Glinical study about low epidural block efficacy of ropivacaine and bupivacaine at the equivalent concentrations
Glinical study about low epidural block efficacy of ropivacaine and bupivacaine at the equivalent concentrations作者机构：Department of Anesthesia The Affiliated Anhui Provincial Hospital of Anhui Medical University Hefei（230001） China
出 版 物：《麻醉与监护论坛》 (Forum of Anesthesia and Monitoring)
年 卷 期：2009年第16卷第3期
页 面：138-141页
学科分类：1002[医学-临床医学] 100217[医学-麻醉学] 10[医学]
摘 要：Objective:The purpose of this prospective, randomized, double-blind study was to compare the low epidural block efficacy of ropivacaine and bupivacaine at the equivalent concentrations. Methods Eighty patients (44 male and 36 female patients) undergoing selective lower abdominal or lower extremity surgery were allocated randomly to four groups with 20 in each, receiving 0.5% bupivacaine (group B0.5), 0.5% ropivacaine (group R0.5), 0.75% bupivacaine (group B0.75) and 0.75% ropivacaine (group R0.75), respectively. Prior to surgery, with double blind method, 0.5%, 0.75% ropivacaine, or 0.5%, 0.75% bupivacaine as local anesthetic solutions were injected respectively via epidural catheters at interspace of L2-3 or L3-4. Patients received the experimental drug 4 ml as a catheter test dose in order to avoid the catheter being improperly placed into the subarechnoid space. Ropivacaine or bupivacaine 3-5ml was administered at five minutes intervals until anesthetic effect had met surgery demand. (The segmental level of sensory block by pinpricking had extended above the top of surgery incision.) During the procedure, no additional study drug was injected into the epidurel space while the patients were being recorded, including onset time, the efficacy of sensory moter block, duration, cardiovascular effects, the quality of analgesia and neuromuscular block, adverse reactions and complications. All subjects were continuously monitored non-invasion blood pressure, heart rate(HR), oxygen saturation measured by pulse oximetry(SpO2) and electrocardiogram(EEG) throughout surgery. Results:The anesthesia of all subjects was appropriate for surgery. With 0.5%, 0.75% ropivacaine, or 0.5%, 0.75% bupivacaine in the equivalent dosages, onset time, duration of sensory block, and the efficacy of motor block(mostly Bromage 3) was not significantly different between the groups(P 0.05). Increasing the concentration of ropivacaine could leaded to a longer duration of motor block, especially i
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