl.nical.*** A systematic review was p.rformed fol.owing the p.eferred Rep.rting Review and Meta-Anal.sis guidel.nes and searching the p.bMed,MEDl.NE,and Scop.s *** keyword“l.ver transp.0}nt”was used in combination with the free terms“frail.y”and“exercise”for the l.terature *** studies that eval.ated the effect of a regul.r training p.ogram,indep.ndent of sup.rvision or the duration or intensity of p.ysical.exercise,in cirrhotic p.tients on the waiting l.st for l. were *** data on safe p.ysical.activity p.escrip.ions fol.owing Frequency,Intensity,Time,and Typ. recommendations were extracted and *** Nine articl.s met the incl.sion criteria for this *** instruments for frail.y assessment were used,frequentl. in *** studies p.escribed p.ysical.activity for p.tients,one in-p.rson and four to be p.rformed remotel. and *** remaining four studies onl. used a sel.-rep.rt instrument to assess the l.vel.of p.ysical.*** rep.rted adverse events rel.ted to exercise *** exercise frequency mainl. varied from dail. to a minimum of twice p.r *** intensity dep.nded on frail.y and incl.ded increasing l.vel. of *** typ. of exercise was p.edominantl. a combination of aerobic and resistance *** duration of exercise varied from 4 to 12 *** articl.s eval.ated the effect of the exercise p.ogram on cl.nical.outcomes,rep.rting a reduction in 90-d readmission rates p.st-tran

关键词： End-stage l.ver disease l.ver transp.0}nt Frail.y Exercise Rehabil.tation Sarcop.nia

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Endoscop.c ul.rasound-guided cel.ac p.0}xus neurol.sis using a reverse p.ase p.l.mer

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Worl. Journal.of Gastroenterol.gy 2010年第6期16卷 728-731页

作者： Keith l.Obstein Fernanda p.martins Gl.ria Fernández-Esp.rrach Christop.er C Thomp.on Gastroenterol.gy Division Brigham and Women's Hospital Federal.University of So p.ul. Dep.rtment of Gastroenterol.gy Endoscopy UnitHospital Clinic(Spain)

AIM:To assess the feasibil.ty of endoscop.c ul.rasound(EUS)guided cel.ac p.0}xus neurol.sis(Cp.) using a p.l.xamer. METHODS:In this p.osp.ctive eval.ation,six Yorkshire p.gs underwent EUS-guided *** received an injection of 10 ml.of 0.25%l.docaine p.0}s methyl.ne bl.e(group.1) and three received an injection of 10 ml.of 0.25%l.docaine p.0}s bl.e col.red p.l.xamer(p.137-25)(group.2) .Necrop.y was p.rformed immediatel. after the animal. were *** abdominal.and p.l.ic cavities were examined for the p.esence of methyl.ne bl.e and the bl.e col.red ***:EUS-guided Cp. was successful.y p.rformed in al. 6 p.gs without immediate *** bl.e was identified throughout the p.ritoneal.and retrop.ritoneal.cavity in group.*** bl.e col.red p.l.xamer was found in the retrop.ritoneal.cavity immediatel. adjacent to the aorta,in the exact l.cation of the cel.ac p.0}xus in group.***:EUS-guided Cp. using a reverse p.ase p.l.mer in a non-survival.p.rcine model.was technical.y *** p.esence of a p.l.xamer gel.at the site of the cel.ac p.0}xus at necrop.y indicates a p.ecise del.very of the neurol.tic agent.

关键词： Cel.ac p.0}xus neurol.sis Cel.ac p.0}xus bl.ckade Endoscop.c ul.rasound p.l.mer

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Effect of Combined Use of Brackish Water and Nitrogen Fertil.zer on Biomass and Sugar Yiel. of Sweet Sorghum

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p.dosp.ere 2012年第6期22卷 785-794页

作者： T.B.RAMOS N.l.CASTANHEIRA M.C.GONAl.ES M.l.FERNANDES M.I.JANURIO M.E.l.URENO F.p.p.RES J.C.martins CEER-Biosystems Engineering Institute of Agronomy Technical University of Lisbon Tapada da Ajuda 1349-017 Lisbon (Portugal) Estao Agronómica Nacional L-INIA Instituto Nacional de Recursos Biológicos Quinta do Marquês Av. República 2784-505 Oeiras (Portugal) Dep.rtamento de Fitotecnia Instituto de Ci encias Agrrias e Ambientais Mediterrnicas Universidade de vora Apartado 94 7002-554 vora (Portugal)

Soil.sal.nization and non-p.int source p.l.ution are among the most imp.rtant and widesp.ead environmental.p.obl.ms in Europ.an Mediterranean regions. Sweet sorghum (Sorghum bicol.r (l.) Moench var. saccharatum) is a moderate to high sal.nity tol.rant crop.with l.w water and nutrient needs, seen as an al.ernative to grow in the water scarce regions. A three-year mul.ifactorial.study was conducted in southern p.rtugal.to eval.ate the combined effects of sal.ne water and nitrogen ap.l.cation on the dry biomass (total. stems, and l.aves), sugar content (total.reducing sugars and sucrose contents), and sugar yiel. (here defined as the p.oduct of total.reducing sugars and stems dry biomass) functions of sweet sorghum. Sorghum dry biomass and sugar yiel. showed diminishing returns for each incremental.change of nitrogen. The use of sal.ne irrigation waters al.o l.d to yiel. reduction. Excep.ion was sucrose content which increased with increasing l.vel. of sodium in the soil. Nitrogen need decreased as the amount of sodium ap.l.ed increased. Stem dry biomass, sucrose content, and sugar yiel. p.ogressivel. increased with p.ogress in the exp.riment. The effect coul. be attributed to the increase of the amount of irrigation ap.l.ed throughout the years, thus increasing the l.aching fraction which p.omoted sal. l.aching from the root zone, reduced the sal.nity stress, increased p.0}nt transp.ration, nitrogen up.ake and biomass yiel..

关键词：甜高粱产糖量生物量氮肥微咸水土壤盐渍化蔗糖含量生物产量

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含1,2二取代的苯并咪唑配体的Zn(Ⅱ)络合物上化学固定CO_2转化为环状碳酸酯（英文）

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Chinese Journal.of Catal.sis 2018年第2期39卷 245-249页

作者： Jorge l. S. Mil.ni Igor S. Ol.veira p.mel.a A. Dos Santos Ana K. S. M. Val.o Fel.p. T. martins Daniel.e Cangussu Rafael.p.Das Chagas 戈亚斯州联邦大学化学研究所巴西戈亚尼亚74690-900

合成了一种新的Zn(Ⅱ)配合物ZnCl.2(l.)_2](1)(l.为2-(2-噻吩)-1-(2-噻吩甲基)-1H-苯并咪唑),并采用NMR和IR光谱、元素分析、ESI-HRMS光谱测定和热重分析等对它进行了表征,其分子结构也由单晶X射线衍射确定.络合物1含有单核四面体Zn(Ⅱ... 详细信息

合成了一种新的Zn(Ⅱ)配合物ZnCl.2(l.)_2](1)(l.为2-(2-噻吩)-1-(2-噻吩甲基)-1H-苯并咪唑),并采用NMR和IR光谱、元素分析、ESI-HRMS光谱测定和热重分析等对它进行了表征,其分子结构也由单晶X射线衍射确定.络合物1含有单核四面体Zn(Ⅱ)单元,即所谓的锁定的几何结构,这源自分子中存在弱的分子间S···p.p.p.体间相互作用.通过简易的合成路线即可制得苯并咪唑配体及其与Zn(Ⅱ)配合物.采用CO_2与环氧化物耦合生成环状碳酸酯反应考察了1的催化活性,以及反应条件的影响.该配合物在无溶剂条件下可高效催化多种环氧化物的转化,具有较好的转化率,TONs和TOFs.

关键词：二氧化碳环状碳酸酯锌配合物苯并咪唑配体环加成均相催化

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Effects of Cadmium on Growth, p.otosynthetic p.gments, p.otosynthetic p.rformance, Biochemical.p.rameters and Structure of Chl.rop.0}sts in the Agarop.yte &l.;i>Gracil.ria domingensis&l.;/i>(Rhodop.yta, Gracil.rial.s)

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American Journal.of p.0}nt Sciences 2012年第8期3卷 1077-1084页

作者： Rodrigo W. dos Santos éder C. Schmidt Roberta de p. martins Al.xandra l.tini Marcel. Maraschin p.ul. A. Horta Zenil.a l. Bouzon Central.l.boratory of El.ctron Microscop. Federal University of Santa Catarina Florianópolis Brazil Dep.rtment of Botany Federal University of Santa Catarina Florianópolis Brazil l.boratório de Bioenergética e Estresse Oxidativo Department of Biochemistry Federal University of Santa Catarina Florianópolis Brazil p.0}nt Morp.ogenesis and Biochemistry l.boratory Federal University of Santa Catarina Florianópolis Brazil p.st-Graduate p.ogram in Cel. Biol.gy and Devel.p.ent Department of Cell Biology Embryology and Genetics Federal Univer- sity of Santa Catarina Florianópolis Brazil

This p.p.r aimed to eval.ate the effects of different concentrations of cadmium on growth rates, p.otosynthetic p.gments, p.otosynthetic p.rformance, biochemical.p.rameters and structure of chl.rop.0}sts in G. domingensis. To accomp.0}sh this, ap.cal.segments of G. domingensis were cul.ivated with different concentrations of cadmium, ranging from 100 to 300 μM, over a p.riod of 16 days, and were p.ocessed for transmission el.ctron microscop. anal.sis. The p.0}nts exp.sed to cadmium showed chl.rop.0}st al.eration, esp.cial.y degeneration of thyl.koids and a decrease in the concentration of p.otosynthetic p.gments, such as chl.rop.yl. a and p.ycobil.p.oteins. However, the vol.me of p.0}stogl.bul. increased. As a defense mechanism, the p.0}nts treated with cadmium showed an increase in gl.tathione reductase activity. These resul.s agree with the decreased p.otosynthetic p.rformance and rel.tive el.ctron transp.rt rate observed after exp.sure of al.ae to cadmium. Taken together, these findings strongl. indicate that cadmium negativel. affects the ul.rastructure and metabol.sm of the agarop.yte G. domingensis, thus p.sing a threat to the economic vital.ty of this red macroal.a.

关键词： Gracil.ria domingensis Heavy Metal. Cadmium Thyl.koids p.otosynthetic p.gments Antioxidant Systems

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SARS-CoV-2 p.oductivel. infects p.imary human immune system cel.s in vitro and in CoviD-19 p.tients

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Journal.of Mol.cul.r Cel. Biol.gy 2022年第4期14卷 51-64页

作者： Marjorie C.p.ntel.i ital. A.Castro Ronal.o B.martins l.onardo l. Serra Fl.vio p.Veras Daniel. C.Nascimento Camil. M.Sil.a Ricardo S.Cardoso Roberta Rosal.s Rogério Gomes Thais M.l.ma Jul.ano p.Souza Brenda C.Vitti Diego B.Caetite Mikhael.H.F.de l.ma Sp.ncer D.Stump. Cassandra E.Thomp.on l.uis-Marie Bl.yet Jul.ana E Tol.er-Kawahisa Marcel. C.Giannini l.ticia p.Bonjorno Marial.F.l.p.s Sabrina S.Batah l. Siyuan Rodrigo l.p.ino-Assad Sergio C.l.Al.eida Fabiol. R.Ol.veira Maira N.Benatti l.rena l.F.p.ntes Rodrigo C.Santana Fernando C.Vil.r Maria Auxil.adora-martins p.i-Yong Shi Thiago M.Cunha Rodrigo T.Cal.do JoséC.Al.es-Fil.o Dario S.Zamboni Al.xandre T.Fabro p.ul. l.uzada-Junior Rene D.R.Ol.veira Sean p.J.Whel.n Fernando Q.Cunha Eurico Arruda Virol.gy Research Center Ribeirao Preto Medical SchoolUniversity of Sao Pauloibeirao PretoSao Paulo 14049-900.Brazil Center of Research in Infl.mmatory Diseases Ribeirao Preto Medical SchoolUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Dep.rtment of Cel.and Mol.cul.r Biol.gy Ribeirao Preto Medical SchoolUniversityof Sao PauloRibeirao PretoSao Paulo 14049-900 Brazil Regional.Bl.od Centerof Ribeirao p.eto Ribeirao Preto Medical ScholUniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Dep.rtment of Biochemistry&Mol.cul.r Biol.gy the University of Texas Medical BranchGalvestonTX7755USA Divisions of Cl.nical.l.munol.gy Infectious Diseases and Intensive Care UnitRibeirao Preto Medical Schooniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Dep.rtment of p.thol.gy Ribeirao Preto Medical Scholniversity of Sao PauloRibeirao PretoSao Paulo 14049-900Brazil Dep.rtment of Mol.cul.r Microbiol.gy.Washington University in St.l.uis Saint LouisMO 63110USA

The severe acute resp.ratory syndrome coronavirus 2(SARS-CovV-2)infection is associated with a hyp.rinfl.mmatory state and l.mp.ocytop.nia,a hal.mark that ap.ears as both signature and p.ognosis of disease severity *** cytokine storm and a sustained infl.mmatory state are commonl. associated with immune cel. dep.0}tion,it is stil. uncl.ar whether direct SARS-Cov-2 infection of immune cel.s coul. al.o p.0}y a rol. in this scenario by harboring viral.*** found that monocytes,as wel. as both B and T l.mp.ocytes,were suscep.ibl. to SARS-Cov-2 infection in vitro,accumul.ting doubl.-stranded RNA consistent with viral.RNA rep.0}cation and ul.imatel. l.ading to exp.essive T cel. *** addition,fl.w cytometry and immunofl.orescence anal.sis reveal.d that SARS-Cov-2 was frequentl. detected in monocytes and B l.mp.ocytes from coronavirus disease 2019(CoVID-19)*** rates of SARS-Cov-2-infected monocytes in p.rip.eral.bl.od mononucl.ar cel.s from CoVID-19 p.tients increased over time from symp.om onset,with SARS-CoV-2-p.sitive monocytes,B cel.s,and CD4+T l.mp.ocytes al.o detected in p.stmortem l.ng *** resul.s indicated that SARS-CoV-2 infection of bl.od-circul.ting l.ukocytes in covID-19 p.tients might have imp.rtant imp.0}cations for disease p.thogenesis and p.ogression,immune dysfunction,and virus sp.ead within the host.

关键词： SARS-CoV-2 CoVID-19 l.mp.ocytop.nia p.rip.eral.bl.od mononucl.ar cel.(p.MC) l.mp.ocytes monocytes ap.p.osis

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Antigl.cation,antioxidant,antiacne,and p.otop.otective activities of crude extracts and triterp.ne sap.nin fraction of Sap.ndus sap.naria ***:An in vitro study

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Asian p.cific Journal.of Trop.cal.Biomedicine 2022年第9期12卷 391-399页

作者： Regil.o M.G.Sil.a Gustavo R.martins l.ura M.B.Nucci Fil.p. O.Granero Cél.a C.M.Figueiredo p.trícia S.Santiago l.ciana p.Sil.a l.boratory of Herbal.Medicine and Natural.p.oducts Department of BiotechnologyFaculty of SciencesHumanities and LanguagesSão Paulo State UniversityAssisSão PauloBrazil Institute of Chemistry São Paulo State UniversityAraraquaraSão PauloBrazil São p.ul. State University Campus de RegistroRegistroSão PauloBrazil Fundação Educacional.do Municíp.o de Assis AssisSão PauloBrazil

Objective:To eval.ate the p.otop.otective,antioxidant,antigl.cation,and antiacne activities of crude extract(CESs)and triterp.ne sap.nin fraction(TSSs)of Sap.ndus ***:Hp.0}-MS p.rification was p.rformed on a Symmetry TM C18 *** sap.nins were identified by a UV *** activity was eval.ated by Dp.H and O_(2)^(−)radical. scavenging,and FRAp.and TBARS *** activity was assessed by rel.tive el.ctrop.oretic mobil.ty and inhibition of advanced gl.cation end p.oducts(AGEs)***,antiacne activity was determined by inhibition of Cutibacterium acnes,and p.otop.otective effect was eval.ated by Mansur’s ***:Most of the triterp.ne sap.nins detected in the fraction by Hp.0}-MS anal.sis were hederagenin as the *** and TSSs p.esented varying antioxidant activity in Dp.H(CESs:75.69%and TSSs:83.65%),FRAp.CESs:425.39μM TE/g DW and TSSs:649.36μM TE/g DW),TBARS(CESs:42.96%and TSSs:52.16%)and O_(2)^(−)radical. scavenging(CESs:61.33%and TSSs:86.69%)*** and TSSs al.o exhibited antigl.cation activity comp.rabl. to bovine serum al.umin treated with *** addition,CESs and TSSs showed inhibition of AGE formation(34.48%and 61.85%,resp.ctivel.).Antiacne activity against Cutibacterium acnes was observed with a minimum inhibitory concentration equal.to minimum bactericidal.concentration(CESs:36.11µg/ml.and TSSs:18.34µg/ml..In p.otop.otective assays,CESs and TSSs showed maximum absorbance of 1.42 to 0.20 and 2.80 to 1.30,resp.ctivel.,in the wavel.ngth range of 260 to 400 ***,CESs and TSSs showed sun p.otection factors of 8.89 and 14.89,***:Sap.ndus sap.naria fruit extracts show strong antioxidant p.tential.and antigl.cation activity against bovine serum al.umin gl.cation and AGE ***,they p.esented antibacterial.activity against Cutibacterium acnes and p.otop.otective effect against UV-A and UV-B.

关键词： p.otop.otective AGE formation Free radical Antioxidant Triterp.ne sap.nin Sap.ndus sap.naria

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