Endoscopic ultrasound-guided celiac plexus neurolysis using a reverse phase polymer

作     者：Keith L Obstein Fernanda P Martins Gloria Fernández-Esparrach Christopher C Thompson 

作者机构：Gastroenterology DivisionBrigham and Women's Hospital Federal University of So Paulo Department of Gastroenterology Endoscopy UnitHospital Clinic(Spain) 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2010年第16卷第6期

页      面：728-731页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 100207[医学-影像医学与核医学] 1002[医学-临床医学] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 10[医学] 

基　　金：Supported by A grant from Generalitat de Catalunya(AGAUR BE-100022) 

主　　题：Celiac plexus neurolysis Celiac plexus blockade Endoscopic ultrasound Polymer 

摘      要：AIM:To assess the feasibility of endoscopic ultrasound(EUS)guided celiac plexus neurolysis(CPN) using a poloxamer. METHODS:In this prospective evaluation,six Yorkshire pigs underwent EUS-guided *** received an injection of 10 mL of 0.25%Lidocaine plus methylene blue(group 1) and three received an injection of 10 mL of 0.25%Lidocaine plus blue colored poloxamer(PS137-25)(group 2) .Necropsy was performed immediately after the animals were *** abdominal and pelvic cavities were examined for the presence of methylene blue and the blue colored ***:EUS-guided CPN was successfully performed in all 6 pigs without immediate *** blue was identified throughout the peritoneal and retroperitoneal cavity in group *** blue colored poloxamer was found in the retroperitoneal cavity immediately adjacent to the aorta,in the exact location of the celiac plexus in group ***:EUS-guided CPN using a reverse phase polymer in a non-survival porcine model was technically *** presence of a poloxamer gel at the site of the celiac plexus at necropsy indicates a precise delivery of the neurolytic agent.