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Clinical and endoscopic features of Chinese reflux esophagitis patients

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World Journal of Gastroenterology 2008年第12期14卷 1866-1871页

作者： Wei Li, Shu-Tian Zhang, Zhong-Lin Yu, Department of Gastroenterology, Beijing Friendship Hospital Affiliated to capital medical university Faculty of Gastroenterology, capital medical university Beijing Digestive Disease Center, Beijing 100050, China Department of Gastroenterology Beijing Friendship Hospital Affiliated to Capital Medical University Beijing Digestive Disease Center Beijing 100050 China.

AIM： To analyze the clinical and endoscopic features of Chinese patients with reflux esophagitis （RE）. METHODS： A total of 1405 RE patients were analyzed retrospectively. Data on gender, age, presence/absence of H pylori infection and associated esophageal hiatal hernia were collected. Esophagitis was divided into different grades according to Los Angeles Classification. RESULTS： Of 18823 patients, 1405 were diagnosed as RE. The ratio of male to female patients was 1.75：1 （P 〈 0.01）. The mean age of male and female patients was significantly different （P = 0.01）. The peak age at onset of the disease was 40-60 years. According to Los Angeles Classification, there were significant differences in the age of patients with grades A and B compared to patients with grades C and D （P 〈 0.01）. Two hundred and seventy-seven patients were infected with H pyiorl, the infection rate was low （P 〈 0.01）. Complication of esophageal hiatal hernia was found to be significantly associated with the severity of esophagitis and age in 195 patients （P 〈 0.01）. Esophageal mucosa damages were mainly located at the right esophageal wall. CONCLUSION： The peak age of onset of RE is 40-60 years and higher in males than in females. The mean age of onset of RE is lower in males than in females. The infection rate of Hpylori is significantly decreased in patients with esophagitis. Old age and esophageal hiatal hernia are associated with more severe esophagitis. Right esophageal mucosal damage can occur more often in RE patients.

关键词： Esophagitis Los Angeles Classification Helicobacterpylori Hiatal hernia

宫颈癌筛查质量控制技术规范(DB11/T 2137—2023)

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中华肿瘤杂志 2024年第4期46卷 269-273页

作者：首都医科大学附属北京妇产医院/北京妇幼保健院韩历丽不详首都医科大学附属北京妇产医院北京妇幼保健院保健部北京100026

一、范围,本文件规定了宫颈癌筛查的基本要求、筛查流程、筛查技术要求和质量控制要求本文件适用于医疗机构开展宫颈癌筛查二、规范性引用文件下列文件中的内容通过文中的规范性引用而构成本文件必不可少的条款。其中,注日期的引用文件... 详细信息

一、范围,本文件规定了宫颈癌筛查的基本要求、筛查流程、筛查技术要求和质量控制要求本文件适用于医疗机构开展宫颈癌筛查二、规范性引用文件下列文件中的内容通过文中的规范性引用而构成本文件必不可少的条款。其中,注日期的引用文件,仅该日期对应的版本适用于本文件;不注日期的引用文件,其最新版本(包括所有的修改单)适用于本文件。

关键词：宫颈肿瘤筛查质量控制标准

Application of synchrotron source based DEI method in guinea pig cochleae imaging

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Progress in Natural Science:Materials International 2007年第1期17卷 59-67页

作者： YIN Hongxia, LIU Bo, GAO Xin, GAO Xiulai and LUO Shuqian ( College of Biomedical Engineering, capital university of medical Sciences, Beijing 100069, China Department of Anatomy, capital university of medical Sciences, Beijing 100069, China) College of Biomedical Engineering Capital University of Medical Sciences Beijing 100069 China Department of Anatomy Capital University of Medical Sciences Beijing 100069 China

Hard X-ray diffraction enhanced imaging (DEI), which is based on a synchrotron source and monochromator-analyzer-crystal system, is an effective method for imaging X-ray phase shift. Utilizing an analyzer crystal with high angular sensitivity of micro-radian, DEI can measure the transmitted, refracted and scattered X-rays when projecting onto a sample. It dramatically improves the contrast and spatial resolution of the resultant images. At the topography station of Beijing Synchrotron Radiation Facilities (BSRF), we implemented DEI method in guinea pig cochleae imaging and acquired a series of DEI images. Based on these images, the apparent absorption and refraction images were calculated. The DEI images revealed the holistic spiral structures and inner details of guinea pig cochleae clearly, even including the structures at the cellular level, such as the static cilia of hairy cells and the limbus of Hansen cell. Due to the advantages of high contrast, high spatial resolution and distinct edge-enhanced effect, DEI method promises extensive applications in biology, medicine and clinic in the near future.

关键词： diffraction enhanced imaging hard X-ray imaging phase-contrast imaging cochlea micro-structure synchrotron source.

Spinal processing of bee venom-induced pain and hyperalgesia

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生理学报 2008年第5期60卷 645-652页

作者： Jun CHEN Institute for Biomedical Sciences of Pain and Institute for Functional Brain Disorders,Tangdu Hospital,the Fourth Military medical university,Xi’an 710038,China Institute for Biomedical Sciences of Pain,capital medical university,Beijing 100069,China Institute for Biomedical Sciences of Pain and Institute for Functional Brain Disorders Tangdu Hospital the Fourth Military Medical University Xi'an 710038

Subcutaneous injection of bee venom causes long-term neural activation and hypersensitization in the dorsal horn of the spinal cord,which contributes to the development and maintenance of various pain-related *** unique behavioral 'phenotypes' of nociception and hypersensitivity identified in the rodent bee venom test are believed to reflect a complex pathological state of inflammatory pain and might be appropriate to the study of phenotype-based mechanisms of pain and *** this review,the spinal processing of the bee venom-induced different 'phenotypes' of pain and hyperalgesia will be *** accumulative electrophysiological,pharmacological,and behavioral data strongly suggest that different 'phenotypes' of pain and hyperalgesia are mediated by different spinal signaling *** the phenotype-based mechanisms of pain might be useful in development of novel therapeutic drugs against complex clinic pathological pain.

关键词：脊髓痛觉过敏蜂毒疼痛治疗方法

Interferon-α induced severe thrombocytopenia:A case report and review of the literature

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World Journal of Gastroenterology 2010年第11期16卷 1414-1417页

作者： Li Li,Da-Kang Han,Jun Lu,Tumor Biotherapy Ward of Beijing Youan Hospital,capital medical university,Beijing 100069,China Tumor Biotherapy Ward of Beijing Youan Hospital Capital Medical University Beijing 100069 China.

We report a case of severe thrombocytopenia following pegylated interferon-α 2a(Peg-IFN-α 2a)treatment of hepatitis C virus infection and summarize the clinical characteristics of 16 cases of IFN-α induced severe thrombocytopenia and its immune-mediated *** of IFN-α and early administration of immunosuppressants are the effective therapy for IFN-αinduced severe thrombocytopenia.

关键词： Interferon-α Severe thrombocytopenia Chronic hepatitis C

中国儿童及青少年初次创伤性髌骨脱位诊疗指南(2024年版)

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中华骨科杂志 2024年第2期44卷 65-69页

作者：首都医科大学附属北京积水潭医院(国家骨科医学中心) 中华医学会小儿外科分会小儿骨科学组中华医学会骨科分会小儿创伤与矫形学组杨征冯超黄林中华医学会小儿外科分会小儿骨科学组中华医学会骨科分会小儿创伤与矫形学组

初次创伤性髌骨脱位(first-time traumatic patellar dislocation,FTPD)是一种常见的儿童及青少年运动损伤,近年来发病率有逐渐升高的趋势。国内骨科医生对儿童及青少年FTPD的诊疗水平也有了长足的进步,但尚未达成一致的共识。本指南由... 详细信息

初次创伤性髌骨脱位(first-time traumatic patellar dislocation,FTPD)是一种常见的儿童及青少年运动损伤,近年来发病率有逐渐升高的趋势。国内骨科医生对儿童及青少年FTPD的诊疗水平也有了长足的进步,但尚未达成一致的共识。本指南由首都医科大学附属北京积水潭医院(国家骨科医学中心)、中华医学会小儿外科分会小儿骨科学组及中华医学会骨科分会小儿创伤与矫形学组发起,采用推荐意见分级的评估、制订及评价分级体系和国际实践指南报告标准,基于文献证据评估形成8条推荐意见。推荐条目1~2为儿童及青少年FTPD发生的危险因素及病理解剖特点,条目3~8为FTPD手术治疗的原则。指南旨在提高儿童及青少年FTPD诊疗的科学性,最终提升以患者为中心的医疗服务质量。

关键词：髌骨脱位儿童青少年中国诊疗指南

The characteristics of action potential and nonselec-tive cation current of cardiomyocytes in rabbit superior vena cava

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Science China(Life Sciences) 2008年第4期51卷 326-335页

作者： WANG Pan, YANG XinChun, LIU XiuLan, BAO RongFeng & LIU TaiFeng Beijing ChaoYang Hospital, capital medical university, Beijing 100020, China Beijing ChaoYang Hospital Capital Medical University Beijing China

As a special focus in initiating and maintaining atrial fibrillation (AF), cardiomyocytes in superior vena cava (SVC) have distinctive electrophysiological characters. In this study, we found that comparing with the right atrial (RA) cardiomyoctyes, the SVC cardiomyoctyes had longer APD90 at the different basic cycle lengths; the conduction block could be observed on both RA and SVC cardiomyoctyes. A few of SVC cardiomyoctyes showed slow response action potentials with automatic activity and some others showed early afterdepolarization (EAD) spontaneously. Further more, we found that there are nonselective cation current (INs) in both SVC and RA cardiomyocytes. The peak density of INs in SVC cardiomyocytes was smaller than that in RA cardiomyocytes. Removal of extracellular divalent cation and glucose could increase INs in SVC cardiomyocytes. The agonist or the antagonist of INs may in-crease or decrease APD. To sum up, some SVC cardiomyocytes possess the ability of spontaneous activity; the difference of transmembrane action potentials between SVC and RA cardiomyocytes is partly because of the different density of INs between them; the agonist or the antagonist of INs can in-crease or decrease APD leading to the enhancement or reduction of EAD genesis in SVC cardiomyo-cytes. INs in rabbit myocytes is fairly similar to TRPC3 current in electrophysiological property, which might play an important role in the mechanisms of AF.

关键词： superior vena cava cardiomyocytes, right atrial cardiomyocytes, nonselective cation current, action potential atrial fibrillation, rabbit heart

Embryonic hepatocyte transplantation for hepatic cirrhosis:Efficacy and mechanism of action

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World Journal of Gastroenterology 2012年第4期18卷 309-322页

作者： Wen-Ting Bin,Qing Xu,Xiao-Lin Shi,Laboratory of Reproductive Biology,Department of Histology and Embryology,School of Basic medical Sciences,capital medical university,Beijing 100069,China Li-Mei Ma,Department of Histology and Embryology,Kunming medical university,Kunming 650031,Yunnan Province,China Laboratory of Reproductive Biology Department of Histology and Embryology School of Basic Medical Sciences Capital Medical University Beijing 100069 China.

AIM： To investigate the efficacy and mechanism of action of allogeneic embryonic hepatocyte transplantation for the treatment of hepatic cirrhosis. METHODS： Rat embryonic hepatocytes were characterized by examining cell markers. Wistar rats with CCl4-induced cirrhosis were randomly divided into two groups： a model group receiving continuous CCl4, and a cell transplantation group receiving continuous CCh and transplanted with embryonic fluorescent-labeled hepatocytes. In addition, a normal control group was composed of healthy rats. All rats were sacrificed after 2 wk following the initiation of the cell transplant. Ul- trasound, pathological analyses and serum biochemical tests were used to evaluate the efficacy of embryonic hepatocyte transplantation. To analyze the recovery status of cirrhotic hepatocytes and the signaling pathways influenced by embryonic hepatocyte transplantation, real-time polymerase chain reaction was performed to examine the mRNA expression of stellate activation-associated protein （STAP）, c-myb, ~ smooth muscle actin （^-SMA） and endothelin-1 （ET-1）. West- ern blotting and immunohistochemistry were employed to detect ^-SMA and ET-1 protein expression in hepatic tissues. RESULTS： Gross morphological, ultrasound and his- topathological examinations, serum biochemical tests and radioimmunoassays demonstrated that hepatic cir- rhosis was successfully established in the Wistar rats. Stem cell factor receptor （c-kit）, hepatocyte growth factor receptor （c-Met）, Nestin, ~ fetal protein, albu- min and cytokeratin19 markers were observed in the rat embryonic hepatocytes. Following embryonic hepa- tocyte transplantation, there was a significant reversal in the gross appearance, ultrasound findings, histo- pathological properties, and serum biochemical param- eters of the rat liver. In addition, after the activation of hepatic stellate cells and STAP signaling, ^-SMA, c-myb and ET-1 mRNA levels became significantly lower than in the untreated cirrhotic g

关键词： Embryonic hepatocytes Cirrhosis Stellateactivation-associated protein Endothelin-1 Cell trans-plantation

Growth induction of hepatic stimulator substance in hepatocytes through its regulation on EGF receptors

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Cell Research 1999年第1期9卷 37-49页

作者： AN WEI XIAO JUN LIU TIAN GUANG LEI JIE DAI GUO GUANG DU(Department of Cell Biology, capital university of medical Sciences, Beijing 100054, China) Department of Cell Biology Capital University of Medical Sciences Beijing China

The cytosolic liver-specific growth factor-hepatic stimulator substance (HSS) has been shown to be able to amplify the rat hepatocyte proliferation responded to EGF. In order to get more insight into the mechanism, the regulatory effect of HSS on EGF-receptor(EGF-R) and the receptor phosphorylation at molecular level was studied. HSS partially purified from weanling rat liver was given to cultured hepatocytes and its influence on EGF-R specific binding and internalization as well as mRNA expression were investigated. The results showed that preincubation of hepatocytes with HSS could lead to an increase in [125I]-EGF binding to its receptors and inhibit EGFinduced receptor down-regulation. Furthermore, the overexpression of EGF-R mRNA stimulated by HSS was seen during 2-12 h after the incubation. Additionally, it was demonstrated with human hepatoma sMMC-7721 cells in Western blot that the EGF-R expression and the receptor autophosphorylation were increased with dose/timedependency after HSS treatment. These results strongly suggest that the mechanism of HSS action on hepatocyte growth might be related to its modulation on EGF-R and receptor-mediated signaling transduction.

关键词： EGF receptor hepatic stimulator substance hepatocyte proliferation