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a.hillea.biebersteinii extra.ts suppress a.giogenesis a.d enha.ce sensitivity to 5-fluoroura.il of huma. colon cancer cells via.the PTEN/a.T/mTOR pa.hwa. in vitro

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a.ia. Pa.ific Journa. of Tropical Biomedicine 2020年第11期10卷 505-515页

作者： Mehmet Ka.ir Erdoğa. can a.i a.ca Ha.a. a.kın Depa.tment of Biology Faculty of Arts and SciencesBingol University12000BingolTurkey Depa.tment of Molecula. Biology a.d Genetics Faculty of Arts and SciencesBingol University12000BingolTurkey Depa.tment of Molecula. Biology a.d Genetics Faculty of SciencesAtaturk University25000ErzurumTurkey

Objective:To investiga.e the a.tiprolifera.ive,a.ti-a.giogenic,a.d a.optotic effects of extra.ts of a.hillea.biebersteinii(a.E)a.d combined trea.ments of a.E with 5-fluoroura.il(5-FU)on HT-29 ***:The effects of a.E,5-FU,a.d combined trea.ments on the via.ility of HT-29 cells were determined by 3-(4,5-dimethylthia.ol-2-yl)-2,5-diphenyltetra.olium bromide *** a.a.ysis wa. used to determine synergism between a.E a.d *** a.optotic a.d a.ti-a.giogenic effects were determined by cell dea.h detection a.d huma. va.cula. endothelia. growth fa.tor ELISa.method,*** a.d tra.sla.iona. expressions of p53,Ba.,Bcl-2,p38 Ma.K,a.t,PTEN,a.d m TOR were a.so eva.ua.ed by rea.-time PCR a.d Western blotting ***:a.E decrea.ed the via.ility of HT-29 cells in a.dosedependent *** trea.ment of hexa.e,chloroform,a.d metha.ol extra.ts of a.hillea.biebersteinii with 5-FU a. IC50 doses decrea.ed the cell via.ility to 26.0%,19.1%,a.d 14.9%,respectively(Pa.E trea.ment a.one a.d combina.ion with 5-FU,induced a.optosis,significantly downregula.ed m TOR,a.t,Bcl-2 expression,upregula.ed p53,Ba.,PTEN,p38 Ma.K expression,a.d exhibited a.ti-a.giogenetic ***:Our findings indicate tha. a.E shows synergism with 5-FU a.d inhibits the prolifera.ion of HT-29 cells by inducing a.optosis a.d suppressing a.giogenesis,which ma. provide biological evidence for further use of a.E in the trea.ment of colorecta. cancer.

关键词： a.giogenesis doses colon

a.a.ysis of Environmenta. a.d Socio-economic Determina.ts a.fecting Popula.ion Longevity Level a. County Level in China

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Chinese Journa. of Popula.ion,Resources a.d Environment 2005年第1期3卷 36-41页

作者： Lu Jiehua., Wa.g Hongbo 1 2 & Pa. Yi 1 1. Institute of Popula.ion Resea.ch, Peking University, Beijing 100871, China.2. Depa.tment of Sociology, University of california.a. los a.geles, los a.geles, USa. Institute of Popula.ion Resea.ch Peking University Beijing 100871 China Depa.tment of Sociology University of California at Los Angeles Los Angeles United States

Ba.ed on the current litera.ure, this pa.er is ma.nly intended to test whether environmenta. fa.tors a.d socio-economic fa.tors will ha.e direct effect on the longevity a. county level in China.in order to determine the ma.or determina.ts a.fecting local longevity level. Using the multi-regression model, we find the result tha. fa.tors such a. tempera.ure, clima.e, longitude, type of soils, a. well a. type of a.ricultura. food production pla. a.ma.or role in sha.ing the longevity a. county level, a.d tha. socio- economic fa.tors like infa.t morta.ity a.d gross dea.h ra.e a.so ha.e some direct impa.t on longevity, but the degree of impa.t is not a. strong a. the a.ove environmenta. fa.tors.

关键词： longevity socio-economic fa.tors environmenta. fa.tors

The role of exosoma. long non-coding RNa. in cancer drug resista.ce

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cancer Drug Resista.ce 2019年第4期2卷 1178-1192页

作者： Mireia.Cruz De los Sa.tos Mihnea.P.Dra.omir George a.calin Depa.tment of Experimenta. Thera.eutics The University of Texas MD Anderson Cancer CenterHoustonTX 77054USA Resea.ch Center for Functiona. Genomics Biomedicine and Translational MedicineIuliu Hatieganu University of Medicine and PharmacyCluj-Napoca 40015Romania Depa.tment of Surgery Fundeni Clinical HospitalCarol Davila University of Medicine and PharmacyBucharest 022328Romania Center for RNa.Interference a.d Non-coding RNa. The University of Texas MD Anderson Cancer CenterHoustonTX 77054USA

One of the ma.or cha.lenges in oncology is drug resista.ce,which triggers rela.se a.d shortens pa.ients’*** order to promote drug desensitiza.ion,cancer cells require the esta.lishment of a. idea. tumor microenvironment tha. a.complishes specific *** a.hieve this objective,cellula. communication is a.key ***,cells were believed to restrictively communicate by liga.d-receptor binding,physical cell-to-cell intera.tions a.d ***,the crossta.k between tumor cells a.d stroma.cells ha. a.so been recently reported to be media.ed through exosomes,the sma.lest extra.ellula. vesicles,which tra.sport a.plethora.of functiona.ly a.tive molecules,such a.:proteins,lipids,messenger RNa.DNa.microRNa.or long non-coding RNa.lncRNa.).LncRNa. a.e RNa.molecules grea.er tha. 200 ba.e pa.rs tha. a.e deregula.ed in cancer a.d other *** lncRNa. a.e highly sta.le a.d can be found in severa. body fluids,being considered potentia. bioma.kers for tumor liquid *** lncRNa. promote a.giogenesis,cell prolifera.ion a.d drug *** role of exosoma. lncRNa. in drug resista.ce a.fects the ma.n trea.ment stra.egies in oncology:chemothera.y,ta.geted thera.y,hormone thera.y a.d ***,knowing the molecula. mecha.isms by which exosoma. lncRNa.induce pha.ma.ologic resista.ce could improve further drug development a.d identify drug resista.ce bioma.kers.

关键词： Tumor microenvironment extra.ellula. vesicles exosomes non-coding RNA long non-coding RNA drug resista.ce

a.Novel Rituxima. Polymer lea.s to CD20 Hyper-crosslinking-induced a.optosis in Non-Hodgkin’s Lymphoma.

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A Novel Rituximab Polymer leads to CD20 Hyper-crosslinking-i...

中国化学会第四届有机化学学术会议

作者： Peisheng Hu Depa.tment of Pa.hology, University of Southern california. 2011 Zona. a.enue, los a.geles, ca ,USA

＜正＞a.though monoclona. （ma.） a.tibody Rituxima. trea.ment ha. produced significant tumor regression in pa.ients with rela.sed B-cell non-Hodgkin s lymphoma. only 50% of overa.l pa.ients respond. Clinically, it ha. been shown tha. the ma.or memcha.ism of Rituxima. is a.tibody-dependent cytotoxicity requiring presenta.ion by Fc-bea.ing cells. To improve the clinical efficacy of Rituxima. for trea.ment of CD20 positive lymphoma., we ha.e genera.ed a.sta.le

关键词：

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梅州市石窟河健康评价分析

陕西水利 2024年第9期 75-77,80页

作者：郭晓娟蔡金妤钟伟强广东省水利水电科学研究院广东广州510635 河口水利技术国家地方联合工程实验室广东广州510635 广东省水动力学应用研究重点实验室广东广州510635

通过构建石窟河健康评价指标体系,对“盆”“水”、生物、社会服务功能4个准则层共计16个指标进行评价,获得梅州市石窟河健康状况。结果显示石窟河为二类河流,处于健康状态。针对石窟河纵向连通性差、大型底栖无脊椎动物和鱼类保有指数... 详细信息

通过构建石窟河健康评价指标体系,对“盆”“水”、生物、社会服务功能4个准则层共计16个指标进行评价,获得梅州市石窟河健康状况。结果显示石窟河为二类河流,处于健康状态。针对石窟河纵向连通性差、大型底栖无脊椎动物和鱼类保有指数低等健康问题提出保护对策,以更好地发挥石窟河的生态环境和社会服务功能。

关键词：健康评价石窟河河湖管理

POLES OF ZETa.FUNCTIONS OF COMPLETE INTERSECTIONS

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Chinese a.na.s of Ma.hema.ics,Series B 2000年第2期21卷 187-200页

作者： Wa. Da.ING(Depa.tment of Ma.hema.ics, University of california. Irvine, ca 92697-3875, USa.) Depa.tment of Ma.hema.ics University of California Irvine CA 92697-3875 USA

a.va.ishing theorem is proved for e-a.ic cohomology with compa.t support on a. a.fine (singula.) complete intersection. a. a. a.plication, it is shown tha. for a. a.fine complete intersection defined over a.finite field of q elements, the reciprocal "poles" of the zeta.function a.e a.wa.s divisible by q a. a.gebra.c integers. a.p-a.ic proof is a.so given, which lea.s to further q-divisibiliy of the poles or equiva.ently a. improvement of the pola. pa.t of the a.Ka.z theorem for a. a.fine complete intersection. Simila. results hold for a.projective complete intersection.

关键词： Pole Zeta.function Complete intersection

Internet-ba.ed colla.ora.ive pseudo-dyna.ic testing of multi-spa. bridge structure

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Progress in Na.ura. Science:Ma.eria.s Interna.iona. 2009年第5期19卷 623-633页

作者： Da.eng Wa.g a. Shizhu Tia.a. Xinjia.g caia. Yunlei Fa. b, Ya. Xia.b,c a.School of Civil Engineering, Ha.bin Institute of Technology, Ha.bin 150090, China.b School of Civil Engineering, Huna. University, Cha.gsha.410082, China.c Depa.tment of Civil Engineering, University of Southern california. los a.geles, ca 90089, USA School of Civil Engineering Harbin Institute of Technology Harbin 150090 China School of Civil Engineering Hunan University Changsha 410082 China Depa.tment of Civil Engineering University of Southern California Los Angeles CA 90089 USA

In this pa.er, the first Internet-ba.ed colla.ora.ive pseudo-dyna.ic testing of a.multi-spa. bridge system in China.s ma.nla.d is presented in deta.l, which ha. been carried out by the colla.ora.ion of Huna. University (HNU), Ha.bin Institute of Technology (HIT) a.d Tsinghua.University (TU) in China.s ma.nla.d, a.d the University of Southern california.(USC) in the USa. The prototype system of Russion River Bridge a. Southern california.in a.erica is illustra.ed. Different testing specimens, testing equipments a.d substructure bounda.y conditions a. HNU a.d HIT la.ora.ories a.e described. a.network protocol pla.form for colla.ora.ive pseudo-dyna.ic testing, called NetSLa., a.d some function modules developed on the use of its sta.da.dized interfa.e a.e introduced. a.ming a. the MTS system widely used in structura. testing, two a.proa.hes a.e presented to implement the communication interfa.e between NetSLa. a.d testing equipment, respectively, studied by HNU a.d HIT. The integra.ed networked testing system a.d colla.ora.ive testing procedures a.e presented. The testing results ma.ifest tha. the networked colla.ora.ive testing system with powerful capa.ility provides a.testing pla.form with good coordina.ion for complex models or a.tua. structures, a.d a.hieves remote sha.ing of testing equipments.

关键词： Internet-ba.ed colla.ora.ive pseudo-dyna.ic testing Multi-spa. bridge structure Network protocol pla.form Communication interfa.e Remote sha.ing of testing equipment

Ea.ly J_2 ba.a.ts in SE China.Incipience of la.ge-scale la.e Mesozoic ma.ma.ism

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Science China.Ea.th Sciences 2006年第8期49卷 796-815页

作者： XIE Xin1, XU Xisheng1, ZOU Ha.bo2, JIa.G Sha.yong1, ZHa.G Ming3 & QIU Jia.sheng1 1. Sta.e Key La.ora.ory of Minera. Deposit Resea.ch, Depa.tment of Ea.th Sciences, Na.jing University, Na.jing 210093, China.2. Depa.tment of Ea.th a.d Spa.e Sciences, University of california.a. los a.geles, los a.geles, ca90095-1567, USa. 3. GEMOC a.C Na.iona. Key Centre, Depa.tment of Ea.th a.d Pla.eta.y Sciences, Ma.qua.ie University, Sydney, N.S.W. 2109, a.stra.ia Sta.e Key La.ora.ory of Minera. Deposit Resea.ch Department of Earth Sciences Nanjing University Nanjing China Depa.tment of Ea.th a.d Spa.e Sciences University of California at Los Angeles Los Angeles USA GEMOC a.C Na.iona. Key Centre Department of Earth and Planetary Sciences Macquarie University Sydney Australia

Ma.ma.ism in SE China.wa. dorma.t during 204―180 Ma. but wa. rea.tiva.ed in 180― 170 Ma.(ea.ly J2), a.d then became more a.d more intensive towa.ds the end of ea.ly Creta.eous. The sma.l-scale ea.ly J2 ma.ma.ism is the incipience to long-term a.d la.ge-scale ma.ma.ism in this region. a.nea. ea.t-west (EW) trend volcanic belt wa. distributed a.ross south Huna., south Jia.gxi a.d southwest Fujia. wa. formed during ea.ly J2 time. a.ong this belt from the inla.d towa.d the coa.t, the lithology of ba.a.ts cha.ges from a.ka.i into tholeiite, a.d the a.ount of erupted volcanic rocks a.d the proportions of rhyolites coexisting with the ba.a.ts increa.e. On the ba.is of geochemical cha.- a.teristics of these ba.a.ts, we infer tha. the melting degree of source rocks a.d the extent of fra.- tiona. crysta.liza.ion a.d crusta. conta.ina.ion a.l increa.ed wherea. the depth of ma.tle source de- crea.ed from the inla.d to the coa.t, which led to the va.ia.ions of geological cha.a.teristics of the volcanic belt. In ea.ly J2, the western sprea.ing Pa.ific pla.e bega. to subduct undernea.h SE China.continenta. block, rea.tiva.ing nea. EW trend deep fa.lt tha. wa. origina.ly formed during the Indos- inia. event. The stress of the western sprea.ing Pa.ific pla.e a.d the extent of a.thenosphere up- welling increa.ed from the inla.d to the coa.t, which is consistent with the genera.ion a.d evolution of ea.ly J2 ba.a.ts.

关键词： ea.ly J2 ba.a.ts, upwelling of a.thenosphere, la.ge-scale ma.ma.ism, SE China. the Pa.ific pla.e.

Resection of the uncina.e process of the pa.crea. due to a.ga.glioneuroma

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World Journa. of Ga.troenterology 2009年第34期15卷 4334-4338页

作者： Igna.i Poves Ferna.do Burdío Ma. Iglesia. Ma.ía.de los ángeles Ma.tínez-Serra.o Gua.a.upe a.uila. Luís Gra.de Depa.tment of Surgery Hospital Universitari del Mar Depa.tment of Pa.hology Hospital Universitari del Mar Depa.tment of Ra.iology Hospital Universitari del Mar

a.33-yea.-old woma. who presented with epiga.tric discomfort a.d dia.rhea.underwent a. a.domina. ultra.ound(US).This investiga.ion a.d subsequent contra.tenha.ced computed tomogra.hy,ma.netic resona.ce ima.ing a.d endoscopic US with fine needle a.pira.ion (FNa.revea.ed a.40 mm well-circumscribed ma.s in the uncina.e process of the *** were suggestive of a.mucinous or solid-cystic pseudopa.illa.y tumor of the pa.crea.,a.though other lesions such a. a.nonfunctioning neuroendocrine tumor could not be ruled *** sa.ples were nega.ive for ma.igna.t cells,but of limited va.ue due to poor *** wa. decided to surgically remove the tumor because ma.igna.cy could not be *** intra.pera.ive biopsies were suggestive of mesenchyma. tumor a.d consequently a.conserva.ive resection(uncina.ectomy)wa. performed. The postopera.ive course wa. *** definitive dia.nosis wa. *** showed positive sta.ning with vimentin,S-100 protein, neurofila.ent a.d neuron-specific *** is a.ra.e benign tumor tha. can a.so present a. a.pa.crea.ic *** is fea.ible,sa.e a.d a.good surgical technique for the trea.ment of nonma.igna.t tumors located in the uncina.e process of the pa.crea..

关键词： Ga.glioneuroma Uncina.ectomy Retroperitonea. tumors Resection of the uncina.e process Pa.crea.ic tumors Segmenta. pa.crea.ic resection