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Glinical study about low epidural block efficacy of ropivacaine and bupivacaine at the equivalent concentrations

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麻醉与监护论坛 2009年第3期16卷 138-141页

作者： Fang cai qin hong Wang Ruiming Department of Anesthesia The Affiliated Anhui Provincial Hospital of Anhui Medical University Hefei（230001） China

Objective:The purpose of this prospective, randomized, double-blind study was to compare the low epidural block efficacy of ropivacaine and bupivacaine at the equivalent concentrations. Methods Eighty patients (44 male and 36 female patients) undergoing selective lower abdominal or lower extremity surgery were allocated randomly to four groups with 20 in each, receiving 0.5% bupivacaine (group B0.5), 0.5% ropivacaine (group R0.5), 0.75% bupivacaine (group B0.75) and 0.75% ropivacaine (group R0.75), respectively. Prior to surgery, with double blind method, 0.5%, 0.75% ropivacaine, or 0.5%, 0.75% bupivacaine as local anesthetic solutions were injected respectively via epidural catheters at interspace of L2-3 or L3-4. Patients received the experimental drug 4 ml as a catheter test dose in order to avoid the catheter being improperly placed into the subarechnoid space. Ropivacaine or bupivacaine 3-5ml was administered at five minutes intervals until anesthetic effect had met surgery demand. (The segmental level of sensory block by pinpricking had extended above the top of surgery incision.) During the procedure, no additional study drug was injected into the epidurel space while the patients were being recorded, including onset time, the efficacy of sensory moter block, duration, cardiovascular effects, the quality of analgesia and neuromuscular block, adverse reactions and complications. All subjects were continuously monitored non-invasion blood pressure, heart rate(HR), oxygen saturation measured by pulse oximetry(SpO2) and electrocardiogram(EEG) throughout surgery. Results:The anesthesia of all subjects was appropriate for surgery. With 0.5%, 0.75% ropivacaine, or 0.5%, 0.75% bupivacaine in the equivalent dosages, onset time, duration of sensory block, and the efficacy of motor block(mostly Bromage 3) was not significantly different between the groups(P >0.05). Increasing the concentration of ropivacaine could leaded to a longer duration of motor block, especially i

关键词：硬脑膜阻塞局部麻醉罗哌卡因治疗方法

Heat Transfer and Flow Structure of a Turbine Blade's Air-cooled Leading Edge Considering Different Hole Shapes and Additional Flow Angles

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Journal of Thermal Science 2024年第4期33卷 1421-1442页

作者： qin Runxuan ZHOU Xun WANG Songtao cai Le School of Energy Science and Engineering Harbin Institute of TechnologyHarbin150001China

A numerical study is conducted to elucidate the impact of hole shapes and additional flow angles on the flow structure of the coolant and temperature field in the leading edge area of the gas turbine *** typical hole shapes are considered for the GE-E3 *** impact of the additional flow angle(E)within each hole shape on the temperature field is *** results indicate that for the leading edge area and suction surface,the fan-shaped hole case performs best in decreasing temperatures,with a decrease of about 43 *** is mainly due to the fact that the fan-shaped hole has the maximum expansion in hole spanwise *** the pressure surface,the console hole case performs best in decreasing temperatures,with a maximum reduction of about 47.2 *** influence of E on the surface temperature at leading edge area varied between the different hole *** the cylinder hole and console hole,the E=-20°case has the lowest area-averaged *** both the fan-shaped hole and the 7-7-7 shaped hole are expansion holes,the pattern of variation of the leading edge area temperature with increasing E is similar for the fan-shaped hole case and 7-7-7 shaped hole *** E=20°case shows the lowest spanwise-averaged temperature near the hole outlet,and the E=-20°case shows the lowest spanwise-averaged temperature further downstream.

关键词： film cooling GE-E3 turbine rotor blade conjugate heat transfer leading edge

Reynolds-number scaling analysis on lift generation of a flapping and passive rotating wing with an inhomogeneous mass distribution

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Chinese Journal of Aeronautics 2024年第2期37卷 259-269页

作者： Suyang qin Haotian HANG Yang XIANG hong LIU J.C.Wu center for aerodynamics school of aeronautics and astronauticsshanghai jiao tong universityshanghai 200240china

Insects usually fly by passively rotating wings,which has been applied to the design of flapping-wing Micro-Air Vehicles(MAVs)to reduce mechanical *** this paper,a robotic passive rotating-wing model is designed to investigate wing kinematics and lift generation,which are measured by a high-speed camera and a force transducer,*** addition,flow fields are measured using the Particle Image Velocimetry(PIV).Experimental results demonstrate that passive rotating motion has a coordinative relationship with actively stroking *** the stroke amplitude or frequency increases,the rotating amplitude is *** characterize the active stroking motion,a driving Reynolds number Redrivingis defined,which varies from 68 to 366 in this *** the gravity center of the wing towards trailing ed ge induces the increase of additional torque M,which decreases the wing rotating amplitude and promotes the advance of wing *** find that the timing of wing rotation is gradually delayed and the mean lift coefficient C^(-)_(L)monotonously decreases as *** increasing the additional torque M,C^(-)_(L)is slightly improved and approaches to the lift coefficient of a real fruit fly at driving Re approximately equal to *** instantaneous lifts combined with the vortical structures further demonstrate that the lift generation associated with wing rotation is mainly attributed to the growth of the LeadingEdge Vortex(LEV)and the passive wake capture *** wake capture is influenced by LEV,reversal stroke motion and wing additional torque together,which can only maintain the lift at a high level for a considerable *** high-lift generation mechanisms of flapping and passive rotating flight could shed light on the simplified design of MAVs and the improvement of their aerodynamic performance.

关键词： Flapping flight Unsteady lift Passive rotation Vortex flow Leading-edge vortex

Construction of Optimal Mixed-Level Uniform Designs

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Journal of Systems Science & Complexity 2024年第2期37卷 841-862页

作者： CHATTERJEE Kashinath LIU Min-Qian qin hong YANG Liuqing Department of Population Health Sciences Division of Biostatistics and Data ScienceAugusta UniversityGA 30912USA NITFID LPMC&KLMDASRSchool of Statistics and Data ScienceNankai UniversityTianjin 300071China School of Statistics and Mathematics Zhongnan University of Economics and LawWuhan 430073China

The theory of uniform design has received increasing interest because of its wide application in the field of computer *** generalized discrete discrepancy is proposed to evaluate the uniformity of the mixed-level factorial *** this paper,the authors give a lower bound of the generalized discrete discrepancy and provide some construction methods of optimal mixed-level uniform designs which can achieve this lower *** methods are all deterministic construction methods which can avoid the complexity of stochastic *** saturated mixed-level uniform designs and supersaturated mixed-level uniform designs can be obtained with these ***,the resulting designs are also χ^(2)-optimal and minimum moment aberration designs.

关键词： Generalized discrete discrepancy Hadamard matrix mixed-level design orthogonal array supersaturated design

Rapid Energy Exchange between In Situ Formed Bromine Vacancies and CO_(2)Molecules Enhances CO_(2)Photoreduction

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Research 2024年第2期2023卷 763-771页

作者： qin Ren Ye He hong Wang Yanjuan Sun Fan Dong Research Center for Environmental and Energy Catalysis Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengdu 611731China School of Resources and Environment University of Electronic Science and Technology of ChinaChengdu 611731China

Photocatalytic reduction of CO_(2)into fuels provides a prospective tactic for regulating the global carbon balance utilizing renewable solar ***,CO_(2)molecules are difficult to activate and reduce due to the thermodynamic stability and chemical *** this work,we develop a novel strategy to promote the adsorption and activation of CO_(2)molecules via the rapid energy exchange between the photoinduced Br vacancies and CO_(2)*** in situ continuous wave-electron paramagnetic resonance(cw-EPR)and pulsed EPR technologies,we observe that the spin-spin relaxation time(T_(2))of BiOBr is decreased by 198 ns during the CO_(2)photoreduction reaction,which is further confirmed by the broadened EPR *** result reveals that there is an energy exchange interaction between in situ formed Br vacancies and CO_(2)molecules,which promotes the formation of high-energy CO_(2)molecules to facilitate the subsequent reduction *** addition,theoretical calculations indicate that the bended CO_(2)adsorption configuration on the surface of BiOBr with Br vacancies caused the decrease of the lowest unoccupied molecular orbital of the CO_(2)molecule,which makes it easier for CO_(2)molecules to acquire electrons and get *** situ diffuse reflectance infrared Fourier transform spectroscopy further shows that the activated CO_(2)molecules are favorably converted to key intermediates of COOH*,resulting in a CO generation rate of 9.1μmol g^(-1)h^(-1)and a selectivity of 100%.This study elucidates the underlying mechanism of CO_(2)activation at active sites and deepens the understanding of CO_(2)photoreduction reaction.

关键词： reaction. adsorption activation

The Multiple Roles of Autophagy in Neural Function and Diseases

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Neuroscience Bulletin 2024年第3期40卷 363-382页

作者： Yan-Yan Li Zheng-hong qin Rui Sheng Department of Pharmacology and Laboratory of Aging and Nervous Diseases Jiangsu Key laboratory of Neuropsychiatric DiseasesCollege of Pharmaceutical Sciences of Soochow UniversitySuzhou 215123China

Autophagy involves the sequestration and delivery of cytoplasmic materials to lysosomes,where proteins,lipids,and organelles are degraded and *** to the way the cytoplasmic components are engulfed,autophagy can be divided into macroautophagy,microautophagy,and chaperone-mediated ***,many studies have found that autophagy plays an important role in neurological diseases,including Alzheimer's disease,Parkinson's disease,Huntington's disease,neuronal excitotoxicity,and cerebral *** maintains cell homeostasis in the nervous system via degradation of misfolded proteins,elimination of damaged organelles,and regulation of apoptosis and ***-mTOR,Beclin 1,TP53,endoplasmic reticulum stress,and other signal pathways are involved in the regulation of autophagy and can be used as potential therapeutic targets for neurological ***,we discuss the role,functions,and signal pathways of autophagy in neurological diseases,which will shed light on the pathogenic mechanisms of neurological diseases and suggest novel targets for therapies.

关键词： Autophagy Neurodegenerative diseases Cerebral ischemia AMPK mTOR Beclin 1 TP53 Endoplasmic reticulum stress

Dynamic ocean inverse modeling based on differentiable rendering

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Computational Visual Media 2024年第2期10卷 279-294页

作者： Xueguang Xie Yang Gao Fei Hou Aimin Hao hong qin State Key Lab of Virtual Reality Technology and Systems Beihang UniversityBeijing 100191China qingdao Research Institute Beihang UniversityQingdao 266100Chinaand Peng Cheng LabShenzhen 518000China SKLCS Institute of SoftwareChinese Academy of SciencesBeijing 100190Chinaand University of Chinese Academy of SciencesBeijing 100049China Department of Computer Science Stony Brook University(SUNY at Stony Brook)Stony BrookNew York 11794-2424USA

Learning and inferring underlying motion patterns of captured 2D scenes and then re-creating dynamic evolution consistent with the real-world natural phenomena have high appeal for graphics and *** bridge the technical gap between virtual and real environments,we focus on the inverse modeling and reconstruction of visually consistent and property-verifiable oceans,taking advantage of deep learning and differentiable physics to learn geometry and constitute waves in a self-supervised ***,we infer hierarchical geometry using two networks,which are optimized via the differentiable *** extract wave components from the sequence of inferred geometry through a network equipped with a differentiable ocean ***,ocean dynamics can be evolved using the reconstructed wave *** extensive experiments,we verify that our new method yields satisfactory results for both geometry reconstruction and wave ***,the new framework has the inverse modeling potential to facilitate a host of graphics applications,such as the rapid production of physically accurate scene animation and editing guided by real ocean scenes.

关键词： inverse modeling surface reconstruction wave modeling ocean waves differentiable rendering(DR)

Role of mitophagy in head and neck squamous cell carcinoma:Prognosis and immune insights

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Radiation Medicine and Protection 2024年第2期5卷 100-112页

作者： qin Ding Wei Liu Junping Pan Lihua Wang Wenquan hong Sunqin cai Xin Chen Duanyu Lin Sufang Qiu Department of Radiation Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer Hospital(Fujian Branch of Fudan University Shanghai Cancer Center)Fuzhou 350014China Fujian Provincial Key Laboratory of Translational Cancer Medicine Fuzhou 350014China Department of Nuclear Medicine Clinical Oncology School of Fujian Medical UniversityFujian Cancer Hospital(Fujian Branch of Fudan University Shanghai Cancer Center)Fuzhou 350014China

Objective:To explore the correlation between mitophagy and the tumor microenvironment(TME)in patients with head and neck squamous cell carcinoma(HNSCC),with an aim to enhance therapeutic efficacy for ***:A machine learning-based multigene prognostic signature was developed based on mitophagy-related differentially expressed genes(MRGs)identified in The Cancer Genome Atlas *** signature was correlated with the TME using gene set enrichment *** association between this prognostic signature and various immunological features of the TME was explored,including status of tumor-infiltrating immune cells,expression of immune checkpoint molecules,and the *** validated the expression of hub gene CSNK2A2 and assessed its relationship with immunomarker *** PCR validated CSNK2A2 knockdown in HNSCC cell *** experiments including Transwell assays to determine cell migration and invasion,Cell Counting Kit 8 assay,and 5-ethynyl-2-deoxyuridine assay were performed to confirm the role of CSNK2A2 in ***,a subcutaneous xenograft model was generated in C3H mice to validate our ***:The MRG-based prognostic signature showed excellent predictive ***-risk patients had significantly shorter progression-free and overall survival(P<0.0001)than low-risk ***8+T cell infiltration was lower in high-risk groups,whereas low-risk groups showed higher immunological marker ***,the low-risk HNSCC subtype may benefit from immune therapy,while high-risk subtypes may benefit from chemotherapy(P<0.001).CSNK2A2 was highly expressed and strongly correlated with CD8 and PD-L1 based on immunohistochemistry of the HNSCC tissue ***2A2 knockdown reduced cell migration,invasion,and proliferation,and arrested cells in G1 *** vivo,it led to slower tumor growth and smaller tumor ***:We established a potential prognostic signature that could impr

关键词： Head and neck squamous cell carcinoma Mitophagy Tumor microenvironment CSNK2A2 Prognostic model

A quasi-zero stiffness energy harvesting isolator with triple negative stiffness

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Acta Mechanica Sinica 2024年第8期40卷 219-238页

作者： Xiangyu cai Tao Yang Weiyang qin Zhongliang Xie Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen518057China Department of Engineering Mechanics Northwestern Polytechnical UniversityXi’an710072China

Vibration isolation for low frequency excitation and the power supply for low power monitoring sensors are important issues in bridge *** main problem is how to effectively combine the vibration isolator with the energy harvester to form a multi-functional *** this paper,a system called quasi-zero stiffness energy harvesting isolator(QZS-EHI)with triple negative stiffness(TNS)is *** TNS structure consists of linear springs,rigid links,sliders,and ring permanent ***’s second law and Kirchhoff’s law construct dynamic equations of the QZS-EHI,and a comparison is made to contrast it with other QZS and linear *** comparison field includes the QZS range,amplitude-frequency relationship,force transmissibility,and energy harvested *** isolator can be applied to many engineering fields such as bridges,automobiles,and railway *** paper selects bridge engineering as the main field for the dynamic analysis of this *** the multi-span beam bridge,this paper compares different situations including the bridge with QZS-EHI support,with linear stiffness isolator support,and with single beam *** results show that the QZS-EHI is not only better than the traditional isolator with linear stiffness under both harmonic and stochastic excitation,but also better than some QZS isolators with double or single negative stiffness in bridge vibration isolation and energy *** analysis is verified to correspond to the simulation analysis,which means the proposed QZS-EHI has practical application value.

关键词： Quasi-zero stiffness Triple negative stiffness Vibration isolation Energy harvesting