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Exocrine pancreatic function assessed by secretin cholangio-Wirsung magnetic resonance imaging

Hepatobiliary & Pancreatic Diseases International 2008年第2期7卷 192-195页

作者： Lucia Calculli Raffaele Pezzilli Marta Fiscaletti Riccardo Casadei carla Brindisi Giampaolo Gavelli Departments of Radiology Digestive Diseases and Internal Medicineand General SurgerySant'Orsola-Malpighi Hospital Bologna Italy

BACKGROUND:Magnetic resonance cholangiopancreato-graphy (MRCP) is useful to assess exocrine pancreatic function by combining rapid imaging acquisition with the administration of secretin, a gastrointestinal hormone that stimulates the secretion of bile and pancreatic juice. However, extensive data on this method are lacking. This study aimed to determine whether MRCP with secretin administration is able to simultaneously detect alterations of both the pancreatic ducts and exocrine pancreatic function. METHODS:All subjects older than 18 years who underwent magnetic resonance imaging (MRI) and cholangio-Wirsung magnetic resonance imaging (CWMRI) for suspicion of benign or malignant pancreatic diseases from January 2006 to December 2006 were enrolled in the study. MRI and CWMRI were carried out using a dedicated apparatus. RESULTS:Eighty-seven patients (46 males, 41 females, mean age 59.7±14.6, range 27-87 years) were enrolled. Of the 87 patients, 39 had a normal pancreas on imaging, 20 had an intrapapillary mucinous tumor (IPMT), and the rest had chronic pancreatitis (7), serous cystadenoma (6), a previous attack of acute biliary pancreatitis (5), congenital ductal abnormalities (5), mucinous cystadenoma (3), previous pancreatic head resection for autoimmune pancreatitis (1), or cholangiocarcinoma (1). Morphologically, we found two pseudocysts (one of the 7 patients with chronic pancreatitis, and one of the 5 patients after an attack of acute pancreatitis;the latter pseudocyst communicated with the main pancreatic duct). Calcifications were found in 3 of the 7 patients with chronic pancreatitis. All patients with IPMT and mucinous cystadenoma and 3 patients with serous cystadenoma were histologically confirmed. The remaining patients were followed up adequately to confirm the diagnosis by imaging. According to the Matos criteria, 73 patients (83.9%) were of grade 3, 8 grade 2, 4 grade 1, and 2 grade 0. The only pancreatic diseases which impaired the exocrine pancreati

关键词： chronic pancreatitis magnetic resonance cholangiopancreatography pancreatic neoplasms pancreatic insufficiency

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Mitochondrial tRNA Glutamic Acid Variant 14709T〉C Manifesting as Myoclonic Epilepsy with Ragged Red Fibers

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Chinese Medical Journal 2018年第20期131卷 2518-2519页

作者： Josef Finsterer Fulvio A Scorza Ana C Fiorini carla A Scorza Antonio Carlos de Almeida Department of Neurology City Hospital Rudolfstiftung Vienna Austria Department of Neuroscience University of Sao Paolo Sao Paolo Brazil Department of Audiology University of Sao Paolo Sao Paolo Brazil Department of Biosystems Engineering Laboratory of Experimental and Computational Neuroscience Sao Paolo Brazi

We read with interest the case report by Ban et al. about a 17-year-old male with myoclonic epilepsy with ragged red fibers （MERRF） syndrome being attributed to the mitochondrial tRNA glutamic acid （tRNA [Glu]） variant mitochondrial 14709T〉C. The authors claimed that the variant occurred sporadically and has not been reported in association with a MERRF phenotype so far. We have the following comments and concerns.

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Immunohistochemical evaluation of vitamin D receptor(VDR) expression in cutaneous melanoma tissues and four VDR gene polymorphisms

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Cancer Biology & Medicine 2017年第2期14卷 162-175页

作者： Francesco La Marra Giuseppe Stinco Cinzia Buligan Giovanni Chiriacò Diego Serraino carla Di Loreto Sabina Cauci Department of Medical Area School of MedicineUniversity of Udine Dermatology Clinic Udine University-HospitalUniversity of Udine Unit of Cancer Epidemiology CRO Aviano National Cancer Institute

Objective:Vitamin D receptor(VDR)mediates vitamin D *** examined whether VDR expression in excised melanoma tissues is associated with VDR gene(VDR)***:We evaluated VDR protein expression(by monoclonal antibody immunostaining),melanoma characteristics,and carriage of VDR-Fok I-rs2228570(C>T),VDR-Bsm I-rs1544410(G>A),VDR-ApaI-rs7975232(T>G),and VDR-TaqI-rs731236(T>C)polymorphisms(by restriction fragment length polymorphism).Absence or presence of restriction site was denoted by a capital or lower letter,respectively:"F"and"f"for Fok I,"B"and"b"for Bsm I,"A"and"a"for ApaI,and "T"and"t"for TaqI ***-four Italian cutaneous primary melanomas(52.1±12.7 years old)were studied;51.4% were stage Ⅰ,21.6% stage Ⅱ ,13.5% stage Ⅲ,and 13.5% stage Ⅳ *** expression was categorized as follows:100% positive vs.1,regression,tumor-infiltrating lymphocytes,tumoral infiltration of vascular tissues,additional skin and non-skin cancers,and melanoma ***:We highlighted that VDR polymorphisms can affect VDR expression in excised melanoma *** VDR expression in AATT carriers is a new finding that merits further *** expression possibly poses implications for vitamin D supplementation against *** expression and VDR genotype may become precise medicinal tools for melanoma in the future.

关键词： Vitamin D receptor VDR protein expression VDR polymorphism cutaneous melanoma metastatic melanoma skin cancer predictive biomarkers FokI polymorphism

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The Saffold Virus-Penang 2B and 3C Proteins, but not the L Protein,Induce Apoptosis in HEp-2 and Vero Cells

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Virologica Sinica 2019年第3期34卷 262-269页

作者： Yishi Xu carla Bianca Luena Victorio Tao Meng Qiang Jia Yee-Joo Tan Kaw Bing Chua Temasek Life Sciences Laboratory 1 Research LinkNational University of SingaporeSingapore 117604Singapore Department of Microbiology and Immunology Yong Loo Lin School of MedicineNational University Health SystemNational University of SingaporeSingapore 117545Singapore Department of Biological Sciences National University of SingaporeSingapore 117543Singapore Institute of Molecular and Cell Biology A*STAR (Agency for ScienceTechnology and Research)Singapore 138673Singapore

Our previous work has shown that Saffold virus(SAFV)induced several rodent and primate cell lines to undergo apoptosis(Xu et *** Emerg Microb Infect 3:1-8,2014),but the essential viral proteins of SAFV involved in apoptotic activity lack *** this study,we individually transfected the viral proteins of SAFV into HEp-2 and Vero cells to assess their ability to induce apoptosis,and found that the 2B and 3C proteins are *** investigation indicated the trans-membrane domain of the 2B protein is essential for the apoptotic activity and tetramer formation of the 2B *** research provides clues for the possible mechanisms of apoptosis induced by SAFV in different cell *** also opens up new directions to study viral proteins(the 2B,3C protein),and sets the stage for future exploration of any possible link between SAFV,inclusive of its related uncultivable genotypes,and multiple sclerosis.

关键词： Saffold virus(SAFV)Apoptosis Viral proteins

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Antibacterial Behavior of Pyridinecarboxylatesilver（Ⅰ） Complexes

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Chinese Journal of Chemistry 2012年第7期30卷 1631-1635页

作者： Abarca, Romina Gomez, Grace Velasquez, carla Paez, Maritza A. Gulppi, Miguel Arrieta, Abel Azocar, Manuell Laboratory of Bioinorganic Chemistry Faculty of Chemistry and Biology University of Santiago of Chile Av. Bernardo O'Higgins 3363 Santiago Chile

FT-1R spectroscopy of carboxylic groups and viability tests were useful to understand the antibacterial proper- ties of six highly efficient silver（I） pyridinecarboxylate （nicotinic, picolinic and isonicotinic acids） and bipiridinecarboxylate （pyridine-2,3-dicarboxylic, pyridine-2,4-dicarboxylic and pyridine-2,5-dicarboxylic acids） complexes with Ag--O and Ag--N bonds against E. coli （ATCC 25922） and Streptococcus＇ agalactiae （ISP 329-09）. The resuits show a tendency between the nature of Ag--X （X=oxygen and nitrogen） bonds and the rate or efficiency of antibacterial behavior.

关键词： silver complexes antibacterial Ag--O and Ag--N bonds FTIR

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Inflammation and colorectal cancer, when microbiota-host mutualism breaks

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World Journal of Gastroenterology 2014年第4期20卷 908-922页

作者： Marco Candela Silvia Turroni Elena Biagi Franck Carbonero Simone Rampelli carla Fiorentini Patrizia Brigidi Department of Pharmacy and Biotechnology University of Bologna Department of Food Science University of Arkansas Department of Therapeutic Research and Medicines Evaluation

Structural changes in the gut microbial community have been shown to accompany the progressive development of colorectal *** this review we discuss recent hypotheses on the mechanisms involved in the bacteria-mediated carcinogenesis,as well as the triggering factors favoring the shift of the gut microbiota from a mutualistic to a pro-carcinogenic *** possible role of inflammation,bacterial toxins and toxic microbiota metabolites in colorectal cancer onset is specifically *** the other hand,the strategic role of inflammation as the keystone factor in driving microbiota to become carcinogenic is *** a common outcome of different environmental and endogenous triggers,such as diet,aging,pathogen infection or genetic predisposition,inflammation can compromise the microbiota-host mutualism,forcing the increase of pathobionts at the expense of health-promoting groups,and allowing the microbiota to acquire an overall pro-inflammatory *** inflammation in the gut,and favoring the bloom of toxigenic bacterial drivers,these changes in the gut microbial ecosystem have been suggested as pivotal in promoting *** this context,it will become of primary importance to implement dietary or probiotics-based interventions aimed at preserving the microbiota-host mutualism along aging,counteracting deviations that favor a pro-carcinogenic microbiota asset.

关键词： Colorectal cancer Inflammation Gut microbiome Co-abundance groups

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Remote platelet function testing using P-selectin expression in patients with recent cerebral ischaemia on clopidogrel

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Stroke & Vascular Neurology 2021年第1期6卷 103-108页

作者： Jason Philip Appleton carla Richardson Natalia Dovlatova Jane May Nikola Sprigg Stan Heptinstall Philip M Bath Stroke Trials Unit Division of Clinical NeuroscienceUniversity of NottinghamNottinghamUK Stroke Division Nottingham University Hospitals NHS TrustNottinghamUK Platelet Solutions Ltd Division of Clinical NeuroscienceQueen's Medical CentreUniversity of NottinghamNottinghamUK Platelet Research Group Division of Clinical NeuroscienceQueen's Medical CentreUniversity of NottinghamNottinghamUK

Background Antiplatelet agents reduce recurrence after cerebral ischaemia but are not effective in all patients,in part because of treatment *** primary aim was to assess the proportion of patients who are insensitive to *** secondary aim was to assess the association between insensitivity to clopidogrel and recurrent cerebrovascular *** Following written informed consent,independent patients with a recent non-cardioembolic ischaemic stroke or transient ischaemic attack,and taking clopidogrel,were *** function was assessed with remote measurement of surface expression of P-selectin(CD62P)using commercial kits sensitive to aspirin or ***’general practitioners provided details on recurrent vascular events at least 90 days *** are mean(SD)and median[IQR].Resistance was defined as:aspirin median fluorescence(MF)>500 units,clopidogrel MF>860 ***-parametric descriptors and tests were *** 63 patients were recruited:mean age 64(13.7)years,women 47%.At baseline,59(95%)patients were taking clopidogrel alone with 3(5%)on combined clopidogrel and *** of platelet surface P-selectin revealed:aspirin test 528[317,834],>50054.8%;clopidogrel test 429[303,656],>86011.3%.No participants on aspirin and clopidogrel showed aspirin ***(20.6%)patients had a recurrent cerebrovascular event;those with an ischaemic stroke had a non-significantly higher baseline P-selectin using the clopidogrel test as compared with those with no recurrence:626[380,801]versus 406[265,609],p=*** Remote measurement of platelet function assessed using the platelet surface expression of P-selectin is feasible.11%of patients taking clopidogrel showed *** significant associations were noted between clopidogrel resistance and recurrent ischaemic events.

关键词： patients cerebral function

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Management of perianal fistulas in Crohn's disease:An upto-date review

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World Journal of Gastroenterology 2015年第5期21卷 1394-1403页

作者： Manuela Marzo carla Felice Daniela Pugliese Gianluca Andrisani Giammarco Mocci Alessandro Armuzzi Luisa Guidi IBD Unit Complesso Integrato ColumbusUniversità Cattolica del Sacro Cuore00168 RomeItaly

Perianal disease is one of the most disabling manifestations of Crohn's disease.A multidisciplinary approach of gastroenterologist,colorectal surgeon and radiologist is necessary for its management.A correct diagnosis,based on endoscopy,magnetic resonance imaging,endoanal ultrasound and examination under anesthesia,is crucial for perianal fistula *** medical and surgical therapies are discussedin this review,including new local treatment modalities that are under investigation.

关键词： Crohn’s disease Perianal fistula Surgery Drug ther

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Fluorination of suspended graphene

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Nano Research 2017年第9期10卷 3151-3163页

作者： Claudia Struzzi Mattia Scardamaglia Nicolas Reckinger Jean-Francois Colomer Hikmet Sezen Matteo Amati Luca Gregoratti Rony Snyders carla Bittencourt Chimie des Interactions Plasma-Surface CIRMAP University of Mons 7000 Mons Belgium Research Group on Carbon Nanostructures (CARBONNAGe) University of Namur 5000 Namur Belgium Elettra - Sincrotrone Trieste S.C.p.A. di interesse nazionale Strada Statale 14 km 163.5 34149 Trieste Italy Materia Nova Research Center B-7000 Mons Belgium

Suspended graphene is exposed to different fluorine-containing species produced by a plasma source fed with CF4 precursor gas. We investigate the fluorination process by selecting two different kinetic energies for the ions striking the graphene surface. The chemical-bonding environment is discussed, and the control of the graphene-fluorination homogeneity is investigated at the individual graphene sheets. The modifications of the electronic and structural properties are examined by scanning photoelectron microscopy, micro-Raman analysis, and scanning electron microscopy. The results are compared with those obtained for supported graphene on copper. Suspended graphene provides a quasi-ideal model for investigating the intrinsic properties of irradiated carbon nano-systems while avoiding damage due to backscattered atoms and recoil due to a supporting substrate.

关键词： graphene fluorination spectromicroscopy X-ray photoelectron spectroscopy (XPS) Raman scanning electron microscopy (SEM)

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The impact of the design of learning spaces on attention and memory from a neuroarchitectural approach:A systematic review

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Frontiers of Architectural Research 2022年第3期11卷 542-560页

作者： Mar Llorens-Gamez Juan Luis Higuera-Trujillo carla Sentieri Omarrementeria Carmen Llinares Department of Architectural Projects Universitat Politecnica de ValenciaValencia 46022Spain Institute for Research and Innovation in Bioengineering(i3B) Universitat Politecnica de ValenciaValencia 46022Spain

Enriched environments in animal models have demonstrated that exposure to an optimal stimulus improves behavior,cognition,and ***,the evidence base for the neurophysiological influence of human environment enrichment has not been extensively *** systematic review compiles indicators about the effect of built,indoor environments on the cognitive processes of memory and attention in *** work pursues two main objectives:(1)to define current knowledge and the methods that are useful and identify whether previously published studies indicate consistencies and(2)to report the approaches and strategies that can be used in evaluating cognitive processes affected by environment *** of this systematic review show that(1)form and geometry,(2)space distribution and context,(3)color and texture,(4)height,width,and enclosure,(5)transition and circulation,and(6)light,sound,and temperature have an impact on memory and/or attention,and they can be assessed *** all the advances in this field,methodological limitations and a lack of cross-validated standard protocols are ***,future research is necessary to provide a deep insight into how human cognition can be heightened by the environment to which it is exposed.

关键词： Built environment Neuroarchitecture Cognition Attention Memory Learning spaces

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