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Surfing the nano-wave:Emerging trends in cancer diagnostics and therapy

Nano Research 2025年第1期18卷 520-544页

作者： Genping Fu Yuting Weng Yunfan Li carl ho Yiyu Fu Wenxuan Wang Songbin Fu Wenjing Sun Jie Lin Xiaoyu Fan Binbin Jia Mengdi Cai Linlin Li Laboratory of Medical Genetics Harbin Medical UniversityHarbin 150081China Key Laboratory of Preservation of Human Genetics Resources and Disease Control in China(Harbin Medical University) Ministry of EducationHarbin 150081China Beijing Key Laboratory for Optical Materials and Photonic Devices Department of ChemistryCapital Normal UniversityBeijing 100048China College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China Washington University School of Medicine in St.Louis St.LouisMO 63110USA Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Aix-Marseille College Wuhan University of TechnologyWuhan 430070China

Facing the growing global challenge posed by cancer,the quest for more accurate and potent cancer diagnostic and therapeutic strategies continues to require a multidisciplinary integration *** review firstly summarizes various types of nanoparticles in cancer ***,it offers a comprehensive overview of signalenhancing techniques for visualizing in situ tumors,along with multimodal diagnostic methods for detecting *** for tumor therapy,cutting-edge drug delivery methods that can cross biological barriers and the pinpoint targeting of tumor lesions for precise medical intervention are *** the domain of therapeutic diagnostics,we elucidate the theoretical underpinnings and structural paradigms that underlie a spectrum of advanced diagnostic and therapeutic ***,we present a compendium of publications delineating the clinical applications of each nano-based theragnostic integration ***,this comprehensive review discusses the safety concerns pertaining to the clinical application of nanoparticles and proposes some strategic recommendations to enhance the precision and safety of theragnostic-guided,nanotechnology-based clinical practices.A deeper understanding of nanomaterials,together with intimate interdisciplinary collaborations,nano-wave will most probably guide human beings to win the battle against cancers.

关键词： nanoparticles drug delivery gastric cancer glioma glioblastoma

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The next detectors for gravitational wave astronomy

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Science China(Physics,Mechanics & Astronomy) 2015年第12期58卷 91-124页

作者： BLAIR David JU Li ZHAO ChunNong WEN LinQing MIAO HaiXing CAI RongGen GAO JiangRui LIN XueChun LIU Dong WU Ling-An ZHU Zonghong HAMMOND Giles PAIK ho Jung FAFONE Viviana ROCCHI Alessio BLAIR carl MA YiQiu QIN JiaYi PAGE Michael School of Physics The University of Western Australia School of Physics and Astronomy University of Birmingham State Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences The School of Physics & Electronic Engineering Shanxi University Laboratory of All-Solid-State Light Sources Institute of Semiconductors Chinese Academy of Science State Key Laboratroy of Modern Optical Instrumentation Department of Optical Engineering Zhejiang University Laboratory of Optical Physics Institute of Physics Chinese Academy of Sciences Gravitational Wave and Cosmology Laboratory Department of Astronomy Beijing Normal University School of Physics and Astronomy SUPA University of Glasgow Department of Physics University of Maryland College Park University of Rome Tor Vergata INFN Roma Tor Vergata

This paper focuses on the next detectors for gravitational wave astronomy which will be required after the current ground based detectors have completed their initial observations, and probably achieved the first direct detection of gravitational waves. The next detectors will need to have greater sensitivity, while also enabling the world array of detectors to have improved angular resolution to allow localisation of signal sources. Sect. 1 of this paper begins by reviewing proposals for the next ground based detectors,and presents an analysis of the sensitivity of an 8 km armlength detector, which is proposed as a safe and cost-effective means to attain a 4-fold improvement in sensitivity. The scientific benefits of creating a pair of such detectors in China and Australia is emphasised. Sect. 2 of this paper discusses the high performance suspension systems for test masses that will be an essential component for future detectors, while sect. 3 discusses solutions to the problem of Newtonian noise which arise from fluctuations in gravity gradient forces acting on test masses. Such gravitational perturbations cannot be shielded, and set limits to low frequency sensitivity unless measured and suppressed. Sects. 4 and 5 address critical operational technologies that will be ongoing issues in future detectors. Sect. 4 addresses the design of thermal compensation systems needed in all high optical power interferometers operating at room temperature. Parametric instability control is addressed in sect. 5. Only recently proven to occur in Advanced LIGO, parametric instability phenomenon brings both risks and opportunities for future detectors. The path to future enhancements of detectors will come from quantum measurement technologies. Sect. 6 focuses on the use of optomechanical devices for obtaining enhanced sensitivity, while sect. 7 reviews a range of quantum measurement options.

关键词： future gravitational wave detectors opto-mechanics quantum limit

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Romance of the three domains:how cladistics transformed the classifi cation of cellular organisms

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Protein & Cell 2013年第9期4卷 664-676页

作者： Chi-Chun ho Susanna K.P.Lau Patrick C.Y.Woo Department of Microbiology The University of Hong KongHong KongChina State Key Laboratory of Emerging Infectious Diseases The University of Hong KongHong KongChina Research Centre of Infection and Immunology The University of Hong KongHong KongChina Carol Yu Centre of Infection The University of Hong KongHong KongChina

Cladistics is a biological philosophy that uses genealogi-cal relationship among species and an inferred sequence of divergence as the basis of classifi *** review critically surveys the chronological development of bio-logical classification from Aristotle through our post-genomic era with a central focus on *** 1957,Julian Huxley coined cladogenesis to denote splitting from *** 1960,the English translation of Willi Hennig’s 1950 work,Systematic Phylogenetics,was published,which received strong opposition from phenet-icists,such as numerical taxonomists Peter Sneath and Robert Sokal,and evolutionary taxonomist,Ernst Mayr,and sparked acrimonious debates in *** 1977-1990,carl Woese pioneered in using small subunit rRNA gene sequences to delimitate the three domains of cellu-lar life and established major prokaryotic *** has since dominated *** being compatible with modern microbiological observations,*** with unusual phenotypes,restricted expression of charac-teristics and occasionally being uncultivable,increasing recognition of pervasiveness and abundance of horizon-tal gene transfer has challenged relevance and validity of *** mosaic nature of eukaryotic and prokary-otic genomes was also gradually *** the mid-2000s,high-throughput and whole-genome sequencing became routine and complex geneologies of organisms have led to the proposal of a reticulated web of *** genomics only indirectly leads to understanding of func-tional adaptations to ecological niches,computational modeling of entire organisms is underway and the gap between genomics and phenetics may soon be *** are not expected to settle as taxonomic classifi cations shall remain subjective to serve the human scientist,not the classifi ed.

关键词： cladistics phenetics phylogeny classifi ca-tion evolution

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在背景干扰条件下大棕蝠对静止及移动目标的探测(英文)

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动物学报 2004年第1期50卷 9-18页

作者： Philip H-S.JEN carl G. GOLD Division of Biological Sciences and Interdisciplinary Neuroscience Program University of Missouri-ColumbiaDivision of Biological Sciences and Interdisciplinary Neuroscience Program University of Missouri-Columbia Missouri 65211-6190Missouri 65211-6190

采用“双选”的心理物理学方法 ,研究了训练后的大棕蝠 (Eptesicusfuscus)在背景干扰的条件下探测半圆形目标的能力。半圆形目标系以静止、旋转、摆动或不同组合的旋转与摆动呈现于蝙蝠。在测试室 ,蝙蝠-目标间距从 3 0cm开始 ,依次递增... 详细信息

采用“双选”的心理物理学方法 ,研究了训练后的大棕蝠 (Eptesicusfuscus)在背景干扰的条件下探测半圆形目标的能力。半圆形目标系以静止、旋转、摆动或不同组合的旋转与摆动呈现于蝙蝠。在测试室 ,蝙蝠-目标间距从 3 0cm开始 ,依次递增 10cm直至 110cm为止。当蝙蝠 -目标间距小于 80cm时 ,目标回声的强度总是大于背景干扰声。由旋转目标反射的回声强度则依正弦波调制。结果发现 :蝙蝠对目标的正确探测率随蝙蝠 -目标间距的增加而降低 ;在每一特定间距。

关键词：大棕蝠静止目标目标探测移动目标

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多元化监测系统应用于台湾浊水溪冲积扇地层下陷监测与分析

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上海国土资源 2014年第4期35卷 58-61,67页

作者：洪伟嘉王传盛陈怡安邱焕钦绿环工程技术顾问有限公司台湾新竹31040

台湾浊水溪冲积扇(行政区域包括彰化县与云林县)在地质条件上富含有易压缩土壤,加上不当过量抽用地下水,导致该区域为台湾目前最严重的地层下陷区,尤其高速铁路正通过该地区最严重的下陷中心,地层下陷将会对高速铁路结构安全产生影响,... 详细信息

台湾浊水溪冲积扇(行政区域包括彰化县与云林县)在地质条件上富含有易压缩土壤,加上不当过量抽用地下水,导致该区域为台湾目前最严重的地层下陷区,尤其高速铁路正通过该地区最严重的下陷中心,地层下陷将会对高速铁路结构安全产生影响,使得地层下陷防治成为目前一个急需解决的重要议题。政府为改善当地严重地层下陷问题,大力投入相关防治工作。本文主要介绍台湾地区应用多元化监测技术监测浊水溪冲积扇的地层下陷,包含全球定位系统(GPS)、永久性雷达干涉技术(PSI)、水平测量、磁环分层式地层下陷监测井与地下水位井等,实现了空中、地面及地下对地层下陷的多维度变形监测,为地层下陷的研究与防治提供了重要的技术支撑。

关键词：地层下陷监测技术多元化监测系统浊水溪冲积扇

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Novel Supramolecular Assemblies Based on[CdCl4]2-Induced Coordination of Lanthanide Metal Ions to Cucurbit[5]uril

Novel Supramolecular Assemblies Based on[CdCl4]2-Induced Coo...

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全国第十六届大环化学暨第八届超分子化学学术讨论会

作者： Li-Li Liang Yi Zhao Xin-Long Ni Kai Chen Xin Xiao Yun-Qian Zhang carl Redshaw Qian-Jiang Zhu Sai-Feng Xue Zhu Tao Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province Guizhou University

In one of our previous works,we used to report a crystal structure of a compound of hydronium dichloroferrate chloride adducts with cucurbituril,we found that it is a novel supramolecular architecture of trans-[FeCl(ho)] with Q[6].In the Ln-Q[6]and Ln-Q[7]systems,the[MCl](M=Cd,Zn) can present the"honeycomb effect"and form the honeycomb hallows in which the one-dimensional supramolecular chains or tubes constructed of Lncations and Q[6]or Q[7]molecules through direct

关键词： cucurbituril lanthanide cation inorganic inducers coordination polymers

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RTiO3（R=Tb、Dy、ho、Er、Tm）零场磁化强度的温度关系

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稀土 1982年第1期 85-85页

作者： carl W.Turner

在 RTiO3（R=Tb、Dy、ho、Er、Tm）系列中用粉末中子衍射技术研究了稀土亚点阵磁化的温度关系。这些材料的临界温度范围是40—65K。在此范围内观察到 Ti 和稀土磁矩是有序的。在每种情

关键词：亚点阵 R=Tb RTiO3 稀土温度关系 ho Dy

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